• The Korean Journal of Pain
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• 제27권4호
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• pp.313-320
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• 2014

Dexmedetomidine, an imidazoline compound, is a highly selective ${\alpha}_2$-adrenoceptor agonist with sympatholytic, sedative, amnestic, and analgesic properties. In order to minimize the patients' pain and anxiety during minimally invasive spine surgery (MISS) when compared to conventional surgery under general anesthesia, an adequate conscious sedation (CS) or monitored anesthetic care (MAC) should be provided. Commonly used intravenous sedatives and hypnotics, such as midazolam and propofol, are not suitable for operations in a prone position due to undesired respiratory depression. Dexmedetomidine converges on an endogenous non-rapid eye movement (NREM) sleep-promoting pathway to exert its sedative effects. The great merit of dexmedetomidine for CS or MAC is the ability of the operator to recognize nerve damage during percutaneous endoscopic lumbar discectomy, a representative MISS. However, there are 2 shortcomings for dexmedetomidine in MISS: hypotension/bradycardia and delayed emergence. Its hypotension/bradycardiac effects can be prevented by ketamine intraoperatively. Using atipamezole (an ${\alpha}_2$-adrenoceptor antagonist) might allow doctors to control the rate of recovery from procedural sedation in the future. MAC, with other analgesics such as ketorolac and opioids, creates ideal conditions for MISS. In conclusion, dexmedetomidine provides a favorable surgical condition in patients receiving MISS in a prone position due to its unique properties of conscious sedation followed by unconscious hypnosis with analgesia. However, no respiratory depression occurs based on the dexmedetomidine-related endogenous sleep pathways involves the inhibition of the locus coeruleus in the pons, which facilitates VLPO firing in the anterior hypothalamus.

• 제어로봇시스템학회논문지
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• 제14권2호
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• pp.168-177
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• 2008

Path finding is a key element in the navigation of a mobile robot. To find a path, robot should know their position exactly, since the position error exposes a robot to many dangerous conditions. It could make a robot move to a wrong direction so that it may have damage by collision by the surrounding obstacles. We propose a method obtaining an accurate robot position. The localization of a mobile robot in its working environment performs by using a vision system and Virtual Reality Modeling Language(VRML). The robot identifies landmarks located in the environment. An image processing and neural network pattern matching techniques have been applied to find location of the robot. After the self-positioning procedure, the 2-D scene of the vision is overlaid onto a VRML scene. This paper describes how to realize the self-positioning, and shows the overlay between the 2-D and VRML scenes. The suggested method defines a robot's path successfully. An experiment using the suggested algorithm apply to a mobile robot has been performed and the result shows a good path tracking.

• 전력전자학회논문지
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• 제9권5호
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• pp.430-437
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• 2004

본 논문에서는 고주파 스위칭 시 스위칭 손실의 감소, 구현의 용이성 및 인버터 제어를 위하여 요구되는 연산시간 감소 등 다양한 장점을 가진 4-Switch 인버터를 대상으로, 새로운 2상 스위칭 패턴(Pattern)과 이에 적용된 새로운 SRP-PWM(Separately Random Pulse Position PWM)기법을 제안한다. 본 논문에서는 고속운전 영역에서의 인버터 출력전류의 고조파 스펙트럼을 넓은 주파수 영역으로 즉, 특정주파수의 side-band로 고루 분산시키는 결과로부터 제안한 스위칭 패턴과 이에 적용된 새로운 SRP-PWM기법의 고조파 저감효과를 확인하고자 한다. 따라서 DSP를 이용한 IGBT인버터에 의한 실험을 수행하고, 이로부터 얻은 결과를 MATLAB/SIMULINK를 이용한 시뮬레이션 결과와 비교ㆍ분석하여 제안된 기법의 타당성을 검증하고자 한다.

• Advances in Computational Design
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• 제4권3호
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• pp.295-305
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• 2019

The sealing cement of total hip arthroplasty is the most widely used binder in orthopedic surgery for anchoring implants to their recipient bones. Nevertheless, this latter remains a fragile material with weak mechanical properties. Inside this material cracks initiate from cavities. These cracks propagate under the effect of fatigue and lead to the failure of this binder and consequently the loosening of the prosthesis. In this context, this work consists to predict the position of cracks initiation and their propagations path using the Extended Finite Element Method (XFEM). The results show that cracks can only be initiated from a sharp edges of an ellipsoidal cavity which the ratio of the minor axis over the major axis is equal to 0.1. A maximum crack length of 19 ?m found for a cavity situated in the proximal zone position under a static loading. All cracks propagate in same(almost) way regardless of the cavity(site of initiation) position and its inclination in the proximal zone.

