• 대한상한금궤의학회지
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• 제13권1호
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• pp.121-132
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• 2021

Objective: This study aimed to report the improvement in a patient with allergic contact dermatitis treated with Sihogyeji-tang based on the Shanghanlun disease pattern identification diagnostic system (DPIDS). Methods: According to the Shanghanlun DPIDS, the patient with allergic contact dermatitis was diagnosed with greater yang disease chest bind (Shanghanlun provision 146), and was administered Sihogyeji-tang for 90 days. The results were evaluated using the Dermatological Life Quality Index (DLQI) and a visual analog scale (VAS). Results: After taking Sihogyeji-tang for 90 days, the DLQI decreased from 28 points to 8 points and the VAS decreased from 10 points to 3 points. Conclusions: This case shows the potential of treatment through herbal medicine for allergic contact dermatitis using the Shanghanlun DPIDS.

• Clinical and Experimental Vaccine Research
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• 제12권1호
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• pp.80-81
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• 2023

This study aimed to evaluate if patients under biologics have a lower risk of psoriasis flares after coronavirus disease 2019 (COVID-19) vaccination than other psoriatic patients. Of 322 recently vaccinated patients admitted for psoriasis at the Dermatological Psoriasis Unit during January and February 2022, 316 (98%) had no psoriasis flares after COVID-19 vaccination (79% under biologic treatment, 21% not biologically treated) and 6 (2%) presented psoriasis flares after COVID-19 vaccination (33.3% under biologic treatment, 66.6% not biologically treated). Overall, psoriasis patients under biologic treatment, developed fewer psoriasis flares after COVID-19 vaccination (33.3%), than patients not under biologic treatment (66.6%) (p=0.0207; Fisher's exact test).

• 사상체질의학회지
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• 제11권1호
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• pp.119-135
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• 1999

본 연구(硏究)는 1996.3월(月)에서 1998.11월(月)사이에 동의대학교(東義大學校) 한의과대학(韓醫科大學) 부속한방병원(附屬韓方病院)에 내원(來院) 가료중(加療中) 환자(患者) 196명을 대상(對象)으로 하였으며 사상체질(四象體質)의 판별(判別)은 사상변증내용(四象辨證內容) 설문조사지(設問調査紙)(I)과 사상체질분류검사(象體質分類檢査)(QSCCII)를 중심으로 하였다. 본 결과는 사상체질(四象體質)과 질병(疾病) 및 증상유형(症狀類形)에 대한 설문지(說問紙)를 비교하여 얻은 것이다. 1. 태음인(太陰인)은 체중증가(體重增加), 땀이 많이 난다. 몸이 붓는다. 허리가 아프다는 증상(症狀)과 기름진 음식(飮食)을 잘 먹으며 음식(飮食)을 짜게 먹는 편이 다른 체질(體質)에 비하여 더욱 유발(頻發)하였다. 2. 소음인(少陰인)은 안색이 나쁘다. 목의 이물감, 수면장애(睡眠障碍) 식욕감퇴(食慾減退), 쉽게 피로(疲勞)해짐, 식사(食事)와 무관한 위(胃)의 통증(痛症), 두통(頭痛), 생리통증상(生理痛症狀)과 기름진 음식(飮食)을 잘 안 먹는다. 음식(飮食)을 싱겁게 먹는 편이 다른 체질(體質)에 비하여 더욱 유발(頻發)하였다. 3. 통계적(統計的)으로 유의성(有意性)을 가지지는 못하였지만, 소양인(少陽人)은 호흡기계질환(呼吸器系疾患)에서 단순한 기침증상(症狀) 근골격계질환(筋骨格系疾患)에서 관절(關節)의 운동장애(運動障碍), 부인과계(歸人科系)에서 월경(月經)의 조기(調期)와 양(量)의 변화(變化)와 생식기(生殖器) 소양증(搔痒症), 피부계(皮膚系)에서 가려움증과 부스럼증 등은 다른 체질(體質)에 비하여 비교적 많았고 심혈관계질환(心血管系疾患), 혈액계질환(血液系疾患)은 비교적 적었다. 소음인(少陰人)은 전반적(全般的)인 소화기계질환(消化器系疾患), 호흡기계질환(呼吸器系疾患)에서 인흡(咽吸)의 이물감 통증, 심혈관계질환(心血管系疾患), 혈액계질환(血液系疾患), 근골격계질환(筋骨格系疾患)에서 통증(痛症)이나 비증(痺症), 정신신경계질환(精神神經系疾患)에서 정신계질환(精神系疾患), 부인과계(婦人科系)에서 월경통(月經痛)을 비롯한 유방(乳房)의 몽우리 냉증(冷症), 피부계(皮膚系)에서 발진(發疹)이나 두드러기, 시각계질환(視覺系疾患)과 청각계질환(聽覺系疾患)등이 다른 체질(體質)에 비해 많았다. 태음인(太陰人) 호흡기계질환(呼吸器系疾患)에서 목이 잘 쉬는 증상, 근골격계질환(筋骨格系疾患)에서 요통(腰痛), 정신신경계질환(精神神經系疾患)에서 신경계질환(神經系疾患), 피부계(皮膚系)에서 발진(發疹)이나 두드러기등이 다른 체질(體質)에 비하여 다소 많았으며 부인과계질환(婦人科系疾患)은 적었다.

