• Korean Management Science Review
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• v.21 no.3
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• pp.115-127
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• 2004

In this paper, we describe an intelligent monitoring and control system for pick-up/delivery service. This system applies geographical information system(GIS), global positioning system(GPS) and wireless communication technologies for managing pick-up/delivery operations more effectively. It consists of three subsystems, pick-up/delivery sequence planning system, pick-up/delivery monitoring system, and PDA execution system. Pick-up/delivery sequence planning system generates routes and schedules for pick-up/delivery using GIS and optimization techniques. Pick-up/delivery monitoring system monitors current positions of vehicles and actual pick-up/delivery results as compared with planned routes and visit times, while PDA execution system transmits information for vehicles positions and actual pick-up/delivery results using GPS and wireless communication technologies. The intelligent monitoring and control system is currently being used for the pick-up parcel service in a local post office of Korea Post.

• Biotechnology and Bioprocess Engineering:BBE
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• v.6 no.4
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• pp.212-230
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• 2001

Recent advances in recombinant DNA technology have resulted in development of many new protein drugs. Due to the unique properties of protein druges, they have to be delivered by parenteral injection Although delivery of protein drugs by other routes, such as pulmonary and nasal routes, has shown some promises, to date most protein drugs are administered by par-enteral routs. For long-term delivery of protein drugs by parenteral administration, they have been formulated into biodegradable microspheres. A number of microencapsulation methods have been developed, and the currently used microencapsulation methods are reviewed here, The microen-capsulation methods have been divided based on the method used. They are: solvent evapora-tion/extraction; phase separation (coacervation);spray drying; ionotropic gelation/polyelectrolyte complexation; interfacial polyumerization and supercritical fluid precipitation. Each method is de-scribed fro its applications, advantages, and limitations.

• KSBB Journal
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• v.25 no.6
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• pp.497-506
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• 2010

Vaccine is a protective clinical measure capable of persuading immune system against infectious agents. Vaccine can be categorized as live attenuated and inactivated. Live attenuated vaccines activate immunity similar to natural infection by replicating living organisms whereas inactivated vaccines are either whole cell vaccines, eliciting immune response by killed organisms,or subunit vaccines, stimulating immunity by non-replicating sub cellular parts. The components of vaccine play a critical role in deciding the immune response mediated by the vaccine. The innate immune responds against the antigen component. Adjuvants represent an importantcomponent of vaccine for enhancing the immunogenicity of the antigens. Subunit vaccines with isolated fractions of killed and recombinant antigens are mostly co-administered with adjuvants. The delivery system of the vaccine is another essential component to ensurethat vaccine is delivered to the right target with right dosage form. Furthermore, vaccine delivery system ensures that the desired immune response is achieved by manipulating the optimal interaction of vaccine and adjuvantwith the immune cell. The aforementioned components along with routes of administration of vaccine are the key elements of a successful vaccination procedure. Vaccines can be administered either orally or by parenteral routes. Many groups had made remarkable efforts for the development of new vaccine and delivery system. The emergence of new vaccine delivery system may lead to pursue the immunization goals with better clinical practices.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.38 no.3
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• pp.1-7
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• 2015

This research is to develop a possible process to apply k-means clustering to an efficient vehicle routing process under time varying vehicle moving speeds. Time varying vehicle moving speeds are easy to find in metropolitan area. There is a big difference between the moving time requirements of two specific delivery points. Less delivery times are necessary if a delivery vehicle moves after or before rush hours. Various vehicle moving speeds make the efficient vehicle route search process extremely difficult to find even for near optimum routes due to the changes of required time between delivery points. Delivery area division is designed to simplify this complicated VRPs due to time various vehicle speeds. Certain divided area can be grouped into few adjacent divisions to assume that no vehicle speed change in each division. The vehicle speeds moving between two delivery points within this adjacent division can be assumed to be same. This indicates that it is possible to search optimum routes based upon the distance between two points as regular traveling salesman problems. This makes the complicated search process simple to attack since few local optimum routes can be found and then connects them to make a complete route. A possible method to divide area using k-means clustering is suggested and detailed examples are given with explanations in this paper. It is clear that the results obtained using the suggested process are more reasonable than other methods. The suggested area division process can be used to generate better area division promising improved vehicle route generations.

