• BMB Reports
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• v.53 no.6
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• pp.299-310
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• 2020

Chronic liver disease progresses through several stages, fatty liver, steatohepatitis, cirrhosis, and eventually, it leads to hepatocellular carcinoma (HCC) over a long period of time. Since a large proportion of patients with HCC are accompanied by cirrhosis, it is considered to be an important factor in the diagnosis of liver cancer. This is because cirrhosis leads to an irreversible harmful effect, but the early stages of chronic liver disease could be reversed to a healthy state. Therefore, the discovery of biomarkers that could identify the early stages of chronic liver disease is important to prevent serious liver damage. Biomarker discovery at liver cancer and cirrhosis has enhanced the development of sequencing technology. Next generation sequencing (NGS) is one of the representative technical innovations in the biological field in the recent decades and it is the most important thing to design for research on what type of sequencing methods are suitable and how to handle the analysis steps for data integration. In this review, we comprehensively summarized NGS techniques for identifying genome, transcriptome, DNA methylome and 3D/4D chromatin structure, and introduced framework of processing data set and integrating multi-omics data for uncovering biomarkers.

• The Journal of Society for e-Business Studies
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• v.15 no.2
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• pp.167-189
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• 2010

As adopting ubiquitous technology into civil engineering, new city model is suggested called U-City. This paper proposes the framework of U-City management center to support effective services operation. The aims of the framework are to provide the development and operation environment for U-City services. Basically, these objectives are achieved by adopting the semantic web service technology to the framework. In this paper, OWL-S is mainly conducted to represent the description of U-City services. In addition, this paper insists that fine grained unit services are required to guarantee reusability, compatibility, and scalability of the services on U-City management center. The documentations conducted by OWL-S are provided as an example of service descriptions. At the last section, this paper also presents the architecture of U-City management center which enables automatic service discovery, selection, composition and interoperation.

• Journal of Korea Society of Industrial Information Systems
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• v.8 no.3
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• pp.19-31
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• 2003

For the implementation of large scale GRID systems, the performance scalability in resource scheduling is clearly to be addressed. In this research, we analyzed existing scheduling frameworks from the viewpoint of the performance and propose a novel resource scheduling framework called resource parameter based scheduling. Proposed scheduling framework consists of three components. The first is the resource parameter graph that expresses resource information via inter-resource relation and the composition base on the hierarchical structure. The second component is the resource parameter tree to be used for the implementation of the memory-based index of resource information. The third component is the resource information repository which mostly consists of static data to be used for the general resource information services. This paper presents the details of the framework.

• Journal of National Security and Military Science
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• s.8
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• pp.271-309
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• 2010

The main theme of this study is about North Korea's contemporary military strategy which remained a blind spot in the 21st century. Indeed, Pyongyang's contemporary military strategy is evolved from the logic of War. On the basis of this logic, this study examined North Korea's contemporary military strategy with three analytical frameworks. The first is the discovery of Clausewitz's dictums and application of the Trinitarian analysis on the Korean cases. During the course of applying Clausewitzian main dictum--War as continuation of politics, the methodological analysis on war played a important role generalizing the pattern and matrix of North Korea's strategic thinking and military strategy. In particular, Clausewitz's Trinitarian framework on war -Government (reason), Army (chance), People (passion)- was a universal framework to scrutinize the North Korean missile and nuclear strategy. The second is about the matrix of North Korea's military strategy, The study suggested the genealogical feature of Pyongyang's military strategy. In principle, the dictum of 'Military-First Politics' 1S the combination of the political philosophy, Chuch'e (self-reliance) of Kim Il Sung and Kin Jong Il reflected in the military readiness. As a result this analysis was able to equate Clausewitz's dictums to explain Pyongyang's idea of the nature of war in that North Korea's military strategy is the central instrument of delivery to achieve political objectives. The third is about the theoretical encounter of 'Clausewitz's Wonderful Trinity' and 'Remarkable Trinity on North Korea's contemporary strategy'. On the basis, three elements are connected to one of three groups in society; the people, the military, and the government. In order to apply the Clausewitz's Trinitarian analysis into Kim Jong Il's 'Military-First' strategy, two case studies (Missile and Nuclear strategy) were examined. The finding of this study is that Clausewitzian dictum in the 19th century is still valid in the 21st century as it provided plausible theoretical framework to explain the North Korean contemporary military strategy with a reminder that the nature and logic of war are fixed in the socially constructed state.

• Journal of KIISE:Computing Practices and Letters
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• v.14 no.2
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• pp.143-157
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• 2008

Ubiquitous Web Services is able to be specified future Web Services technology for connecting with various application services in any device and network environments. The devices, in ubiquitous environment, have dynamic characteristic such as location and statuse. So, we must support methods of dynamic service discovery in ad-hoc network. There are many related works at transaction, security, QoS, semantic and Web Services composition with various fields. Recently, the studies are interested in the Ubiquitous by development of computing and network technology. However, they are an early stage. For this reason, in this paper, we propose a WSUN(Web Services on Universal Networks) for Ubiquitous Web Services. It is a SOA based framework. And this paper extracts necessity of WSUN environment from scenario. The framework is composed of US Broker(Universal Service Broker). It is designed for satisfying the conditions and supports dynamic service discovery using a US Registry (Universal Service Registry). Consequently. clients are able to discover and use Universal Service by protocol stack of the US Broker for Web Services. And it is a strong point which supports interoperability between heterogeneous networks.

