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Visibility of Internal Target Volume of Dynamic Tumors in Free-breathing Cone-beam Computed Tomography for Image Guided Radiation Therapy

  • Kauweloa, Kevin I.;Park, Justin C.;Sandhu, Ajay;Pawlicki, Todd;Song, Bongyong;Song, William Y.
    • Progress in Medical Physics
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    • v.24 no.4
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    • pp.220-229
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    • 2013
  • Respiratory-induced dynamic tumors render free-breathing cone-beam computed tomography (FBCBCT) images with motion artifacts complicating the task of quantifying the internal target volume (ITV). The purpose of this paper is to study the visibility of the revealed ITV when the imaging dose parameters, such as the kVp and mAs, are varied. The $Trilogy^{TM}$ linear accelerator with an On-Board Imaging ($OBI^{TM}$) system was used to acquire low-imaging-dose-mode (LIDM: 110 kVp, 20 mA, 20 ms/frame) and high-imaging-dose-mode (HIDM: 125 kVp, 80 mA, 25 ms/frame) FBCBCT images of a 3-cm diameter sphere (density=0.855 $g/cm^3$) moving in accordance to various sinusoidal breathing patterns, each with an unique inhalation-to-exhalation (I/E) ratio, amplitude, and period. In terms of image ITV contrast, there was a small overall average change of the ITV contrast when going from HIDM to LIDM of $6.5{\pm}5.1%$ for all breathing patterns. As for the ITV visible volume measurements, there was an insignificant difference between the ITV of both the LIDM- and HIDM-FBCBCT images with an average difference of $0.5{\pm}0.5%$, for all cases, despite the large difference in the imaging dose (approximately five-fold difference of ~0.8 and 4 cGy/scan). That indicates that the ITV visibility is not very sensitive to changes in imaging dose. However, both of the FBCBCT consistently underestimated the true ITV dimensions by up to 34.8% irrespective of the imaging dose mode due to significant motion artifacts, and thus, this imaging technique is not adequate to accurately visualize the ITV for image guidance. Due to the insignificant impact of imaging dose on ITV visibility, a plausible, alternative strategy would be to acquire more X-ray projections at the LIDM setting to allow 4DCBCT imaging to better define the ITV, and at the same time, maintain a reasonable imaging dose, i.e., comparable to a single HIDM-FBCBCT scan.

Flash Lamp Annealing of Ag Organometallic Ink for High-Performance Flexible Electrode (플래시 기반 유기금속화합물 열처리를 통한 고성능 유연 전극 제조)

  • Yu Mi Woo;Dong Gyu Lee;Yun Sik Hwang;Jae Chan Heo;SeongMin Jeong;Yong Jun Cho;Kwi-Il Park;Jung Hwan Park
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.36 no.5
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    • pp.454-462
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    • 2023
  • Flash lamp annealing (FLA) of metal nanoparticle (NP) ink has provided powerful strategies to fabricate high-performance electrodes on a flexible substrate because of its rapid processing capability (in milliseconds), low-temperature process, and compatibility with to roll-to-roll process. However, metal NPs [e.g., gold (Au), silver (Ag), copper (Cu), etc.] have limitations such as difficulty in synthesizing fine metal NPs (diameter less than 10 nm), high price, and degradation during ink storage and FLA processing. In this regard, organometallic ink has been proposed as a material that can replace metal NPs due to their low-cost (usually 1/100 times cheaper than metal nano inks), low-temperature processability, and high material stability. Despite these advantages, the fabrication of flexible electrodes through FLA treatment of organometallic compounds has not been extensively researched. In this paper, we experimentally guide how to determine the optimal conditions for forming electrodes on flexible substrates by considering material parameters, and flashlight processing parameters (energy density, pulse duration, etc) to minimize the difficulties that may arise during the FLA of organometallic ink.

An Analysis of the Rice Situation in Nicaragua for Improving National Production.

