• Spatial Information Research
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• 제18권3호
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• pp.63-72
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• 2010

일반적인 Vehicle Routing Problem with Simultaneous Pick-ups and Deliveries (VRPSPD)는 배송과 수거가 동시에 발생하는 문제를 고려한 차량경로 문제이며, 차량의 운행 거리등의 비용을 최소화하는 것을 결정하는 문제이다. 그러나 기존의 VRPSPD는 이미 차량이 출발하기 전에 경로가 정해져 있어서 차량 운행 중 발생하는 고객의 수거 요청을 기존의 경로에 효율적으로 추가하여 서비스하기가 어렵다. 따라서 본 논문에서는 이러한 문제를 위치기반의 서비스를 이용하여 이동 중인 차량의 위치정보를 파악하고 이를 바탕으로 실시간 재경로 탐색을 통해 해결하는 휴리스틱을 제안한다. 그리고 실험을 통해 기존의 방식과 비교하여 차량을 운행하는데 소요되는 비용을 줄이는 결과를 보였다.

• 한국컴퓨터정보학회논문지
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• 제26권9호
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• pp.143-153
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• 2021

본 논문의 목적은 빠른 배송을 위한 배송 차량의 유연 회차와 크라우드쉬핑(Crowd Shipping) 배달원인 플렉스를 활용한 "유연 회차와 플렉스" 방식을 제안하고, 풀이 알고리즘을 제안하는 것이다. 알고리즘은 선행 연구에서 성능이 검증된 2-opt를 사용하여 차량 경로를 계산하고, 절약 휴리스틱(Saving heuristic)을 변형한 방식으로 플렉스에 할당할 고객을 계산한다. 알고리즘은 차량과 플렉스를 분리하는 것이 아니라, 상호 보완적으로 운용될 수 있게 한다. 이를 위해 차량 정보가 플렉스 할당 과정에 고려되도록 하였다. 본 연구의 실험은 다양한 도심지의 상황을 상정한 Random, Mixed, Cluster 인스턴스로 구성되었다. 실험 결과 모든 인스턴스에서는 플렉스의 사용이 차량 유연 회차의 효율성을 높여주는 것을 확인하였다. 또 플렉스와 배송 지연 시간 비용에 대한 민감도 분석에서는 "유연 회차와 플렉스"가 차량만을 사용하는 방식의 차량 대수에 따라 값에 차이를 보였지만, 플렉스 비용이나 배송 지연 시간 비용이 200% 증가하는 경우에도 우위를 유지하는 것을 확인하였다. 본 연구의 결과는 플렉스가 차량과 연계되어 활용되는 경우, 플렉스에 의해 서비스되는 고객뿐만 아니라 차량으로 서비스되는 고객들의 서비스 품질을 높일 수 있음을 보여준다.

• 한국컴퓨터정보학회논문지
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• 제27권11호
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• pp.107-114
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• 2022

본 논문은 자율주행 학습이 가능한 택배 로봇을 제안한다. 제안하는 로봇은 지상 주차시설이 없는 공원형 아파트에서 활용 가능하도록 설계되었으며 지상 및 지하 경로가 복잡한 기존 아파트에 비해 공원형 아파트는 이동 경로가 정형화되어 있어 로봇의 안정적인 주행이 가능하여 학생들의 초기 교육 환경으로 적합하다. 택배 로봇은 경로학습을 위한 머신러닝 기술과 카메라와 라이다 센서를 이용한 자율주행을 통하여 택배 운반이 가능하도록 구성하였다. 또한, 수준별 학습이 가능하도록 제어 MCU를 3개로 분리하여 설계하였으며 자율주행, 장애물 인식 등의 동작 테스트를 통하여 학습용 택배 로봇으로 활용될 수 있음을 확인하였다. 향후 정밀한 실내 위치정보 인식 기술과 아파트의 공공기술 플랫폼과 연동하여 다양한 배송 서비스를 위한 교육용 배송 로봇으로 발전시키고자 한다.

• 한국응용과학기술학회지
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• 제27권4호
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• pp.407-414
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• 2010

New biological treatments were being developed at a record place, but their potential could be compromised by a significant obstacle: the delivery of these drugs into a body. Pharmaceutical delivery is now nearly as important as product. New systems are being developed, and Drug Delivery Markets Series cover these new systems. Transdermal Delivery System(TDS) is often used as a method of drug dosage into the epidermic skin. An approach used to delivery drugs through the skin for therapeutic use as an alternative to oral, intravascular, subcutaneous and transmucosal routes. Various transdermal drug delivery technologies are described including the use of suitable formulations, carriers and penetration enhancers. The most commonly used transdermal system is the skin patch using various types of technologies. Compared with other methods of dosage, it is possible to use for a long term. It is also possible to stop the drug dosage are stopped if the drug dosage lead to side effect. Polysaccharides, such as karaya gum and glucomannan, were selected as base materials of TDS. Also, these polymers were characterized in terms of enhancers, drug contents. Among these polysaccharide, the permeation rate of karaya gum matrix was fastest in fibric acid(ciprofibrate) such as lipophilic drug in vitro. We used glycerin, PEG400 and PEG800 as enhancers. Since dermis has more water content(hydration) than the stratum corneum, skin permeation rate at steady state was highly influenced when PEG400 was more effective for lipophilic drug. Proper selection of the polymeric materials which resemble and enhance properties of the delivering drug was found to be important in controlling the skin permeation rate. Especially, this result suggests a possible use of polysaccharide gel ointment matrix as a transdermal delivery system of anti-hyperlipoproteinemic agent.

