• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.11 no.sup2
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• pp.59-66
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• 2008

Genome-wide association studies using large case-control samples and several hundred thousand genetic markers efficiently and powerfully assay common genetic variations. The application of these studies to inflammatory bowel disease has led to the identification of susceptibility genes and affirmed the importance of innate and adaptive immunity in the pathogenesis of disease. Efforts directed towards the identification of environmental factors have implicated commensal bacteria as determinants of dysregulated immunity and inflammatory bowel disease. Host genetic polymorphisms most likely interact with functional bacterial changes to stimulate aggressive immune responses that lead to chronic tissue injury.

• Korean Journal of Poultry Science
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• v.6 no.1
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• pp.38-46
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• 1979

This study was directed to the Peizootics of Newcastle disease in Korea. Since 1960 New-castle disease epizootics have been observed at an interval of one or two years. The frequency of Newcastle disease outbreaks was related to the amount of the vaccine used, being the more sufficient vaccine produced the fewer outbreaks. Regional distribution of Newcastle disease outbreaks was most frequent in the capital area, being the center of poultry raising and Poultry product marketing, and infrequent in areas distant from the capital. Spreading of Newcastle disease appears to be mainly due to the movement of infected chickens. More than 60 percent of the total outbreaks of Newcastle disease diagnosed at the Veterinary Research Institute in Anyang were observed in young chickens aged less than 60 days. Improper vaccination, interference by maternally derived antibody with the immune response following vaccination, ana immaturity of immune systems of young chickens might have contributed to the results. This view was further supported by the findings that 23 percent of the total flocks experienced Newcastle disease were not vaccinated at all and, in vaccinated flocks, virtually all of the flocks were vaccinated by the drinking water method, which has been known less effective compared to individual application or spraying methods.

• Journal of Power Electronics
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• v.9 no.6
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• pp.919-928
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• 2009

Microgrids (MGs) are typically comprised of distributed generators (DGs) including renewable energy sources (RESs), storage devices and controllable loads, which can operate in either interconnected or isolated mode from the main distribution grid. This paper introduces a novel dynamic programming (DP) approach to MG optimization which takes into consideration the coordination of energy supply in terms of heat and electricity. The DP method has been applied successfully to several cases in power system operations. In this paper, a special emphasis is placed on the uncontrollability of RESs, the constraints of DGs, and the application of demand response (DR) programs such as directed load control (DLC), interruptible/curtaillable (I/C) service, and/or demand-side bidding (DSB) in the deregulated market. Finally, in order to illustrate the optimization results, this approach is applied to a couple of examples of MGs in a certain configuration. The results also show the maximum profit that can be achieved.

• Proceedings of the Korean Information Science Society Conference
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• 2003.10a
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• pp.589-591
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• 2003

현재 대부분 e-Learning에서 이루어지고 있는 교육은 학습(Loaming)이 아닌 단순 훈련(Trainning)만이 이루어지고 있다. e-Learning에서 진정한 학습이 이루어지기 위해서는 학습자의 수준에 맞는 적응적(Adaptive), 적시적(Just-in-Time) 학습이 단편적이 아닌 연속적, 통합적으로 이루어져야 한다. 이를 위해서는 기술적 관점뿐만 아니라, 발견적 학습(heuristic learning)관점에서 학습자원이 기술되고, 컴퓨터(에이전트)가 학습자원의 구성요소인 학습목표(Goal), 학습내용(Content), 학습맥락(Context), 학습구조(Structure), 학습전략(Strategy)의 의미(Semantic)와 관계(Relation)를 이해해 학습자에게 필요한 정보만을 검색, 추론해주고 이를 학습자 수준에 맞게 재가공해 학습자에게 지식(Knowledge)을 적응적(Adaptive), 적시적(Just-in-Time)으로 전달해주는 e-Learning 학습 환경이 필수적이다. 메타데이터(RDF), 온톨로지(Ontology), 에이전트(Agent) 매커니즘의 시멘틱 웹을 e-Learning 환경에 적용함으로써 학습자원의 구성요소의 의미와 관계를 파악해 적응적(Adaptive)으로 지식을 전달해 주어 자기 주도적 학습(Self-directed Loaming)을 실현해 줄 수 있다.

