• IMMUNE NETWORK
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• v.7 no.3
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• pp.109-116
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• 2007

Background: Human papillomavirus (HPV) infection is responsible for cervical cancer, a common cancer in women. Since HPV infection and cancer development are controlled by the host immune system, immunotherapy against HPV can be helpful in preventing or treating HPV-associated cervical cancer. Two oncoproteins of HPV16, E6 and E7, are promising targets for immunotherapy against cervical cancer, because they are constitutively expressed in cervical cancer. Methods: Since cellular vaccines using B cells as well as dendritic cells offer an efficient approach to cancer immunotherapy, we opted to use B cells. We evaluated the immunogenicity and anti-tumor effects of a B cell vaccine transduced with HPV16 E6/E7-expressing adenovirus. Results: Vaccination with HPV16 E6/E7-transduced B cells induced E6/E7-specific $CD8^+$ T cell-dependent immune responses and generated anti-tumor effects against E6/E7-expressing TC-1 tumor. The anti-tumor effect induced by this B cell vaccine was similar to that elicited by DC vaccine, showing that B cells can be used as an alternative to dendritic cells for cellular vaccines. Conclusion: Thisstudy has shown the feasibility of using B cells as immunogenic APCs and the potential for developing prophylactic and therapeutic vaccines against HPV-associated cervical cancer using a B cell vaccine transduced with adenovirus expressing HPV16 E6/E7.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.45 no.3
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• pp.77-85
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• 2008

This work proposes a 12b 130MS/s 108mW $1.8mm^2$ 0.18um CMOS ADC for high-quality video systems such as TFT-LCD displays and digital TVs requiring simultaneously high resolution, low power, and small size at high speed. The proposed ADC optimizes power consumption and chip area at the target resolution and sampling rate based on a three-step pipeline architecture. The input SHA with gate-bootstrapped sampling switches and a properly controlled trans-conductance ratio of two amplifier stages achieves a high gain and phase margin for 12b input accuracy at the Nyquist frequency. A signal-insensitive 3D-fully symmetric layout reduces a capacitor and device mismatch of two MDACs. The proposed supply- and temperature- insensitive current and voltage references are implemented on chip with a small number of transistors. The prototype ADC in a 0.18um 1P6M CMOS technology demonstrates a measured DNL and INL within 0.69LSB and 2.12LSB, respectively. The ADC shows a maximum SNDR of 53dB and 51dB and a maximum SFDR of 68dB and 66dB at 120MS/s and 130MS/s, respectively. The ADC with an active die area of $1.8mm^2$ consumes 108mW at 130MS/s and 1.8V.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.20 no.5
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• pp.216-220
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• 2010

Ni-Fe alloys have various applications such as thin film inductor, thin film transformer, magnetic head's shield case, etc. Magnetic properties of Ni-Fe thin films depend on the process parameters such as thickness, contents, deposition rate, substrates, etc. In this study, NiFe films with a thickness of about 150nm were deposited on Si(100) wafer and $SiO_2$/Si(100) substrate at room temperature by a DC magnetron co-sputtering using Fe and Ni targets. Their phase formation and magnetic properties as a function of annealing temperature were investigated with XRD, FE-SEM and VSM. The assputtered films have BCC structure. With increasing annealing temperature, NiFe thin film for $SiO_2$/Si(100) substrate transformed completely from BCC to FCC phase above $500^{\circ}C$, but some BCC phase remained above $500^{\circ}C$ on Si(100) wafer. For samples annealed at $450^{\circ}C$, squareness ratio of NiFe thin film shows peak value and its saturation magnetization is around 0.0118 emu, which means that the optimum annealing temperature of NiFe thin film seems to be $450^{\circ}C$. The saturation magnetization of films decreased rapidly above the annealing temperature of $500^{\circ}C$ due to phase transformation from BCC to FCC phase.

