• Clinical and Experimental Reproductive Medicine
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• v.48 no.3
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• pp.211-220
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• 2021

Objective: The present study aimed to investigate the possibility that curcumin (CMN) protects against methotrexate (MTX)-induced testicular damage by affecting the phospho-p38 (p-p38) mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) signaling pathways. Methods: Eighteen male Wistar albino rats were randomly divided into three groups. The control group was given an intragastric administration of dimethyl sulfoxide (DMSO) daily for 14 days, the MTX group was given a single intraperitoneal dose of MTX (20 mg/kg) on the 11th day, and the MTX+CMN group was given intragastric CMN (100 mg/kg/day, dissolved in DMSO) for 14 days and a single intraperitoneal dose of MTX (20 mg/kg) on the 11th day. At the end of the experiment, all animals were sacrificed and the testicular tissues were removed for morphometry, histology, and immunohistochemistry. Body and testicular weights were measured. Results: Body weights, seminiferous tubule diameter, and germinal epithelium height significantly decreased in the MTX group compared to the control group. Whereas, the number of histologically damaged seminiferous tubules and interstitial space width significantly increased in the MTX group. In addition, the number of p-p38 MAPK immunopositive cells and the immunoreactivity of NF-κB also increased in the MTX group compared to the control group. CMN improved loss of body weight, morphometric values, and histological damage due to MTX. CMN also reduced the number of p-p38 MAPK immunopositive cells and the NF-κB immunoreactivity. Conclusion: CMN may reduce MTX-induced testicular damage by suppressing the p38 MAPK and NF-κB signaling pathways.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.26 no.8
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• pp.1599-1607
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• 2002

The purpose of this work is to suggest a new non-contact damage detection method for rotating ferromagnetic shafts. The presence and the location of a damage in rotating shafts are assessed by means of longitudinal elastic waves propagating along the shafts. These waves are measured by non-contact magnetostrictive sensors consisting of a coil and bias magnets. This paper shows the effectiveness of the sensors in the damage detection of rotating shafts. Several issues occurring in the application of the sensors to rotating shafts are carefully investigated.

• Structural Engineering and Mechanics
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• v.39 no.3
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• pp.411-425
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• 2011

This paper illustrates the results of a seismic vulnerability study aimed to derive the fragility curves for typical Algerian reinforced concrete bridge piers using an analytical approach. Fragility curves express the probability of exceeding a certain damage state for a given ground motion intensity (e.g., PGA). In this respect, a set of 41 worldwide accelerometer records from which, 21 Algerian strong motion records are included, have been used in a non-linear dynamic response analyses to assess the damage indices expressed in terms of the bridge displacement ductility, the ultimate ductility, the cyclic loading factor and the cumulative energy ductility. Combining the damage indices defined for 5 damage rank with the ground motion indices, the fragility curves for the bridge piers were derived assuming a lognormal distribution.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.26 no.1
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• pp.153-159
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• 2002

Brittle materials such as ceramics and glasses show fragile fracture due to the low toughness and the crack sensitivity. When brittle materials are subjected to impact loading by small spheres, high contact pressure occurs to the surface of the specimen. Local damage is subsequently generated in the specimen. This local damage is a dangerous factor which gives rise to the final fracture of structures. In this research, impact damage of soda-lime glass plates by small spheres was evaluated by considering the effects of impact directions of indenter, pressure condition of specimen and residual strength after impact loading.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2004.11a
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• pp.870-874
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• 2004

This work presents a study on development of a practical and quantitative technique for assessment of the structural health condition by Piezoelectric impedance-based technique associated with longitudinal wave propagation method. The bolt fastening condition is adjusted by torque wrench. In order to estimate the damage condition numerically, three damage indices, impedance peak frequency shift ${\Delta}F$, peak amplitude ratio $\delta$ and quality factor ratio $\gamma$, are proposed in this paper. Furthermore, an assessment method is described for estimation of the damage by using these three damage indices.

• Earthquakes and Structures
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• v.9 no.1
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• pp.93-109
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• 2015

Based on the reconnaissance of buildings in Dujiangyan City during 2008 Wenchuan earthquake, China, structural damage characteristics and the spatial distribution of structural damage are investigated, and the possible reasons for the extraordinary features are discussed with consideration of the influence of urban historical evolution and spatial variation of earthquake motions. Firstly, the urban plan and typical characteristics of structural seismic damage are briefly presented and summarized. Spatial distribution of structural damage is then comparatively analyzed by classifying all surveyed buildings in accordance with different construction age, considering the influence of seismic design code on urban buildings. Finally, the influences of evolution of seismic design code, topographic condition, local site and distance from fault rupture on spatial distribution of structural damage are comprehensively discussed. It is concluded that spatial variation of earthquake motions, resulting from topography, local site effect and fault rupture, are very important factor leading to the extraordinary spatial distribution of building damage except the evolution of seismic design codes. It is necessary that the spatial distribution of earthquake motions should be considered in seismic design of structures located in complicated topography area and near active faults.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2021.04a
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• pp.52-52
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• 2021