• 대한기계학회논문집A
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• 제35권4호
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• pp.347-352
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• 2011

일반 산업용 로봇의 위치정밀도는 $100{\mu}m$ 정도임에 반해, 정밀부품의 조립공차는 수십 ${\mu}m$ 이내이다. 또한, 조립공차가 작을 경우 미소한 위치/각도 오차에 의해 재밍 또는 웨징이 쉽게 발생하며, 위치제어 기반의 로봇인 경우 부품 조립 시 접촉력을 적절히 조절하지 못하여 조립물이 파손될 가능성이 크다 이와 같은 문제를 해결하기 위하여 접촉력에 능동적으로 반응할 수 있는 힘제어 기반의 로봇조립에 대한 연구가 진행되고 있다. 본 연구에서는 기존의 산업용 로봇에 적용하기 용이하도록 위치제어 기반의 머니퓰레이터에 힘제어를 적용할 수 있는 시스템을 구현하였다. 머니퓰레이터에 어드미턴스 필터를 이용한 임피던스 제어를 적용하여 안정적인 접촉운동을 구현하였다. 또한, 임피던스 제어와 blind 검색을 적용하여 정밀부품을 조립할 수 있음을 검증하였다.

• 기본간호학회지
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• 제21권3호
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• pp.226-234
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• 2014

Purpose: This study was done to present guidelines for deciding appropriate times for measuring blood pressure (BP) in patients with neurological disorders who had surgery due to brain damage. Method: It was a repeated measures-experimental research on time variants in BP after nursing care. SBP (Systolic BP) and DBP (Diastolic) were measured every 2 minutes up to 5 times using an EKG patient monitor. Measured data were analyzed using repeated measures ANOVA and paired t-test. Results: For suctioning, there were significantly higher differences for SBP averages after 2 min. (138mmHg, p<0.01) and 4 min. (133mmHg, p<0.01) compared to before suctioning (120mmHg). For position change, there were significant differences in SBP averages after 2 min. (136mmHg, p<0.01) and 4 min. (130mmHg, p=0.01) compared to before changing position (121mmHg). For position change followed by suctioning there were significant differences in SBP averages after 2 min. (136mmHg, p<0.01), 4 min. (136mmHg, p<0.01) and 6 min. (125mmHg, p=0.003) compared to before the interventions (121mmHg). Conclusions: Results indicate that there are significant differences in SBP and DBP over time during nursing interventions, suggesting clinical measurement of BP after 6 min. or 8 min. be done for patients with neurological disorders in neurosurgery clinics.

• 한국지반공학회논문집
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• 제18권3호
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• pp.51-59
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• 2002

이 논문에서는 터널막장 주변지반의 3차원적 지반거동을 고려한 인접건물의 손상위험도 평가시스템 개발에 관한 내용을 다루었다 이 시스템은 크게 건물 및 지반정보 모듈, 계측데이터 모듈, 침하평가모듈 및 건물 손상평가모듈로 구성되어 있다. 지반 침하평가 및 건물 손상평가 모듈은 이 시스템의 핵심 모듈로서 Attewell 등(1982)이 제안한 침하평가 모형을 토대로 터널시공으로 인한 침하량 및 범위를 정량적으로 평가한 후, 터널노선에 인접한 건물의 손상위험도를 Mair 등(1996)이 제시한 건물손상 평가방법을 근거로 평가한다. 터널굴착으로 인한 지반거동 평가에서 가장 큰 영향인자인 지반손실률($V_{s}$)또는 최대침하량($w_{max}$)및 변곡점(i)의 위치는 계측자료, 수치 해석 결과 그리고 각종 경험식을 사용하여 자동적으로 계산되도록 구축하였다. 한편, 건물 손상평가는 터널막장의 위치를 변화시키며 임의 구간의 인접건물에 대한 손상위험도 평가가 수행될 수 있는 기능을 부여하였다. 개발된 시스템 검증은 Boscardin과 Cording(1989)이 워싱턴 DC의 매트로 터널에 인접한 2층 조적식 건물의 계측사례를 적용하여 수행하였다.

• Journal of Biosystems Engineering
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• 제42권2호
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• pp.117-125
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• 2017

