폴리머 (Polymer(Korea))

  • 제36권6호
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  • Pages.699-704
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  • 2012
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  • 0379-153X(pISSN)
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  • 2234-8077(eISSN)
한국고분자학회 (The Polymer Society of Korea)
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DOI QR코드

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Poly(D,L-lactide)를 외부 껍질로 하고 Alginate 또는 Chitosan을 내부 코어로 구성한 이중미립구 담체의 약물방출 특성

Drug-release Properties of Double-layered Microspherical Carriers which Consist of Outer Shell of Poly(D,L-lactide) and Inner Core of Alginate or Chitosan

  • 김자원 (부산대학교 헬스테크놀로지 협동과정) ;
  • 송민정 (부산대학교 바이오소재과학과) ;
  • 이상민 (부산대학교 바이오소재과학과) ;
  • 임소령 (부산대학교 바이오소재과학과) ;
  • 정수진 (부산대학교 바이오소재과학과) ;
  • 김홍성 (부산대학교 바이오소재과학과)
  • Kim, Ja Won (Dept. of Health Technology, Pusan National University) ;
  • Song, Min Jeong (Dept. of Biomaterial Engineering, Pusan National University) ;
  • Lee, Sang Min (Dept. of Biomaterial Engineering, Pusan National University) ;
  • Lim, So Ryong (Dept. of Biomaterial Engineering, Pusan National University) ;
  • Jung, Su Jin (Dept. of Biomaterial Engineering, Pusan National University) ;
  • Kim, Hong Sung (Dept. of Biomaterial Engineering, Pusan National University)
  • 투고 : 2012.04.05
  • 심사 : 2012.06.04
  • 발행 : 2012.11.25
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초록

경구투여를 통한 친수성 약물의 방출조절을 위하여 이중층으로 된 고분자 담체를 설계하였다. 생체고분자인 alginate와 chitosan은 각각 극성 흡수성분으로, poly(D,L-lactide)는 소수성 피막으로, 그리고 theophylline과 diclofenac sodium은 모델 약물로 사용하였다. 담체는 지연방출과 이어지는 지속방출을 위하여 외부 껍질은 poly(D,L-lactide)로, 내부중심은 약물과 함께 알지네이트 또는 키토산으로 구성되어진 이중층의 미립구 담체로 성형하였다. 담체와 약물간의 극성 조합으로 인한 담체의 모폴로지와 약물방출 거동을 조사하였다. 담체와 약물 그리고 pH 환경의 상대적 극성이 약물방출 특성에 상당한 영향이 있음을 확인하였다.

Double-layered polymeric carrier was designed for release control of hydrophilic drug in oral administration. Biopolymeric chitosan and alginate were examined as polar absorbents, poly(D,L-lactide) as a hydrophobic shell, and theophylline and diclofenac sodium as loading drugs. The fabrication of the carriers was prepared in the form of double-layered microsphere for delayed and successively extended release, which consisted of outer shell of poly(D,L-lactide) and inner core of alginate or chitosan with drugs. Morphologies and drug-release behaviors of the carriers were investigated, which were influenced by a combination of polarity between carrier and drug. It was confirmed that the relative polarities of the carriers, the drugs, and the environmental pH affected significantly the drug-release property.

