• Polymer(Korea)
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• v.36 no.6
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• pp.699-704
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• 2012

Double-layered polymeric carrier was designed for release control of hydrophilic drug in oral administration. Biopolymeric chitosan and alginate were examined as polar absorbents, poly(D,L-lactide) as a hydrophobic shell, and theophylline and diclofenac sodium as loading drugs. The fabrication of the carriers was prepared in the form of double-layered microsphere for delayed and successively extended release, which consisted of outer shell of poly(D,L-lactide) and inner core of alginate or chitosan with drugs. Morphologies and drug-release behaviors of the carriers were investigated, which were influenced by a combination of polarity between carrier and drug. It was confirmed that the relative polarities of the carriers, the drugs, and the environmental pH affected significantly the drug-release property.

• Journal of the Korea institute for structural maintenance and inspection
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• v.23 no.7
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• pp.152-163
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• 2019

In this paper, effect of steel fiber inclusion, compressive strength of matrix, shear reinforcement and shear span to depth ratio on the flexural behavior of UHPFRC(Ultra High Performance Fiber Reinforced Concrete) were investigated with test of 10-UHPFRC beam specimens. All test specimens were subjected to the flexural static loading. It was shown that steel fiber significantly improve the shear strength of UHPFRC beams. 2% volume fraction of steel fiber change the mode of failure from shear failure to flexural failure and delayed the failure of compressive strut with comparatively short shear span to depth ratio. UHPFRC beams without steel fiber had a 45-degree crack angle and fiber reinforced one had lower crack angle. Shear reinforcement contribution on shear strength of beams can be calculated by 45-degree truss model with acceptable conservatism. Using test results, French and Korean UHPFRC design recommendations were evaluated. French recommendation have shown conservative results on flexural behavior but Korean recommendation have shown overestimation for flexural strength. Both recommendations have shown the conservatism on the flexural ductility and shear strength either.

• Journal of Environmental Science International
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• v.21 no.1
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• pp.83-88
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• 2012

This study was divided to three experiments for evaluating the effects of pre- or post-load 1-MCP on quality of 'Fuji' apples exposed to ethylene. The first experiment was compared for fruit quality at room temperature at 7, 14, 21, and 28 days between the control and 1-MCP-treated fruits followed storage of 130, 150, and 170 days. 1-MCP-treated fruits maintained higher fruit titratable acidity and firmness than those of control fruits. The second experiment was compared for fruit quality at room temperature at 7, 14, 21, and 28 days between fruits applied with pre-loaded-1-MCP on ethylene treatments (10 ${\mu}L/L$, 20 ${\mu}L/L$, and 40 ${\mu}L/L$) and control fruits. 1-MCP-treated fruits were not affected by ethylene concentrations, and had higher fruit weight and firmness than those of control. The third experiment was compared for fruit quality at room temperature at 7, 14, 21, and 28 days between fruits applied with pre-loading with ethylene (10 ${\mu}L/L$) followed by ventilation (8 h, or 32 h, or 56 h) and 1.0 ${\mu}L/L$ 1-MCP treatment. As observed above experiments, 1-MCP-treated fruits had higher fruit weight and firmness than those of control fruits, regardless of the delayed applications of 1-MCP.

• Journal of Periodontal and Implant Science
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• v.45 no.2
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• pp.62-68
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• 2015

Purpose: The goal of this study was to investigate the histomorphometric characteristics of the healing process of microcracks in the cortical bone after the installation of mini-implants (MIs). Methods: Self-drilling MIs were inserted into the tibial diaphysis of twelve adult male New Zealand rabbits. Four MIs per rabbit were placed randomly. The animals were divided into four groups according to the length of the healing period: group A was sacrificed immediately, group B was sacrificed after one week, group C was sacrificed after two weeks, and group D was sacrificed after four weeks. Cortical bone thickness was measured using micro-computed tomography, and histomorphometric analyses of the cumulative length of the microcracks (CLCr) and the total number of microcracks (NCr) were performed using hematoxylin and eosin staining. Results: The microcracks were radially and concentrically aligned in the peri-MI bone. The CLCr decreased significantly one week after the surgery, mainly due to healing of the concentrically aligned microcracks. The CLCr showed another significant decrease from two weeks after the surgery to four weeks after the surgery, mainly reflecting healing of the radially aligned microcracks. A statistically significant decrease in the NCr occurred as the microcracks healed from zero weeks to two weeks. However, no significant difference in the NCr was found between groups C and D. Conclusions: In order to improve the primary stability of MIs, delayed loading and a healing period of a certain length are recommended to ensure the optimal healing of microcracks and bone remodeling.

• Nutritional Sciences
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• v.8 no.2
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• pp.83-88
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• 2005

This study was to investigate the effect of psyllium seed husk (PSYL) on postprandial glucose control and insulin secretion dynamics in Sprague-Dawley rats. In experiment 1, the rise in postprandial serum glucose was monitored during a 240-min period using a maltose loading test In normal rats given 16.6 mg/l00 g B.W./ml of PSYL orally, all the blood glucose levels during the 240-min period did not show statistically significant differences from the corresponding levels in normal rats given water. However, in streptozotocin-induced diabetic rats given the same amount of PSYL, the blood glucose level at 30 min was significantly lower than that in diabetic rats given water, and the peak time of the rise in the postprandial glucose was delayed In experiment 2, the normal (N) and diabetic (Db) rats were given PSYL (25 mg/l00 g B.W./ml/day) orally for 5 days. Blood samples were collected in order to measure the s-glucose and s-insulin levels. The final s-glucose level at day 5 in Db-PSYL was significantly lower than that in the corresponding control rats (Db-CONT) and the final s-insulin level in Db-PSYL was significantly greater than that in Db-CONT. In vitro 40-min pancreas perfusion was performed at day 5 in order to examine the insulin secretion dynamics. Results showed that the amounts of insulin secreted during the first phase (11-20 min) and the second phase (21-40 min) in the Db-PSYL were significantly greater than those in Db-CONT. Therefore, it is concluded that psyllium seed husk could be beneficial for controlling postprandial glucose levels in the stretozotocin-induced diabetic rats, and it may be partially mediated by insulin secretion dynamics.