• Journal of the Korea Society for Simulation
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• v.5 no.2
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• pp.25-40
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• 1996

Modeling of systems for intensive knowledge-based processing requires a modeling methodology that makes efficient access to the information in huge data base models. The proposed level access mothodology is a modeling approach applicable to systems where data is stored in a hierarchical and modular modules of active memory cells(processor/memory pairs). It significantly reduces the effort required to create discrete event simulation models constructed in hierarchical, modular fashion for above application. Level access mothodology achieves parallel access to models within the modular, hierarchical modules(clusters) by broadcasting the desired operations(e.g. querying information, storing data and so on) to all the cells below a certain desired hierarchical level. Level access methodology exploits the capabilities of object-oriented programming to provide a flexible communication paradigm that combines port-to-port coupling with name-directed massaging. Several examples are given to illustrate the utility of the methodology.

• Journal of the Korean Institute of Telematics and Electronics
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• v.26 no.10
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• pp.1598-1605
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• 1989

This paper describes an efficient global cell (module) placement strategy called HALO (Hierarchical Alternating Linear Ordering)which generates global 2-D placement of circuit modules by hierarchical application of linear ordering in alternating direction. We tried, in principle, to explain why HALO should perform better than other typical, somehat successful, analytical approaches such as min-cut, force-directed relaxation(FDR)or its likes. We have implemented HALO as a program for standard cell placement. Experimental results on two benchmark circuits, primary and primary 2 consisting of 752 and 2907 cells, respectively have shown a decrease of half-perimeter routing length by 7% and 24%, respectively compared to the best available results obtained so far. Total CPU time including the following detailed placement was less than half of the earlier work.

• Proceedings of the Korean Fiber Society Conference
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• 1998.04a
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• pp.28-31
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• 1998

Photoresponsive polymers are being intensely investigated over last two decades, which can be attributed to both fundamental and applied significance. Presently the attention is being directed to these materials in view of their possible application in nonlinear optics and optoelectronics. It was demnstrated quite early that by covalent fixation of both photochromic group and the mesogenic group to the same polymer main chain high concentration of photochromic group can be attained.(omitted)

• Biomedical Science Letters
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• v.26 no.3
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• pp.136-148
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• 2020

A bispecific antibody (BsAb) is an artificial protein containing two kinds of specific antigen binding sites. BsAb can connect target cells to functional cells or molecules, and thus stimulate a directed immune response. Last several decades a wide variety of bsAb formats and production technologies have been developed. BsAbs are constructed either chemically or biologically, exploiting techniques like cell fusion and recombinant DNA technologies. There are over 100 different formats of bsAb so far developed, but they could be classified into the two main categories such as Fc-based (with a Fc region) bsAbs and fragment-based (without a Fc region) bsAbs. BsAb has a broad application prospect in tumor immunotherapy and drug delivery. Here, we present a brief introduction to the structure of antibody, pharmacological mechanisms of antibodies and the trend in the production technologies of therapeutic antibodies. In addition, we address a review on the current status of various bsAb format development and their production technologies together with global situation in the clinical studies of bsAb.

• Journal of Plant Biotechnology
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• v.5 no.4
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• pp.197-200
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• 2003

Scalable Vector Graphics (SVG) has enabled a visually appealing, browser-based application for the display of Brassica sequences relative to Arabidopsis thaliana, and there are currently more than 70,000 B. napus Expressed Sequence Tags (ESTs) displayed. The client side of this browser is based on a Custom Graphical User Interface (CGUI) library which uses SVG, a new web graphics standard, to provide windowing functionality inside the web browser. This windowing functionality, combined with asynchronous data retrieval and client side rendering overcomes two of the key technology imposed drawbacks of current web based browsers: Fixed displays and frequent page reloads. The end result is an intuitive and enjoyable browsing experience. The browser is accessible online from the Brassica / Arabidopsis Genomics Initiative (http://brassica.agr.gc.ca). Inquiries about the browser should be directed to LewisCT@agr.gc.ca.

• Journal of Korean Medical classics
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• v.23 no.1
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• pp.125-128
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• 2010

The visceral manifestation theory in the "Hwangjenaegyeong(黃帝內經)" was constructed by the reference of the study of Confucian classics which main characteristics is the extensive application of the five phase theory. "Image" plays an important role in the thinking of the Chinese ancient people and it is the basis of the construction of the visceral manifestation theory. "Concept of holism" is the main directed thinking of the "Hwangjenaegyeong(黃帝內經)" "Four seasons, five viscera, Yin yang" theory is the core contents of the visceral manifestation theory in the "Hwangjenaegyeong(黃帝內經)".