• 한국간호교육학회지
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• 제12권2호
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• pp.214-223
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• 2006

Purpose: This study is to find the significant symptoms related to bone density, from which a cost-effective nursing diagnosis and intervention can be derived. Method: The research sample was 102 women, the sampling was designed by the researcher's convenience, and the subjects of the sample voluntarily participated in a questionnaire survey and measurements. The questionnaire asked socio-demographics, women' reproductive health symptoms, and the life style of the subject. Osteometer DTX-200 for bone density measure and a ruler for measuring spinal curvature were used. All the data were collected at the two public health clinics in a city in Korea. Result: The subjects' current and completed menopause ages, duration of menopause, degree of spinal curvature, BMI, frequency of parity and etc. showed significant correlations with bone density. However, only the degree of spinal curvature(p<.001, r=-.22) was found to be meaningful as a predicted factor for self diagnosis of bone density level. Conclusions: Since most of the subjects have not recognized the relationships between changes in spinal curvature and lowered bone densities, nurse needs to educate clients to get medical assistance to prevent from further bone density reduction by earlier finding of spinal curvature.

• 자동차안전학회지
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• 제12권1호
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• pp.15-25
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• 2020

This paper presents a longitudinal control algorithm for ensuring takeover time of autonomous vehicle using V2V communication. In the autonomous driving of more than level 3, autonomous systems should control the vehicles by itself partially. However if the driver's intervention is required for functional safety, the driver should take over the control reasonably. Autonomous driving system has to be designed so that drivers can take over the control from autonomous vehicle reasonably for driving safety. In this study, control algorithm considering takeover time has been developed based on computation method of takeover time. Takeover time is analysed by conditions of longitudinal velocity of preceding vehicle in time-velocity plane. In addition, desired clearance is derived based on takeover time. The performance evaluation of the proposed algorithm in this study was conducted using 3D vehicle model with actual driving data in Matlab/Simulink environment. The results of the performance evaluation show that the longitudinal control algorithm can control while securing takeover time reasonably.

• Asian-Australasian Journal of Animal Sciences
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• 제33권7호
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• pp.1167-1179
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• 2020

Objective: This study was conducted to fathom the underlying mechanisms of nutrition intervention and redox sensitive transcription factors regulated by Antrodia cinnamomea fermented product (FAC) dietary supplementation in broiler chickens. Methods: Four hundreds d-old broilers (41±0.5 g/bird) assigned to 5 groups were examined after consuming control diet, or control diet replaced with 5% wheat bran (WB), 10% WB, 5% FAC, and 10% FAC. Liver mRNA expression of antioxidant, inflammatory and lipid metabolism pathways were analyzed. Prostaglandin E2 (PGE₂) concentration in each group were tested in the chicken peripheral blood mononuclear cells (cPBMCs) of 35-d old broilers to represent the stress level of the chickens. Furthermore, these cells were stimulated with 2,2'-Azobis(2-amidinopropane) dihydrochloride (AAPH) and lipopolysaccharide (LPS) to evaluate the cell stress tolerance by measuring cell viability and oxidative species. Results: Heme oxygenase-1, glutathione S-transferase, glutamate-cysteine ligase, catalytic subunit, and superoxide dismutase, and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) that regulates the above antioxidant genes were all up-regulated significantly in FAC groups. Reactive oxygen species modulator protein 1 and NADPH oxygenase 1 were both rather down-regulated in 10% FAC group as comparison with two WB groups. Despite expressing higher level than control group, birds receiving diet containing FAC had significantly lower expression level in nuclear factor-kappa B (NF-κB) and other genes (inducible nitric oxide synthase, tumor necrosis factor-α, interleukin-1β, nucleotide-binding domain, leucine-richcontaining family, pyrin domain-containing-3, and cyclooxygenase 2) involving in inflammatory pathways. Additionally, except for 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase that showed relatively higher in both groups, the WB, lipoprotein lipase, Acetyl-CoA carboxylase, fatty acid synthase, fatty acid binding protein, fatty acid desaturase 2 and peroxisome proliferator-activated receptor alpha genes were expressed at higher levels in 10% FAC group. In support of above results, promoted Nrf2 and inhibited NF-κB nuclear translocation in chicken liver were found in FAC containing groups. H₂O₂ and NO levels induced by LPS and AAPH in cPBMCs were compromised in FAC containing diet. In 35-d-old birds, PGE₂ production in cPBMCs was also suppressed by the FAC diet. Conclusion: FAC may promote Nrf2 antioxidant pathway and positively regulate lipid metabolism, both are potential inhibitor of NF-κB inflammatory pathway.

