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http://dx.doi.org/10.7317/pk.2012.36.6.699

Drug-release Properties of Double-layered Microspherical Carriers which Consist of Outer Shell of Poly(D,L-lactide) and Inner Core of Alginate or Chitosan  

Kim, Ja Won (Dept. of Health Technology, Pusan National University)
Song, Min Jeong (Dept. of Biomaterial Engineering, Pusan National University)
Lee, Sang Min (Dept. of Biomaterial Engineering, Pusan National University)
Lim, So Ryong (Dept. of Biomaterial Engineering, Pusan National University)
Jung, Su Jin (Dept. of Biomaterial Engineering, Pusan National University)
Kim, Hong Sung (Dept. of Biomaterial Engineering, Pusan National University)
Publication Information
Polymer(Korea) / v.36, no.6, 2012 , pp. 699-704 More about this Journal
Abstract
Double-layered polymeric carrier was designed for release control of hydrophilic drug in oral administration. Biopolymeric chitosan and alginate were examined as polar absorbents, poly(D,L-lactide) as a hydrophobic shell, and theophylline and diclofenac sodium as loading drugs. The fabrication of the carriers was prepared in the form of double-layered microsphere for delayed and successively extended release, which consisted of outer shell of poly(D,L-lactide) and inner core of alginate or chitosan with drugs. Morphologies and drug-release behaviors of the carriers were investigated, which were influenced by a combination of polarity between carrier and drug. It was confirmed that the relative polarities of the carriers, the drugs, and the environmental pH affected significantly the drug-release property.
Keywords
chitosan; alginate; poly(D; L-lactide); microsphere; release;
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