• Animal cells and systems
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• 제3권4호
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• pp.413-415
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• 1999

Our previous report demonstrated that the rhp51$^＋$, a recA and RAD51 homolog of the fission yeast, encodes three transcripts of 1.9, 1.6 and 1.3 kb which have at least six polyadenylation sites. The 3'-end of the gene alone can direct the formation of multiple, discrete 3'ends of the transcripts. To identify the regulatory element required for the 3'-end formation of -rhp51$^＋$ deletion mapping analysis was performed. Northern blot analysis revealed that the 254-bp DNA fragment including 4 distinct poly (A) sites downstream from the Hindlll site, is crucial for normal 3'-end formation. Deletion of the 3'-terminal AU rich region caused appearance of read-through RNA, leading to enhancement of survival rate of the rhp51 deletion mutant in response to DNA damaging agent, methylmethane sulfonate (MMS). The results imply that the rhp51$^＋$ system may be useful for molecular analysis of the 3'-end formation of RNA in the fission yeast.

• 영어어문교육
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• 제11권1호
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• pp.137-154
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• 2005

The purpose of this paper is to analyze vowel lengthening triggered by resyllabification. In general, short vowels become long when a following consonant is deleted, as shown in stehli 'steel' > st$\bar{e}$li and *fimf 'five' > five. We can account for the phenomenon in a straightforward way within the framework of CV phonology (Clements & Keyser, 1983) : deletion of a coda consonant C slot and then the preceding vowel spreads onto it, resulting in a long vowel. The analysis, however, cannot hold for words like ealhes 'temple', where deletion of an onset segment eventually triggers vowel lengthening in the preceding syllable. In order to account for this, I propose resyllabification. That is, ealhes first becomes eales by /h/-deletion. Next, the /l/ in coda is resyllabified as the onset of the following syllable, leaving its C slot unoccupied. Finally, the vowel spreads onto the empty slot, producing a long vowel.

• 대한기계학회논문집A
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• 제32권6호
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• pp.496-503
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• 2008

With the improvement of computer power and technology, fracture modelling by finite element methods has become a topic of extensive studies. However, fracture simulation much limited to an academic study of crack propagation with a fine mesh. Element deletion method is a useful tool for estimating damage due to accidental or extreme loads on structures, provided that an effective and realistic criterion is established for simulating the material failure and subsequent element deletion. In this study, ABAQUS/Explicit is used to simulate the material failure on the basis of experimental results by X. Huang et al. Through numerical experiments, we suggest a formulation to determine the failure strain associated with the size and thickness of removed elements.

• Journal of Life Science
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• 제9권1호
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• pp.1-4
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• 1999

Large-scale deletions of mitochondrial DNA(mtDNA) have been documented in patients with mitochondrial myopathies and seem to be especially frequent in patients with Kearns-Sayre syndrome (KSS). About one third of all patients shows a 4,977 bp deletion, known as the "common deletion", that removes a segment of DNA that includes several genes encoding for respiratory chain subunits. In this disorder, the population of deleted mtDNA molecules coexists with population of normal, wild-type full length mtDNAs, a situation known as heteroplasmy. We have performed polymerase chain reaction (PCR) on paraffin-embedded muscle tissues from two korean KSS patients. The PCR analysis revealed the existence of two amplified fragments, the deleted fragments, the deleted fragment of 123 bp characteristic for common deletion and the wild-type fragment of 152 bp.of 152 bp.

• Environmental Analysis Health and Toxicology
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• 제23권4호
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• pp.277-284
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• 2008

The ecotoxicological effects of 4-tert-octylphenol were observed on non-biting midge, Chironomus plumosus collected from Anyang stream in Seoul. The survival rate and adult emergence rate on C. plumosus exposed to octylphenol were not significantly affected. However, 4-tert-octylphenol induced developmental delay and disrupted sex ratio in high concentration of octylphenol. The mouth deformity such as tooth deletion or fusion in mentum, and tooth deletion in mandible were observed exposure to 4-tert-octylphenol. The deformity type of the mentum showed deletion (LT, 6.7%), and fusion (LT, 6.3%). Moreover, tooth deletion of mandible was observed in 4-tert-octylphenol treated groups (6.7%, 3 ppm).

• Journal of the Korean Statistical Society
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• 제16권2호
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• pp.55-70
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• 1987

The principal components regression is one of the substitues for least squares method when there exists multicollinearity in the multiple linear regression model. It is observed graphically that the performance of the principal components regression is strongly dependent upon the values of the parameters. Accordingly, a new deletion criterion which determines proper principal components to be deleted from the analysis is developed and its usefulness is checked by simulations.

