Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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Diffuse Alveolar Damage Associated with Polymyositis

다발성 근염에 동반된 Diffuse Alveolar Damage 1예

  • Park, Tae-Eung (Department of Internal Medicine, College of Medicine, Soonchunhyang University) ;
  • Lee, Se-Young (Department of Internal Medicine, College of Medicine, Soonchunhyang University) ;
  • Lee, Kwang-Hi (Department of Internal Medicine, College of Medicine, Soonchunhyang University) ;
  • Jung, Sung-Hwan (Department of Internal Medicine, College of Medicine, Soonchunhyang University) ;
  • Uh, Soo-Taek (Department of Internal Medicine, College of Medicine, Soonchunhyang University) ;
  • Lim, Kun-Il (Department of Internal Medicine, College of Medicine, Soonchunhyang University) ;
  • Park, Choon-Sik (Department of Internal Medicine, College of Medicine, Soonchunhyang University) ;
  • Jin, Byung-Won (Department of Internal Medicine, College of Medicine, Soonchunhyang University) ;
  • Park, Jai-Sung (Department of Radiology, College of Medicine, Soonchunhyang University) ;
  • Choi, Deuk-Lin (Department of Radiology, College of Medicine, Soonchunhyang University) ;
  • Jin, So-Young (Department of Pathology, College of Medicine, Soonchunhyang University)
  • 박태응 (순천향대학교 의과대학 내과학교실) ;
  • 이세영 (순천향대학교 의과대학 내과학교실) ;
  • 이광희 (순천향대학교 의과대학 내과학교실) ;
  • 정성환 (순천향대학교 의과대학 내과학교실) ;
  • 어수택 (순천향대학교 의과대학 내과학교실) ;
  • 임건일 (순천향대학교 의과대학 내과학교실) ;
  • 박춘식 (순천향대학교 의과대학 내과학교실) ;
  • 진병원 (순천향대학교 의과대학 내과학교실) ;
  • 박재성 (순천향대학교 의과대학 방사선과학교실) ;
  • 최득린 (순천향대학교 의과대학 방사선과학교실) ;
  • 진소영 (순천향대학교 의과대학 임상병리학교실)
  • Published : 1995.06.30
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Abstract

Interstitial pneumonitis may be the presenting manifestation of polymyositis-dermatomyositis (PM-DM), or may occur later in the evolution of disease. The clinical picture is characterized by non-productive cough, dyspnea and hypoxemia. The chest radiograph demonstrates interstitial infiltrates with predilection for the lung bases, often with an alveolar pattern in addition. We experienced a case of polymyositis associated with diffuse alveolar damage(DAD) that was proven in open lung biopsy. The patient was a 52 year-old woman who was presented with 6 months' duration of generalized ache, edema on ankle and wrist, non-productive cough and mild dyspnea. She had typical symptoms and physical findings of interstitial pneuminitis, and elevated muscle enzyme levels in serum with characteristic histologic findings of myositis on muscle biopsy. She also had typical interstitial lung disease pattern on high resolution CT and restrictive pattern on pulmonary function tests. The findings of open lung biopsy was compatible with diffuse alveolar damage(DAD). She failed to respond to the therapeutic trials with corticosteroid and cyclophosphamide, and finally expired due to acute respiratory distress syndrome.

저자들은 개흉폐조직검사상 확진된 DAD가 병발된 다발성근염환자 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

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