• Journal of Korean Society of Forest Science
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• v.88 no.2
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• pp.240-248
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• 1999

On the basis of data obtained from five forest roads collapsed due to a heavy rainfall of 1995 in Chunchon, Kangwon-do, this study was carried out to evaluate and predict the fill slope failure of forest roads with four factors of forest road structure and those of location condition by using Quantification theory(II). The results were summarized as follows ; In the structure factors of forest road, the fill slope failure was mainly occurred in longitudinal gradients less than $2^{\circ}$ or more than $4^{\circ}$, distance of surface-flow longer than 80m, fill slope length greater than 6m, and fill slope gradients steeper than $35^{\circ}$. In the factors of location condition, the failure was mainly occurred in ridge portion of road position, weathered rock and soft rock of constituent material, slope gradients in the range from $35^{\circ}$ to $45^{\circ}$, and concave and convex of longitudinal slope forms. The priority order for factors influencing on fill slope failure was ranked by fill slope length, constituent material, road position, and so on. And the rate of correct discrimination by analysis of fill slope failure was estimated at the high prediction of 86.5%.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.3
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• pp.147-155
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• 2020

The purpose of this study was to compare the risk factors of pressure sores and preventive intervention strategies and to provide basic data for the management of pressure sores prevention for long-term care facilities. It was a mixed method study using a systematic literature review and focus group interviews for analysis. A PRISMA flow diagram was prepared in accordance with the research selection process for the systemic literature review. The studies were retrieved from domestic and international studies from 2010 to June, 2019. A total of 8 studies were selected according to the selection criteria. The studies were searched electronically using a search engine with the key words of 'pressure ulcers', 'bedsore', 'decubitus ulcers', 'intervention', 'prevention', 'elderly', and 'long term'. Focus group interviews were conducted through a semi-structured questionnaire for nurses who had worked for more than three years in long-care facilities. The study results suggest that position change and pressure reduction device reduced the incidence of pressure sores and were important for prevention. The use of standardized care protocols is necessary. Multidisciplinary cooperation was an important issue.

• The Korean Journal of Financial Management
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• v.26 no.1
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• pp.1-29
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• 2009

As foreign investors' share holdings in Korean firms have dramatically increased since 1998 following the financial deregulation on the limit of foreign stock investment, the concern over the negative impacts the foreign investors would bring on the firms' financial policy has been growing too. Foreign investors were perceived to require the firms of excessive payments of cash dividends sometimes with threat of hostile takeover trials detering the firm from investing its cash flow in the physical facilities and RandD eroding their potential growth capabilities. We examine the impact of foreign investment on the firms' dividend policy using 234 listed firms' panel data over the sample periods of 1998 to 2005 employing various panel regression methodology. Foreign shareholders are found not to be related or even negatively related to the payout ratio(dividend/net income), but positively and statistically significantly related to the ratio of cash dividends to book of asset, negatively to the dividend yields. Considering the payout ratio is the most appropriate measure for the dividend payment, we can not support the arguments that the foreign investors' holdings have induced the excessive dividend level in Korean firms.

• Journal of Environmental Impact Assessment
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• v.27 no.1
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• pp.73-82
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• 2018

The purpose of this study is the evaluation of the impact of increase in impervious areas due to urbanization on the pollutant discharge using the HSPF model at Musim watershed. Model calibration and validation were performed based on the observed data 2015 and 2014, all simulation items have been successfully simulated such as flow, BOD, and TP. The land cover map used in the model reflected on the land use status of the Musim watershed in 2015 and the application of the development areas and locations. As a result of simulation, during rainfall daily pollutant load with the increased impervious land increased more than that before the development. However, the pollutant load decreased during the non-rainfall time. Annual pollutant load in rainfall time was significantly higher than that in non-rainfall time, BOD and TP increased. The simulation of non-point source pollutant load was applied under two assumptions, such as the increased area of impervious land and the non-change number of point source load before and after development. As the result of a simulation, the non-point source pollutant load after development was bigger than those before development. It was necessary to take measures to control non-point source pollution at the consideration status of development.

