• Journal of Sensor Science and Technology
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• v.18 no.1
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• pp.33-41
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• 2009

A multilevel acoustic Fresnel lens (MAFL) for the ultrasonic imaging transducer of which center frequency is approximately 5.MHz was newly designed and fabricated. The phase level of the lens was 64, and the focal length and the aperture width were 30.mm and 11.mm, respectively. The characteristics of impulse response, acoustic field and imaging performance of the transducer attached the lens were compared with the transducer attached a conventional refraction type acoustic lens (RAL). The results show that the center frequency, the loop sensitivity, and the focal depth of the MAFL transducer were higher or larger than those of the RAL transducer by approximately 0.2.MHz, 1.4.dB, and 2.mm, respectively. Consequently, it was shown that the brighter acoustic images with higher lateral resolution and the increased imaging performance for deep targets can be obtained by using the MAFL transducer.

• Archives of Plastic Surgery
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• v.42 no.5
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• pp.626-629
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• 2015

Peripheral nerve injuries remain a challenge for reconstructive surgeons with many patients obtaining suboptimal results. Understanding the level of injury is imperative for successful repair. Current methods for distinguishing healthy from damaged nerve are time consuming and possess limited efficacy. Confocal laser endomicroscopy (CLE) is an emerging optical biopsy technology that enables dynamic, high resolution, sub-surface imaging of live tissue. Porcine sciatic nerve was either left undamaged or briefly clamped to simulate injury. Diluted fluorescein was applied topically to the nerve. CLE imaging was performed by direct contact of the probe with nerve tissue. Images representative of both damaged and undamaged nerve fibers were collected and compared to routine H&E histology. Optical biopsy of undamaged nerve revealed bands of longitudinal nerve fibers, distinct from surrounding adipose and connective tissue. When damaged, these bands appear truncated and terminate in blebs of opacity. H&E staining revealed similar features in damaged nerve fibers. These results prompt development of a protocol for imaging peripheral nerves intraoperatively. To this end, improving surgeons' ability to understand the level of injury through real-time imaging will allow for faster and more informed operative decisions than the current standard permits.

• Journal of radiological science and technology
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• v.43 no.4
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• pp.243-249
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• 2020

Examination with medical radiography is the most significant advances in medicine in the 21st century. Diagnostic imaging occupies an important position in all medical subjects, surgical and internal medicine, including radiology, orthopedics, and neurosurgery. However, the invention associated with conventional radiography devices has focused only on emphasizing the efficient aspects of the examination or obtaining clearer images without considering the age and disease-induced constraints of the patient's posture. The newly developed X-ray aids to solve this problem can effectively perform X-ray imaging of children's who have difficulty communicating and controlling. It is also thought to be a good way to provide accurate imaging information and minimize radiation exposure for children.

• Journal of radiological science and technology
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• v.35 no.4
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• pp.321-326
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• 2012

Used as an ingredient in the hospital for orthopedic prosthetic stainless and titanium metal the same size as on the MRI diagnostic value of imaging were compared. Center of images, background high band portion of the video signal is converted into a weighted intensity values Normal images and compared. The area of normal slice and also the distortion of images and cross-sectional imaging of a range of quantitative and sagittal planes were compared. As a result, the periphery high band signal intensity values of Stainless video phantom 2, pig bone 1.8, Titanium imaging of phantom 1.7 has higher value than Normal video pig bone 1.3 times the signal strength rivers. MRI distortion of the shape and the distortions of the range, if the cross-sectional area compared to Normal Slice Stainless case of phantom 65.8 %, pig bone 61.5 %, Titanium distortion phantom 23.1 %, pig bone 38.5 % of the range of community found. In this experiment, as a result, MRI was found to be Titanium more diagnostic value than the specimen with respect to the signal intensity weighted value and low distortion range, Stainless.

• Journal of Industrial Technology
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• v.28 no.B
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• pp.129-133
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• 2008

A method to reduce seam line artifact in spatial compounding of ultrasonic images is presented. Spatial compounding is a speckle reducing imaging technique in which a number of ultrasound images of a given target that have been obtained from multiple view angles are combined into a single compounded image by combining the data received from each data point in the compounded image. Since different view angle results in different view area, and the images of different view arms are combined into an image, the compounded image consists of regions with different signal to noise ratio, and the boundary lines between these regions are visible as seam lines in the compounded images. In this paper, we present an algorithm that reduces the visibility of this seam line in the spatially compounded images. Design procedure for a FIH filter is described and the results of applying the filter to in-vivo ultrasonic images are analyzed.

• Nuclear Medicine and Molecular Imaging
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• v.42 no.2
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• pp.83-87
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• 2008

Diagnostic and functional imaging device have been developed independently. The recognition that combining of these two devices can provide better diagnostic outcomes by fusing anatomical and functional images. The representative examples of combining devices would be PET/CT and SPECT/CT. Development and their applications of animal imaging and instrumentation have been very active, as new drug development with advanced imaging device has been increased. The development of advanced imaging device resulted in researching and developing for detector technology and imaging systems. It also contributed to develop a new software, reconstruction algorithm, correction methods for physical factors, image quantitation, computer simulation, kinetic modeling, dosimetry, and correction for motion artifacts. Recently, development of MRI and PET by combining them together was reported. True integration of MRI and PET has been making the progress and their results were reported. The recent status of imaging and instrumentation in nuclear medicine is reported in this paper.

