• Journal of Preventive Medicine and Public Health
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• 제41권3호
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• pp.147-152
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• 2008

Objectives : Fluoridation of drinking water is known to decrease dental caries, particularly in children. However, the effects of fluoridated water on bone over several decades are still in controversy. To assess the risk of hip fracture related to water fluoridation, we evaluated the hip fracture-related hospitalizations of the elderly between a fluoridated city and non-fluoridated cities in Korea. Methods : Cheongju as a fluoridated area and Chungju, Chuncheon, Suwon, Wonju as non-fluoridated areas were chosen for the study. We established a database of hip fracture hospitalization episode based on the claims data submitted to the Health Insurance Review Agency from January 1995 to December 2002. The hip fracture hospitalization episodes that satisfied the conditions were those that occurred in patients over 65 years old, the injuries had a hip fracture code (ICD-9 820, ICD-10 S72) and the patients were hospitalized for at least 7days. A total of 80,558 cases of hip fracture hospitalization episodes were analyzed. Results : The admission rates for hip fracture increased with the age of the men and women in both a fluoridated city and the non-fluoridated cities (p<0.01). The relative risk of hip fracture increased significantly both for men and women as their age increased. However, any difference in the hip fracture admission rates was not consistently observed between the fluoridated city and the non-fluoridated cities. Conclusions : We cannot conclude that fluoridation of drinking water increases the risk of hip fracture in the elderly.

• 미생물학회지
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• 제40권4호
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• pp.364-366
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• 2004

본 연구는 차 카테킨인 EGCG (epigallocatechin gallate)에 의한 구강세균의 살균효과를 조사하기 위하여 수행되었다. 초기 세포밀도 $10^{7}$ cell/ml의 대상 세균에 대한 항세균 활성은 EGCG 1ml당 5mg에서 조사하였다. 선택 또는 복합배지상에서 집락생성단위(colony-forming unit, CFU)에 근거하여 EGCG의 항세균 활성은 농도에 비례하는 것을 확인하였다. Streptococcus mutans와 Streptococcus sobrinus는 5mg/ml의 EGCG에서 8시간 이내에 완전히 살균되었다. Lactobacillus acidophilus와 Lactobacillus plantarum도 동일한 조건에서 각각 2시간과 4시간 이내에 살균되었다. 2.5 mg/ml의 EGCG로 처리한 사람의 타액에서 유래하는 총 구강세균의 생존율을 BHI 고체배지상에서 조사하였으며, 총 구강세균은 10시간 이내에 완전히 살균되었다. MS 고체배지상에서 S. mitis and S. salivarius의 집락은 감소되었으며 배양 12시간 이내에서는 집락은 관찰되지 않았다. 그 결과, EGCG는 입냄새와 치석의 원인이 되는 구강세균을 살균시키고 충치를 예방하는 자연적이며 효과적인 물질임이 입증되었다.

• Restorative Dentistry and Endodontics
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• 제18권2호
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• pp.341-356
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• 1993

In the prevention of root surface caries, antimicrobial therapy for the control of subgingival and supragingival plaque is seriously considered as a long term suppression of pathogenic microflora. Recently, varnishes containing antimicrobial agents have been developed to control the supragingival microflora. The purpose of this study was to determine the antimicrobial effects of 20% chlorhexidine varnish and 2.6% silane fluoride varnish with sealant. In clinical experiments, 12 subjects were selected from the periodontally treated patient and divided into 3 groups. After a dental prophylaxis, the subjects were treated with single application of placebo varnish (group I), 20% chlorhexidine varnish (group II), and 2.6% silane fluoride varnish (group III). Root surface plaque samples were taken before (baseline) and one, two, four, and 8 weeks after the treatments. Microbiological examinations of root surface plaque were performed with culture study and indirect immunoflorescence (I.I.F.) study, and immunological examination of gingival crevicular fluid antibody titers was performed with ELISA study. The results were as follows: 1. Pathogenic microflora on the root surface including S. mutans, S. sanguis, S. mitis, A. naeslundii, A. viscosus were 24 - 37% on I.I.F. study. 2. S. mutans, S. sanguis, S. mitis, A. naeslundii, A. viscosus of the root surface plaque was significantly reduced from 1 week to 8 weeks after antimicrobial varnish treatment, but showed generally increasing tendency in control group. 3. Gingival crevicular fluid antibody titers were significantly reduced from 1 or 2 weeks to 4 weeks after antimicrobial varnish treatment.

