• Preventive Nutrition and Food Science
• /
• v.15 no.4
• /
• pp.255-261
• /
• 2010

Ischemic stroke, a major cause of death and disability worldwide, is caused by occlusion of cerebral arteries that, coupled with or without reperfusion, results in prolonged ischemia (hypoxia and hypoglycemia) and, ultimately, brain damage. In this study, we examined whether methanol extract of the whole plant of Cassia mimosoides var. nomame Makino that grows naturally in Korea, as well as Japan and China, and some of its fractions obtained by partitioning with organic solvents could protect human hepatocellular carcinoma cells (HepG2) under hypoxic condition by inhibiting apoptosis. We also investigated if these extracts could attenuate brain damage in a rat model of 2 hr of ischemia, generated by middle cerebral artery occlusion, and 22 hr of reperfusion. The whole extract ($100{\mu}g$/mL) maintained the cell number at more than half of that initially plated, even after 24 hr of cell culture under hypoxic condition (3% $O_2$). In the absence of the whole extract, almost all of the cells were dead by this time point. This improvement of cell viability came from a delay of apoptosis, which was confirmed by observing the timing of the formation of a DNA ladder when assessed by gel electrophoresis. Of fractions soluble in hexane, ethyl acetate (EA), butanol and water, EA extracts were selected for the animal experiments, as they improved cell viability at the lowest concentration ($10{\mu}g$/mL). The whole extract (200 mg/kg) and EA extract (10 and 20 mg/kg) significantly reduced infarct size, a measure of brain damage, by 34.7, 33.8 and 45.2.0%, respectively, when assessed by 2,3,5-triphenyl tetrazolium chloride staining. The results suggest that intake of Cassia mimosoides var. nomame Makino might be beneficial for preventing ischemic stroke through inhibition of brain cell apoptosis.

• The Transactions of The Korean Institute of Electrical Engineers
• /
• v.64 no.1
• /
• pp.182-187
• /
• 2015

In the three-phase power system, when any one-phase or two-phases is open-phase, the unbalanced current flows and the single-phase power supplies to three-phase loads. Specially, motor coil and transformer coil receive over-current. As a result, great damage as well as electrical fire can occur to the power system. In order to improve these problems, this paper proposes that an open-phase detection device is designed by a new algorithm using electric potential difference between the resultant voltage of neutral point and ground, and a control circuit topology of open-phase protector is composed of highly efficient semiconductor devices. It improves response speed and reliability. The control algorithm circuit also operates the cut-off of a conventional residual current protective device (RCD) which flows an enforced leakage current to ground wire at open-phase accident. Furthermore, time delay circuit is added to prevent the incapable operation of open-phase protector about instantaneous open-phase not open-phase fault. The time delay circuit improves more reliability.

• Explosives and Blasting
• /
• v.26 no.2
• /
• pp.99-107
• /
• 2008

This study, to reduce a ground vibration damage of the structures in an area adjacent to housing structures located closely above the tunnel section, is the ground vibration reduction instance of a tunnel blasting selectively applied the ground vibration-controlled blasting method (delay time applied blasting method, large center hole cut method, Line Drilling method, etc) with an originally planned blasting method connected, but with it's workability and economic efficiency is satisfactory, so, the results says the ground vibration-controlled blasting method on a similar condition is very effective, even if the applicability is depend on the blasting method and ground condition of the work area.

• Journal of the Korea Institute of Military Science and Technology
• /
• v.8 no.3 s.22
• /
• pp.73-82
• /
• 2005

This paper describes shock waveform synthesis methods for a shock response spectnlm over a short time interval with which intereference between parts within a test item is increased to perform a sufficient shock test for damage or malfunction which may be caused by the interference between parts, and a digital filter for obtaining a shock response history required for the shock waveform synthesis and a digital inverse filter for restoration by inversely using the digital filter. The time at which the maximax value occurs in the response history is detected in order to establish a delay time which is one of the parameters in the wavelet, on the condition that the natural frequency of SDOF system with a Q (quality factor) of 10 equals to the wavelet frequency of the zero delay wavelet input. A shock response spectrum over a short time interval and an abrupt change in the acceleration for an instant are illustrated as features of the synthesized waveform.

• Progress in Superconductivity and Cryogenics
• /
• v.23 no.4
• /
• pp.44-48
• /
• 2021

In order to obtain ultra-high resolution MRI images, research and development of 11 T or higher superconducting magnets have been actively conducted in the world, recently. The high-temperature superconductor (HTS), first discovered in 1986, was very limited in industrial application until mid-2010, despite its high critical current characteristics in the high magnetic field compared to the low-temperature superconductor. This is because HTS magnets were unable to operate stably due to the thermal damage when a quench occurred. With the introduction of no-insulation (NI) HTS magnet winding technology that does not burn electrically, it could be expected that the HTS magnets are dramatically reduced in weight, volume, and cost. In this paper, a 6 T-class NI HTS magnet for basic characteristic analysis was designed, and a distributed equivalent circuit model of the NI coils was configured to analyze the charging current characteristics caused by excitation current, and the charge delay phenomenon and loss were predicted through the development of a simulation model. Additionally, the critical current of the NI HTS magnets was estimated, considering the magnetic field, its angle and temperature with a given current. The loss due to charging delay characteristics was analyzed and the result was shown. It is meaningful to obtain detailed operation technology to secure a stable operation protocol for a 6T NI HTS magnet which is actually manufactured.

