• 한국공작기계학회논문집
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• 제13권6호
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• pp.64-73
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• 2004

A fatigue damage accumulation model based on the continuum damage mechanics theory was developed where modulus decay ratios in tension and shear were used as indicators for damage variables D. In the model, the damage variables are considered to be second-order tensors. Then, the maximum principal damage variable, $D^*$ is introduced. According to the similarity to the principal stress, $D^*$ is obtained as the maximum eigen value of damage tensor [D]. Under proportional tension and torsion loadings, fatigue lives were satisfactorily predicted at any combined stress ratios using the present model in which the Fatigue characteristics only under uniaxial tension and pure torsion loadings were needed. Fatigue life prediction under uniaxial tension and pure torsion loadings, was performed based on the damage mechanics using boundary element method.

• 한국공작기계학회:학술대회논문집
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• 한국공작기계학회 2003년도 춘계학술대회 논문집
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• pp.352-361
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• 2003

A fatigue damage accumulation model based on the continuum damage mechanics theory was develope(1 where modules decay ratios in tension and shear on used as indicators for damage variables D . In the model, the damage variables are considered to be second-order tensors. Then the maximum principal damage variable, $D^*$ is introduced According to the similarity to the Principal stress, $D^*$ is obtained as the maximum eigen value of damage tensor [D']. Under proportional tension and torsion loadings, fatigue lives were satisfactorily predicted at any combined stress ratios using the present model in which the fatigue characteristics only under uniaxial tension and pure torsion loadings on needed. Fatigue life prediction under uniaxial tension and pure torsion loadings, was performed based on the damage mechanics using boundary element method.

• 대한한의학방제학회지
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• 제26권4호
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• pp.363-380
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• 2018

Objectives : We analyzed the principle of compatibility of socheongnyong-tang and expanded the range of application in clinical practice. Methods : Socheongnyong-tang was analyzed by the compatibility principle through the system of chief, deputy, assistant, and envoy, but the basic formulas of "Discussion of Cold Damage" and "Synopsis of the Golden Chamber" was used. Results : Socheongnyong-tang treats exterior wind-cold and interior water accumulation. Exterior wind-cold is treated mainly by exterior-releasing herbs constituting mahwang-tang and gyeji-tang in "Discussion of Cold Damage", and interior water accumulation is treated mainly by retained fluid-resolving herbs constituting yeonggamomigangsinha-tang, yeonggamomigagangsinbanhahaengin-tang and yeonggamomigagangsinbanhaengdaehwang-tang in "Synopsis of the Golden Chamber". Depending on the weight of exterior wind-cold and interior water accumulation, the disease condition is classified as a case where exterior wind-cold is heavier than interior water accumulation, a case where exterior wind-cold is lighter than interior water accumulation, and a case where it is equivalent. When exterior wind-cold is heavier than interior water accumulation, chief herbs are Ephedrae Herba and Cinnamomi Ramulus of exterior-releasing herbs series and deputy herbs are Zingiberis Rhizoma and Asari Radix et Rhizoma of retained fluid-resolving herbs series. When exterior wind-cold is equal to the disease condition of interior water accumulation, chief herbs are Ephedrae Herba of exterior-releasing herbs series and Zingiberis Rhizoma of retained fluid-resolving herbs series, and deputy herbs are Cinnamomi Ramulus of the exterior-releasing herbs series and Asari Radix et Rhizoma of retained fluid-resolving herbs series. When exterior wind-cold is lighter than interior water accumulation, chief herbs are Zingiberis Rhizoma and Asari Radix et Rhizoma of retained fluid-resolving herbs series and deputy herbs are Ephedrae Herba and Cinnamomi Ramulus of exterior-releasing herbs series. In any case, assistant herbs are Pinelliae Rhizoma, Paeoniae Radix alba, and Schisandrae Fructus, and envoy herb is Glycyrrhizae Radix preparata. Conclusions : In conclusion, socheongnyong-tang must differently formulate the system of chief, deputy, assistant, and envoy according to the grade of exterior wind-cold and interior water accumulation. These results suggest that socheongnyong-tang can be applied flexibly when applied in clinical practice to enhance the therapeutic effect.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2023년도 임시총회 및 춘계학술대회
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• pp.55-55
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• 2023