• Restorative Dentistry and Endodontics
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• 제8권1호
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• pp.69-76
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• 1982

The purpose of this study was to evaluate the color penetration of cavity margin with composite resin restorations in some Korean foods substance-soy sauce and hot bean paste. Fifty specimans which were extracted caries free third molar of young adults recently. All of the prepared 100 cavities were filled with two kinds of composite resin (Hipol$^{(R)}$and Restodent$^{(R)}$). The experimental specimans were divided into five groups by the following procedures. Group I : Filling of composite resin and polishing. Group II : Filling, polishing, etching of cavity and sealing. Group III : Etching, sealing, filling and polishing. Group IV : Etching, sealing, filling, polishing, and repeated of etching of cavity margin and sealing. Group V : Etching, sealing, filling, polishing, and sealing again without etching. Before examination, the restorated teeth were subjected to thermal cycling ($4^{\circ}C$ and $60^{\circ}C$). All the specimens were immersed in soy and 30% hot bean paste solution under $37^{\circ}C$ incubator during six weeks. Then, the specimens were sectioned bucco-lingually through the center of two restorations with diamond disk and examined under a. metallographic microscope. (Union 6617 U.S.A.) Thereafter, the degree of color penetration was calculated and analyzed. The obtained results were as follows: 1. The color penetration was the lowest in the procedure of Group III which was acid etching, sealing, composite resing filling, and polishing. 2. The color penetration occured in soy and hot bean paste, but the degree of penetration was not so significant statistically between them. 3. The degree of color penetration was not so significant statistically between Hipol$^{(R)}$ and Restondent$^{(R)}$.

• 한국식품과학회지
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• 제31권2호
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• pp.522-526
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• 1999

S. mutans에 대한 키토산의 항균효과는 그 분자량에 따라 뚜렷한 차이를 보였으며, 약 30,000의 분자량을 갖는 키토산이 가장 높은 항균활성을 보였다. 키토산 처리에 의해 세포로부터 단백질, 핵산, 2가 양이온 등이 상당량 유출되는 것이 관찰되었으며, 세포내 물질의 유출정도는 키토산의 항균효과와 밀접한 상관성을 보였다. 이러한 세포내 물질의 유출은 양이온성을 띠는 키토산의 아민기와 세포벽내의 음이온 성분과의 강한 결합에 의해 세포벽의 결합력이 약화되면서 생기는 결과로서 추측되었다. 키토산처리에 의해 S. mutans의 세포벽이 원형질로부터 분리되고 세포내 물질이 세포벽 내에서 밖으로 유출되는 현상은 투과전자현미경(TEM)에 의해 확인되었다.

• Imaging Science in Dentistry
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• 제37권1호
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• pp.35-43
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• 2007

Purpose : To observe direct effect of irradiation on cariogenic Streptooccus mutans. Materials and Methods : S. mutans GS5 was exposed to irradiation with a single absorbed dose of 10, 20, 30, and 40Gy. Viability and changes in antibiotic sensitivity, morphology, transcription of virulence factors, and protein profile of bacterium after irradiation were examined by pour plate, disc diffusion method, transmission electron microscopy, RT-PCR, and SDS-PAGE, respectively. Results : After irradiation with 10 and 20Gy, viability of S. mutans was reduced. Further increase in irradiation dose, however, did not affect the viability of the remaining cells of S. mutans. Irradiated 5. mutans was found to have become sensitive to antibiotics. In particular, the bacterium irradiated with 40Gy increased its susceptibility to cefotaxime, penicillin, and tetracycline. Under the transmission electron microscope, number of morphologically abnormal cells was increased as the irradiation dose was increased. S. mutans irradiated with 10 Gy revealed a change in the cell wall and cell membrane. As irradiation dose was increased, a higher number of cells showed thickened cell wall and cell membrane and Iysis, and appearance of ghost cells was noticeable. In RT-PCR, no difference was detected in expression of gtfB and spap between cells with and without irradiation of 40Gy. In SDS-PAGE, proteins with higher molecular masses were gradually diminished as irradiation dose was increased. Conclusion : These results suggest that irradiation affects the cell Integrity of S. mutans, as observed by SDS-PAGE, and as manifested by the change in cell morphology, antibiotic sensitivity, and eventually viability of the bacterium.

• Imaging Science in Dentistry
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• 제48권3호
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• pp.201-212
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• 2018

Purpose: The aim of this study was to compare cone-beam computed tomography (CBCT) and digital panoramic radiography (DPR) for the detection of pulp stones. Materials and Methods: DPR and CBCT images of 202 patients were randomly selected from the database of our department. All teeth were evaluated in sagittal, axial, and coronal sections in CBCT images. The systemic condition of patients, the presence of pulp stones, the location of the tooth, the group of teeth, and the presence and depth of caries and restorations were recorded. The presence of pulp stones in molar teeth was compared between DPR and CBCT images. Results: Pulp stones were identified in 105 (52.0%) of the 202 subjects and in 434 (7.7%) of the 5,656 teeth examined. The prevalence of pulp stones was similar between the sexes and across various tooth locations and groups of teeth (P>.05). A positive correlation was observed between age and the number of pulp stones(${\rho}=0.277$, P<.01). Pulp stones were found significantly more often in restored or carious teeth (P<.001). CBCT and DPR showed a significant difference in the detection of pulp stones(P<.001), which were seen more often on DPR than on CBCT. Conclusion: DPR, as a 2D imaging system, has inherent limitations leading to the misinterpretation of pulp stones. Restored and carious teeth should be carefully examined for the presence of pulp stones. CBCT imaging is recommended for a definitive assessment in cases where there is a suspicion of a pulp stone on DPR.