• 대한화장품학회지
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• 제38권1호
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• pp.51-55
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• 2012

포름알데히드는 그 자체가 보존제로 또는 다른 보존제로부터 유리된 형태로 화장품에 일반적으로 존재한다. 포름알데히드는 낮은 농도로도 민감한 피부 반응을 일으킬 수 있으므로 화장품에서 그 사용을 규제하고 있다. 본 연구에서는 팩 및 마스크와 같은 화장품 114 품목을 시중에서 구입하여 포름알데히드의 함량을 분석하였다. 검사 품목의 36%에서 $0.3{\sim}9.7{\mu}g/mL$ (ppm) 수준의 포름알데히드가 검출되었다. 포름알데히드 유리 보존제를 함유한다고 표시되어 있는 12개 제품의 포름알데히드 함량을 조사하였다. Imidazolidinyl urea를 사용한 화장품 10품목과 1,3-Dimethylol-5,5-dimethylhydantoin (DMDM hyantoin)을 사용한 화장품 2품목에서 평균 $1.7{\mu}g/mL$ (ppm)의 포름알데히드가 검출되었다. 식품의약품안전청 고시 최대 허용 포름알데히드 농도 0.2 % (2,000 ppm)을 고려할 때, 이번 조사에서 분석한 화장품에서는 비교적 낮은 수준의 포름알데히드 함량을 보였다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6357-6362
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• 2014

Background: Globally, the overall incidence of cancer is increasing as a result of ageing populations and changing lifestyles. Cancer is one of the leading causes of death, especially in the developed nations. Cancers affecting the young population are generally considered uncommon. This study assessed the demography and trends of cancers of the young in Brunei Darussalam, a small and developing Southeast Asia nation. Materials and Methods: All patients diagnosed with cancers between 2000 and 2012 were identified from the cancer registry maintained by the State Histopathology Laboratory. Cancers of the young was defined as any cancers diagnosed under the age of 40 years. Demographic data and the type of cancers were collected and analysed using SPSS Statistics 17.0. Results: Among the 6,460 patients diagnosed with cancer over the study period, 18.7% (n=1,205) were categorized as young with an overall decline in the proportion from 26.6% in 2000 to 18.8% in 2012 (p<0.001 for trend). Among all cancers of the young, the most common systems affected were gynecological (24.1%), hematological/lymphatic (15.8%), subcutaneous/dermatological/ musculoskeletal (10.5%), breast (10.5%) and gastrointestinal (9.9%). Overall, among the different systems, neurological (54.9%) had the highest proportion of cancers of the young followed by gynecological/reproductive (30.6%), hematological/lymphatic (39.9%), endocrine (38.7%), subcutaneous/dermatological/ musculoskeletal (22.3%) and the head and neck region (20.1%). There was a female predominance (66.9%) and the incidence was significantly higher among the Malays (20.1%) and expatriates (25.1%) groups compared to the Chinese (10.7%) and indigenous (16.8%) groups (p<0.001 for trend). Conclusions: Cancers of the young (<40 years) accounted for almost a fifth of all cancers in Brunei Darussalam with certain organ systems more strongly affected. There was a female preponderance in all racial groups. Over the years, there has been a decline in the overall proportion of cancers of the young. Selective screening programs should nevertheless be considered.

• 대한임상검사과학회지
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• 제37권2호
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• pp.118-122
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• 2005

An epidemiological study was performed on zoophilic dermatophytes. The number of patients with zoophilic dermatophytes diagnosed on clinical findings and culture at the Catholic Dermatological Clinic in Daegu City were 1,339 for 10 years from January 1995 to December 2004. Species of zoophilic dermatophytes isolated from 47,925 patients with dermatophytes were as follows; Trichophyton(T.) rubrum was isolated from 43,702 (91.2%), T. interdigitale 2,660 (5.6%), Epidermophyton(E.) floccosum 43 (0.1%), T. tonsurans 131 (0.3%), T. mentagrophytes 625 (1.3%), T. verrucosum 56 (0.2%), Microsporum(M.) canis 658 (1.4%), and M. gypseum 50 (0.1%). Zoophilic dermatophytes infections were chiefly Tinea facial in the cases of T. mentagrphytes and Tinea corporis in the cases of T. verrucosum, but Tinea capitis in the cases of M. canis. Number of patients with zoophilic dermatophytes by site and age were as follows; Most patients with infected scalps were young people under 15 years old. Infection of the trunk area (neck,chest,back) and extremities (arms, legs, hands, feet) were relatively high in those patients over 15 years old. M. canis were most frequently isolated in autumn and winter, and T. mentagrophyts and T. verrucosum were mostly in spring and winter.

