• Journal of the Society of Cosmetic Scientists of Korea
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• v.43 no.3
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• pp.239-245
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• 2017

Aging is a physiological and irreversible, progressive process involving changes in the ability to maintain cellular functionality. It affects tissues, organs and the whole organism and thus finally cause to death. Oxidative stress has been postulated to contribute significantly to the accelerated accumulation of advanced glycation endproducts (AGEs) in collagen, which is implicated in the process of skin aging. In the present study, glycation inhibitory activity of methoxy PEG-45 thioctate (LA-PEG), and its inhibitory effect of cellular oxidation and senescence was investigated. Treatment of LA-PEG significantly showed lower fluorescent intensity induced by AGEs. In addition, LA-PEG was significantly reduced the formation of ROS induced by AGEs. High antioxidant and anti-glycation activities of LA-PEG in glycated collagen model indicated its contribution to anti-aging process. Cellular senescence leads to an increase in senescence-associated ${\beta}$-galactosidase ($SA-{\beta}-gal$) activity, which can be used as a biomarker to identify senescent cells. Treatment with LA-PEG showed a dose-dependent, statistically significant decreased in $SA-{\beta}-gal$ indicating reduced senescence. These results suggest that LA-PEG may have potent anti-aging effects and can be used as new functional materials against cellular accumulation of AGEs.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.44 no.2
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• pp.133-139
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• 2018

Chemically damaged hair is vulnerable to external stimuli in daily life due to the weakened physical properties of the hair strand itself. The purpose of this work was to determine whether chemical conjugation between hair keratin proteins restores tensile strength and thus results inpreventing further deterioration under repeated combing. A model damaged hair tress was produced by a typical perm-process. Then, it was internally crosslinked by the bifunctional crosslinker (3-aminopropyl)triethoxysilane (APTES), via both silane coupling and carbodiimide chemistry. Physical properties, including tensile strength, Young's modulus, and plateau stress, were measured to verify the effect of internal crosslinking, and the existence of crosslinking was verified by Fourier transform infrared (FT-IR) spectroscopy. The degrees of hair breakage and split ends were evaluated by repeated combing-drying tests. Physical properties of chemically damaged hair were restored by internal crosslinking. Successful crosslinking of APTES via both silane coupling and carbodiimide chemistry was verified by FT-IR spectra. Prevention of breakage and split ends after repeated combing with heat was observed. Human hair can be weakened by chemical damage including perm-processing, so restoring such properties is a major issue in the hair care industry. This work shows that internal crosslinking of damaged hair via chemical conjugation would be a potent method to restore the healthy hair.

• Journal of Acupuncture Research
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• v.25 no.4
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• pp.81-94
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• 2008

Rheumatoid arthritis(RA) is a general, chronic, inflammatory and auto-immune disease and it can lead to joint edema, pain, stiffness which are caused by an inflammation in synovium covering our joints. Ulmus davidiana Planchon is a traditional herb used for the treatment on various inflammations, gastrointestinal trouble, ENT(ear, nose, and throat) disease, edema, cancer etc. and it works effectively on arthritis as well. In these study to search for the treatment efficacy of Ulmus davidiana Planchon in RA, I measure manifestation of cytokine gene in synoviocyte treated with Ulmus davidiana Planchon herbal acupuncture and in EL-4 cell, manifestation of cytokine gene cell related to T-cell. And after Ulmus davidiana Planchon herbal acupuncture treatment in Collagen induced arthritis(CIA) which has been known by a general model of RA, DBA mice, I observed foot thickness, general shape of synovium, early cytokine induce CIA and, generation and mutation of cytokine related to the control of T-cell specialization. It comes to conclusion as belows. 1. In synovium treated with Ulmus davidiana Planchon herbal acupuncture, there was the decrease in MIF mRNA does-dependently. Incase of CIA mice treated with Ulmus davidiana Planchon herbal acupuncture, there were the decrease in the damage in synovium and generation of the MIF which is related to induction of the early RA cytokine and IL-6 proinflammatory cytokine. 2. In case of EL-4 treated with Ulmus davidiana Planchon herbal acupuncture, there were decrease in the manifestation of the IL-2 mRNA, but the increase in the manifestation of the IL-4 does-dependently. 3. In the synovium of CIA mice treated with Ulmus davidiana Planchon herbal acupuncture, there were the decrease in generation of IL-2, IL-12 and CD-28, but the increase in generation of IL-4. These result suggest that Ulmus davidiana Planchon can block the process of the early RA by Inhibiting MIF activation, and mitigate Rheumatoid Arthritis by controlling Tcell specialization.