• 디지털산업정보학회논문지
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• 제11권2호
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• pp.73-90
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• 2015

When we apply file commands on files in a directory, the directory as well as the file suffer changes in timestamps of MFT entry. Based on understanding of these changes, this work provides a digital forensic analysis on the timestamp changes of the directory influenced by execution of file commands. NTFS utilizes B-tree indexing structure for managing efficient storage of a huge number of files and fast lookups, which changes an index tree of the directory index when files are operated by commands. From a digital forensic point of view, we try to understand behaviors of the B-tree indexes and are looking for traces of files to collect information. But it is not easy to analyze the directory index entry when the file commands are executed. And researches on a digital forensic about NTFS directory and B-tree indexing are comparatively rare. Focusing on the fact, we present, in this paper, directory timestamp changes after executing file commands including a creation, a copy, a deletion etc are analyzed and a method for finding forensic evidences of a deletion of directory containing files. With some cases, i.e. examples of file copy and file deletion command, analyses on the problem of timestamp changes of the directory are given and the problem of finding evidences of a deletion of directory containging files are shown.

• Journal of Microbiology
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• 제41권2호
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• pp.129-136
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• 2003

The Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMPI) exhibits considerable sequence heterogeneity among EBV isolates. Seven distinct EBV strains have been defined based on sequence polymorphisms in the LMPI gene, which are designated China 1, China 2, China 3, Alaskan, Mediterranean, NC, and the B95-8 strains. In this study, we analyzed a 30-bp deletion and sequence variations in the carboxy-terminal region of the LMPl gene in 12 EBV isolates from spontaneous lym-phoblastoid cell lines derived from individuals with non-EBV associated cancers in Korea. Eleven of the 12 isolates showed a 30-bp deletion spanning LMPI amino acids 342 to 353, suggesting a high prevalence of the LMPI 30-bp deletion variant among EBV isolates in Korea. In addition, all 12 isolates had a 15-bp common deletion in the 33-bp repeat region and multiple base-pair changes relative to the prototype B95-8 EBV strain along with variations in the number of the 33-bp repeats. The bp changes at positions 168746, 168694, 168687, 168395, 168357, 168355, 168631, 168320, 168308, 168295, and 168225 were highly conserved among the isolates. Comparative analysis of sequence change patterns in the LMPI carboxy-terminal coding region identified nine 30-bp deletion variants as China 1, two deletion variants as a possible interstrain between the Alaskan and China 1 strains, and a single undeleted variant as a possible variant of the Alaskan strain. These results suggest the predominance of the China 1 EBV strain in the Korean population.

• 대한음성학회지:말소리
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• 제25_26호
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• pp.38-51
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• 1993

Korean phonology has not recognised metrical foot as a phonological unit to account for certain phonological processes. This paper, however, suggests that an optional h-deletion process in Korean should require the notion of metrical foot as an independent phonological domain. The previous analyses rely on the notion of speech speed to explain optional h-deletion : i. e. an intervocalic h is deleted in fast speech, but in slow speech it remains. This paper claims that the notion of speech speed should be reinterpreted in terms of metrical foot : i.e. foot-internal t is deleted, but foot-initial h remains. Such analysis provides evidence that metrical foot constitutes a phonological unit in Korean phonology. With the notion of metrical foot, it enables us to achieve more detailed and accurate analysis of the optional h-deletion process in Korean.

• Asian Pacific Journal of Cancer Prevention
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• 제17권5호
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• pp.2629-2635
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• 2016

Genetic polymorphisms constitute one of the reasons behind the racial variation in prostate cancer occurrence. Published studies regarding genetic associations of glutathione S-transferase mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1) null deletion polymorphisms with prostatic carcinoma have generated inconsistent results among different populations. To date, even a single meta-analysis is not available representing the association of these genes with prostate cancer in different ethnic groups. Therefore, the aim of the current study was to provide a clear picture of GSTM1 and GSTT1 null deletion and risk of prostate cancer among different ethnic groups (i.e. Asians, Europeans, Americans, Africans and Eurasians). A systematic search was performed with the help of various search engines to find out the all the recent studies (2004 to 2015) evaluating the role of GSTM1 and GSTT1 deletion in prostate cancer development. Odds ratios (ORs) with 95% confidence interval (CI) of a total of 34 studies with 7,281 cases and 9,082 controls was analyzed using STATA and MedCalc software. Overall, GSTM1 deletion (OR 3.67; CI 1.39-9.85; P= 0.001) was strongly associated with prostatic cancer. In the sub group analysis GSTM1 null deletion was also significantly associated with prostate cancer among Asians (OR 4.84; CI 1.08-21.5; P= 0.03), Eurasians (OR 17.69; CI 9.87-31.70; P< 0.001) and Americans (OR 0.11; CI 0.01-1.06; P= 0.05). No association was observed among Europeans (P=0.42) and Africans (P= 0.40). As a whole GSTT1 null deletion (OR 0.85; CI 0.28-2.58; P= 0.77) did not show anyt significant association with prostate cancer risk among different populations. When the data were stratified into different groups, however, Africans demonstrated a significant association of GSTT1 null deletion (OR 1.95; CI 1.57-2.39; P<0.001) with prostate cancer, whereas no association was found among Asians (P= 0.90), Americans (P= 0.50), Europeans (P= 0.89) and Eurasians (P= 1.0). In conclusion, both GSTM1 and GSTT1 may contribute to prostate cancer development but GSTM1 may prove to be a stronger candidate risk factor.