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The Clinical and Microbiological Study of the Effect of Minocycline Strip Locally Administrated on Adult Periodontitis (성인성 치주질환에서 미노클린 국소송달제 효과에 대한 연구)

  • Choi, Seong-Ho;Hyun, Suk-Ju;Koo, Hyun-Seo;Suh, Jong-Jin;Cho, Kyoo-Sung;Chai, Jung-Kui;Kim, Chong-Kwan
    • Journal of Periodontal and Implant Science
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    • v.28 no.2
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    • pp.193-203
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    • 1998
  • 20 Subjects with clinical diagnosis of adult periodontitis with sites having average pocket depth of 4mm were selected for the study. After scaling and root planing of those sites, 30% minocycline-HCI contained in biodegradable device were inserted in one group, scaling and root planing was carried out in another group and the last group was without any periodontal treatment. the difference between the group was detemined by pocket dept, bleeding on prbing, attachment level, distribution of subgingval plaque bacteria. Conclusion was made for the comparisons between baseline and 4 week and the groups. 1. In analysis of pocket depth, there was significant sifference in scaling and root planing group only. 2. Both the scaling and root planing group and minocycline group showed significant decrease in bleeding on probing. 3. There was significant increase in the attachment level in scaling and root planing group, but no difference was foundbetween the groups. 4. There was significant decrease in the total number of subgingival bacteria in all groups and the number of motile bacteria decreased significantly in the minocycline group. These result indicate that insertion of Minocycline-HCI at the base of periodntal pocket was useful as an additional aid of mechanical trarment at the point of periodontal pocket, bleeding on probing, attachment level, microbial distribution.

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Detection of Innate and Artificial Mitochondrial DNA Heteroplasmy by Massively Parallel Sequencing: Considerations for Analysis

  • Kim, Moon-Young;Cho, Sohee;Lee, Ji Hyun;Seo, Hee Jin;Lee, Soong Deok
    • Journal of Korean Medical Science
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    • v.33 no.52
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    • pp.337.1-337.14
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    • 2018
  • Background: Mitochondrial heteroplasmy, the co-existence of different mitochondrial polymorphisms within an individual, has various forensic and clinical implications. But there is still no guideline on the application of massively parallel sequencing (MPS) in heteroplasmy detection. We present here some critical issues that should be considered in heteroplasmy studies using MPS. Methods: Among five samples with known innate heteroplasmies, two pairs of mixture were generated for artificial heteroplasmies with target minor allele frequencies (MAFs) ranging from 50% to 1%. Each sample was amplified by two-amplicon method and sequenced by Ion Torrent system. The outcomes of two different analysis tools, Torrent Suite Variant Caller (TVC) and mtDNA-Server (mDS), were compared. Results: All the innate heteroplasmies were detected correctly by both analysis tools. Average MAFs of artificial heteroplasmies correlated well to the target values. The detection rates were almost 90% for high-level heteroplasmies, but decreased for low-level heteroplasmies. TVC generally showed lower detection rates than mDS, which seems to be due to their own computation algorithms which drop out some reference-dominant heteroplasmies. Meanwhile, mDS reported several unintended low-level heteroplasmies which were suggested as nuclear mitochondrial DNA sequences. The average coverage depth of each sample placed on the same chip showed considerable variation. The increase of coverage depth had no effect on the detection rates. Conclusion: In addition to the general accuracy of the MPS application on detecting heteroplasmy, our study indicates that the understanding of the nature of mitochondrial DNA and analysis algorithm would be crucial for appropriate interpretation of MPS results.