• BMB Reports
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• 제45권3호
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• pp.177-182
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• 2012

Camellia japonica oil (CJ oil) has been used traditionally in East Asia to nourish and soothe the skin as well as help restore the elasticity of skin. CJ oil has also been used on all types of bleeding instances. However, little is known about its anti-inflammatory effects. Therefore, the anti-inflammatory effects of CJ oil and its mechanisms of action were investigated. CJ oil inhibited LPS-induced production of NO, $PGE_2$, and TNF-${\alpha}$ in RAW264.7 cells. In addition, expression of COX-2 and iNOS genes was reduced. To evaluate the mechanism of the anti-inflammatory activity of CJ oil, LPS-induced activation of AP-1 and NF-${\kappa}B$ promoters was found to be significantly reduced by CJ oil. LPS-induced phosphorylation of $I{\kappa}B{\alpha}$, ERK, p38, and JNK was also attenuated. Our results indicate that CJ oil exerts anti-inflammatory effects by downregulating the expression of iNOS and COX-2 genes through inhibition of NF-${\kappa}B$ and AP-1 signaling.

• IMMUNE NETWORK
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• 제11권5호
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• pp.227-244
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• 2011

MicroRNAs (miRNAs) are small noncoding RNA molecules that negatively regulate gene expression via degradation or translational repression of their target messenger RNAs (mRNAs). Recent studies have clearly demonstrated that miRNAs play critical roles in several biologic processes, including cell cycle, differentiation, cell development, cell growth, and apoptosis and that miRNAs are highly expressed in regulatory T (Treg) cells and a wide range of miRNAs are involved in the regulation of immunity and in the prevention of autoimmunity. It has been increasingly reported that miRNAs are associated with various human diseases like autoimmune disease, skin disease, neurological disease and psychiatric disease. Recently, the identification of miRNAs in skin has added a new dimension in the regulatory network and attracted significant interest in this novel layer of gene regulation. Although miRNA research in the field of dermatology is still relatively new, miRNAs have been the subject of much dermatological interest in skin morphogenesis and in regulating angiogenesis. In addition, miRNAs are moving rapidly center stage as key regulators of neuronal development and function in addition to important contributions to neurodegenerative disorder. Moreover, there is now compelling evidence that dysregulation of miRNA networks is implicated in the development and onset of human neruodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Tourette's syndrome, Down syndrome, depression and schizophrenia. In this review, I briefly summarize the current studies about the roles of miRNAs in various autoimmune diseases, skin diseases, psychoneurological disorders and mental stress.

• 지역사회간호학회지
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• 제19권3호
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• pp.459-468
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• 2008

Purpose: The purpose of this study was to examine the presenteeism and absenteeism in relation to the health problems of nurses. Method: Informed consent was provided before study. Data was collected from January 7 to March 6, 2008 by Stanford Presenteeism Scale-13. Data was collected from 3 hospitals in Seoul Gyeonggi area. The response rate of the questionnaires was 96.2%. Incomplete data was analyzed using SPSS program. Results: Shoulder, back and neck pain were the highest reported health problems and primary health Problem of nurses. Impaired presenteeism was ranked in this order: depression or anxiety, cold, and uterus or ovary disorder. Absenteeism was ranked in this order: uterus or ovary disorder, cold, and dermatological problem. Impaired presenteeism was significantly increasing according to the number of health problems. But Absenteeism was not. Presenteeism was significantly different by age, educational level, religion, whether or not the worker lived with their family, marital status, whether or not the worker has children, time spent in the workforce, experience of turnover, shift work, night work, and level of satisfaction with salary. But absenteeism was not significantly different given these criteria. Conclusions: Health problems of nurses can negatively effect the quality of nursing service and productivity at hospital. Therefore the hospital administrator should control the presenteeism and absenteeism through the management of health problems of nurses.

• 한국의류학회지
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• 제11권3호
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• pp.101-109
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• 1987

This study was designed to measure the amount of formaldehyde in the disposable diapers of seven different products. It was aimed to investigate the actual situation of the diaper consumption and to relate it to the amount of formaldehyde measured. The degree of recognizability on the harmfulness of formaldehyde was also studied. The amount of formaldehyde was measured by means of the Acetyl Acetone method. The a ual situation of consumption and the recognizability of the formaldehyde were investigated by questionnaire. In the survey, the subjects had their babies aged from 0$\~$3 years and lived in Seoul. The statistical methods used were simple frequency and chi-square. The results obtained from this study were as follows; 1) Among seven (7) different disposable diapers, two were found to have less amount of formaldehyde than the Japanese regulation. 2) From the survey on the actual situation of consumption most respondents ($53.7\%$) experienced the dermatological problem after using the disposable diapers. Actually for the diapers which had a lot of formaldehyde, the respondents experienced the problems more severely. 3) The recognizability of formaldehyde was very low. The recognizability on the harnfulness of formaldehyde was lower, which represented the consumers had least or no knowledge about the formaldehyde release problem.