• 대한방사선기술학회지:방사선기술과학
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• 제35권4호
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• pp.315-319
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• 2012

본 연구는 위치 민감형 광 증폭 다이오드로부터 나오는 신호를 증폭 및 파형 변화 후 신호의 크기를 검출하여 일정시간 동안 유지시키는 뒷단 회로 개발에 관한 연구이다. 신호발생기에서 발생한 소신호를 증폭 소자를 통한 안정적인 증폭 후 미분회로를 통하여 신호 파형을 검출하기 수월한 형태로 변형 하고, peak/hold 회로에서 피크의 최대점을 일정시간 유지하여 신호의 수집을 원활하게 하였다. 본 회로에 대한 독립적인 성능 평가를 위하여 상용 장비로부터의 검사신호를 입력으로 사용하였다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제26권4호
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• pp.355-362
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• 2000

Neoplastic growth is characterized by alterations of oncogenes and antioncogenes. The interaction between activated oncogenes and functional deletion of antioncogene appears to be the driving force directing normal cells to uncontrolled growth resulting in tumor. In addition to those genes mentioned, other genes controlling the entry of cells into the cell cycle have recently been implicated in cancer development. The overexpression of the cyclin D1 gene, which has been mapped to 11q13, either by gene rearrangement or amplification has been noted in various malignant tumors. The product of the cyclin D1 gene forms a complex with cyclin-dependent protein kinases(CDK4) that governs a key transition in the cell cycle. The relationships between the overexpression of cyclin D1 assessed by immunihistochemistry and the amplification of the cyclin D1 gene by differential polymerase chain reaction(DPCR) using primers for dopamin D2 receptor gene in 13 cases of squamous cell carcinomas of the oral cavity have been studied. The semiquantitative assay of cyclin D1 amplification has been made by cyclin D1/dopamin D2 receptor(CD/DR) ratio. The results were as follows; 1. In the normal tissue and the tumor, the CD/DR ratios were 0.82 and 1.36 respectively. This implicates 1.65-fold amplification of cyclin D1 gene in tumor compared to that in normal tissue. 2. The tumor tissue which showed overexpression of cyclin D1 by immunohistochemistry revealed 2-fold amplification of cyclin D1 compared to the normal tissue. 3. The tumor tissue which showed mild expression of cyclin D1 by immunihistochemistry revealed 1.7-fold amplification of cyclin D compared to the normal tissue. 4. The cyclin D1 was overexpressed in the tumor tissue at the rate of 38%. Above results suggest that cyclin D1 has close correlation with the development of carcinoma in the oral cavity. But further studies were needed to elucidate the carcinogeneic mechanisms by comparative studies among cyclin D1, pRb and p53.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1988년도 전기.전자공학 학술대회 논문집
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• pp.356-359
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• 1988

An FET type urea sensing device has been developed using the ISFET and platinum reference electrode and by employing the differential amplification. The performance characteristics of the fabricated sensor show a good linearity in the urea concentration range of $5{\times}10^{-5}$ to $10^{-3}$g/ml and a stable response.

• 한국광학회지
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• 제25권1호
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• pp.44-49
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• 2014

평판 도파로에서 pump가 체렌코프 복사(Cerenkov radiation)의 파동인 경우, pump, signal, 그리고 idler 사이의 매개적 상호작용에 의한 signal의 증폭현상을 해석하였다. 결합모드 이론을 사용하여 pump의 고갈(depletion)을 무시할 수 있는 경우, 수치적 계산으로 쉽게 풀 수 있는 1차 결합모드 미분방정식을 유도하였다. 이 미분방정식의 근사해와 수치적 계산 예를 통해서 signal이 매개적으로 증폭될 수 있음을 보였다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2002년도 합동 추계학술대회 논문집 정보 및 제어부문
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• pp.517-520
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• 2002

This paper has been studied Operational Amplification Circuit that has high power specification of 90 W is designed. In the input differential amplifier stage, the current source for circuit bias is designed to protect device from high voltage source. the criving state has the voltage gain more than input differential stage. With temperature compensation design, output stage works stable in different to temperature.

• 융합신호처리학회논문지
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• 제2권1호
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• pp.108-112
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• 2001

Heart sound contains rich information regarding the dynamics of the heart and the auscultation has been a first choice of routine procedures for diagnosis of the heart. However, heart sounds captured using a conventional stethoscope are not often loud or clear enough for doctors to precisely classify their characteristics, especially, under the noisy environments of the hospital. A simple auscultation device that removed shortcomings of the conventional stethoscope was constructed in the study. The device employed a polymer based adherent differential output sensor which was on contact with skin through a coupling medium and appropriated electronic circuits for signal amplification and conditioning An ordinary headphone is taken to hear the captured heart sounds and the volume can be adjusted to hear well. It is also possible that the device sends the captured heart sound signals to a PC where the signals are further processed and viualized.