Periodontal regenerative therapy in endo-periodontal lesions: a retrospective study over 5 years

  • Oh, Soram;Chung, Shin Hye;Han, Ji-Young
    • Journal of Periodontal and Implant Science
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    • v.49 no.2
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    • pp.90-104
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    • 2019
  • Purpose: The aim of this study was to evaluate clinical and radiographic changes and the survival rate after periodontal surgery using deproteinized bovine bone mineral (DBBM) with 10% collagen or DBBM with a collagen membrane in endo-periodontal lesions. Methods: A total of 52 cases (41 patients) with at least 5 years of follow-up were included in this study. After scaling and root planing with or without endodontic treatment, periodontal regenerative procedures with DBBM with 10% collagen alone or DBBM with a collagen membrane were performed, yielding the DBBM + 10% collagen and DBBM + collagen membrane groups, respectively. Changes in clinical parameters including the plaque index, bleeding on probing, probing pocket depth, gingival recession, relative clinical attachment level, mobility, and radiographic bone gains were evaluated immediately before periodontal surgical procedures and at a 12-month follow-up. Results: At the 12-month follow-up after regenerative procedures, improvements in clinical parameters and radiographic bone gains were observed in both treatment groups. The DBBM + 10% collagen group showed greater probing pocket depth reduction ($4.52{\pm}1.06mm$) than the DBBM + collagen membrane group ($4.04{\pm}0.82mm$). However, there were no significant differences between the groups. Additionally, the radiographic bone gain in the DBBM + 10% collagen group ($5.15{\pm}1.54mm$) was comparable to that of the DBBM + collagen membrane group ($5.35{\pm}1.84mm$). The 5-year survival rate of the teeth with endo-periodontal lesions after periodontal regenerative procedures was 92.31%. Conclusions: This study showed that regenerative procedures using DBBM with 10% collagen alone improved the clinical attachment level and radiographic bone level in endo-periodontal lesions. Successful maintenance of the results after regenerative procedures in endo-periodontal lesions can be obtained by repeated oral hygiene education within strict supportive periodontal treatment.

Monitoring on Bolboschoenus planiculmis Restoration in Nakdong River Estuary: Implications for Wetland Restoration Using Shoot Transplantation (낙동강하구 새섬매자기(Bolboschoenus planiculmis) 복원 모니터링: 식물체(shoot) 식재를 이용한 습지복원)

  • Gu-Yeon Kim;Hee Sun Park;Hwa Young Kim;Ji-Young Lee
    • Korean Journal of Ecology and Environment
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    • v.55 no.4
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    • pp.406-414
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    • 2022
  • Bolboschoenus planiculmis has been acknowledged as a key species in whooper swans (Cygnus cygnus) habitat by providing food for this migratory waterfowl. B. planiculmis wetlands are being degraded by water shortages and salinization caused by anthropogenic activities and climate changes. In 2004, the distribution of B. planiculmis in the tidal flats of the Nakdong Estuary was 2,475,568 m2, and in 2021, the distribution area was 798,731 m2, which decreased by 32.3%. In order to restore the degraded B. planiculmis wetlands, shoot transplantation and seed sowing were tentatively used in three places with different salinity and water levels. The average density per unit area in September at the optimal growth period after planting were A (fresh water level 50 cm) 58±15.65 m-2, B (brackish water level 0~5 cm) 188±63.83 m-2, C (brackish water level 0 cm or less) 188±45.13 m-2. The tubers were observed as A 0 g dw m-2, B 25.32±2.94 g dw m-2, and C 13.39±0.91 g dw m-2. Tubers were distributed in the soil, with only 3.0% at the 10~20 cm depth but 97.0% at the 0~10 cm depth. In contrast, the germination rate of B. planiculmis seeds was observed to be 0%. Results of this study provide technical support for the restoration of B. planiculmis wetland and the improvement in the quality of whooper swans habitat.