• Journal of Wetlands Research
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• v.20 no.2
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• pp.181-189
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• 2018

This study was performed to analyze the dynamics and distributional condition of biological community and to support the basic information about the estuarine ecosystem management by using the intensively surveyed results by each taxon experts around Tamjin river. We analyzed the biological diversity, abundance, correlation among species, and ecological characteristics about 11 taxa groups including vegetation, fish, birds, mammals, etc. in the Tamjin river estuarine ecosystem. We classified vegetation types into 7 physiognomic types and 18 communities according to habitat conditions with the physical environments and salinity. In total, 1125 species including 9 species of endangered species were identified in research area. The species composition and distributional characteristics of each taxon were corresponded to the environmental characteristics of the estuarine ecosystem. Especially, the species diversity and distribution were clearly distinguished in the river according to the difference of the environmental factors such as flow rate, salinity, and soil. Despite the disturbance factors such as barrage and levees, the biodiversity and its distribution were evaluated to be high level under the current environmental conditions. However, loss or reduction of wildlife habitat due to reclamation, embankment, barrage installation and expansion of farmland has been identified as a major threat to the diversity and health of the local ecosystem. The results of this study can be used as a basic data to cope with various development pressure and damage crisis of the whole estuaries including Tamjin river.

• Journal of Pharmaceutical Investigation
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• v.40 no.2
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• pp.117-123
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• 2010

Ibudilast, 3-isobutyryl-2-isopropyrazolo[1,5-a]pyridine, is a nonselective inhibitor of cyclic nucleotide phosphodiesterase (PDE). It preferentially inhibits PDE 3A, PDE4, PDE10 and PDE11 as well as a number of the other PDE families, albeit to a lesser extent. Ibudilast is used clinically to treat bronchial asthma and cerebrovascular disorders. Thes e clinical uses are based on the ability of ibudilast to inhibit platelet aggregation, improve cerebral blood flow and attenuate allergic reactions. The purpose of the present study was to evaluate the bioequivalence of two ibudilast capsules, Ketas capsule (Handok Pharmaceuticals Co., Ltd.) and Pinatos capsule (Sam Chun Dang Pharm. Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The in vitro release of ibudilast from the two ibudilast formulations was tested using KP Apparatus method with various dissolution media. Twenty six healthy male subjects, 23.31${\pm}$1.09 years in age and 70.45${\pm}$8.51 kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After a single capsule containing 10 mg as ibudilast was orally administered, blood samples were taken at predetermined time intervals and the concentrations of ibudilast in serum were determined using HPLC/UV detector. The dissolution profiles of two formulations were similar in all tested dissolution media. The pharmacokinetic parameters such as $AUC_t$, $C_{max}$ and $T_{max}$ were calculated, and computer programs (Equiv Test and K-BE Test 2002) were utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$, $C_{max}$ and untransformed $T_{max}$. The results showed that the differences between two formulations based on the reference drug, Ketas, were 6.99%, -2.48% and 9.93% for $AUC_t$, $C_{max}$ and $T_{max}$, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., log 0.8791~log 1.1861 and log 0.8347~log 1.1199 for $AUC_t$ and $C_{max}$, respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating Pinatos capsule was bioequivalent to Ketas capsule.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.4
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• pp.743-751
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• 2016

It is critical to effectively change the measures of prevention from the breakdown maintenance proceeding an apartment housing maintenance task scope. It is necessary that systematization be performed for a series of tasks, such as facility inspection, diagnosis and replacement. In addition, it is preceded by establishing a standardization for maintenance work scope. Therefore, this study examined the problems related to public rental housing maintenance work scope to manage it more systematically. In addition, the study suggests a work process section for facility repairs, long term replacement and general maintenance using one on one interviews with experts to classify the occupants, management office and head office. This study's standard work system is expected to provide fairness and transparency in addition to improving the productivity in public rental housing maintenance via an efficiency promotion plan. In addition, it is used as the basic reference for developing a system of public rental housing maintenance costs and diagnosis actions. Finally, it is necessary to create improvements that provide a more objective work system standardization throughout the analysis of the productivity data according to the work flow and the review of the occupants, management office and head office in the future applications of the pilot site.