• 대한치과보철학회지
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• 제55권1호
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• pp.79-87
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• 2017

전치부 개방 교합은 다양한 원인이 복합적으로 작용하고, 진단에 따라 효과적인 치료 계획과 적절한 유지 방법을 선택할 수 있다. 대부분의 경우 교정과 악교정 수술을 통해 안정적인 교합을 얻고, 기능과 심미를 회복한다. 하지만 전체 치열에서 심한 우식증이 있는 경우 광범위한 수복이 필요하게 되므로, 보철 수복을 통해서도 교합을 재형성할 수 있다. 본 증례는 심한 우식을 동반한 골격성 전치부 개방 교합 환자에서 안모 분석 및 진단 납형으로부터 가장 효과적인 치료로 전악 보철 수복을 선택하였다. 교합력을 균등하게 분산하고 심미적인 임시 수복물을 제작하였고, 악간 관계 평가, 혀 등 연조직의 적응, 입술과의 조화를 관찰하고 수정하였다. 충분한 기간 동안 사용한 임시 수복물을 CAD/CAM (Computer-aided design/computer-aided manufacturing)을 이용하여 단일구조 지르코니아 최종 보철물로 이행하였고, 치료 종결 후 3개월 간 주기적으로 관찰하였을 때 만족스러운 결과를 얻었다.

• 대한소아치과학회지
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• 제39권1호
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• pp.84-89
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• 2012

치근낭은 가장 흔한 치성기원 낭으로 치수감염, 치수실활, 외상으로 인한 이차감염 또는 치아 우식에 의해 발생한다. 보통치근낭은 무증상이나 이차 감염이 발생할 경우 통증, 부종, 발적 등을 유발할 수 있으며, 크기가 커질수록 치근낭은 인접한 신경을 압박하여 안면비대칭 또는 마비증세를 일으킬 수 있다. 치료는 보존적 신경치료 또는 외과적 처치를 요하며, 낭의 크기가 크거나 인접 조직의 침범을 야기할 가능성이 있는 경우에는 낭적출술을 시행해야 한다. 대부분의 증례에서 완벽한 치료가 가능하고 재발율이 낮다. 본 증례의 환아들은 하악전치부 낭을 주소로 내원하여 임상검사에서 일부 하악전치가 괴사되었음을 발견하였으므로 근관치료를 시행한 후 전신마취하에 치근단절제술 및 치근낭 적출술을 시행하였다. 이후 컴퓨터단층촬영을 시행하여 이환부의 골생성 및 재발여부를 관찰하였으며 성공적인 결과를 보였기에 이를 보고하는 바이다.

• 대한소아치과학회지
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• 제38권1호
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• pp.82-87
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• 2011

유치의 치수 감염에 대한 적절한 치료가 이루어지지 않거나 치료가 실패한 경우 치근단 병소를 야기할 수 있다. 이는 발육중인 계승 영구치에도 영향을 주어 법랑질 형성 부전, 치배의 위치 및 맹출 경로 변화, 치근 만곡, 치아 매복 등의 합병증을 유발할 수 있다. 계승 영구치의 맹출 방향에 이상을 일으키는 장애 요인으로는 유치의 만기 잔존, 유구치의 불균형적인 치근 흡수, 유치의 치근단 병소 등의 맹출 전 장애 요인과 외상이나 구강 악습관과 같은 맹출 후 장애 요인이 있다. 맹출 경로의 이상을 보이는 계승 영구치의 치료 방법으로는 주기적인 관찰, 외과적 노출, 교정적 견인, 치아 이식, 발치 등이 있으며 치료 방법 선택시 치아의 위치, 상태, 치근 형성 정도 및 만곡 여부, 맹출 방향, 인접 구조물과의 관계 등을 고려하여야 한다. 본 증례들은 유치의 치근단 병소에 의해 비정상적인 맹출 경로를 보이는 소구치를 가진 환자들에서 감염된 유치의 발거와 공간 유지만으로 이환된 소구치의 양호한 자발적 맹출을 보였기에 보고하는 바이다.