• Journal of Environmental Science International
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• v.15 no.1
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• pp.9-19
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• 2006

The purpose of this research is development of radar data assimilation observed at Jindo S-band radar The accurate observational data assimilation system is one of the important factors to meteorological numerical prediction of the region scale. Diagnostic analysis system LAPS(Local Analysis and Prediction System) developed by US FSL(Forecast Systems Laboratory) is adopted assimilation system of the Honam district forecasting system. The LAPS system was adjusted in calculation environment in the Honam district. And the improvement in the predictability by the application of the LAPS system was confirmed by the experiment applied to Honam district local severe rain case of generating 22 July 2003. The results are as follows: 1) Precipitation amounts of Gwangju is strong associated with the strong in lower level from analysis of aerological data. This indicated the circulation field especially, 850hPa layer, acts important role to precipitation in Homan area. 2) Wind in coastal area tends to be stronger than inland area and radar data show the strong wind in conversions zone around front. 3) Radar data assimilation make the precipitation area be extended and maximum amount of precipitation be smaller. 4) In respect to contribution rate of different height wind field on precipitation variation, radar data assimilation of upper level is smaller than that of lower level.

• KIPS Transactions on Computer and Communication Systems
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• v.11 no.8
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• pp.259-268
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• 2022

With prosperous usage of cloud services to improve management efficiency due to the explosive increase in data volume, various cryptographic techniques are being applied in order to preserve data privacy. In spite of the vast computing resources of cloud systems, decrease in storage efficiency caused by redundancy of data outsourced from multiple users acts as a factor that significantly reduces service efficiency. Among several approaches on privacy-preserving data deduplication over encrypted data, in this paper, the research results for improving efficiency of encrypted data deduplication using trusted execution environment (TEE) published in the recent USENIX ATC are analysed in terms of security and efficiency of the participating entities. We present a way to improve the stability of a key-managing server by integrating it with individual clients, resulting in secure deduplication without independent key servers. The experimental results show that the communication efficiency of the proposed approach can be improved by about 30% with the effect of a distributed key server while providing robust security guarantees as the same level of the previous research.

• Bulletin of the Korean Chemical Society
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• v.32 no.5
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• pp.1613-1619
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• 2011

A hybrid thermosetting maleimido epoxy compound 4-(N-maleimidophenyl) glycidylether (N-MPGE) containing Co(II), Ni(II) and Cu(II) ions was prepared by curing N-MPGE and tetradentate Schiff base Co(II), Ni(II) and Cu(II) complexes. The curing polymerization reaction of N-MPGE with metal complexes as curing agents was studied. The cured samples were studied for thermal stability, chemical (acid/alkali/solvent) and water absorption resistance and homogeneity of the cured systems. The tetradentate Schiff base, 3-[(Z)-2-piperazin-1-yl-ethylimino]-1,3-dihydro indol-2-one was synthesized by the condensation of Isatin (Indole-2, 3-dione) with 1-(2-aminoethyl)piperazine (AEP). Its complexes with Co(II), Ni(II) and Cu(II) have been synthesized and characterized by microanalysis, conductivity, Uv-Visible, FT-IR, TGA and magnetic susceptibility measurements. The spectral data revealed that the ligand acts as a neutral tetradentate Schiff base and coordinating through the azomethine nitrogen, two piperazine nitrogen atoms and carbonyl oxygen.

• Molecules and Cells
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• v.37 no.5
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• pp.389-398
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• 2014

Siah acts as an E3 ubiquitin ligase that binds proteins destined for degradation. Extensive homology between siah and Drosophila Siah homologue (sina) suggests their important physiological roles during embryonic development. However, detailed functional studies of Siah in vertebrate development have not been carried out. Here we report that Siah2 specifically augments nodal related gene expression in marginal blastomeres at late blastula through early gastrula stages of zebrafish embryos. Siah2 dependent Nodal signaling augmentation is confirmed by cell-based reporter gene assays using 293T cells and 3TP-luciferase reporter plasmid. We also established a molecular hierarchy of Siah as a upstream regulator of FoxH1/Fast1 transcriptional factor in Nodal signaling. Elevated expression of nodal related genes by overexpression of Siah2 was enough to override the inhibitory effects of atv and lft2 on the Nodal signaling. In particular, E3 ubiquitin ligase activity of Siah2 is critical to limit the duration and/or magnitude of Nodal signaling. Additionally, since the embryos injected with Siah morpholinos mimicked the atv overexpression phenotype at least in part, our data support a model in which Siah is involved in mesendoderm patterning via modulating Nodal signaling.

• Journal of Microbiology and Biotechnology
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• v.18 no.3
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• pp.397-403
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• 2008

Nikkomycins are a group of peptidyl nucleoside antibiotics with potent fungicidal, insecticidal, and acaricidal activities. sanN was cloned from the partial genomic library of Streptomyces ansochromogenes 7100. Gene disruption and complementation analysis demonstrated that sanN is essential for nikkomycin biosynthesis in S. ansochromogenes. Primer extension assay indicated that sanN is transcribed from two promoters (sanN-P1 and sanN-P2), and sanN-P2 plays a more important role in nikkomycin biosynthesis. Purified recombinant SanN acts as a dehydrogenase to convert benzoate-CoA to benzaldehyde in a random-order mechanism in vitro, with respective $K_{cat}/K_m$$ values of $3.8mM^{-1}s^{-1}\;and\;12.0mM^{-1}s^{-1}$ toward benzoate-CoA and NADH, suggesting that SanN catalyzes the formation of picolinaldehyde during biosynthesis of nikkomycin X and Z components in the wild-type stain. These data would facilitate us to understand the biosynthetic pathway of nikkomycins and to consider the combinatorial synthesis of novel antibiotic derivatives.