• Korean Journal of Agricultural Science
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• v.32 no.1
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• pp.29-42
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• 2005

During a long journey of agricultural products from the production area to markets, the quality of agricultural products was always affected by some degree of vibration. The vibration input during the transportation may cause serious agricultural product injury, and this damage is particularly severe whenever the vegetable inside package is free to bounce, and is vibrated at its resonant frequency. The objectives of this study were to determine the resonant frequency of the oriental melon and to investigate the relationships between resonant frequency and physical properties of the oriental melon such as mass, volume and major and minor axes. In this study vibration testing device was constructed to determine the vibration response of the oriental melon in frequency ranges of 5 to 150 Hz. The computer program for controlling the vibration shaker and the function generator and measuring the vibration characteristics of the oriental melon was developed. The ranges of resonant frequency and peak acceleration at resonance of the oriental melon were 51 to 73 Hz and 1.24 to 1.92 G-rms, respectively. The resonant frequency and the peak acceleration decreased with the increase of the sample mass, volume, major and minor axes of the oriental melon. Multiple regression models for resonant frequency and peak acceleration of the oriental melon as a function of mass, major axis and minor axis of the sample were developed and analyzed.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.39 no.1
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• pp.31-38
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• 2013

To substitute animal test, skin equivalents (SEs) have been developed for skin irritation and corrosion test. Recently, we have developed new SEs containing Cervi cornus Colla (CCC). In the present study, we used the SEs for cutaneous cytotoxicity test. Sodium dodecylsulfate (SDS) or sodium carbonate was applied to the SEs-, and the epidermal damage by H&E and immunohistochemical stains was evaluated. Our results showed that SDS or sodium carbonate affected the epidermal part of SEs containing CCC in a dose-dependent manner and decreased the expression of p63. It is concluded that SEs containing CCC could be used for an alternative model of animal test and would be greatly helpful in the development of in vitro irritation and corrosion test.

• Journal of Ginseng Research
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• v.41 no.1
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• pp.103-112
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• 2017

Background: 20(S)-Protopanaxadiol 20-O-D-glucopyranoside, also called compound K (CK), exerts antidiabetic effects that are mediated by insulin secretion through adenosine triphosphate (ATP)-sensitive potassium ($K_{ATP}$) channels in pancreatic ${\beta}$-cells. However, the antidiabetic effects of CK may be limited because of its low bioavailability. Methods: In this study, we aimed to enhance the antidiabetic activity and lower the toxicity of CK by including it with ${\beta}$-cyclodextrin (CD) (CD-CK), and to determine whether the CD-CK compound enhanced pancreatic islet recovery, compared to CK alone, in an alloxan-induced diabetic zebrafish model. Furthermore, we confirmed the toxicity of CD-CK relative to CK alone by morphological changes, mitochondrial damage, and TdT-UTP nick end labeling (TUNEL) assays, and determined the ratio between the toxic and therapeutic dose for both compounds to verify the relative safety of CK and CD-CK. Results: The CD-CK conjugate ($EC_{50}=2.158{\mu}M$) enhanced the recovery of pancreatic islets, compared to CK alone ($EC_{50}=7.221{\mu}M$), as assessed in alloxan-induced diabetic zebrafish larvae. In addition, CD-CK ($LC_{50} =20.68{\mu}M$) was less toxic than CK alone ($LC_{50}=14.24{\mu}M$). The therapeutic index of CK and CD-CK was 1.98 and 9.58, respectively. Conclusion: The CD-CK inclusion complex enhanced the recovery of damaged pancreatic islets in diabetic zebrafish. The CD-CK inclusion complex has potential as an effective antidiabetic efficacy with lower toxicity.