  • Chang-Min Lee;Oporta Juan;Ho-Ki Park;Hyun-Su Park;Jeonghwan Seo;Man-Kee Baek;Jae-Ryoung Park;O-Young Jeong
    • Proceedings of the Korean Society of Crop Science Conference
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    • 2022.10a
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    • pp.90-90
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    • 2022
  • Nicaragua is located in Central America, climatic conditions are considered tropical dry forest. Statistics reflex that in Nicaragua exits 24,000 rice farmers. National rice production only covers 73% of the national consumption. It exists two sowing system: irrigation and rainfed. Varieties used in both systems are mid-late maturity (120-135 days), there are 14 released varieties for irrigation, eight for rainfed, and eight landraces used in rainfed. The current breeding system (introduction of lines from Colombia) has increased the national production, however, has some limitation due to the lack of enough variability, reducing the proability of finding good genotypes and therefore the possibility of satisfying 100% of the demand. The purpose of this study was to analyze the problems that must be resolved in the short and long term to improve rice productivity in Nicaragua. In this paper we explain some proposal for an improvement plan. The selection of varieties with high adaptability to various cultivation environmental conditions it is necessary, also to thoroughly manage seed purity to supply certified seeds. In rice cultivation technology, it needs to improve seedling standing and weeding effect by improving soil leveling and water-saving cultivation technology. Also, proper fertilization and planting density must be established in irrigated and rain-fed areas. Furthermore, capacity must be strengthened by collecting and training with the most recent agricultural technology information, as well as by revitalizing the union rather than the individual farmer. It is necessary to develop varieties highly adaptable to the Nicaraguan cultivation environment, as well as to expand irrigation facilities and cultivation technology suitable for weather conditions in rain-fed areas. Last, it is necessary to maintain the consistency of agricultural policy for continuous and stable rice production in response to climate change events such as drought or intermittent heavy rain.

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AN IN-VITRO WEAR STUDY OF INDIRECT COMPOSITE RESINS AGAINST HUMAN ENAMEL (법랑질에 의한 수종의 간접복합레진의 마모에 관한 연구)

  • Yi, Hyun-Jeong;Jeon, Young-Chan;Jeong, Chang-Mo;Jeong, Hee-Chan
    • The Journal of Korean Academy of Prosthodontics
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    • v.45 no.5
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    • pp.611-620
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    • 2007
  • Statement of problem: Second-generation indirect composite resins have been improved flexural strength, compressive strength, hydrolytic degradation resistance, wear resistance compared to first-generation indirect composite resins, but there are still some problems as hydrolysis and low wear resistance. Some manufacturers claim that wear resistance of their materials has been improved, but little independent study has been published on wear properties of these materials and the properties specified in the advertising materials are largely derived from in-house or contracted testing. Purpose: This study was to evaluate the wear of indirect composite resins (SR Adore, Sinfony, Tescera ATL) and gold alloy against the human enamel. Material and method: Extracted human incisors and premolars were sectioned to $2{\times}2{\times}2mm$ cube and embedded in the clear resin and formed conical shaped antagonist to fit the jig of pin-on-disk tribometer. Total 20 antagonists were stored in distilled water. Five disk samples, 24mm in diameter and 1.5mm thick, were made for each of three groups of indirect composite resins and gold alloy group, and polished to #2,000 SiC paper on auto-polishing machine. Disk specimens were tested for wear against enamel antagonists. Wear test were conducted in distilled water using a pin-on-disk tribometer under condition (sliding speed 200rpm contact load 24N, sliding distance 160m). The wear of the enamel was determined by weighing the enamel antagonist before and after test, and the weight was converted to volumes by average density. The wear tracks were analyzed by scanning electron microscopy and surface profilometer to elucidate the wear mechanisms. Statistical analysis of the enamel wear volume, wear track depth and wear tract width of disk specimens were accomplished with one-way ANOVA and the means were compared for significant differences with Scheffe's test. Results: 1. The enamel wear was most in gold alloy, but there were no statistically significant differences among all the groups (P>.05). 2. In indirect composite resin groups, the group to make the most shallow depth of wear tract was Sinfony, followed by Tescera ATL, SR Adoro (P<.05). Gold alloy was shallower than Sinfony, but there was no statistically significant difference between Sinfony and gold alloy (P>.05). 3. The width of wear tract of SR Adore was larger than the other groups (P<.05), and there were no statistically significant differences among the other groups (P>.05). 4. SEM analysis revealed that Sinfony and gold alloy showed less wear scars after test, Tescera ATL showed more wear scars and SR Adore showed the most. Conclusion: Within the limits of this study, Sinfony and gold alloy showed the least wear rates and showed similar wear patterns.