• 한국콘텐츠학회논문지
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• 제20권1호
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• pp.505-518
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• 2020

본 연구는 단주과정에 있는 여성의 자기실현에 관한 생애사 연구이다. 연구의 목적은 여성 알코올 중독에 관한 정황들을 탐색하여 치료 및 회복을 위한 논의의 지평을 확장시키고 사회복지적인 개입방안을 제시하는데 있다. 이를 위해 7년 이상 단주 중인 여성 알코올 중독 회복자가 참여했으며, 생애사 분석을 위한 텍스트는 Mandelbaum이 제안한 생애사 분석틀에 의거하여 '삶의 영역', '전환점', '적응'으로 나눴다. 자료분석 결과 <삶의 영역>은 '개인적인 삶의 차원', '자족차원의 삶의 차원', '사회적인 삶의 차원'의 총 3개의 영역으로 분석되었다. <전환점>은 '술을 마시고 폭력을 행사하는 아버지로부터 탈출', '상사의 폭행을 피해 직장을 포기함', 'AA(단주 자조모임) 참여로 서서히 치유의 길을 걸어감'으로 드러났다. <적응>은 '공부를 잘하는 적응전략', '술을 마심으로써 분노를 삭이는 적응전략', 'AA로의 의탁과 자기실현을 생각하는 적응전략' 으로 도출되었다. 이러한 연구결과를 바탕으로 자기실현에 입각한 사회복지 실천 및 정책 차원의 논의를 제시하였다.

• 대한약침학회지
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• 제26권3호
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• pp.211-226
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• 2023

Objectives: Crohn's disease is a chronic gastrointestinal disease that belongs to inflammatory bowel disease. This systematic review aims to assess the level of evidence in randomized controlled trials (RCTs) on the effects of acupuncture for Crohn's disease. Methods: We searched 12 databases from the date of the establishment of each database up to May, 2023 for relevant RCTs. The risk of bias of each study was assessed independently by three reviewers. The level of evidence of meta-analysis was assessed using GRADE (Grading of Recommendations, Assessment, Development, and Evaluation). Results: A total of 12 studies were included. The effective rate (odds ratio [OR] 3.23, 95% confidence interval [CI] 1.43, 7.30) for mild to moderate Crohn's disease patients showed a significant difference between the acupuncture with moxibustion group and the sham-acupuncture with sham-moxibustion group. CDAI change (mean difference [MD] -74.15, 95% CI -93.28, -55.01) for mild to moderate Crohn's disease showed a significant difference between the acupuncture with moxibustion group and the sham-acupuncture with sham-moxibustion group. Conclusion: Although acupuncture with moxibustion showed significant effects compared to sham-acupuncture with sham-moxibustion, the effect of acupuncture alone is inconclusive. Moreover, only the effect of acupuncture treatment on mild to moderate Crohn's disease patients was derived as a remarkable result. To confirm the effectiveness of acupuncture treatment for Crohn's disease, studies using only acupuncture for intervention or more RCTs targeting various Crohn's disease patients according to the CDAI are required.

• Biomolecules & Therapeutics
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• 제17권4호
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• pp.348-352
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• 2009

Over the last decade, the incidence of overweight and obesity has nearly doubled in many countries and is considered a pandemic. Obesity was identified as a major risk factor for cardiovascular disease as the same level as smoking and diabetes. Visceral fat is considered one of the key contributors to outcome and certain ethnic groups such as Asians seem to be more affected than others. Weight reduction through lifestyle changes was found to be impactful to improve overall health, but weight loss and maintenance thereof is limited and difficult to sustain. Surgical intervention demonstrated a greater weight loss in the severely obese and was associated with improved all-cause mortality. Despite numerous pharmacological targets and a high medical need, only few drugs have been successfully developed. Earlier studies with amphetamine-derived compounds showed significant weight loss but their critical safety profiles led to market withdrawals and disappointment. More recent compounds; orlistat - a lipase inhibitor, rimonabant - a cannaboid-1-receptor antagonist, and sibutramine - a combined serotonin/norepinephrine re-uptake inhibitor, all demonstrated similar significant efficacy; however, they carry specific safety profiles making them unsuitable for every patient. The main limitation of pharmacotherapy is the absence of clear benefit-risk assessments through outcome studies. Such a study - the SCOUT trial - was designed to compare sibutramine versus placebo and the effect on morbidity and mortality in nearly 10,000 obese patients with additional risk factors. Such studies could provide new scientific evidence for obesity treatment and may support future pharmacological approaches.

