• Child Health Nursing Research
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• v.16 no.2
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• pp.164-174
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• 2010

Purpose: The purpose of this study was to evaluate the physical growth and developmental status of infants and children of married immigrant women. Methods: The participants were 92 infants and children aged from birth to 6 yr whose mothers were married immigrant women living in one rural area. Physical growth and developmental status were evaluated by using anthropometric assessment, and Korean Denver II developmental screening test. Results: Of the participants, 10.8% were below the 3rd percentile for weight, 13.0% for length, 5.4% for head circumference, and from 69.6% to 79.3% were distributed below the 50th percentile on growth charts. Further, 18.5% were classified as having questionable development. Factors related to low physical growth in infants and children were mother's weight and mother's level in Korean language classes. Conclusion: The physical growth and developmental status of children is vulnerable and serious. The study results suggest a need for regular growth and developmental evaluations. Political support is important for these mothers. In addition, there also is a need to develop early intervention strategies to promote growth and development of the infants and children of these married immigrant women.

• The Journal of Korean Academy of Sensory Integration
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• v.1 no.1
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• pp.1-8
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• 2003

Objective : To describe the sensory-based behaviors of children with developmental disorders as reported on the JSI-2. Methods : The scores of children with disability were compared with those of children without disability. JSI-2 was completed by parents of 38 children with disability 3 through 6 years of age and 36 children without disability 3 through 6 years of age. Results : The scores of children with disability were significantly different from that of children without disability for 6 of 8 factors, including vestibular, tactile, auditory, visual and other. There is no significant differences of age or sex. Conclusion : From this study, it is found that children with disability have deficit in a variety of sensory processing abilities as measured by JSI-2. Further research is needed to replicate and develop these findings.

• Journal of Families and Better Life
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• v.22 no.2
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• pp.13-21
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• 2004

This study examined the role of maternal attribution in parenting behaviors of mothers who have a child with developmental disabilities. Using an attributional model, it assessed whether maternal attributions about the child's knowledge, capacity, expectation, and responsibility for behavior problems have effects on maternal behaviors of affect, authoritarian control, and overprotect. The sample consisted of 161 mothers of elementary children with developmental disabilities. Multivariate regression analysis revealed that maternal attribution about the child's capacity for misbehavior had positive influence on maternal affect and negative influence on authoritarian control behaviors, and that maternal attribution of responsibility for misbehavior positively influenced maternal authoritarian control and overprotect behaviors. Also, maternal attribution about the child's knowledge for misbehavior had negative influence on maternal overprotect behaviors. In addition, such background factors as number of disability, maternal education, and job of mother were significant predictors for maternal attribution, while maternal self-esteem was a strong significant predictor for mothering behaviors. The findings suggest the importance of maternal attributions in parenting.

• Reproductive and Developmental Biology
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• v.30 no.2
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• pp.75-79
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• 2006

The developmental regulation of the preimplantation mammalian embryos is a fundamental step for preparing the implantation and it may be regulated by several autocrine and paracrine factors including platelet-activating factor. PAF improved the embryonic survival and implantation but its role during blastocyst development is still largely unknown. In this study, the effects and the possible pathway of PAF on developmental regulation of blastocyst to hatching stage were investigated. Developmental pattern in hatching embryo was a concentration-response curve showing maximal activity at 1 nM PAF, with decreasing activity at higher concentrations. $50{\mu}M$ 1-(5-isoquinolimnesulfonyl)-2-methylpiperazinme dihydrochloride (H-7), a PKC inhibitor, inhibited the progression of blastocyst to hatching embryo. In addition H-7 blocked the PAF effects on the blastocyst development. Besides tetradecanoylphorbol acetate (TPA), a PKC activator stimulated development of blastocyst to the hatching stage. These finding revealed that PAF support the blastocyst development to the hatching embryo. Also it is suggested that PAF action pathways in hatching supporting include the PKC signaling pathway.

• Korean Journal of Child Studies
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• v.26 no.6
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• pp.29-43
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• 2005

Emotional intelligence is a relatively new concept and little research to date has examined age differences. In order to examine developmental patterns in emotional intelligence(En, the Emotional Intelligence Test for Children(EITC, Lee, 2003) was administered to 367 children, 4- to 8-years of age. Data were analyzed by Multivariate Analysis of Variance(MANOVA) and post hoc univariate analyses of variables. Results showed significant differences by age in total and sub-total scores of EITC. When the means of test scores were presented graphically as developmental curves, EI totals and sub-scores showed the increases in EI that occurred with increased maturity. Additional research is needed to verify developmental models of EI and to explore which factors have an effect on EI.

• Korean Journal of Animal Reproduction
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• v.27 no.4
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• pp.349-357
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• 2003

Although nuclear transfer (NT) techniques are used to clone animals, its efficiency is very low. Moreover, nuclear transfer has resulted in offspring with severe developmental problems, probably due to incomplete nuclear reprogramming. Nuclear reprogramming is characterized by functional modification of the transferred nucleus to allow it to direct normal embryo development with the potential to grow to term. Although the nature of the reprogramming factor(s) in mammals is not clear, various nuclear as well as cytoplasmic components are involved in the processes. In this article we review recent data on factors involved in the nuclear reprogramming of cloned embryos.