Quantitative Analysis of Quadrupole Noise Sources upon Quick Opening The Throttle (쓰로틀밸브 급개방시 기류소음의 4극음원에 대한 정량적 해석)

  • Kim Jaeheon;Cheong Cheolung;Kim SungTae;Lee Soogab
    • Proceedings of the Acoustical Society of Korea Conference
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    • spring
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    • pp.469-474
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    • 2002
  • In recent years, modularization of engine parts has increased the application of plastic products in air intake systems. Plastic intake manifolds provide many advantages including reduced weight, contracted cost, and lower intake air temperatures. These manifolds, however, have some weakness when compared with customary aluminium intake manifolds, in that they have low sound transmission loss because of their lower material density. This low transmission loss of plastic intake manifolds causes several problems related to flow noise, especially when the throttle is opened quickly. The physical processes, responsible for this flow noise, include turbulent fluid motion and relative motion of the throttle to the airflow. The former is generated by high-speed airflow in the splits between the throttle valve and the inner-surface of the throttle body and surge-tank, which can be categorized into the quadrupole source. The latter induces the unsteady force on the flow, which can be classified into the dipole source. In this paper, the mechanism of noise generation from the turbulence is only investigated as a preliminary study. Stochastic noise source synthesis method is adopted for the analysis of turbulence-induced, i.e. quadrupole noise by throttle at quick opening state. The method consists of three procedures. The first step corresponds to the preliminary time-averaged Navier-Stokes computation with a $k-\varepsilon$ turbulence model providing mean flow field characteristics. The second step is the synthesis of time-dependent turbulent velocity field associated with quadrupole noise sources. The final step is devoted to the determination of acoustic source terms associated with turbulent velocity. For the first step, we used market available analysis tools such as STAR-CD, the trade names of fluid analysis tools available on the market. The steady state flows at three open angle of throttle valve, i.e. 20, 35 and 60 degree, are numerically analyzed. Then, time-dependent turbulent velocity fields are produced by using the stochastic model and the flow analysis results. Using this turbulent velocity field, the turbulence-originated noise sources, i.e. the self-noise and shear-noise sources are synthesized. Based on these numerical results, it is found that the origin of the turbulent flow and noise might be attributed to the process of formulation and the interaction of two vortex lines formed in the downstream of the throttle valve. These vortex lines are produced by the non-uniform splits between the throttle valve and inner cylinder surface. Based on the analysis, we present the low-noise design of the inner geometry of throttle body.

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A Method for Evaluation of Mechanical Accuracy of a Teletherapy Machine Using Beam Directions (방사선 진행방향을 이용한 원격치료장치의 기계적 정확성 평가방법)

  • 강위생
    • Progress in Medical Physics
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    • v.7 no.1
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    • pp.53-64
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    • 1996
  • Purpose: The purposes of this paper are to develop a theoretical basis that the beam directions should be considered when the mechanical accuracy of teletherapy machine is evaluated by the star pattern test, to develop methods using asymmetric field in length to simulate beam direction for the case that beam direction does not appear on film. Method: In evaluating mechanical rotational accuracy of the gantry of teletherapy unit by the star pattern test, the direction of radiation beams was considered. A star pattern using some narrow beams was made. Density profiles at 10cm far from estimated gantry axis on the star pattern were measured using an optical densitometer. On each profile, one coordimate of a beam axis was determined. A pair of coordinates on a beam axis form an equation of the axis. Assume that a unit vector equation omitted is with same direction as radiation beam and a vector equation omitted is a vector directing to the beam axis from the estimated gantry axis. Then, a vector product equation omitted ${\times}$ equation omitted is an area vector of which the absolute value is equal to the distance from the estimated gantry axis to the beam axis. The coordinate of gantry axis was obtained by using least-square method for the area vectors relative to the average of whole area vectors. For the axis, the maximum of absolute value of area vectors would be an accuracy of the gantry rotation axis. For the evaluation of mechanical accuracies of collimator and couch axes for which beam direction could not be depicted on a star pattern test film, narrow beams asymmetric in field length was used to simulate beam direction. Result: For a star test pattern to evaluate the mechanical accuracy of rotational axes of a telectherapy machine, the result considering beam direction was different from that ignoring beam direction. For the evaluation of mechanical accuracies of collimator and couch axes by means of a star pattern test, narrow asymmetric beams could simulate beam direction. Conclusion: When a star pattern test is used to evaluate the mechanical accuracy of a teletherapy unit, beam direction must be considered or simulated, and quantitatively evaluated.