• Journal of Medicine and Life Science
• /
• v.16 no.1
• /
• pp.13-16
• /
• 2019

In a patient with blunt abdominal trauma with small bowel injury, early diagnosis is clinically challenging due to unclear clinical symptoms and signs in the early stage of an injury. On the other hand, a delay of diagnosis of bowel disruption may lead to increased complication and mortality. The diagnostic laparoscopy is very useful for the evaluation of the small bowel injury. Laparoscopy can reduce unnecessary open surgery in a patient with blunt abdominal trauma with subtle symptoms and imprecise findings on abdominal computed tomography. Also it can prevent delay of treatment and be converted immediately to open surgery as soon as bowel damage is revealed. Furthermore, extracorporeal repair of small bowel via mini-laparotomy after a single incision diagnostic laparoscopy in a patient with traumatic small bowel perforation was a feasible and safe alternative to conventional laparoscopy. We are pleased to introduce successfully treated cases by extracorporeal repair of small bowel via mini-laparotomy after a single incision diagnostic laparoscopy in a patient with small bowel perforation after blunt trauma.

• Archives of Plastic Surgery
• /
• v.46 no.3
• /
• pp.255-261
• /
• 2019

Cross-leg flaps are a useful reconstructive option for complex lower limb defects when free flaps cannot be performed owing to vessel damage. We describe the use of the extended distally based sural artery flap in a cross-leg fashion for lower extremity coverage in three patients. To maximise the viability of these extended flaps, a delay was performed by raising them in a bipedicled fashion before gradual division of the tip over 5 to 7 days for cross-leg transfer. Rigid coupling of the lower limbs with external fixators was critical in preventing flap avulsion and to promote neovascular takeover. The pedicle was gradually divided over the ensuing 7 to 14 days before full flap inset and removal of the external fixators. In all three patients, the flaps survived with no complications and successful coverage of the critical defect was achieved. One patient developed a grade 2 pressure injury on his heel that resolved with conservative dressings. The donor sites and external fixator pin wounds healed well, with no functional morbidity. The cross-leg extended distally based sural artery flap is a reliable reconstructive option in challenging scenarios. Adequate flap delay, manoeuvres to reduce congestion, and postoperative rigid immobilization are key to a successful outcome.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2012.05a
• /
• pp.880-883
• /
• 2012

In this paper, CMOS logic device, the INVERTER, NAND, NOR were designed and fabricated using 0.18um CMOS process for analyzing the effect of transient radiation damage. Fabricated logic devices were measured by applying a 1kHz input at 1.8V supply. As a result, the current consumption of less than 70uA and Rising time, Falling time was within a 4us. Experimental results transmission delays occurred when using a 50M cable for pulse radiation experiments.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.28 no.4
• /
• pp.379-383
• /
• 2014

The purpose of this study is to investigate the effects of silkworm extracts (SWE) on reactive oxygen species formation in mice (C57BL/6). Mice were administrated intraperitoneally with SWE (20 mg/kg/day) for 14 days. All animals were sacrificed 24 hours after the last SWE treatment and then extracted the blood and brain tissue in mouse. The researcher measured several parameters related to reactive oxygen species formation, malondialdehyde (MDA) and hydrogen peroxide ($H_2O_2$) contents in serum, whole brain, cerebral cortex and cerebellum. The results showed that MDA content of pre-SWE treatment was decreased significantly in serum, mitochondrial and cytosolic fraction of whole brain and cerebellum (P<0.01). The $H_2O_2$ content of pre-SWE treatment was decreased significantly in mitochondrial fraction of whole brain, cerebral cortex and cerebellum (P<0.01). These results suggest that SWE plays an important role for inhibition of oxidative damage of cells as well as antioxidant effect, aging delay and cells protected from irradiation.

• Restorative Dentistry and Endodontics
• /
• v.43 no.1
• /
• pp.13.1-13.7
• /
• 2018

Dental erosion is frequently overlooked in clinical practice. The management of erosion-induced damage to the dentition is often delayed, such that extensive occlusal rehabilitation is required. These cases can be diagnosed by a careful clinical examination and a thorough review of the patient's medical history and/or lifestyle habits. This case report presents the diagnosis, categorization, and management of a case of gastro-esophageal reflux disease-induced palatal erosion of the maxillary teeth. The early management of such cases is of utmost importance to delay or prevent the progression of damage both to the dentition and to occlusal stability. Non-invasive adhesively bonded restorations aid in achieving this goal.