• Journal of the Korea Society of Computer and Information
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• v.19 no.5
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• pp.43-52
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• 2014

In this paper, we propose Gravity Removal and Vector Rotation algorithm for counting steps of wearable device, and we evaluated the proposed GRVR algorithm with Micro-Electro-Mechanical (MEMS) 3-axis accelerometer equipped in low-power wearable device while the device is mounted on various positions of a walking or running person. By applying low-pass filter, the gravity elements are canceled from acceleration on each axis of yaw, pitch and roll. In addition to DC-bias removal and the low-pass filtering, the proposed GRVR calculates acceleration only on the yaw-axis while a person is walking or running thus we count the step even if the wearable device's axis are rotated during walking or running. The experimental result shows 99.4% accuracies for the cases where the wearable device is mounted in the middle and on the right of the belt, and 91.1% accuracy which is more accurate than 83% of commercial 3-axis pedometer when worn on wrist for the case of axis-rotation.

• Korean Journal of Crystallography
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• v.7 no.1
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• pp.36-43
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• 1996

The crystal structure Tris(ethylenediamine)nickel(II)Dichromate has been determined by X-ray crystallography. Crystal data: a=8.268(2), b=13.865(2), c=14.921(2)Å, γ=102.04(2)°, V=1672.9(5)Å3, Z=4, Monocline, P21/b (space group No.=14), Dcalc=1.806 gcm-3, μ=24.05 cm-0.1. The intensity data were collected with Mo-Kα radiation(λ=0.7107Å) on an automatic four-circle diffractometer with a graphite monochromator. The structure was solved by Patterson method and refined by full matrix least-square methods using unit weights. The final R and S values were R=0.045, Rw=0.051, Rall=0.059 and S=2.171for 2248 observed reflections. The two carbon atoms of a ring of Ni(en)-ion were split into crossed four atoms. In consideration of α- and β-angles of two rings of a disordered ethylenediamine of Nien3-ion and the hydrogen bonds between Ni(en)3-cation and Cr2O7-anion, the configuration of Ni(en)3-ion is assumed to be disordered with Λδδδ and Λδδλ.

• Publications of The Korean Astronomical Society
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• v.21 no.2
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• pp.67-74
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• 2006

We have developed a control electronics system for an infrared detector array of KASINICS (KASI Near Infrared Camera System), which is a new ground-based instrument of the Korea Astronomy and Space science Institute (KASI). Equipped with a $512{\times}512$ InSb array (ALADDIN III Quadrant, manufactured by Raytheon) sensitive from 1 to $5{\mu}m$, KASINICS will be used at J, H, Ks, and L-bands. The controller consists of DSP(Digital Signal Processor), Bias, Clock, and Video boards which are installed on a single VME-bus backplane. TMS320C6713DSP, FPGA(Field Programmable Gate Array), and 384-MB SDRAM(Synchronous Dynamic Random Access Memory) are included in the DSP board. DSP board manages entire electronics system, generates digital clock patterns and communicates with a PC using USB 2.0 interface. The clock patterns are downloaded from a PC and stored on the FPGA. UART is used for the communication with peripherals. Video board has 4 channel ADC which converts video signal into 16-bit digital numbers. Two video boards are installed on the controller for ALADDIN array. The Bias board provides 16 dc bias voltages and the Clock board has 15 clock channels. We have also coded a DSP firmware and a test version of control software in C-language. The controller is flexible enough to operate a wide range of IR array and CCD. Operational tests of the controller have been successfully finished using a test ROIC (Read-Out Integrated Circuit).

• Journal of The Korean Association For Science Education
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• v.21 no.4
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• pp.697-709
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• 2001

Researchers on conceptual change have been proposed that confronting a cognitive conflict situation would be important for a student to change his/her preexisting conception. There have been reported that there are three different methods of producing a cognitive conflict situation; the first is logical argument(LC), the second is demonstration of an actual phenomenon(DC), and the third is kinesthetic conflict which is a kind of physical experience(EC). In this study, the researcher tried to find out the differences in the conceptual changes by the three different conflict situations. Seventy two high school students were chosen in a high school in Kyungkido, Korea. The students were tested four times; pretest, posttest, one week delayed posttest, and one month delayed posttest. Six different test situations on mechanics were developed for this study. Test item for each situation was developed. Each item consisted of a multiple choice question and explanation of the choice. The result showed a clear differences among the three conflict groups. In general, kinesthetic conflict which is a kind of physical experience(EC) was proved to be the most efficient strategy for the conceptual change; however, logical argument(LC) seemed to be the least efficient. However, the effectiveness was not uniform from situation to situation. Results of some items showed that even the LC was quite good for the conceptual change. Therefore, it seems to be important to develope appropriate method for the target concept.