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Sodium Sulfur Battery for Energy Storage System (대용량 에너지 저장시스템을 위한 나트륨 유황전지)

  • Kim, Dul-Sun;Kang, Sungwhan;Kim, Jun-Young;Ahn, Jou-Hyeon;Lee, Chang-Hui;Jung, Keeyoung;Park, Yoon-Cheol;Kim, Goun;Cho, Namung
    • Journal of the Korean Electrochemical Society
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    • v.16 no.3
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    • pp.111-122
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    • 2013
  • Sodium sulfur (NAS) battery is a high energy storage system (ESS). These days, as the use of renewable green energy like wind energy, solar energy and ocean energy is rapidly increasing, the demand of ESS is increasing and NAS battery is considered to be one of the most promising ESS. Since NAS battery has a high energy density(3 times of lead acid battery), long cycle life and no self-charge and discharge, it is a good candidate for ESS. A NAS battery consists of sulfur as the positive electrode, sodium as the negative electrode and ${\beta}$"-alumina as the electrolyte and a separator simultaneously. Since sulfur is an insulator, carbon felt should be used as conductor with sulfur and so the composition and property of the cathode could largely influence the cell performance and life cycle. Therefore, in this paper, the composition of NAS battery, the property of carbon felt and sodium polysulfides ($Na_2S_x$, intermediates of discharge), and the effects of these factors on cycle performance of cells are described in detail.

Geology and Constituent Rocks, and Radioactive Values of the Eoraesan Area, Chungju, Korea (충주 어래산지역의 지질 및 구성암류와 방사능 값)

  • Kang, Ji-Hoon;Lee, Deok-Seon;Koh, Sang-Mo
    • The Journal of the Petrological Society of Korea
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    • v.27 no.2
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    • pp.85-96
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    • 2018
  • The Neoproterozoic Gyemyeongsan Formation and the Mesozoic igneous rocks are distributed in the Eoraesan area, Chungju which is located in the northwestern part of Ogcheon metamorphic zone, Korea, and the rare earth element (REE) mineralized zone has been reported in the Gyemyeongsan Formation. We drew up the detailed geological map by the lithofacies classification, and measured the radioactivity values of the constituent rocks to understand the distribution and characteristics of the source rocks of REE ore body in this paper. It indicates that the Neoproterozoic Gyemyeongsan Formation is mainly composed of metapelitic rock, granitic gneiss, iron-bearing quartzite, metaplutonic acidic rock (banded type, fine-grained type, basic-bearing type, coarse-grained type), metavolcanic acidic rock, and the Mesozoic igneous rocks, which intruded it, are divided into pegmatite, biotite granite, gabbro, diorite, basic dyke. The constituent rocks of Gyemyeongsan Formation show a zonal distribution of mainly ENE trend, and the distribution of basic-bearing type of metaplutonic acidic rock (MPAR-B) is very similar to that of the previous researcher's REE ore body. The Mesozoic biotite granite is regionally distributed unlike the result of previous research. The radioactive value of MPAR-B, which has a range of 852~1217 cps (average 1039 cps), shows a maximum value among the constituent rocks. The maximum-density distribution of radioactive value also agrees with the distribution of MPAR-B. It suggests that the MPAR-B could be a source rock of the REE ore body.

