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http://dx.doi.org/10.5483/BMBRep.2012.45.3.177

Anti-inflammatory activity of Camellia japonica oil  

Kim, Seung-Beom (Biospectrum Life Science Institute)
Jung, Eun-Sun (Biospectrum Life Science Institute)
Shin, Seung-Woo (Biospectrum Life Science Institute)
Kim, Moo-Han (Biospectrum Life Science Institute)
Kim, Young-Soo (Biospectrum Life Science Institute)
Lee, Jong-Sung (Department of Dermatological Health Management, Eul-Ji University)
Park, Deok-Hoon (Biospectrum Life Science Institute)
Publication Information
BMB Reports / v.45, no.3, 2012 , pp. 177-182 More about this Journal
Abstract
Camellia japonica oil (CJ oil) has been used traditionally in East Asia to nourish and soothe the skin as well as help restore the elasticity of skin. CJ oil has also been used on all types of bleeding instances. However, little is known about its anti-inflammatory effects. Therefore, the anti-inflammatory effects of CJ oil and its mechanisms of action were investigated. CJ oil inhibited LPS-induced production of NO, $PGE_2$, and TNF-${\alpha}$ in RAW264.7 cells. In addition, expression of COX-2 and iNOS genes was reduced. To evaluate the mechanism of the anti-inflammatory activity of CJ oil, LPS-induced activation of AP-1 and NF-${\kappa}B$ promoters was found to be significantly reduced by CJ oil. LPS-induced phosphorylation of $I{\kappa}B{\alpha}$, ERK, p38, and JNK was also attenuated. Our results indicate that CJ oil exerts anti-inflammatory effects by downregulating the expression of iNOS and COX-2 genes through inhibition of NF-${\kappa}B$ and AP-1 signaling.
Keywords
AP-1; Camellia japonica oil; COX-2; iNOS; NF-${\kappa}B$;
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