Predisposing, Enabling, and Reinforcing Factors of COVID-19 Prevention Behavior in Indonesia: A Mixed-methods Study

  • Putri Winda Lestari;Lina Agestika;Gusti Kumala Dewi
    • Journal of Preventive Medicine and Public Health
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    • v.56 no.1
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    • pp.21-30
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    • 2023
  • Objectives: To prevent the spread of coronavirus disease 2019 (COVID-19), behaviors such as mask-wearing, social distancing, decreasing mobility, and avoiding crowds have been suggested, especially in high-risk countries such as Indonesia. Unfortunately, the level of compliance with those practices has been low. This study was conducted to determine the predisposing, enabling, and reinforcing factors of COVID-19 prevention behavior in Indonesia. Methods: This cross-sectional study used a mixed-methods approach. The participants were 264 adults from 21 provinces in Indonesia recruited through convenience sampling. Data were collected using a Google Form and in-depth interviews. Statistical analysis included univariate, bivariate, and multivariate logistic regression. Furthermore, qualitative data analysis was done through content analysis and qualitative data management using Atlas.ti software. Results: Overall, 44.32% of respondents were non-compliant with recommended COVID-19 prevention behaviors. In multivariate logistic regression analysis, low-to-medium education level, poor attitude, insufficient involvement of leaders, and insufficient regulation were also associated with decreased community compliance. Based on in-depth interviews with informants, the negligence of the Indonesian government in the initial stages of the COVID-19 pandemic may have contributed to the unpreparedness of the community to face the pandemic, as people were not aware of the importance of preventive practices. Conclusions: Education level is not the only factor influencing community compliance with recommended COVID-19 prevention behaviors. Changing attitudes through health promotion to increase public awareness and encouraging voluntary community participation through active risk communication are necessary. Regulations and role leaders are also required to improve COVID-19 prevention behavior.

Design and Implementation of Machine Learning System for Fine Dust Anomaly Detection based on Big Data (빅데이터 기반 미세먼지 이상 탐지 머신러닝 시스템 설계 및 구현)

  • Jae-Won Lee;Chi-Ho Lin
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.24 no.1
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    • pp.55-58
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    • 2024
  • In this paper, we propose a design and implementation of big data-based fine dust anomaly detection machine learning system. The proposed is system that classifies the fine dust air quality index through meteorological information composed of fine dust and big data. This system classifies fine dust through the design of an anomaly detection algorithm according to the outliers for each air quality index classification categories based on machine learning. Depth data of the image collected from the camera collects images according to the level of fine dust, and then creates a fine dust visibility mask. And, with a learning-based fingerprinting technique through a mono depth estimation algorithm, the fine dust level is derived by inferring the visibility distance of fine dust collected from the monoscope camera. For experimentation and analysis of this method, after creating learning data by matching the fine dust level data and CCTV image data by region and time, a model is created and tested in a real environment.

A Study on the Level of Value of Rural Adolescents (농촌 청소년의 가치 수준에 관한 연구)

  • Cheong, Deuk-Jin
    • Journal of Agricultural Extension & Community Development
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    • v.4 no.1
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    • pp.339-351
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    • 1997
  • This study intended to enhance the quality of life of rural adolescents through survey 185 young people in YeonChun County, in the course of measuring the level of life of adolescents and finding several variables related with the level and drawing some applications for enhancement. As a result of this study we had some findings 1) the most young people were belonging to the second (vital feeling value) level and third (mental value) level 2) Sex, religion, tendency oriented to other person were three related variables with the level. The more the people having other-oriented tendency the higher the level of value. Female, Christian is higher in the level. 3) Many adolescents showed little hearty satisfaction concering their own life 4) The level of act in their real life were corresponded with the level of value 5) Characteristics of high value-level adolescents against low value-level ones were that they had high level of value-recognition, less family member. The hit ratio was 83.7 percent. On the basis of this study the following suggestions for the improvement of quality of life for youth in the rural area in the future. First, we should make a great effort in value education in order to clearly get the goal of the true life. The quality improvement such as the education of mental life and religion for the young people by developing programs to continously improve the value of life. Second, the necessity of behavior guiding other oriented tendency should be emphasized. We should connect adolescents with value recognition through more interest in actions. And third, it is necessary to make a professional effort for the improvement of level of value, that is, an in depth study of the theoretical systemization.