• Journal of Plant Biotechnology
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• 제30권4호
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• pp.307-313
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• 2003

파리지옥풀 first trap leaf에만 발현하는 유전자군을 탐색하기 위하여 기내배양 식물체와 포충능력을 가진 3년생 실생주을 이용하여 각각의 포충잎 (leaf base), 꽃조직 (flower tissue) 및 포충잎트랩 (first trap leaf)으로부터 분리한 RNA로 Fluorescent differential display (FDD)를 실시하였다. First trap leaf특이발현 유전자 15개를 screening하여 염기서열을 분석하였다. 분리된 DNA들은 protease inhibitor (Pl), myo-inositol-1-phosphate synthase 및 lipocalin-type prostaglandin D syn-thase 유전자들과 매우 유사하였다. 또한 Northern blot분석 결과, 이들 유전자들이 first trap leaf에 특이적으로 발현하고 있는 것을 확인하였다 FDD방법은 세포, 조직 및 기관에 특이적으로 발현하고 있는 유전자들을 선발하는데 매우 유용한 수단으로 사용될 수 있다.

• Molecular & Cellular Toxicology
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• 제1권2호
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• pp.92-98
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• 2005

DNA microarray analysis of gene expression in toxicogenomics typically requires relatively large amounts of total RNA. This limits the use of DNA microarray when the sample available is small. To confront this limitation, different methods of linear RNA amplification that generate antisense RNA (aRNA) have been optimized for microarray use. The target preparation strategy using amplified RNA in DNA microarray protocol can be divided into direct-incorporation labeling which resulted in cDNA targets (Cy-dye labeled cDNA from aRNA) and indirect-labeling which resulted in cRNA targets (i.e. Cy-dye labeled aRNA), respectively. However, despite the common use of amplified targets (cDNA or cRNA) from aRNAs, no systemic assessment for the use of amplified targets and bias in terms of hybridization performance has been reported. In this investigation, we have compared the hybridization performance of cRNA targets with cDNA targets from aRNA on a 10 K cDNA microarrays. Under optimized hybridization conditions, we found that 43% of outliers from cDNA technique and 86% from the outlier genes were reproducibly detected by both targets hybridization onto cDNA microarray. This suggests that the cRNA labeling method may have a reduced capacity for detecting the differential gene expression when compared to the cDNA target preparation. However, further validation of this discordant result should be pursued to determine which techniques possesses better accuracy in identifying truly differential genes.

• 한국토양환경학회지
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• 제5권1호
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• pp.3-12
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• 2000

다영역 모델은 Preferential 흐름에 대한 해석을 위하여 토양을 여러개의 공극군으로 나누고 각 토양의 수리학적 특성을 이용하여 토양내의 흐름을 표현한 방정식이다. 이 모델을 유한차분법을 이용하여 수치적으로 풀이할 때 해의 정확도와 일관성을 분석하기위해 수정등가편미분방정식(MEPDE)을 구하고, 안정성을 분석하기위해 Von Neumann법을 이용한다. 수정등가편미분방정식을 이용하여 얻은 유한차분계에 대한 평가는 모델방정식에 대하여 일관성이 있는 것으로 나타났고 모델방정식에 대한 유한차분법은 2차의 정확도를 얻었다. 모델방정식의 안정성 해석은 Von Neumann방법을 이용하여 진폭도와 위상지연을 구하고 이를 분석하였다. 유한차분계의 진폭비는 Peclet수의 변화에 관계없이 비분산적이었으며 Peclet수가 1.0일때 가장 큰 값을 나타냈고, 위상지연은 참값에 대한 빈도요소보다 더 느리게 파동함을 나타냈다. 모델방정식의 안정성 해석 결과, 모델의 영역분해는 보다 정확한 결과를 얻기 위해서 Peclet수는 1.0보다 작고 Courant수는 3.0보다 작은 범위 안에서 분해하는 것이 좋은 것으로 분석된다.

• 한국소음진동공학회논문집
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• 제14권4호
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• pp.352-357
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• 2004

This paper studies the errors that associated with particle velocity and intensity in a space. We theoretically derived their bias error and random error. The analysis shows that the more samples do not always guarantee the better results. The random error of the velocity and intensity are increased when we have many samples. The characteristics of the amplification of the random error are analyzed in terms of the sample spacing. The amplification was found to be related to the spatial differential of random noise. The numerical simulations are performed to verify theoretical results.