Persicaria amphibia as an England native plant, is a rhizomatous perennial, one of the rather amphibious plants. Its aquatic form contains water-soluble sugars, starch, and protein. P. amphibia have up to 18% tannins in stems and rhizomes. Previous studies have confirmed the anti-inflammatory activity of live bacteria roots, but no studies on bioactivity are known. DNA damage responses (DDRs) pathways are considered a crucial factor affecting the alleviation of cellular damage. The ataxia-telangiectasia mutated and Rad3 related (ATM) and checkpoint kinase 2 (Chk2) pathways are the main pathways of DNA damage response. Also, p53 is a key integrator of cellular response to oxidative DNA damage, contributing repair, or leading transcription including apoptosis. In the present study, we conducted an investigation into the inhibitory effects of P. amphibia on oxidative DNA damage for confirming potential to complementary medicine and therapies. In conclusion, P. amphibia can provide protective effects against double-stranded DNA break (DSB) caused by oxidative DNA damage.

• Journal of Korean Society of Environmental Engineers
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• v.30 no.12
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• pp.1245-1254
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• 2008

Proposing a method for the estimation of the social cost for global warming impact (external cost) is the aim of this paper. Both the endpoint approach and conjoint analysis were applied to estimating the social cost for global warming. The endpoint approach was used to assess the damage on the safeguard subjects by global warming due to the emission of greenhouse gases into the atmosphere. The conjoint analysis was used to estimate the economic values for safeguard subjects which measure the social preferences and willingness to pay (WTP) on safeguard subjects. The economic values of human health and social asset were estimated at 62,261,700 Won / DALY (yr) and 10,000 Won / 10,000 Won, respectively. Moreover, cost factors of GHGs were calculated by multiplying the damage factor which is quantified the unit damage on safeguard subject and the economic value. In the case of CO$_2$, the cost factor was calculated at 13.52 Won / kg (13,520 Won / ton). External cost of products or services can be calculated by multiplying the GHG inventory result of products or services by the cost factor of each GHG. inventory.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2023.04a
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• pp.54-54
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• 2023

Nypa fruticans Wurmb (N. fruticans) is a plant that belongs to Araceae and N. fruticans is mainly found in tropical mangrove systems. The parts (leaves, stems, and roots) of N. fruticans are traditionally used for asthma, sore throat, and liver disease. N. fruticans contains flavonoids and polyphenols, which are substances that have inhibitory effects on cancer and oxidant. In previous studies, some pharmaceutical effects of N. fruticans on melanogenesis and inflammation have been reported. The present study is conducted to investigate the effect of the ethyl acetate fraction of N. fruticans (ENF) on oxidative DNA damage and UVB-induced DNA damage. DNA damage response (DDR) pathway is important in research on cancer, apoptosis, and so on. DDR pathways are considered a crucial factor affecting the alleviation of cellular damage. ENF could reduce oxidative DNA damage derived from reactive oxygen species by the Fenton reaction. Also, ENF reduced the intensity of intracellular ROS in the live cell image by DCFDA assay. UVB is known to cause skin and cellular damage, then finally contribute to causing the formation of tumors. As for the strategies of reducing DNA damage by UVB, inhibition of p53, H2AX, and Chk2 can be important indexes to protect the human body from DNA damage. As a result of confirming the protective effect of ENF for UVB damage, MMPs significantly decreased, and the expression of apoptosis-related factors tended to decrease. In conclusion, ENF can provide protective effects against double-stranded DNA break (DSB) caused by oxidative DNA damage and UVB-induced DNA damage. These results are considered to be closely related to the protective effect against radicals based on catechin, epicatechin, and isoquercitrin contained in ENF. Based on these results, it is thought that additional mechanism studies for inhibiting cell damage are needed.

• Journal of Korean Society of Forest Science
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• v.113 no.2
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• pp.259-270
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• 2024

Since 2013, Korea has allocated significant budgets and manpower nationwide to prevent the spread of pine wilt disease and to reduce damage. As a result, the number of damaged trees decreased from 2.18 million in 2014 to 310,000 in 2021. However, the damage has increased again since then. Despite the overall decrease in the number of damaged trees, the scope of the damage continues to expand every year. Previous studies have develope In order to judge the control performance, a quantitative control performance analysis method to objectively evaluate control performance. This method takes into consideration two factors-quantity change and the change in the damage area, which is an area factor. This approach provides a more comprehensive assessment than the control guidelines that only suggest changes in damage grade based on the volume of damaged trees. The expansion of the damage range is also an important factor in analyzing control performance, but previous studies have not reflected this. Therefore, this study calculates the change in the distance of the pine wilt disease boundary area for Gyeongsangbuk-do, where changes in the damage range can easily be observed from year to year. The study then creates application criteria and coefficients and uses them to improves control performance index calculation formula. As a result, it was possible to calculate a quantitative analysis of the control performance, taking into account the changes in the damage range. When the improved formula was applied to 26 cities, counties, and districts in Gyeongsangbuk-do, it slightly decreased or increased compared to the existing calculation formula. This confirmed that the control performance index can change from a positive value (+), indicating increased damage, to a negative value (-), indicating reduced damage.