• 한방안이비인후피부과학회지
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• 제17권3호
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• pp.107-113
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• 2004

Objective: This study was performed to evaluate the effects of venesection on palpebral conjunctiva, on the stoke patients complaint of defective vision. Methods: We studied four selected stroke patients with defective vision which start with stroke. Venesection was performed with syringe needleonce or several times on upper or lower palpebral conjunctiva. After every venesection we washed the eye(s) with normal saline. We evaluated the effects by VAS. Results & conclusion: Venesection on palpebral conjunctiva was efficacious against defective vision occured on the stoke patients. But more clinical & scienific trials are expected to follow this study.

• 의료법학
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• 제8권1호
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• pp.235-277
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• 2007

In Product Liability law, the 'defection' of the manufactured products is its key concept, defined in detail. The concept had been already developed through the precedents and theories for the past years even before the PL law was enacted and the concept was listed. Especially, the medicine products need the different approach, because they might directly harm to the human life and body due to their being injected or taken, unlikely other manufactured articles. Since the medical products have the double contradictory functions such as effects and side effects, the defection decisions become so difficult. However, because there are high concerns that wrong medical products will directly harm the human life and body, the decision standards should be more strengthened. The decision standards should include the risk-effect standard as the considered components and make the customer-expecting standard as the final standard. The decision time for defection should be made considering the science technology level when the medical products were provided, not when the accident occurred. It is the most important for the manufacturers to prevent the damages by making and selling the non-defective medicine products for themselves, rather than by taking the legal remedy means afterwards. Therefore, the non-defective guidelines for the medicine manufacturers will help increase the effects and minimize the side-effects.

• 한국도로학회논문집
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• 제15권5호
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• pp.157-166
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• 2013

PURPOSES : This study is to analyze expected effect of a accident decrease when motorcycle safety inspection is introduced. METHODS : Based on the literature review of effect of 4-wheel vehicle inspection, probability of occurring accidents among defective motorcycles are calculated by using the number of estimated defective motorcycles and accidents resulting from defects of motorcycles. Then, the number of decreased accidents which is resulting from eliminating defects of motorcycles by safety inspection is estimated by using probability of occurring accidents among defective motorcycles. RESULTS : If the ratio of eliminating defects of motorcycles is 95% after motorcycle safety inspection, the effects of accident decrease of motorcycle safety inspection are analyzed from 2005 to 2008. As a result, 46,292 defective motorcycles are repaired and 1,376 accidents are prevented when the probability of occurring accidents among defective motorcycles is 2.97%. CONCLUSIONS : This study suggests the expected effect of motorcycle safety inspection is that the inspection can prevent 1,376 motorcycle accidents. However, the number of preventing motorcycle accidents are small, compared with the total number of motorcycle accidents because there are limitations to investigate the causes of defective motorcycle accidents. A more precise analysis of the expected effect of motorcycle inspection is possible when a systematic investigation of the causes of the accidents is implemented.

• Molecules and Cells
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• 제37권2호
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• pp.140-148
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• 2014

We identified four basic amino acid residues as nuclear localization signals (NLS) in the C-terminal domain of the prototype foamy viral (PFV) integrase (IN) protein that were essential for viral replication. We constructed seven point mutants in the C-terminal domain by changing the lysine and arginine at residues 305, 308, 313, 315, 318, 324, and 329 to threonine or proline, respectively, to identify residues conferring NLS activity. Our results showed that mutation of these residues had no effect on expression assembly, release of viral particles, or in vitro recombinant IN enzymatic activity. However, mutations at residues 305 (R ${\rightarrow}$ T), 313(R ${\rightarrow}$ T), 315(R ${\rightarrow}$ P), and 329(R ${\rightarrow}$ T) lead to the production of defective viral particles with loss of infectivity, whereas non-defective mutations at residues 308(R ${\rightarrow}$ T), 318(K ${\rightarrow}$ T), and 324(K ${\rightarrow}$ T) did not show any adverse effects on subsequent production or release of viral particles. Sub-cellular fractionation and immunostaining for viral protein PFV-IN and PFV-Gag localization revealed predominant cytoplasmic localization of PFV-IN in defective mutants, whereas cytoplasmic and nuclear localization of PFV-IN was observed in wild type and non-defective mutants. However sub-cellular localization of PFV-Gag resulted in predominant nuclear localization and less presence in the cytoplasm of the wild type and non-defective mutants. But defective mutants showed only nuclear localization of Gag. Therefore, we postulate that four basic arginine residues at 305, 313, 315 and 329 confer the karyoplilic properties of PFV-IN and are essential for successful viral integration and replication.