• Journal of Intelligence and Information Systems
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• v.16 no.2
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• pp.33-54
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• 2010

The World Wide Web is transitioning from being a mere collection of documents that contain useful information toward providing a collection of services that perform useful tasks. The emerging Web service technology has been envisioned as the next technological wave and is expected to play an important role in this recent transformation of the Web. By providing interoperable interface standards for application-to-application communication, Web services can be combined with component based software development to promote application interaction both within and across enterprises. To make Web services for service-oriented computing operational, it is important that Web service repositories not only be well-structured but also provide efficient tools for developers to find reusable Web service components that meet their needs. As the potential of Web services for service-oriented computing is being widely recognized, the demand for effective Web service discovery mechanisms is concomitantly growing. A number of public Web service repositories have been proposed, but the Web service taxonomy generation has not been satisfactorily addressed. Unfortunately, most existing Web service taxonomies are either too rudimentary to be useful or too hard to be maintained. In this paper, we propose a Web service taxonomy generation framework that combines an artificial neural network based clustering techniques with descriptive label generating and leverages the semantics of the XML-based service specification in WSDL documents. We believe that this is one of the first attempts at applying data mining techniques in the Web service discovery domain. We have developed a prototype system based on the proposed framework using an unsupervised artificial neural network and empirically evaluated the proposed approach and tool using real Web service descriptions drawn from operational Web service repositories. We report on some preliminary results demonstrating the efficacy of the proposed approach.

• Education of Primary School Mathematics
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• v.7 no.2
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• pp.85-99
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• 2003

In this paper, firstly examined various proofs types that cover informal empirical justifications by Balacheff, Miyazaki, and Harel ＆ Sowder and Tall. Using these theoretical frameworks, justification activities by 5th graders were analyzed and several conclusions were drawn as follow: 1) Children in 5th grade could justify using various proofs types and method ranged from external proofs schemes by Harel & Sowder to thought experiment by Balacheff This implies that children in elementary school can justify various mathematical statements of ideas for themselves. To improve children's proving abilities, rich experience for justifying should be provided. 2) Activities that make conjectures from cases then justify should be given to students in order to develop a sense of necessity of formal proof. 3) Children have to understand the meaning and usage of mathematical symbol to advance to formal deductive proofs. 4) New theoretical framework is needed to be established to provide a framework for research on elementary school children's justification activities. Research on proof mainly focused on the type of proof in terms of reasoning and activities involved. But proof types are also influenced by the tasks given. In elementary school, tasks that require physical activities or examples are provided. To develop students'various proof types, tasks that require various justification methods should be provided. 5) Children's justification type were influenced not only by development level but also by the concept they had. 6) Justification activities provide useful situation that assess students'mathematical understanding. 7) Teachers understanding toward role of proof(verification, explanation, communication, discovery, systematization) should be the starting point of proof activities.

• Journal of Communications and Networks
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• v.15 no.3
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• pp.301-311
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• 2013

This paper proposes a policy-based quality of service (QoS) management framework for adaptive routing decisions. We present an approach considering interior gateway protocol (IGP) for path discovery mechanisms and QoS-aware policies for configuring the network elements. The integration of the aforementioned modules into this policy-based network management (PBNM) system is demonstrated by conducting experiments in a real environment, the hellenic public administration network SYZEFXIS. These experiments combine different traffic conditioning mechanisms through event detectors, consider IP service level agreement mechanisms that interoperate with the PBNM system and analyze the enforcement of IGP and QoS policies. Finally, validation and measurement tools are used to prove the efficiency of this framework. It is shown that this architecture offers significantly increased performance and learning capabilities, while the PBNM system achieves adaptive QoS routing through automated configuration considering the avoidance of suboptimal routing issues or under-performance conditions of the network entities.

• Advances in nano research
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• v.9 no.3
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• pp.183-191
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• 2020

The content of this study focuses on bending of flexoelectric Magneto-Electro-Elastic (MEE) nanobeams inserted within the foundation of Winkler-Pasternak according to nonlocal elasticity theory. Applying Hamilton's principle, the nonlocal nanobeams' governing equations in the framework higher order refined beam theory are attained and resolved through adapting an analytical solution. A parametric research is demonstrated for studying the effects that magneto-electro-mechanical loadings, the nonlocal parameter, flexoelectric, as well as the aspect ratio all have on the deflection properties of nanobeams. A discovery lead to beam geometrical parameters, the boundary conditions, flexoelectricity and nonlocal parameter partake substantial effects on nanoscale beams' dimensionless deflection.

• Journal of the Korean Geographical Society
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• v.39 no.3
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• pp.444-456
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• 2004

Recently spatial modeling that combined GIS and Cellular Automata(CA) which are based on dynamic process modeling has been discussed and investigated. However, CA-based spatial modeling in previous research only provides the general modeling framework and environment, but lacks of providing simulation or transition rules for modeling. This study aims to propose a methodology for extracting spatial relation rules using GIS and Knowledge Discovery in Database(KDD) methods. This new methodology has great potentials to improve CA-based spatial modeling and is expected to be applied into several examples including urban growth simulation modeling.