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Late Quaternary stratigraphy and sea-level change in the tidal flat of Gomso Bay, West Coast of Korea (한국 서해안 곰소만 조간대의 제 4기 층서와 해수면 변화)

  • 장진호;박용안
    • The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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    • v.1 no.2
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    • pp.59-72
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    • 1996
  • The stratigraphy of the Gomso-Bay tidal flat consists of basement, preHolocene oxidized unit, and Holocene tidal sequence in ascending order. The oxidized unit is a yellowish brown stiff mud of the last stadial (or subglacial) stage before 12,000 yr B.P. This yellowish brown preHolocene unit does not contain any marine fossils, but contains plant roots, plant fragments, and also vertical and horizontal microfractures indicating soil-formation when exposed. It is regarded as interfluve deposits. The Holocene tidal sequence is composed of lower mud facies (upper-flat muds), upper sand and muddy sand facies (middle to lower-flat sands). This coarsening-upward and retrograding pattern of Holocene tidal deposits reflects a Holocene sea-level rise. The plots of $\^$14/C-age versus depth of dated samples (peats and shells) show that the sea level of 7,000 yr B.P. was located about 6.5 m below the present mean sea level, and the sea levels of 4,000 yr B.P. and 2,000 yr B.P. were also situated about 3 m and 2.5 m below the present mean sea level, respectively.

A Bed Level Change Model(SED-FLUX) by Suspended Sediment Flux and Bed Load Flux in Wave-Current Co-existing Fields (파-흐름 공존장에서 부유사와 소류사 flux에 의한 지형변화모델)

  • Lee, Jong Sup;Yoon, Eun Chan;Park, Seok Hee
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.26 no.3B
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    • pp.311-319
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    • 2006
  • A bed level change model(SED-FLUX) is introduced based on the realistic sediment transport process including bed load and suspended load behaviours at the bottom boundary layer. The model SED-FLUX includes wave module, hydrodynamic module and sediment transport and diffusion module that calculate suspended sediment concentration, net sediment erosion flux($Q_s$) and bed load flux. Bed load transport rate is evaluated by the van Rijn's TRANSPOR program which has been verified in wave-current fields. The net sediment erosion flux($Q_s$) at the bottom is evaluated as a source/sink term in the numerical sediment diffusion model where the suspended sediment concentration becomes a verification parameter of the $Q_s$. Bed level change module calculates a bed level change amount(${\Delta}h_{i,j}$) and updates a bed level. For the model verification the limit depth of the bed load transport is compared with the field experiment data and some formula on the threshold depth for the bed load movement by waves and currents. This model is applied to the beach profile changes by waves, then the model shows a clear erosion and accumulation profile according to the incident wave characteristics. Finally the beach evolution by waves and wave-induced currents behind the offshore breakwater is calculated, where the model shows a tombolo formation in the landward area of the breakwater.

The Effects of Intention Inferences on Scarcity Effect: Moderating Effect of Scarcity Type, Scarcity Depth (소비자의 기업의도 추론이 희소성 효과에 미치는 영향: 수량한정 유형과 폭의 조절효과)