• Journal of Korean Society for Geospatial Information Science
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• v.16 no.1
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• pp.23-32
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• 2008

According to recent frequent local flash flood due to climate change, the very short-term rainfall forecast using remotely sensed rainfall like radar is necessary to establish. This research is to evaluate the feasibility of GIS-based distributed model coupled with radar rainfall, which can express temporal and spatial distribution, for multipurpose dam operation during flood season. $Vflo^{TM}$ model was used as physically based distributed hydrologic model. The study area was Yongdam dam basin ($930\;km^2$) and the 3 storm events of local convective rainfall in August 2005, and the typhoon.Ewiniar.and.Bilis.collected from Jindo radar was adopted for runoff simulation. Distributed rainfall consistent with hydrologic model grid resolution was generated by using K-RainVieux, pre-processor program for radar rainfall. The local bias correction for original radar rainfall shows reasonable results of which the percent error from the gauge observation is less than 2% and the bias value is $0.886{\sim}0.908$. The parameters for the $Vflo^{TM}$ were estimated from basic GIS data such as DEM, land cover and soil map. As a result of the 3 events of multiple peak hydrographs, the bias of total accumulated runoff and peak flow is less than 20%, which can provide a reasonable base for building operational real-time short-term rainfall-runoff forecast system.

• Korean Journal of Agricultural and Forest Meteorology
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• v.12 no.4
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• pp.264-276
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• 2010

The objectives of this study were to introduce the methods of soil respiration measurement, to review soil respiration studies conducted in Korea, and to suggest potential issues generated from using various methods for soil respiration measurement. According to the measurement principles, the methods of soil respiration measurements are classified as: alkali absorption method (AA), closed chamber method (CC), closed dynamic chamber method (CDC), and open flow method (OF). Based on the litereaure review on soil respiration studies in Korea, the CDC method was mostly used by the researchers (62%), followed by the AA (17%), OF (13%) and CC (8%) methods. Along with these methods, various instruments were used such as LI-6400-09, EGM-3, EGM-4, and automatic soil respiration chamber. Most of the soil respiration measurements were carried out in forest ecosystems and the reported soil respiration showed a wide range of variations from 130 to 900 mg $CO_2\;m^{-2}h^{-1}$. Continuous monitoring of soil respiration with minimal disturbance and the potential inconsistency in measurements are still the challenges facing the researchers, causing a paucity in quality datasets of sufficient quantity. Few attempts of intercomparison among different methods hinder the data users from synthetic analysis and assessment of the collected datasets. In order to better estimate soil carbon budget and understand their exchange mechanisms in key ecosystems of Korea, it is necessary to measure soil respiration at various plant functional types, soils, and climate conditions over a decadal time scale along with the study on the partitioning of soil respiration into autotrophic and heteorotrophic components.

• Korean Journal of Head & Neck Oncology
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• v.35 no.2
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• pp.19-25
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• 2019

Background/Objectives: Although anaplastic thyroid carcinoma (ATC) is rare, it is one of the deadliest forms of thyroid cancer. The fatality rate for ATC is high, and the survival rate at one year after diagnosis is <20%. The present study aimed to investigate the anti-tumor activities of paclitaxel, radiation, and tyrosine kinase inhibitor (TKI) combined therapy in anaplastic thyroid cancer cells both in vitro and in vivo and explore its effects on apoptotic cell death pathways. Materials & Methods: ATC cell line was exposed to TKI, lenvatinib in the presence or absence of paclitaxel with radiation, and cell viability was determined by MTT assay. Effects of the combined treatment on cell cycle and intracellular signaling pathways were assessed by flow cytometry and western blot analysis. The ATC cell line xenograft model was used to examine the anti-tumor activity in vivo. Results: Our data revealed that the combined administration of paclitaxel, TKI, and radiation decreased cell viability in ATC cells, and also significantly increased apoptotic cell death in these cells, as demonstrated by the cleavage of caspase-3 and DNA fragmentation. This combination therapy reduced anti-apoptotic factor levels in ATC cells, while significantly decreasing tumor volume and increasing survival in ATC xenografts. Conclusion: These results indicate that administering the combination of paclitaxel, TKI, and radiation therapy may exert significant anticancer effects in preclinical models, potentially suggesting a new clinical approach for treating patients with ATC.