• Journal of the Korea Concrete Institute
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• v.28 no.4
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• pp.481-488
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• 2016

Concrete member has been subjected to dead and live loads in use, and the induced stress can affect not only structural but also durability behavior. In mass concrete construction, construction joint are required, however cold joint usually occur due to poor surface treatment and delayed concrete placing. The concrete with joint is vulnerable to both shear stress and chloride ingress. This paper presents a quantitative evaluation of cold joint and loading conditions on chloride diffusion behavior. With increasing tensile stress from 30% to 60%, chloride diffusion coefficient gradually increases, which shows no significant difference from result in the sound concrete. However chloride diffusion coefficient under 30% level of compressive stress significantly increases by 1.70 times compared with normal condition. Special attention should be paid for the enlarged diffusion behavior cold joint concrete under compressive stress.

• Journal of the Korean Geosynthetics Society
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• v.11 no.1
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• pp.47-56
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• 2012

Discharge capacity of PBD is sensitive in proportion to thickness and ground condition, and drainage of PBD declines due to disturbance effect in surrounding ground by mandrel used for vertical drainage setting and setting machines and type. Also, deviation of discharge capacity gets larger according to ground condition, construction condition and soil properties. But cause and analysis of those problems like reduced discharge of capacity and delayed dissipation of pore water pressure for discharge capacity is lack. Thus, in this text, ground improvement and discharge capacity is investigated by implementing composite discharge capacity test for analysis of an effect factor of PBD discharge capacity with in-situ ground condition. After fixing the vertical drain on a cylindrical cylinder, put churned sample into the cylinder. After in-situ ground and reclamation of ground are dredged, load following the loading step of 30, 70 and 120kPa using a pressure device. Result of the test, The discharge capacity was SM>ML>CL>CL(dredged soil) in situ condition and more fine-grained content, the amount of discharge was greater.

• The Journal of Korean Academy of Prosthodontics
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• v.35 no.4
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• pp.781-792
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• 1997

This study was peformed to evaluate the dynamic fatigue characteristics of the dental ceramics for all-ceramic crown. A feldspathic porcelain of VMK68. glass ceramic of IPS-Empress, and glass infiltrated alumina ceramic of In-Ceram were used. Disc specimens were prepared to the final dimensions of 12 mm in diameter and 1 mm in thickness. The biaxial flexure test was conducted using a ball-on-three-ball method. 240 specimens were tested in $37^{\circ}C$ water by testing 20 samples at each of four loading rates:0.05, 0.2, 1, and 5mm/min. 60 specimens were tested in a moisture-free environment by testing 20 samples at 5mm/min. The inert strength of VMK68 was 80.25MPa, and the fatigue parameters were n=29.1, ${\sigma}_{fo}=52.90MPa$. The inert strength of IPS-Empress was 104.76MPa, and the fatigue parameters were n=32.46, ${\sigma}_{fo}=67.52MPa$. The inert strength of In-Ceram was 429.33MPa, and the fatigue parameters were n=31.46, ${\sigma}_{fo}=258.36MPa$. 10-year failure stresses of VMK68, IPS-Empress, and In-Ceram were 20.3MPa, 24.8MPa, and 93.6MPa, respectively. Failure strength and fatigue life showed the highest value in In-Ceram, and then, IPS-Empress and VMK68.

• Applied Chemistry for Engineering
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• v.7 no.4
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• pp.735-742
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• 1996

Polymeric matrices were prepared with dextran and silver sulfadiazine by adding glycerine as a plasticiser. Namely, the release rate of the drug from the polymeric matrix formulations in dissolved phases was determined in a phosphate buffer solution. The results were as follows : The drug release time was delayed as drug loading contents increased, whereas it decreased as the glycerine concentration increased. The drug release time was not changed with varying the molecular weight of the dextran. The apparent release rate constant (k) increased as the composition of silver sulfadiazine and glycerine was increased. But the apparent release rate constant (k) was not changed with increasing molecular weight of the dextran.

• Journal of the Korean Geotechnical Society
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• v.19 no.2
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• pp.75-85
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• 2003

Laboratory model blast and in-situ rock blast tests were conducted to determine blast-induced stress wave propagation characteristics under different explosive types, different loading conditions and different mediums. Dynamic numerical approaches were conducted under the same conditions as experimental tests. Stress magnitudes at mid-point between two blast holes which were detonated simultaneously increased up to two times those of single hole detonation. The rise time of maximum stress in a decoupled charge condition was delayed two times that of a fully charged condition. Dynamic numerical analysis showed almost similar results to blast test results, which verifies the effectiveness of numerical approaches fur optimizing the tunnel blast design. Dynamic numerical analysis was executed to evaluate rock behavior and damage of the contour hole, the sloping hole adjacent to the contour hole in the road tunnel blasting pattern. The rock damage zone of the sloping hole from the numerical analysis was larger than that of the contour hole. Damage in the sloping hole can be reduced by using lower density explosive, by applying decoupled charge, or by increasing distance between the sloping hole and the contour hole.