Purpose: Damage to pulse crops by wild birds is a serious problem. The damage is to such an extent that the rate of damage during the period between seeding and cotyledon stages reaches 54.6% on an average. In this study, a crop-position detection method was developed wherein infrared (IR) sensors were used to determine the cotyledon position under a vinyl mulch. Methods: IR sensors that helped measure the temperature were used to locate the cotyledons below the vinyl mulch. A single IR sensor module was installed at three locations of the crops (peanut, red lettuce, and crown daisy) in the cotyledon stage. The representative thermal response of a $16{\times}4$ pixel area was detected using this sensor in the case where the distance from the target was 25 cm. A spatial image was applied to the two-dimensional temperature distribution using a non-integral moving-average method. The collected data were first processed by taking the moving average via interpolation to determine the frame where the variance was the lowest for a resolution unit of 1.02 cm. Results: The temperature distribution was plotted corresponding to a distance of 10 cm between the crops. A clear leaf pattern of the crop was visually confirmed. However, the temperature distribution after the normalization was unclear. The image conversion and frequency-conversion graphs were obtained based on the moving average by averaging the points corresponding to a frequency of 40 Hz for 8 pixels. The most optimized resolutions at locations 1, 2, and 3 were found on 3.4, 4.1, and 5.6 Pixels, respectively. Conclusions: In this study, to solve the problem of damage caused by birds to crops in the cotyledon stage after seeding, the vinyl mulch is punched after seeding. The crops in the cotyledon stage could be accurately located using the proposed method. By conducting the experiments using the single IR sensor and a sliding mechanical device with the help of a non-integral interpolation method, the crops in the cotyledon stage could be precisely located.

• Biomolecules & Therapeutics
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• 제23권3호
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• pp.275-282
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• 2015

In the present study, we synthesized a series of novel 7-methoxy-N-(substituted phenyl)benzofuran-2-carboxamide derivatives in moderate to good yields and evaluated their neuroprotective and antioxidant activities using primary cultured rat cortical neuronal cells and in vitro cell-free bioassays. Based on our primary screening data with eighteen synthesized derivatives, nine compounds (1a, 1c, 1f, 1i, 1j, 1l, 1p, 1q and 1r) exhibiting considerable protection against the NMDA-induced excitotoxic neuronal cell damage at the concentration of $100{\mu}M$ were selected for further evaluation. Among the selected derivatives, compound 1f (with $-CH_3$ substitution at R2 position) exhibited the most potent and efficacious neuroprotective action against the NMDA-induced excitotoxicity. Its neuroprotective effect was almost comparable to that of memantine, a well-known NMDA antagonist, at $30{\mu}M$ concentration. In addition to 1f, compound 1j (with -OH substitution at R3 position) also showed marked anti-excitotoxic effects at both 100 and $300{\mu}M$ concentrations. These findings suggest that $-CH_3$ substitution at R2 position and, to a lesser degree, -OH substitution at R3 position may be important for exhibiting neuroprotective action against excitotoxic damage. Compound 1j was also found to scavenge 1,1-diphenyl-2-picrylhydrazyl radicals and inhibit in vitro lipid peroxidation in rat brain homogenate in moderate and appreciable degrees. Taken together, our structure-activity relationship studies suggest that the compound with $-CH_3$ substitution at R2 and -OH substitution at R3 positions of the benzofuran moiety might serve as the lead exhibiting potent anti-excitotoxic, ROS scavenging, and antioxidant activities. Further synthesis and evaluation will be necessary to confirm this possibility.

• 한국산림과학회지
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• 제96권3호
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• pp.295-299
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• 2007

밤 주산지별로 최적 재배품종을 선발하기 위하여 현재 재배되고 있는 주요 품종 및 국립산림과학원에서 육성된 신품종, 그리고 민간에서 육성된 지방품종을 대상으로 밤나무혹벌 (Dryocosmus kuriphilus)에 대한 내충성을 검정하였다. 2004년~2006년 3년간 밤나무혹벌 피해를 조사한 결과 중부지방의 공주와 충주 검정림에서는 모든 품종에서 밤나무혹벌의 피해가 전혀 나타나지 않았으나 남부지방의 광양, 산청 및 합천 검정림에서는 대부분의 품종에서 밤나무혹벌 피해를 관찰할 수 있었다. 지역별로는 합천지역이 밤나무혹벌 피해가 가장 심각함을 알 수 있었으며, 품종별로는 국립산림과학원에서 육성된 광은, 산대, 은산, 이대 품종이 저항성이 가장 높았고, 반면에 단택, 이평, 창방감율, 평기, 광덕, 세일, 신이평, 유마변이 품종은 20% 이상의 높은 피해율을 보여 상대적으로 밤나무혹벌에 대한 저항성이 낮은 것으로 판단되었다. 조사부위별로 결과지보다는 소약지에서 피해율이 월등히 높은 것으로 나타났다. 밤나무혹별 피해가 심한 광양, 산청 및 합천에서 주요 재배품종을 대상으로 년차별 밤나무혹벌 피해율의 변동을 조사한 결과 2005년을 기점으로 2006년에는 피해율이 현저히 감소함을 관찰할 수 있었는데, 이는 밤나무혹벌의 천적인 기생벌류의 밀도변동 등 생물학적 요인에 크게 영향을 받은 것으로 판단되었다.