• Korean Management Science Review
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• v.24 no.2
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• pp.43-56
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• 2007

VRP(Vehicle Routing Problem) is studied in this paper, where two different kinds of missions are to be completed. The objective is to minimize the total vehicle operating distance. A mixed integer programming formulation and a heuristic algorithm for a practical use are suggested. A heuristic algorithm consists of three phases such as clustering, constructing routes, and adjustment. In the first phase, customers are clustered so that the supply nodes are grouped with demand nodes to be served by the same vehicle. Vehicle routes are generated within the cluster in the second phase. Clusters and routes are adjusted in the third phase using the UF (unfitness) rule designed to determine the customers and the routes to be moved properly. It is shown that the suggested heuristic algorithm yields good performances within a relatively short computational time through computational experiment.

• Journal of Pharmaceutical Investigation
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• v.22 no.4
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• pp.251-266
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• 1992

A major problem with the peptide-based drugs is that these drugs must generally be administered by injection. Therefore, there is considerable research interest in alternative routes of delivery, such as buccal, nasal, gastrointestinal route and etc. Site-specific drug delivery to the colon, as an alternative to parenteral drug delivery, is of interest for the delivery of peptide-based drugs as well as the delivery of low molecular weight drugs for the treatment of colonic disease, This review describes some considerations of colon-specific drug delivery using hydrogels.

• Journal of Korea Society of Digital Industry and Information Management
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• v.11 no.3
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• pp.145-158
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• 2015

Disposable marine product packaging materials such as wooden, Styrofoam, and corrugated cardboard boxes have a very low reuse rate, thus causing the logistics costs to rise and making it difficult to establish a unit load system for marine products. Disposable packing containers to be discarded are accompanied by resource and environmental issues home and abroad. Transportation vehicles for marine products have to return empty without loading different kinds of products after delivery due to the smell and properties of marine products, thus posing as an obstacle to logistics rationalization. In an effort to overcome those limitations, this study examined the stages of transportation including "producer-wholesale market in the producing area-commission merchant-wholesale market in the consumption area-commission merchant-quasi-wholesale market-consumer" and also analyzed the utilization and distribution of disposable packaging materials currently used in the circulation of marine products including wooden, Styrofoam, and corrugated cardboard boxes. Based on the analysis results, the investigator developed a logistics rationalization model capable of promoting semi-permanent reuse and lowering empty vehicle rate on return routes as an alternative to address environmental issues caused by disposable packaging materials, which have been an obstacle to the logistics rationalization of marine products, packaging costs in the process of repeating packing and unpacking at each stage of marine products circulation, and empty vehicle rates on return routes after marine products delivery.

• Journal of the Korea Safety Management & Science
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• v.13 no.3
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• pp.97-105
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• 2011

In order to determine home delivery service routes, conditions specified for each parcel such as customer-assigned delivery times and parcel contents should be considered, so the conventional route search algorithms have some limits to be applied for home delivery services. In this study, a multi-purpose route searching algorithm is suggested in order to deal with every requirement of deliveries that vary in delivery distances, contents and appointed times. A simulation study to verify the performances of the system with example data of Seoul and Kyungki provinces shows that it significantly improves the customer satisfaction and the productivity of delivery businesses.

• International Journal of Computer Science & Network Security
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• v.21 no.12spc
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• pp.443-450
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• 2021

The study is devoted to the formation of a economic principles cargo delivery management in global supply chains. Mathematical model of delivering special categories of goods by road is a key element of these principles. The article analyzes the existing studies on solving the problem of cargo delivery in various aspects. It was noted that the greatest attention is paid to legal regulation, last mile delivery, optimization of routes and delivery schemes, information support, technological innovations, cluster routing, etc. In the developed mathematical model a minimum of total costs of forming loading units and freight shipments was defined as the criterion of optimality of organizing delivery by motor transport. The authors propose the creation of logistics clusters allowing the integration of urban transport flows and global supply chains.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2009.06a
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• pp.149-150
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• 2009

The problem of vehicle routing problem(VRP) with pair operations of pick up and delivery are well-known in real applications in logistics networks, as in planning the routes for automatic guided vehicles(AGVs) in an automatic container terminal(ACT), warehouses or in some just-in-time services. This paper will present a formulation to modeling the problem mathematically which can be used to generate optimal routes of carried vehicles in the field to reduce the incurred cost of moving goods. This selected model could be used in (semi-)automatic short-term planning systems for vehicle fleet working in ACT, or in modern warehouses which the long list of requests is parted and sorted in preprocessing orders systems.