• Archives of Pharmacal Research
• /
• v.25 no.4
• /
• pp.457-462
• /
• 2002

Oregonin, a diarylheptanoid derivative from Alnus hirsuta Turcz, Betulaceae, was evaluated for its antitumor activity. Oregonin, known to have an antitumor function, and is a novel immunomodulator, which may augment macrophage activity. MTT assays and NO production tests were performed in order to investigate the cytotoxicity of oregonin in tumor cells and to examine its influence on macrophage in detail. In this study, the tumoricidal activity was also evaluated by a MTT assay. The cytotoxicity measurements in the oregon in-treated group both in vitro and in vivo showed a significant difference from that of the control group. In vivo, oregonin significantly increased NO production in a dose-dependent manner, and in vitro, the thioglycolate-induced inflammatory macrophages increased NO production in a dose-dependent manner after incubation. These results suggest that oregonin reacts with both the inflammatory and non-inflammatory macrophages in a similar way.

• Computers and Concrete
• /
• v.23 no.4
• /
• pp.255-265
• /
• 2019

The potential of using genetic programming to predict engineering data has caught the attention of researchers in recent years. The present paper utilized weighted genetic programming (WGP), a derivative model of genetic programming (GP), to model the compressive strength of concrete. The calculation results of Abrams' laws, which are used as the design codes for calculating the compressive strength of concrete, were treated as the inputs for the genetic programming model. Therefore, knowledge of the Abrams' laws, which is not a factor of influence on common data-based learning approaches, was considered to be a potential factor affecting genetic programming models. Significant outcomes of this work include: 1) the employed design codes positively affected the prediction accuracy of modeling the compressive strength of concrete; 2) a new equation was suggested to replace the design code for predicting concrete strength; and 3) common data-based learning approaches were evolved into knowledge-based learning approaches using historical data and design codes.

• Journal of the Korean Society for Precision Engineering
• /
• v.14 no.10
• /
• pp.164-169
• /
• 1997

The aim of this paper is to present some results of sensitivity analysis in frequency domain. The sensitivity fonctions in frequency domain is not depend on the external excitation but depend on the frequency of the system's resonance. The sensitivity functions are determined as function of partial derivatives of system transfer functions taken with respect to system design parameters. The logarithmic sensitivity function is the dimensionless sensitivity funciton available, making it useful to compare the influence of various parameters on system variables. Two degree of fredom system is used to illustrate the procedure for sensitivity analysis proposed in this paper.

• Advances in nano research
• /
• v.16 no.2
• /
• pp.141-154
• /
• 2024

This study aims to develop explicit models to investigate thermo-mechanical interactions in moving nanobeams. These models aim to capture the small-scale effects that arise in continuous mechanical systems. Assumptions are made based on the Euler-Bernoulli beam concept and the fractional Zener beam-matter model. The viscoelastic material law can be formulated using the fractional Caputo derivative. The non-local Eringen model and the two-phase delayed heat transfer theory are also taken into account. By comparing the numerical results to those obtained using conventional heat transfer models, it becomes evident that non-localization, fractional derivatives and dual-phase delays influence the magnitude of thermally induced physical fields. The results validate the significant role of the damping coefficient in the system's stability, which is further dependent on the values of relaxation stiffness and fractional order.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
• /
• 2014.06a
• /
• pp.15-16
• /
• 2014

As trade cross the world is increasing these days, safe and effective management of harbour system is becoming important issue. With this background, the development of automatic time-domain simulation programme for ship berthing operation has been being peformed and PD (Proportional Derivative) controller has been used to control the speed and the heading angle of ships. This paper provides feasibility study for developing the time-domain simulation programme for berthing operation of ships with analysing advantages and drawbacks of the two different mathematical models, one is for low advance speed of ships by Kose (1984) and the other is MMG model for normal advance speed, through the simulations with various initial heading angles and positions of the ship.

• Biomolecules & Therapeutics
• /
• v.11 no.1
• /
• pp.41-50
• /
• 2003

General pharmacological properties of DA-8159, a new pyrazolopyrimidinone derivative were examined in laboratory animals to investigate its safety profile. The oral administration of DA-8159 (1, 5 or 30 mg/kg) in mice and rats had no effect on general behaviors and central nervous system of the animals in test systems, such as hexobarbital-induced sleeping time, motor coordination, normal body temperature, writhing syndromes induced by 0.75% acetic acid solution, chemo-shock produced by pentetrazole solution and rotar rod test. Anesthetized cats treated intravenously with DA-8159 (0.1, 0.3, 1, 3 or 10 mg/kg) showed transient and mild decrease in blood pressure. However, heart rate, respiration rate and tidal volume were not changed by intravenous DA-8159. In the isolated organs including ileum, heart (sinus rate of atria and contractility of papillary muscle), trachea of guinea pigs and phrenic nerve of rats, DA-8159 ($10^{-8}$ ∼$10^{-5}$ mg/L) did not elicit any effect or inhibitory action on the chemically or electrically stimulated contraction. DA-8159 did not influence gastric secretion, pH and total acid output in rats and intestinal propulsion in mice. The administration of DA-8159 in rats had no effect on the platelet aggregation induced by ADP in rabbit plasma, urinary volume and electrolyte ion ($Na^{+}$, $K^{+}$, $Cl^{-}$) excretion in rats. Prothrombin time (PT) of the rats showed a mild but significant increase after administration of DA-8159. Activated partial thromboplastin time (APTT), however, was not affected by DA-8159. These results indicate that DA-8159 does not exert any of serious pharmacological effects.

