한국자원식물학회:학술대회논문집 (Proceedings of the Plant Resources Society of Korea Conference)
- 한국자원식물학회 2021년도 춘계학술대회
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- Pages.52-52
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- 2021
Inhibition Effects of Persicaria amphibia (L.) Delarbre on Oxidative DNA Damage via ATM/Chk2/p53 pathway
- So-Yeon Han (Pharmaceutical Science, Jungwon University) ;
- Hye-Jeong Park (Medicinal Plant Science, Jungwon University) ;
- Jeong-Yong Park (Medicinal Plant Resources, Andong National University) ;
- Seo-Hyun Yun (Department of Medical Beautycare, Jungwon University) ;
- Mi-Ji Noh (Department of Medical Beautycare, Jungwon University) ;
- Soo-Yeon Kim (Pharmaceutical Science, Jungwon University) ;
- Tae-Won Jang (Pharmaceutical Science, Jungwon University) ;
- Jae-Ho Park (Pharmaceutical Science, Jungwon University)
- 발행 : 2021.04.29
초록
Persicaria amphibia as an England native plant, is a rhizomatous perennial, one of the rather amphibious plants. Its aquatic form contains water-soluble sugars, starch, and protein. P. amphibia have up to 18% tannins in stems and rhizomes. Previous studies have confirmed the anti-inflammatory activity of live bacteria roots, but no studies on bioactivity are known. DNA damage responses (DDRs) pathways are considered a crucial factor affecting the alleviation of cellular damage. The ataxia-telangiectasia mutated and Rad3 related (ATM) and checkpoint kinase 2 (Chk2) pathways are the main pathways of DNA damage response. Also, p53 is a key integrator of cellular response to oxidative DNA damage, contributing repair, or leading transcription including apoptosis. In the present study, we conducted an investigation into the inhibitory effects of P. amphibia on oxidative DNA damage for confirming potential to complementary medicine and therapies. In conclusion, P. amphibia can provide protective effects against double-stranded DNA break (DSB) caused by oxidative DNA damage.