Locational Patterns of Domestic Stores and Global Purchsing Offices of Multinational Retail Corporation: A Case Study of Daiei Superchain in Japan (다국적 소매기업의 국내 점포와 세계 사업소망의 입지전개: 日本 다이에 슈퍼체인을 사례로)

  • 한주성
    • Journal of the Economic Geographical Society of Korea
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    • v.2 no.1_2
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    • pp.183-194
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    • 1999
  • This paper examines the relationship between the locational patterns of global and domestic stores. Objective corporation for this research is the Daiei Inc., which is multinational retail corporation of general merchandise store industry. Used data are For the Customers and 1997 Annual Report published by the Daiei Inc. in 1997, and Worldwide Branch Location of Multinational Companies published by the Gale Researchy Inc. As a result it is recognized that the headquarters of supermarket companies are not necessarily established in the largest city of the store networks. In addition, the chani o stores does not always correspond to the economic territory area of a city or a regional urban system. Usually, supermarkets are established first one after another around the headquarter, so that the store network becomes intensive. Moreover, supermarket companies exhibit a tendence of expanding after having increased density of their stores in their indigenous regions. It seems that supermarket companies try to lay the foundation of their operation firmly on their indigenous regions, while they expand the store network into neighboring regions in order to enlarge their profits. This phenomenon appears more and less partly in the location of oversea purchasing offices. First oversea office location appears in neighboring countries whose headquarter is located in Japan. Another oversea office location is established in higher order city of another continent. Usally after the number of oversea offices increases in their headquarter's neighboring region, the oversea office network exhibits a tendency of expanding in another continents. in addition, network of oversea offices does not always correspond with world urban system. The location of oversea offices is formed, after internalization of supermarket stores was established in Japan. And when increasing rates of supermarket stores was low in Japan, number of oversea offices increased.

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Rat Liver $AT_1$ Receptor Binding Analysis for Drug Screening

  • Lee, Sunghou;Lee, Buyean;Hwasup Shin;Jaeyang Kong
    • Biomolecules & Therapeutics
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    • v.3 no.1
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    • pp.21-27
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    • 1995
  • The only compounds with antagonistic activity via AT$_1$receptor, one of two subtypes of angiotensin II (AII) receptor, have been demonstrated to block the vasoconstriction effects of AII and thereby provide therapeutic potential. This initiated the search for compounds with high specific affinity to AT$_1$receptor and their effective screening methods. The radioligand binding assay for the AII receptor is regarded as the primary method for the evaluation of AT$_1$receptor antagonists for their activity. In this paper, we characterized the liver AT$_1$receptor and describe the efficient method of the radioligand binding assay using rat liver as a source of AT$_1$receptor. Equilibrium binding studies with rat adrenal cortex, adrenal medulla, liver and bovine adrenal showed that the specific bindings of [$^3$H] AII were saturable in all tissues and the Scatchard plots of those data were linear, suggesting a single population of binding sites. Hill slopes were very near to the unity in all tissues. Kinetic studies of [$^3$H) AII binding in rat liver homogenates yielded two association rate constants, 4.10$\times$10$^{7}$ M$^{-1}$ min$^{-1}$ and 4.02$\times$10$^{9}$ M$^{-1}$ min$^{-1}$ , with a single dissociation rate constant, 7.07$\times$10$^{-3}$ min-$^{-1}$ , possibly due to the partial dissociation phenomenon. The rank order of inhibition potencies of [$^3$H] AII binding in rat liver was AII>Sarile>Losartan>PD 123177. Rat liver homogenates revealed to have very high density of homogeneous population of the AT$_1$receptor subtype, as the specifically bound [$^3$H] AII was not inhibited by PD 123177, the nonpeptide antagonist of AT$_2$. The results of this study demonstrated that the liver homogenates from rats could be the best receptor preparation for the AT$_1$receptor binding assay and provide an efficient system for the screening of newly synthesized candidate compounds of AT$_1$receptor antagonist.

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