• Corrosion Science and Technology
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• 제15권2호
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• pp.84-91
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• 2016

The transport and deposition of corrosion products in pressurized water nuclear reactor (PWR) steam generators have led to corrosion (SCC, denting etc.) problems. Lancing, mechanical cleaning and chemical cleaning have been used to reduce these problems. The methods of lancing and mechanical cleaning have limitations in removing corrosion products due to the structure of steam generator tubes. But high temperature chemical cleaning (HTCC) with EDTA is the most effective method to remove corrosion products regardless of the structure. However, EDTA in chemical cleaning aqueous solution and chemical cleaning environments affects the integrity of materials used in steam generators. The nuclear power plants have to perform the pre-test (also called as qualification test (QT)) that confirms the effect on the integrity of materials after HTCC. This is one of the series studies that assess the effect, and this study determines the effects of 20 % EDTA aqueous solution on defective tubes in high temperature chemical cleaning environments. The depth and magnitude of defects in steam generator (SG) tubes were measured by eddy current test (ECT) signals. Surface analysis and magnitude of defects were performed by using SEM/EDS. Corrosion rate was assessed by weight loss of specimens. The ECT signals (potential and depth %) of defective tubes increased marginally. But the lengths of defects, oxides on the surface and weights of specimens did not change. The average corrosion rate of standard corrosion specimens was negligible. But the surfaces on specimens showed traces of etching. The depth of etching showed a range on the nanometer. After comprehensive evaluation of all the results, it is concluded that 20 % EDTA aqueous solution in high temperature chemical cleaning environments does not have a negative effect on defective tubes.

• Computers and Concrete
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• 제33권5호
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• pp.621-630
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• 2024

This study presents novel electromagnetic wave-based methods for evaluating the integrity of cement-based structures using time domain reflectometry (TDR). Two cement-based plates with embedded rebars are prepared under sound and defective conditions. TDR tests are carried out using transmission lines with various numbers of artificial joints, and electromagnetic waves are measured to assess the integrity of the plates. The experimental results show that the travel time of electromagnetic waves is consistently longer in sound plates than in defective ones, and an increase in the reflection coefficients is observed in the defect zone of the defective plates. Electromagnetic wave velocities are higher in the defective plates, especially when connectors are present in the transmission line. A novel approach based on the area of the reflection coefficient provides larger areas in the defective plates, and the attenuation effect of the electromagnetic waves induces a difference in the areas of the reflection coefficient between the two defect conditions. An alternative method using the centroid of the defect zone slightly overestimates the location of the defect zone. The length of the defect zone is estimated using the defect ratio and wave velocities of cement, air, and plate. The length of the defect zone can also be calculated using the travel times within the plate, total measured length of the plate, and wave velocities in the cement and air. Therefore, the electromagnetic wave-based methods proposed in this study may be useful for estimating the location and length of defect zones by considering attenuation effects.

• 대한안전경영과학회지
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• 제16권1호
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• pp.169-176
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• 2014

This research discusses the characteristics and the implementation strategies for two types of quality metrics to analyze innovation effects in six sigma projects: fixed specification type and moving specification type. $Z_{st}$, $P_{pk}$ are quality metrics of fixed specification type that are influenced by predetermined specification. In contrast, the quality metrics of moving specification type such as Strictly Standardized Mean Difference(SSMD), Z-Score, F-Statistic and t-Statistic are independent from predetermined specification. $Z_{st}$ sigma level obtains defective rates of Parts Per Million(PPM) and Defects Per Million Opportunities(DPMO). However, the defective rates between different industrial sectors are incomparable due to their own technological inherence. In order to explore relative method to compare defective rates between different industrial sectors, the ratio of specification and natural tolerance called, $P_{pk}$, is used. The drawback of this $P_{pk}$ metric is that it is highly dependent on the specification. The metrics of F-Statistic and t-Statistic identify innovation effect by comparing before-and-after of accuracy and precision. These statistics are not affected by specification, but affected by type of statistical distribution models and sample size. Hence, statistical significance determined by above two statistics cannot give a same conclusion as practical significance. In conclusion, SSMD and Z-Score are the best quality metrics that are uninfluenced by fixed specification, theoretical distribution model and arbitrary sample size. Those metrics also identify the innovation effects for before-and-after of accuracy and precision. It is beneficial to use SSMD and Z-Score methods along with popular methods of $Z_{st}$ sigma level and $P_{pk}$ that are commonly employed in six sigma projects. The case studies from national six sigma contest from 2011 to 2012 are proposed and analyzed to provide the guidelines for the usage of quality metrics for quality practitioners.