  • Park, Jong-Chul;Na, June-Hee
    • Journal of Global Scholars of Marketing Science
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    • v.18 no.4
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    • pp.195-215
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    • 2008
  • The scarcity is pervasive aspect of human life and is a fundamental precondition of economic behavior of consumers. Also, the effect of scarcity message is a power social influence principle used by marketers to increase the subjective desirability of products. Because valuable objects are often scare, consumers tend to infer the scarce objects are valuable. Marketers often do base promotional appeals on the principle of scarcity to increase the subjective desirability their products among consumers. Specially, advertisers and retailers often promote their products using restrictions. These restriction act to constraint consumers' ability th take advantage of the promotion and can assume several forms. For example, some promotions are advertised as limited time offers, while others limit the quantity that can be bought at the deal price by employing the statements such as 'limit one per consumer,' 'limit 5 per customer,' 'limited products for special commemoration celebration,' Some retailers use statements extensively. A recent weekly flyer by a prominent retailer limited purchase quantities on 50% of the specials advertised on front page. When consumers saw these phrase, they often infer value from the product that has limited availability or is promoted as being scarce. But, the past researchers explored a direct relationship between the purchase quantity and time limit on deal purchase intention. They also don't explored that all restriction message are not created equal. Namely, we thought that different restrictions signal deal value in different ways or different mechanism. Consumers appear to perceive that time limits are used to attract consumers to the brand, while quantity limits are necessary to reduce stockpiling. This suggests other possible differences across restrictions. For example, quantity limits could imply product quality (i.e., this product at this price is so good that purchases must be limited). In contrast, purchase preconditions force the consumer to spend a certain amount to qualify for the deal, which suggests that inferences about the absolute quality of the promoted item would decline from purchase limits (highest quality) to time limits to purchase preconditions (lowest quality). This might be expected to be particularly true for unfamiliar brands. However, a critical but elusive issue in scarcity message research is the impacts of a inferred motives on the promoted scarcity message. The past researchers not explored possibility of inferred motives on the scarcity message context. Despite various type to the quantity limits message, they didn't separated scarcity message among the quantity limits. Therefore, we apply a stricter definition of scarcity message(i.e. quantity limits) and consider scarcity message type(general scarcity message vs. special scarcity message), scarcity depth(high vs. low). The purpose of this study is to examine the effect of the scarcity message on the consumer's purchase intension. Specifically, we investigate the effect of general versus special scarcity messages on the consumer's purchase intention using the level of the scarcity depth as moderators. In other words, we postulates that the scarcity message type and scarcity depth play an essential moderating role in the relationship between the inferred motives and purchase intention. In other worlds, different from the past studies, we examine the interplay between the perceived motives and scarcity type, and between the perceived motives and scarcity depth. Both of these constructs have been examined in isolation, but a key question is whether they interact to produce an effect in reaction to the scarcity message type or scarcity depth increase. The perceived motive Inference behind the scarcity message will have important impact on consumers' reactions to the degree of scarcity depth increase. In relation ti this general question, we investigate the following specific issues. First, does consumers' inferred motives weaken the positive relationship between the scarcity depth decrease and the consumers' purchase intention, and if so, how much does it attenuate this relationship? Second, we examine the interplay between the scarcity message type and the consumers' purchase intention in the context of the scarcity depth decrease. Third, we study whether scarcity message type and scarcity depth directly affect the consumers' purchase intention. For the answer of these questions, this research is composed of 2(intention inference: existence vs. nonexistence)${\times}2$(scarcity type: special vs. general)${\times}2$(scarcity depth: high vs. low) between subject designs. The results are summarized as follows. First, intention inference(inferred motive) is not significant on scarcity effect in case of special scarcity message. However, nonexistence of intention inference is more effective than existence of intention inference on purchase intention in case of general scarcity. Second, intention inference(inferred motive) is not significant on scarcity effect in case of low scarcity. However, nonexistence of intention inference is more effective than existence of intention inference on purchase intention in case of high scarcity. The results of this study will help managers to understand the relative importance among the type of the scarcity message and to make decisions in using their scarcity message. Finally, this article have several contribution. First, we have shown that restrictions server to activates a mental resource that is used to render a judgment regarding a promoted product. In the absence of other information, this resource appears to read to an inference of value. In the presence of other value related cue, however, either database(i.e., scarcity depth: high vs. low) or conceptual base(i.e.,, scarcity type special vs. general), the resource is used in conjunction with the other cues as a basis for judgment, leading to different effects across levels of these other value-related cues. Second, our results suggest that a restriction can affect consumer behavior through four possible routes: 1) the affective route, through making consumers feel irritated, 2) the cognitive making route, through making consumers infer motivation or attribution about promoted scarcity message, and 3) the economic route, through making the consumer lose an opportunity to stockpile at a low scarcity depth, or forcing him her to making additional purchases, lastly 4) informative route, through changing what consumer believe about the transaction. Third, as a note already, this results suggest that we should consider consumers' inferences of motives or attributions for the scarcity dept level and cognitive resources available in order to have a complete understanding the effects of quantity restriction message.

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