• Advances in nano research
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• 제13권1호
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• pp.87-96
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• 2022

Drug self-delivery systems can easily realize combination drug therapy and avoid carrier-induced toxicity and immunogenicity because they do not need non-therapeutic carrier materials. So, designing appropriate drug self-delivery systems for specific diseases can settle most of the problems existing in traditional drug delivery systems. Retinal pigment epithelium is very important for the homeostasis of retina. However, it is vulnerable to oxidative damage and difficult to repair. Worse still, the antioxidants can hardly reach the retina by non-invasive administration routes due to the ocular barriers. Herein, the targeted group (folic acid) and antioxidant (melatonin) have been grafted on the surface of ZnO quantum dots to fabricate a new kind of drug self-delivery systems as a protectant via eyedrops. In this study, the negative nanoparticles with size ranging in 4~6 nm were successfully synthesized. They could easily and precisely deliver drugs to retinal pigment epithelium via eyedrops. And they realized acid degradation to controlled release of melatonin and zinc in retinal pigment epithelium cells. Consequently, the structure of retinal pigment epithelium cells were stabilized according to the expression of ZO-1 and β-catenin. Moreover, the antioxidant capacity of retinal pigment epithelium were enhanced both in health mice and photic injury mice. Therefore, such new drug self-delivery systems have great potential both in prevention and treatment of oxidative damage induced retinal diseases.

• 산업경영시스템학회지
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• 제19권37호
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• pp.263-269
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• 1996

The cost and customer service level of a logistics system depend primarily on the system design of the physical supply system and physical distribution system. The study presents the mathematical model and a huristic solution method of a combined location - vehicle routing problem(LVRP). In LVRP the objective is to determine the number and location of the distribution centers, the allocation of customers to distribution centers, and the vehicle delivery routes, so as to minimize the logistics total cost and satisfy the customer.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2003년도 추계학술대회
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• pp.154-154
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• 2003

The primary routes of drug administration include oral, intramuscular, subcutaneous and intravenous dosing for toxicological risk assessment purpose in dog. There has been an increase applying transdermal patches as an alternate method for systemic delivery. The present study was performed to establish the transdermal delivery method of medicated ointment, liquid and powder material to beagle dog.(omitted)

• Biomolecules & Therapeutics
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• 제31권1호
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• pp.16-26
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• 2023

Diabetes is an untreatable metabolic disorder characterized by alteration in blood sugar homeostasis, with submucosal insulin therapy being the primary treatment option. This route of drug administration is attributed to low patient comfort due to the risk of pain, distress, and local inflammation/infections. Nanoparticles have indeed been suggested as insulin carriers to allow the drug to be administered via less invasive routes other than injection, such as orally or nasally. The organic-based nanoparticles can be derived from various organic materials (for instance, polysaccharides, lipids, and so on) and thus are prevalently used to enhance the physical and chemical consistency of loaded bioactive compounds (drug) and thus their bioavailability. This review presents various forms of organic nanoparticles (for example, chitosan, dextron, gums, nanoemulsion, alginate, and so on) for enhanced hypoglycemic drug delivery relative to traditional therapies.

• 한국멀티미디어학회논문지
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• 제13권6호
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• pp.849-864
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• 2010

This paper proposes a multipath routing protocol called cross-layer multipath AODV (CM-AODV) for wireless ad hoc networks, which selects multiple routes on demand based on the signal-to-interference plus noise ratio (SINR) measured at the physical layer. Note that AODV (Ad hoc On-demand Distance Vector) is one of the most popular routing protocols for mobile ad hoc networks. Each time a route request (RREQ) message is forwarded hop by hop, each forwarding node updates the route quality which is defined as the minimum SINR of serialized links in a route and is contained in the RREQ header. While achieving robust packet delivery, the proposed CM-AODV is amenable to immediate implementation using existing technology by neither defining additional packet types nor increasing packet length. Compared to the conventional multipath version of AODV (which is called AOMDV), CM-AODV assigns the construction of multiple paths to the destination node and makes it algorithmically simple, resulting in the improved performance of packet delivery and the less overhead incurred at intermediate nodes. Our performance study shows that CM-AODV significantly outperforms AOMDV in terms of packet delivery ratio and average end-to-end delay, and results in less routing overhead.

• 무역상무연구
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• 제49권
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• pp.359-378
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• 2011

UCP600 Article 20 (a) (v) states that contents of terms and conditions of carriage will not be examined and Article 34 states that a bank assumes no liability or responsibility for the general or particular conditions stipulated in a document. From this perspective, banks may seem to have no obligation to examine the pre-printed clause of B/L. However, ICC decided that no opinion could be given in relation to the issues surrounding B/Ls that contain delivery clauses. Accordingly, it is agreed by previous cases and some scholars that banks may refuse the B/Ls that contain delivery clauses which are not present in other B/Ls of the same goods and transport routes. Also, ICC published ICC Decision in July 2010 regarding on board notation. In this decision, if a B/L indicates a place of receipt that is different from the port of loading and there is an indication of a means of pre-carriage, then a dated on board notation will be required indicating the name of the vessel and the port of loading. Therefore, banks may,, in some cases, need to scrutinize the pre-printed clauses especially appearing in the front page of B/Ls.