키워드

과제정보

연구 과제 주관 기관 : 부산대학교

참고문헌

  1. L. Illum, Pharm Res., 15, 9 (1998).
  2. P. Baldric, Regul. Tox. Pharm., 32, 210 (2000). https://doi.org/10.1006/rtph.2000.1421
  3. I. F. Uchegbu and A. G. Schtzlein, Polymer in Drug Delivery, CRC Press, New York, 2006.
  4. H. Y. Zhou, X. G. Chen, C. S. Liu, X. H. Meng, C. G. Liu, and L. J. Yu, Biochem. Eng. J., 31, 228 (2006). https://doi.org/10.1016/j.bej.2006.08.007
  5. Z. Lqbal, A. Babar, and M. Ashraf, Drug Dev. Ind. Pharm., 28, 129 (2002). https://doi.org/10.1081/DDC-120002445
  6. A. Dashevsky, K. Wagner, K. Kolter, and R. Bodmeier, Int. J. Pharm., 290, 15 (2005). https://doi.org/10.1016/j.ijpharm.2004.10.024
  7. D. N. Robinson and N. A. Peppas, Macromolecules, 35, 3668 (2002). https://doi.org/10.1021/ma011525u
  8. G. R. Mahdavinia, A. Pourjavadi, H. Hosseninzadeh, and M. J. Zohuriaan, Eur. Polym. J., 40, 1399 (2004). https://doi.org/10.1016/j.eurpolymj.2004.01.039
  9. Y. Shin, K. S. Kim, and B. Kim, Polymer(Korea), 32, 421 (2008).
  10. W. Xu, Q. Gao, Y. Xu, D. Wu, and Y. Sun, Mater. Res. Bull., 44, 606 (2009). https://doi.org/10.1016/j.materresbull.2008.07.001
  11. H. Hosseinkhani, M. Hosseinkhani, E. V. Farahani, and M. N. Haghighi, Adv. Sci. Lett., 2, 70 (2009). https://doi.org/10.1166/asl.2009.322
  12. A. Kader and R. Jalil, Drug Dev. Ind. Pharm., 24, 527 (1998). https://doi.org/10.3109/03639049809085653
  13. A. Kumari, S. K. Yadav, and S. C. Yadav, Colloid Surface B: Biointerfaces, 75, 1 (2010). https://doi.org/10.1016/j.colsurfb.2009.09.001
  14. S. S. Guterres, H. Fessi, G. Barratt, F. Puisieux, and J.-P. Devissaguet, Pharm. Res., 12, 1545 (1995). https://doi.org/10.1023/A:1016208125979
  15. J. Herrmann and R. Bodmeier, J. Control. Release, 36, 63 (1995). https://doi.org/10.1016/0168-3659(95)00051-9
  16. S. Mao, J. Xu, C. Cai, O. Germershaus, A. Schaper, and T. Kissel, Int. J. Pharm., 334, 137 (2007). https://doi.org/10.1016/j.ijpharm.2006.10.036
  17. J. S. Park, J. C. Yang, S. H. Yuk, H. S. Shin, J. M. Rhee, M. S. Kim, H. B. Lee, and G. Khang, Polymer(Korea), 31, 189 (2007).
  18. W. L. Lee, C. Loei, E. Widjaja, and S. C. J. Loo, J. Control. Release, 151, 229 (2011). https://doi.org/10.1016/j.jconrel.2011.02.012
  19. S. H. Yuk, B. C. Shin, S. H. Cho, and H. B. Lee, Polymer(Korea), 14, 675 (1990).
  20. M. George and T. E. Abraham, J. Control. Release, 114, 1 (2006). https://doi.org/10.1016/j.jconrel.2006.04.017
  21. M. L. Gonzalea-Rordriguz, M. A. Holgado, C. Sanchez-Lafuente, A. M. Rabassco, and A. Fini, Int. J. Pharm., 232, 225 (2002). https://doi.org/10.1016/S0378-5173(01)00915-2
  22. F. A. Simek-Ege, G. M. Bond, and J. Stringer, J. Appl. Polym. Sci., 88, 346 (2003). https://doi.org/10.1002/app.11989
  23. P. R. Hari, T. Chandy, and C. P. Sharma, J. Appl. Polym. Sci., 59, 1795 (1996). https://doi.org/10.1002/(SICI)1097-4628(19960314)59:11<1795::AID-APP16>3.0.CO;2-T
  24. F. Maestrelli, N. Zerrouk, C. Chemtob, and P. Mura, Int. J. Pharm., 271, 257 (2004). https://doi.org/10.1016/j.ijpharm.2003.11.024
  25. J. K. Park, D. Kim, C. Choi, Y. Jeong, M. Kim, M. Jang, and J. Nah, Polymer(Korea), 32, 263 (2008).
  26. S. H. Yuk, S. H. Cho, B. C. Shin, S. S. Kim, and H. B. Lee, Polymer(Korea), 18, 113 (1994).
  27. S. Puttipipatkhachorn, J. Nunthanid, K. Yamamoto, and G. E. Peck, J. Control. Release, 75, 143 (2001). https://doi.org/10.1016/S0168-3659(01)00389-3
  28. P. B. O'Donnell and J. W. McGinity, Adv. Drug Deliv. Rev., 28, 25 (1997). https://doi.org/10.1016/S0169-409X(97)00049-5
  29. M. D. Kurkuri and T. M. Aminbhavi, J. Control. Release, 96, 9 (2004). https://doi.org/10.1016/j.jconrel.2003.12.025
  30. O. Sanli, N. Ay, and N. Isklan, Eur. J. Pharm. Biopharm., 65, 204 (2007). https://doi.org/10.1016/j.ejpb.2006.08.004
  31. F. Mi, N. Her, C. Kuan, T. Wong, and S. Shyu, J. Appl. Polym. Sci., 66, 2495 (1997). https://doi.org/10.1002/(SICI)1097-4628(19971226)66:13<2495::AID-APP12>3.0.CO;2-X