• Journal of the Korean Magnetics Society
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• v.22 no.2
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• pp.37-41
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• 2012

The Ag nanoparticles attached $La_{0.7}Sr_{0.3}Co_{0.3}Fe_{0.7}O_{3-{\delta}}$ (LSCF) perovskites were prepared by plasma method. The Ag nanoparticles with size of several nanometers deposited from the Ag target were coated on the surface of LSCF powders with size range from 0.2 to 3 ${\mu}m$. The agglomeration of Ag particles annealed at $800^{\circ}C$ under inert gas of Ar were rarely observed. The inter-diffusion between surface Ag and core LSCF is effectively strong to prevent aggregation of Ag nanoparticles. The wave number of FT-IR spectra for LSCF were largely shifted as the concentration of Ag on LSCF up to 2.11 wt.%. The ionic states of irons in LSCF were measured by M$\ddot{o}$ssbauer spectroscopy. The small amount of $Fe^{4+}$ ions are converted to $Fe^{3+}$ ions after Ag nanopartcles were coated on LSCF.

• Polymer(Korea)
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• v.33 no.4
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• pp.377-383
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• 2009

Ionic polymer-metal composite (IPMC) actuator generates bending actuation via ion/water flux to the cathode side under an electric field. Polyelectrolytes in IPMC should possess high water-retention capability, proton conductivity, and Young's modulus. In this study. for endowing IPMCs with these properties, Nafion-alumina composite membranes containing $\alpha$- or $\gamma$-aluminas of $4{\sim}8$ wt% were prepared. Mechanical moduli of Nafion-alumina composite membranes were $7{\sim}3$ MPa higher than that of Nafion, with the slight decrease in proton conductivity. At DC 3 V. the actuation performance of the Nafion-$\alpha$-alumina (8 wt%)-IPMC was superior to that of the typical Nafion-IPMC. exhibiting 2.7 times the displacement with an enhanced blocking force. The enhanced actuation performance with the Nafion-$\alpha$-alumina composite membranes was attributed to the higher proton conductivity, the elevated ion/water flux, and the lower interfacial electric resistance of platinum electrodes and membrane, compared with those containing $\gamma$-alumina.

• Korean Journal of Plant Taxonomy
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• v.39 no.4
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• pp.264-276
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• 2009

To elucidate the distribution of halophytes in Korea, we surveyed 95 coastal salt marsh and sand dune areas. As a result, 62 halophytes of 57 species, 4 varieties and 1 form belonging to 44 genera and 21 families were recorded from coastal regions and islands of South Korea. Of these, 33 taxa were plants growing on sand dunes and the other 29 in salt marsh. Fifty eight taxa were found on the west coast, which was surveyed at 61 areas. The most common species among them were Suaeda glauca (Bunge) Bunge, Suaeda japonica Makino, Phragmites communis Trin., Zoysia sinica Hance, Carex scabrifolia Steud. in salt marsh, and Salsola komarrovii Iljin, Lathyrus japonicus Willd., Limonium tetragonum (Thunb.) A.A. Bulloc, Calystegia soldanella Roem. & Schult. on sand dunes. On the other hand, only 45 taxa were found on the southern coast, surveyed at 15 areas. On the east coast, surveyed at 13 areas, 44 taxa were found. The most common species were Salsola komarrovii Iljin, Lathyrus japonicus Willd., Calystegia soldanella Roem. & Schult., on sand dunes and Linaria japonica Miq., which on the Korean peninsula is found only on the east coast. On Jeju Island, surveyed at 6 areas, 30 taxa of halophytes were found. Canavalia lineata (Thunb.) DC. is found in Korea only on Jeju Island. About half of the Korean halophytes were members of three families (Chenopodiaceae: 12 species, Poaceae: 12 species and Asteraceae: 7 species).