• Perspectives in Nursing Science
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• v.8 no.2
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• pp.156-166
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• 2011

Purpose: The purpose of this study was to understand the process of exercise adherence in middle aged women. Methods: The qualitative theme analysis method was used. The participants were 11 middle-aged women who had exercised over 6 months. Data were collected through in-depth interviews and recorded by and transcribed immediately. The data were coded with similar meaning and analysis themes with the constant comparative method. Results: The core theme was Stepping Stones Across the Stream (SSAS). The Stone means the adherence factors in exercise. The stream means the interrupting factors in exercise adherence. The subcategories were 1) feeling of developmental crisis, 2) searching for exit (from the developmental crisis), 3) finding a surprising new world (full of fun), 4) confronting the situation of dropout, and 5) adherence to exercise by SSAS. Conclusion: The predisposition of fun in middle aged women for the adherence of exercise should be explored along with more adherent factors.

• Asian-Australasian Journal of Animal Sciences
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• v.28 no.12
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• pp.1721-1728
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• 2015

Embryonic stem cells (ESCs) have been used as a powerful tool for research including gene manipulated animal models and the study of developmental gene regulation. Among the critical regulatory factors that maintain the pluripotency and self-renewal of undifferentiated ESCs, NANOG plays a very important role. Nevertheless, because pluripotency maintaining factors and specific markers for livestock ESCs have not yet been probed, few studies of the NANOG gene from domestic animals including bovine have been reported. Therefore, we chose mouse ESCs in order to understand and compare NANOG expression between bovine, human, and mouse during ESCs differentiation. We cloned a 600 bp (-420/+181) bovine NANOG 5'-flanking region, and tagged it with humanized recombinant green fluorescent protein (hrGFP) as a tracing reporter. Very high GFP expression for bovine NANOG promoter was observed in the mouse ESC line. GFP expression was monitored upon ESC differentiation and was gradually reduced along with differentiation toward neurons and adipocyte cells. Activity of bovine NANOG (-420/+181) promoter was compared with already known mouse and human NANOG promoters in mouse ESC and they were likely to show a similar pattern of regulation. In conclusion, bovine NANOG 5-flanking region functions in mouse ES cells and has characteristics similar to those of mouse and human. These results suggest that bovine gene function studied in mouse ES cells should be evaluated and extrapolated for application to characterization of bovine ES cells.

• Child Health Nursing Research
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• v.22 no.3
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• pp.199-206
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• 2016

Purpose: This study was conducted to monitor the development of Korean premature infant at six-month age and to explore factors related to developmental status of the premature infants. Methods: Participants were 58 premature infants whose corrected age was six-months old and their mothers. The developmental states of infants were followed-up with the Korean Prescreening Developmental Questionnaire (KPDQ-II). Clinical characteristics of the infants were identified from the medical records. Other characteristics including Edinburgh Postnatal Depression Scale, husband's support, social support, and mother-infant attachment were assessed using self-report questionnaires from the mothers. Results: Forty three percent of the infants were in the group of questionable status of development on the KPDQ-II. There were significant differences between the premature infants with normal developmental status and those with questionable developmental status depending on gender ($x^2$=5.03, p=.034), gestational age (t=2.59, p=.012), hospital stay (p=.013), revised Neurobiologic Risk Score (p=.005) and mother-infant attachment score (t=2.12, p=.040). Conclusion: Mother-infant attachment, as well as physiological state of premature infants, is an important variable in early development. Therefore, early monitoring for the development has to be done for physiologically vulnerable premature groups. Also, providing proper nursing support to improve maternal attachment needs to be considered.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.33 no.1
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• pp.16-23
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• 2022

Objectives: Early detection of developmental issues in infants and necessary intervention are important. To identify the comorbid conditions, a comprehensive evaluation is required. The study's objectives were to 1) generate scale items by identifying and eliciting concepts relevant to young children (12-71 months) with developmental delays, 2) develop a comprehensive screening tool for developmental delay and comorbid conditions, and 3) assess the tool's validity and cut-off. Methods: Multidisciplinary experts devised the "Infant Comprehensive Evaluation for Neurodevelopmental Delay (ICEND)," an assessment method that comes in two versions depending on the age of the child: 12-36 months and 37-71 months, through monthly seminars and focused group interviews. The ICEND is composed of three parts: risk factors, resilience factors, and clinical scales. In parts 1 and 2, there were 41 caretakers responded to the questionnaires. Part 3 involved clinicians evaluating ten subscales using 98 and 114 questionnaires for younger and older versions, respectively. The Child Behavior Checklist, Strengths and Difficulties Questionnaire, Infant-Toddler Social Emotional Assessment, and Korean Developmental Screening Test for Infants and Children were employed to analyze concurrent validity with the ICEND. The analyses were performed on both typical and high-risk infants to identify concurrent validity, reliability, and cut-off scores. Results: A total of 296 people participated in the study, with 57 of them being high-risk (19.2%). The Cronbach's alpha was positive (0.533-0.928). In the majority of domains, the ICEND demonstrated a fair discriminatory ability, with a sensitivity of 0.5-0.7 and specificity 0.7-0.9. Conclusion: The ICEND is reliable and valid, indicating its potential as an auxiliary tool for assessing neurodevelopmental delay and comorbid conditions in children aged 12-36 months and 37-71 months.