• Journal of the Korea Society of Computer and Information
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• v.12 no.1 s.45
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• pp.161-168
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• 2007

Web attack uses structural, logical and coding error or web application rather than vulnerability to Web server itself. According to the Open Web Application Security Project (OWASP) published about ten types of the web application vulnerability to show the causes of hacking, the risk of hacking and the severity of damage are well known. The detection ability and response is important to deal with web hacking. Filtering methods like pattern matching and code modification are used for defense but these methods can not detect new types of attacks. Also though the security unit product like IDS or web application firewall can be used, these require a lot of money and efforts to operate and maintain, and security unit product is likely to generate false positive detection. In this research profiling method that attracts the structure of web application and the attributes of input parameters such as types and length is used, and by installing structural database of web application in advance it is possible that the lack of the validation of user input value check and the verification and attack detection is solved through using profiling identifier of database against illegal request. Integral security management system has been used in most institutes. Therefore even if additional unit security product is not applied, attacks against the web application will be able to be detected by showing the model, which the security monitoring log gathering agent of the integral security management system and the function of the detection of web application attack are combined.

• Journal of Wetlands Research
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• v.21 no.4
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• pp.305-311
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• 2019

Recently, global climate change causes abnormal weather and disaster countermeasures do not provide sufficient defense and mitigation because they were established according to the historical climate condition. Repeated torrential rains, in particular, are causing damage even in the robust urban flood defense system. Therefore, in this study, the change of runoff considering the spatial distribution of rainfall and urban characteristics was analyzed. For rainfall concentrated in small catchment, rainfall in the watershed must be accurately measured. This study is based on the rainfall data observed with Automated Surface Observing System (ASOS) and Automatic Weather Stations (AWS) provided by the Seoul Meteorological Administration. Effluent from the pumping station was estimated using the EPA-SWMM model and compared and analyzed. Catchments with rainwater pumping station are small with large portion of impermeable areas. Thus, when the ASOS data where is located from from the chatchment, runoff is often calculated using rainfall data that is different from rainfall in the catchment. In this study, the difference between rainfall data observed in the AWS near the catchment and ASOS away from the catchment was calculated. It was found that accurate rainfall should be used to operate rainwater pumping stations or forecast urban flooding floods. In addition, the results of this study may be helpful for estimating design rainfall and runoff calculation.

• Journal of Korea Water Resources Association
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• v.48 no.2
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• pp.115-126
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• 2015

In recent years, debris flow disaster has occurred in multiple locations between high and low mountainous areas simultaneously with a flooding disaster in urban areas caused by heavy and torrential rainfall due to the changing global climate and environment. As a result, these disasters frequently lead to large-scale destruction of infrastructures or individual properties and cause psychological harm or human death. In order to mitigate these disasters more effectively, it is necessary to investigate what causes the damage with an integrated model of both disasters at once. The objectives of this study are to analyze the mechanism of debris flow for real basin, to determine the PMP and run-off discharge due to the DAD analysis, and to estimate the influence range of debris flow for fan area according to the scenario. To analyse the characteristics of debris flow at the real basin, the parameters such as the deposition pattern, deposit thickness, approaching velocity, occurrence of sediment volume and travel length are estimated from DAD analysis. As a results, the peak time precipitation is estimated by 135 mm/hr as torrential rainfall and maximum total amount of rainfall is estimated by 544 mm as typhoon related rainfall.

• Journal of Korea Water Resources Association
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• v.42 no.3
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• pp.191-200
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• 2009

A localized torrential rainfall and flash floods which are more frequently occurred by extraordinary atmospheric phenomena and rising sea surface temperature require more hydrological data collecting and analysis for small watershed. Urban watershed hydrological data monitoring system is needed because of big flood potential damage and lack of urban watershed hydrological data. Therefore, Urban Flood Disaster Management Research Center operates small experimental catchments(Sinnae1, Gunja, and Children's Park) observing and analyzing hydrological data(rainfall, stage, and discharge). In this study, the discharge of combined sewage for Gunja experimental drainage is analyzed with weekly data and day of the week data. Through several analyses in analyzing the urban runoff characteristics and managing the urban sewage system, direct runoff is calibrated and verified by the estimated values of rainfall-runoff model(SWMM).