• Journal of the Korean Society for Industrial and Applied Mathematics
• /
• v.26 no.4
• /
• pp.185-223
• /
• 2022

The classical equation of Jonathan Homer Lane and Robert Emden, a nonlinear second-order ordinary differential equation, models the isothermal spherical clouded gases under the influence of the mutual attractive interaction between the gases' molecules. In this paper, the Adomian decomposition method (ADM) is presented to obtain highly accurate and reliable analytical solutions of a class of generalised Lane-Emden equations with strong nonlinearities. The nonlinear term f(y(x)) of the proposed problem is given by the integer powers of a continuous real-valued function h(y(x)), that is, f(y(x)) = h^m(y(x)), for integer m ≥ 0, real x > 0. In the end, numerical comparisons are presented between the analytical results obtained using the ADM and numerical solutions using the eighth-order nested second derivative two-step Runge-Kutta method (NSDTSRKM) to illustrate the reliability, accuracy, effectiveness and convenience of the proposed methods. The special cases h(y) = sin y(x), cos y(x); h(y) = sinh y(x), cosh y(x) are considered explicitly using both methods. Interestingly, in each of these methods, a unified result is presented for an integer power of any continuous real-valued function - compared with the case by case computations for the nonlinear functions f(y). The results presented in this paper are a generalisation of several published results. Several examples are given to illustrate the proposed methods. Tables of expansion coefficients of the series solutions of some special Lane-Emden type equations are presented. Comparisons of the two results indicate that both methods are reliably and accurately efficient in solving a class of singular strongly nonlinear ordinary differential equations.

• Journal of Gastric Cancer
• /
• v.18 no.1
• /
• pp.48-57
• /
• 2018

Purpose: Postoperative adjuvant chemotherapy is usually prescribed to improve the survival of patients with advanced gastric cancer who undergo curative surgery. This study was designed to determine the impact that the degree of compliance with chemotherapy has on the prognosis of patients with gastric cancer. Materials and Methods: Among 252 patients with stage III gastric cancer who underwent curative surgery between July 2004 and December 2014, 85 patients were postoperatively treated with S-1, the oral fluoropyrimidine derivative, 23 received no chemotherapy, and 144 received other regimens. Overall survival was compared between the complete compliance group (who received 8 cycles of S-1 chemotherapy, n=44) and the incomplete compliance group (who received less than 8 cycles of S-1 chemotherapy, n=41). Factors that influenced patient compliance with chemotherapy were also analyzed. Results: The overall 5-year survival rate was significantly different between the complete chemotherapy and incomplete chemotherapy groups (80.0% vs. 42.7%, P<0.001). Based on univariate and multivariate survival analyses of patients who received S-1 chemotherapy, the independent prognostic factors were tumor, node, and metastasis (TNM) stage (IIIa vs. IIIb vs. IIIc) and compliance with chemotherapy. TNM stage and age are significant factors that influence compliance with chemotherapy. Conclusions: TNM stage and compliance with chemotherapy are independent prognostic factors in patients with stage III gastric cancer who received postoperative chemotherapy. TNM stage and age are significant factors that influence patient compliance with chemotherapy.

• Journal of the Korean Chemical Society
• /
• v.52 no.2
• /
• pp.148-154
• /
• 2008

A simple and fast method for extraction and determination of trace amounts of copper(II) ions using octadecyl-bonded silica membrane disks modified with 2-propylpiperidine-1-carbodithioate (PPCD)I and atomic absorption spectrometry (AAS) is introduced. Extraction efficiency and the influence of flow rates, pH, and type and smallest amount of stripping acid were investigated. Maximum capacity of the membrane disks modified with 2 mg of the anthraquinone derivative used was found to be 425μg Cu2+. The limit of detection of the proposed method is 7 ng/ml. The method is applied to the recovery of Cu2+ from different synthetic samples and a spring water sample.

• Journal of Power Electronics
• /
• v.17 no.2
• /
• pp.358-367
• /
• 2017

This paper presents a novel filtering method for speed measurements to improve the low-speed performance of the direct-drive permanent magnet traction machines for elevators. Based on the theory of nonlinear tracking differentiator (NTD), this method, which can act as a high performance filter of a raw speed signal, obtains a more accurate speed feedback signal when applying a low-resolution encoder. In addition, it can relieve the interference caused by the position derivative for speed sampling. By analyzing the frequency response of the NTD, the influence of its parameters on the performance of the speed filtering is investigated. Compared with different types of low-pass filters, the proposed method shows a shorter time delay and a stronger ability in terms of noise suppression when the parameters are selected carefully. In addition, when using the measured speed signal through a nonlinear tracking differentiator as the feedback of the system, the motor runs more steadily at low speeds. As a result, the riding comfort of a direct-drive elevator can be improved. The feasibility of the proposed strategy was verified on an 11.7kW elevator traction machine using a commercial inverter.