• Journal of the Korean Society of Safety
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• v.35 no.1
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• pp.34-44
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• 2020

The purpose of this study is to suggest ways to improve the transparency of occupational safety and health management cost (OSHMC) in order to create a safe working environment that can guarantee the health of construction workers. It was performed in the following procedures and methods. (1) collecting and analyzing resources related to the OSHMC in construction, (2) gathering stakeholder opinions for interviewing actual conditions, (3) deriving the improvement plans based on survey results and (4) suggesting direction for improvement of related laws based on the results of the research. As a result of this study, the following ways were found to be effective for enhancing transparency of the OSHMC in construction. (1) disclosure of usage details in sites, (2) Expansion of the standard for the OSHMC in construction, (3) Increase in fines for false use, (4) Establishment of the plan to improve the OSHMC ratio of small-scale construction sites, (5) Strengthen the role of supervisory and support organizations such as the Ministry of Employment and Labor and the Korea Occupational Safety & Health Agency. The result of this study is expected to be used as a basic data for future improvement of the occupational safety and health acts in Korea.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.16 no.1
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• pp.17-26
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• 2006

In order to obtain basic reference information for the establishment of effective industrial safety programmes in migrant workers who live in Seoul and Kyungin Area, accident causes were investigated among 210 injured workers. The data were analyzed according to the USA Standards Institute and International Labour Organization method. The results obtained were as follows: 1. The major distribution of national were mostly from china(82.9%), ages are mostly between 30 and 40 years old(32%), and males are more than females, and mostly married. 2. The parts of body most frequently injured were hand and finger, foot and toe, which were 55.3% of total 210 cases. 3. According to the accident type, caught in, under or between were most frequently observed, 40.2% of the total number of injuries. 4. The most responsible source of injuries were power machine, others, moving machine and tool, building construction. 5. According to the unsafe acts, carelessness and unsafety information were most frequently observed, 66.7% of the total number of injuries. 6. There were significantly difference(p<0.05), between type of accident and source of injury, and between working period and unsafe act.

• The Korean Journal of Physiology and Pharmacology
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• v.14 no.5
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• pp.325-329
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• 2010

Vascular NADPH oxidase plays a pivotal role in producing superoxide in endothelial cells and thus acts in the initiation and development of inflammatory cardiovascular diseases such as atherosclerosis. Epigallocatechin-3-gallate (EGCG), the major catechin derived from green tea, has multiple beneficial effects for treating cardiovascular disease but the effect of EGCG on the expression of vascular NADPH oxidase remains unknown. In this study, we investigated the mechanism(s) by which EGCG might inhibit the expression of subunits of NADPH oxidase, namely $p47^{phox}$, $p67^{phox}$ and $p22^{phox}$, induced by angiotensin II (Ang II) in human umbilical vein endothelial cells. Ang II increased the expression levels of $p47^{phox}$, $p67^{phox}$, and $p22^{phox}$, but EGCG counteracted this effect on $p47^{phox}$. Moreover, EGCG did not affect the production of reactive oxygen species induced by Ang II. These data suggest a novel mechanism whereby EGCG might provide direct vascular benefits for treating inflammatory cardiovascular diseases.

• Biomolecules & Therapeutics
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• v.25 no.2
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• pp.165-170
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• 2017

Cordyceps bassiana is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities. This mushroom has recently demonstrated to have an ability to reduce 2,4-dinitrofluorobenzene-induced atopic dermatitis symptoms in NC/Nga mice. In this study, we further examined phytochemical properties of this mushroom by column chromatography and HPLC analysis. By chromatographic separation and spectroscopic analysis, 8 compounds, such as 1,9-dimethylguanine (1), adenosine (2), uridine (3), nicotinamide (4), 3-methyluracil (5), 1,7-dimethylxanthine (6), nudifloric acid (7), and mannitol (8) were identified from 6 different fractions and 4 more subfractions. Through evaluation of their anti-inflammatory activities using reporter gene assay and mRNA analysis, compound 1 was found to block luciferase activity induced by $NF-{\kappa}B$ and AP-1, suppress the mRNA levels of cyclooxygenase (COX)-2 and tumor necrosis factor $(TNF)-{\alpha}$. Therefore, our data strongly suggests that compound 1 acts as one of major principles in Cordyceps bassiana with anti-inflammatory and anti-atopic dermatitis activities.

• Journal of Animal Science and Technology
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• v.65 no.3
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• pp.579-587
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• 2023

In this study, rumen temperature and environment in estral and non-estral Korean Native breeding cattle were evaluated by using a bolus sensor. Behavioral and physiological changes in study animals were also assessed. To assess the rumen temperature and environment, we inserted bolus sensors into 12 Korean Native cattle with an average age of 35.5 months, then measured temperature and activity within the rumen using the wireless bolus sensor. Drinking, feeding and mounting behavior, and measured vaginal temperature and levels of intravaginal mucus resistance were recorded. We found that cattle in estrus exhibited more acts of mounting (37.4 vs. 0 times/day), increased vaginal temperature (39.0℃ vs. 38.4℃), and decreased vaginal mucus resistance (136.3 Ω vs 197.4 Ω), compared with non-estral animals. Furthermore, increased levels of rumen activity were most significant in estrus cattle at the highest activity levels (p < 0.01). Overall, the estrus group exhibited increased rumen temperature (p = 0.01), compared with the non-estrus group. In conclusion, the results of this study not only provide basic physiological data related to estrus in improved Korean Native breeding cattle, but also suggest that monitoring of rumen temperature and activity might be used as an effective smart device for estrus detection.