• 품질경영학회지
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• 제34권2호
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• pp.1-11
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• 2006

This paper is related to the effect analysis of certification of ISO 9000 Quality Management System. We collect and analyze the field data of certification costs and profit from companies that are located at southeast area in Korea. The effect analysis is based on the type and scale of companies. We use defective rate and inventory turnover rate as the criterion of positive effect after certification. As a result, we may conclude that the certification of ISO Quality Management System gives companies positive effects.

• Imaging Science in Dentistry
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• 제38권3호
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• pp.133-146
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• 2008

Purpose : To observe and evaluate the effects of Simvastatin-induced osteogenesis on the wound healing of defective bone. Materials and Methods : 64 defective bones were created in the parietal bone of 32 New Zealand White rabbits. The defects were grafted with collagen matrix carriers mixed with Simvastatin solution in the experimental group of 16 rabbits and with collagen matrix carriers mixed with water in the controlled group. The rabbits were terminated at an interval of 3, 5, 7, and 9 days, 2, 4, 6, and 8 weeks after the formation of defective bone. The wound healing was evaluated by soft X-ray radiography. The tissues within defective bones were evaluated through the analysis of flow cytometry for the manifestation of Runx2 and Osteocalcin, and observed histopathologically by using H-E stain and Masson's trichrome stain. Results : 1. In the experimental group, flow cytometry revealed more manifestation of Runx2 at 5, 7, and 9 days and Osteocalcin at 2 weeks than in the controlled groups, but there was few difference in comparison with the controlled group. 2. In the experimental group, flow cytometry revealed considerably more cells and erythrocytes at 5, 7, and 9 days in comparison with the controlled group. 3. In the experimental group, soft x-ray radiography revealed the extended formation of trabeculation at 2, 4, 6, and 8 weeks. 4. Histopathological features of the experimental group showed more fibroblasts and newly formed vessels at 5 and 7 days, and the formation of osteoid tissues at 9 days, and the newly formed trabeculations at 4 and 6 weeks. Conclusion : As the induced osteogenesis by Simvastatin, there was few contrast of the manifestation between Runx2 and Osteocalcin based on the differentiation of osteoblasts. But it was considered that the more formation of cells and erythrocytes depending on newly formed vessels in the experimental group obviously had an effect on the bone regeneration.

• 한국지하수토양환경학회지:지하수토양환경
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• 제6권1호
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• pp.53-62
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• 2001

표면결함이 고밀도 폴리에틸렌 지오멤브레인의 열적 안정성과 응력균열저항성에 미치는 영향을 온도와 표면 결함 부여조건을 달리한 환경조건에서 역학적 특성, 화학저항성 및 피로시간을 측정하여, 조사하였다. 특별 고안된 장치를 사용하여 인위적으로 지오멤브레인 표면에 결함을 부여하였다. 표면결함은 표면결함 유도매체의 전단속도 100mm/min에서 표면결함 유도매체의 크기가 작을수록, 표면결함 부여횟수가 커질수록 증가하였다. 또한 이 조건에서 인장강도는 감소하였지만 인장신도는 증가하였다. 표면결함 부여조건이 같을 경우 고온으로 갈수록 그리고 침지시간이 길어질수록 인장강도는 감소되고 인장신도는 증가하여 표면결함이 부여된 지오멤브레인의 화학저항성은 저하되었다. 끝으로 응력균열저항성 시험 결과 온도가 높아질수록 표면결함이 부여된 지오멤브레인의 피로시간은 단시간 영역으로 이동되었다.