• Korean Journal of Radiology
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• v.25 no.8
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• pp.742-748
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• 2024

Objective: ¹⁸F-N-(2-(Diethylamino)ethyl)-5-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy) picolinamide (¹⁸F-PFPN) is a novel positron emission tomography (PET) probe designed to specifically targets melanin. This study aimed to evaluate the diagnostic feasibility of ¹⁸F-PFPN in patients with ocular or orbital melanoma. Materials and Methods: Three patients with pathologically confirmed ocular or orbital melanoma (one male, two females; age 41-59 years) were retrospectively reviewed. Each patient underwent comprehensive ¹⁸F-PFPN and ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) PET scans. The maximum standardized uptake value (SUV_max) of the lesion and the interference caused by background tissue were compared between ¹⁸F-PFPN and ¹⁸F-FDG PET imaging. In addition, the effect of intrinsic pigments in the uvea and retina on the interpretation of the results was examined. The contralateral non-tumorous eye of each patient served as a control. Results: All primary tumors (3/3) were detected using ¹⁸F-PFPN PET, while only two primary tumors were detected using ¹⁸F-FDG PET. Within each lesion, the SUV_max of ¹⁸F-PFPN was 2.6 to 8.3 times higher than that of ¹⁸F-FDG. Regarding the quality of PET imaging, the physiological uptake of ¹⁸F-FDG PET in the brain and periocular tissues limited the imaging of tumors. However, ¹⁸F-PFPN PET minimized this interference. Notably, intrinsic pigments in the uvea and retina did not cause abnormal concentrations of ¹⁸F-PFPN, as no anomalous uptake of ¹⁸F-PFPN was detected in the healthy contralateral eyes. Conclusion: Compared to ¹⁸F-FDG, ¹⁸F-PFPN demonstrated higher detection rates for ocular and orbital melanomas with minimal interference from surrounding tissues. This suggests that ¹⁸F-PFPN could be a promising clinical diagnostic tool for distinguishing malignant melanoma from benign pigmentation in ocular and orbital melanomas.

• Journal of the Microelectronics and Packaging Society
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• v.29 no.4
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• pp.55-61
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• 2022

There is a major interest in diagnostic technology for multiple cancers worldwide. In order to reduce the difficulty of cancer diagnosis, a liquid biopsy technology based on a microfluidic device using trace amounts of biofluids such as blood is being studied. And optical biosensing, which measures the concentration of analytes through fluorescence imaging using biofluids, requires various strategies to improve sensitivity, and specialists and equipment are needed to carry out these strategies. This leads to an increase in diagnostic and production costs, and it is necessary to develop a technology to solve this problem. In this paper, we design and propose a fluorescent multi-cancer diagnostic sensing platform structure that implements passive self-separation technology and molecular recognition activation functions by fluid mixing, only with the geometry and microfluidic phenomena of microchannels based on self-driven flow by capillary force. In order to check the parameters affecting the performance of the plasma separation part of the designed sensor, the hydrodynamic diameter of the channel and the viscosity of the fluid were set as variables to confirm the formation of plasma separation flow through simulation. And finally, we propose an optimal sensor platform structure.

• Korean Journal of Radiology
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• v.24 no.11
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• pp.1131-1141
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• 2023

Objective: Cortical iron deposition has recently been shown to occur in Alzheimer's disease (AD). In this study, we aimed to evaluate how cortical gray matter iron, measured using quantitative susceptibility mapping (QSM), differs in the clinical cognitive impairment spectrum. Materials and Methods: This retrospective study evaluated 73 participants (mean age ± standard deviation, 66.7 ± 7.6 years; 52 females and 21 males) with normal cognition (NC), 158 patients with mild cognitive impairment (MCI), and 48 patients with AD dementia. The participants underwent brain magnetic resonance imaging using a three-dimensional multi-dynamic multi-echo sequence on a 3-T scanner. We employed a deep neural network (QSMnet+) and used automatic segmentation software based on FreeSurfer v6.0 to extract anatomical labels and volumes of interest in the cortex. We used analysis of covariance to investigate the differences in susceptibility among the clinical diagnostic groups in each brain region. Multivariable linear regression analysis was performed to study the association between susceptibility values and cognitive scores including the Mini-Mental State Examination (MMSE). Results: Among the three groups, the frontal (P < 0.001), temporal (P = 0.004), parietal (P = 0.001), occipital (P < 0.001), and cingulate cortices (P < 0.001) showed a higher mean susceptibility in patients with MCI and AD than in NC subjects. In the combined MCI and AD group, the mean susceptibility in the cingulate cortex (β = -216.21, P = 0.019) and insular cortex (β = -276.65, P = 0.001) were significant independent predictors of MMSE scores after correcting for age, sex, education, regional volume, and APOE4 carrier status. Conclusion: Iron deposition in the cortex, as measured by QSMnet+, was higher in patients with AD and MCI than in NC participants. Iron deposition in the cingulate and insular cortices may be an early imaging marker of cognitive impairment related neurodegeneration.

• Korean Journal of Digital Imaging in Medicine
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• v.7 no.1
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• pp.33-38
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• 2005

Modern hospitals have been greatly facilitated with information technology (IT) such as hospital information system (HIS). One of the most prominent achievements is medical imaging and image data management so-called Picture Archiving and Communication Systems (PACS). Due to inevitable use of diagnostic images (such as X-ray, CT, MRI), PACS made tremendous impact not only on radiology department but also nearly all clinical departments for exchange and sharing image related clinical information. There is no doubt that better use of PACS leads to highly efficient clinical administration and hospital management. However, due to rapid and widespread acceptance of PACS storage and management of digitized image data in hospital introduces overhead and bottleneck when transferring images among clinical departments within and/or across hospitals. Despite numerous technical difficulties, financing for installing PACS is a major hindrance to overcome. In addition, a mirroring or a clustering backup can be used to maximize security and efficiency, which may not be considered as cost-effective approach because of extra hardware expenses. In this study therefore we have developed a new based on grid of distributed PACS in order to balance between the cost and network performance among multiple hospitals.