• 척추신경추나의학회지
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• 제15권1호
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• pp.89-100
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• 2020

Objectives : This study aimed to verify the clinical effectiveness of Baduanjin for shoulder pain. Methods : We searched 10 electronic databases (PubMed, EMBASE, Cochrane Library, CAJ, KISS, KISTI, KMBASE, RISS, NDSL, and OASIS) up to May 2020. We included randomized controlled trials (RCTs) using Baduanjin for shoulder pain. The methodological quality of each RCT was assessed using the Cochrane risk of bias tool. Results : As a result of the search, a total of 6 RCTs were eligible for analysis. Of these 6 studies, one applied Baduanjin alone and 5 cases used Baduanjin in combination with other treatments, such as acupuncture or electroacupuncture. Except for 2 studies, descriptive analysis was performed without meta-analysis due to the high level of heterogeneity between studies. A high risk of bias was observed in all studies. Conclusions : When considering the results of the included papers, there was limited information derived on the therapeutic effect of using Baduanjin as a single intervention, but the results showed significant effectiveness when Baduanjin was combined with other oriental interventions, such as acupuncture and electroacupuncture, in the clinical field. Although all RCTs included in the analysis were biased to CAJ and the number was limited, this study was conducted in accordance with the methodological process of systematic literature reviews and revealed the clinical effects of Baduanjin on shoulder pain.

• 디지털융복합연구
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• 제17권10호
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• pp.381-393
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• 2019

본 연구는 농촌여성노인의 베트남며느리 뒷바라지 체험의 의미와 본질을 탐색하기 위하여 van Manen의 해석학적 현상학 연구방법을 사용하였다. 연구 참여자는 베트남며느리와 동거하는 농촌지역 여성노인 8명을 대상으로 하였으며, 자료수집은 면대면 심층면접과 관찰을 통해 이루어졌다. 연구결과 8개의 본질적 주제와 28개의 주제가 도출되었다. 농촌지역 여성노인들은 베트남며느리를 맞아 아들가정을 지속적으로 지원해 주어야만 했고, 한국과 베트남의 문화 차이로 인한 높은 스트레스를 경험하고 있었다. 이상의 연구결과는 실용적이고 포괄적인 지역사회 간호 중재 개발에 기여할 수 있을 것으로 여겨지며, 향후 모든 가족 구성원의 관점에 기초하여 베트남며느리, 아들 및 손자 관점에서의 경험을 탐구하는 후속 연구가 필요할 것으로 사료된다.

• 한국임상약학회지
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• 제29권1호
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• pp.18-24
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• 2019

Background: Although a growing number of guidelines and clinical researches are available for immunosuppressive treatment of post-transplantation, there is no clinical practice guideline for the care of kidney transplant recipients in Korea. Selection of a researchable question is the most important step in conducting qualified guideline development. Thus, we aimed to formulate key questions for Korean guideline to aid clinical decision-making for immunosuppressive treatment. Methods: Based on previous published guidelines review, a first survey was constructed with 29 questions in the range of immunosuppressive treatments. The experts were asked to rate the clinical importance of the question using a 5-point Likert scale. The questions reached 60% or more from the first survey and additional new questions were included in the second survey. In analyzing the responses to items rated on the 9-point scale, consensus agreement on each question was defined as 75% or more of experts rating 7 to 9. Results: In the first survey, 50 experts were included. Among the 29 questions, 27 were derived to get 60% or more importance and 3 new questions were additionally identified. Through the second survey, 9 questions were selected that experts reached consensus on 75% and over of the options. Finally, we developed key questions using PICO (patient, intervention, comparison, and outcome) methodology. Conclusion: The experts reached a high level of consensus on many of key questions in the survey. Final key questions provide direction for developing clinical practice guideline in the immunosuppressive treatment of transplantation.

• 한국사회정책
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• 제25권2호
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• pp.333-366
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• 2018

본 연구는 비행청소년의 사회적 자본 인식유형을 Q방법론을 활용하여 비행청소년의 사회적 자본 유형별 특성을 밝히고, 사회적 자본 형성방안을 모색하고자 한다. 이를 위해 사회적 자본에 관한 진술문 33문항을 비행청소년 16명을 대상으로 조사를 실시한 결과, 5가지의 유형이 도출되었다. 유형 I은 '친구 지지형', 유형 II는 '가족친화형', 유형 III은 '능력자형', 유형 IV는 '정의사회형', 유형 V는 '학교 신뢰형'으로 명명하였다. 이를 토대로 사회적 자본 형성방안을 제시해 보면, 첫째, 또래관계 내 사회적 자본을 향상시킬 수 있도록 친한 친구를 활용한 프로그램 개발이 요구된다. 둘째, 부모 자녀간의 직접적인 관계에서의 개입 즉, 대화, 관심, 의사소통 뿐만 아니라 자녀와 간접적으로 형성하고 있는 자녀의 친구, 자녀의 학교에 대한 개입이 요구된다. 셋째, 일상생활에서의 지속적인 감정 통제 능력을 조절할 수 있도록 개입할 필요가 있다. 넷째, 사회제도의 불합리성과 유해환경에 대한 감시감독을 강화할 필요가 있다. 마지막으로 학교 규범의 수준을 강화하여 학교에 대한 신뢰를 높일 수 있도록 환경을 개선할 필요가 있다.