With the COVID-19 pandemic, there is increasing interest in anti-obesity strategies. According to the National Statistical Office, the obesity rate in Korea was 38.3% in 2020 and 37.1% in 2021. Obesity is a risk factor for several severe diseases, including stroke, heart disease, type 2 diabetes, and certain types of cancer. Pinus rigida × Pinus taeda is a hybrid of Pinus rigida Mill and Pinus taeda Linn, and its cones are considered a by-product. Although previous studies have investigated their pharmacological effects on antioxidant activity and protection against oxidative DNA damage, few researchers have explored their potential as functional natural materials. Therefore, we evaluated the anti-obesity effects of the cone of ethyl acetate fraction of P. rigida × P. taeda (ERT), specifically its ability to inhibit lipid accumulation. Our analysis showed that ERT contains phytochemicals (catechin and caffeic acid) which are known to improve immune function and inhibit cell damage. ERT inhibited lipid droplet accumulation at the cellular levels through Oil Red O staining. Furthermore, ERT suppressed the expression of adipogenic transcription factors (PPARγ and CEBP/α) as well as downstream lipogenic target genes (FAS and SREBP-1) thereby inhibiting adipogenesis. ERT also down-regulated key adipogenic markers, including aP2α, while inducing the phosphorylation of AMPK. It has been reported that PPARγ and CEBP/α are expressed in the early stages of adipose differentiation, while SREBP-1 is expressed in the late stage. Therefore, our findings suggest that ERT activates AMPK signaling pathways, which inhibits adipogenic transcription factors (PPARγ, C/EBPα, and SREBP1) and lipogenic genes (FAS and aP2α), thereby blocking lipid accumulation and preventing obesity and related disorders. ERT showed potential as a new resource for developing a functional material for anti-obesity agents.

• Composites Research
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• 제13권4호
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• pp.1-10
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• 2000

SiC가 강화된 금속복합재료는 기존의 금속재료에 비하여 비탄성계수와 비강도가 높기 때문에 자동차 및 항공산업에 많은 응용이 기대되고 있다. 금속복합재료의 파손기구는 적용된 하중에 의한 미시적 손상의 축적에 의해 많은 영향을 받기 때문에 금속복합재료의 광범위한 응용을 위해서는 금속복합재료가 반복 하중을 받을 때 미시적 파손기구를 이해하는 것이 대단히 중요하다. 따라서 본 연구에서는 SiCp/A356 금속복합재료의 미시적 손상 축적을 모니터링 하기 위하여 초음파와 음향방출기법을 적용하였다. 반복하중의 증가에 따라 초음파의 속도와 감쇠의 변화는 각 미시적 손상기구에 따라 3영역으로 나눌 수 있었다. 또한 각 영역에서 발생하는 AE 신호의 특징은 초음파의 속도 및 감쇠 변화와 비교, 분석되었다.

• Advanced Composite Materials
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• 제16권3호
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• pp.223-244
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• 2007

This study experimentally and numerically investigated the tensile damage progress in stitched laminates. In particular, it focused on the effects of stitching on the damage progress. First, we experimentally confirmed that ply cracks and delamination appeared under load regardless of stitching. We then performed damage-extension simulation for stitched laminates using a layer-wise finite element model with stitch threads as beam elements, in which the damage (ply cracks and delamination) was represented by cohesive elements. A detailed comparison between observation and the simulated results confirmed that stitching had little effect on the onset and accumulation of ply cracks. Furthermore, we demonstrated that the stitch threads significantly suppressed the extension of the delamination.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2003년도 추계학술대회 논문집(III)
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• pp.79-84
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• 2003

A fictitious crack model was used to analyze fatigue crack growth under the influence of residual stress. In the fictitious crack model, crack is represented in terms of the separation of two adjacent interfaces and the constitutive equation between the separation and traction is assumed. The effect of fatigue loading was included in the constitutive equation by considering damage accumulation in the cohesive zone. To investigate the effect of the residual stress on the fatigue crack growth, we calculated the residual stress distribution due to transient heat flux to the specimen by finite element method. Fatigue crack growth was simulated by the fictitious crack model with repeated loading. The mode-I crack growth rates were compared for the cases with and without the compressive residual stress around the crack tip. It was observed that the mode-I crack growth can be suppressed by compressive residual stress.

• Biomolecules & Therapeutics
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• 제31권5호
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• pp.559-565
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• 2023

Ataxia-telangiectasia mutated (ATM), a master kinase of the DNA damage response (DDR), phosphorylates a multitude of substrates to activate signaling pathways after DNA double-strand breaks (DSBs). ATM inhibitors have been evaluated as anticancer drugs to potentiate the cytotoxicity of DNA damage-based cancer therapy. ATM is also involved in autophagy, a conserved cellular process that maintains homeostasis by degrading unnecessary proteins and dysfunctional organelles. In this study, we report that ATM inhibitors (KU-55933 and KU-60019) provoked accumulation of autophagosomes and p62 and restrained autolysosome formation. Under autophagy-inducing conditions, the ATM inhibitors caused excessive autophagosome accumulation and cell death. This new function of ATM in autophagy was also observed in numerous cell lines. Repression of ATM expression using an siRNA inhibited autophagic flux at the autolysosome formation step and induced cell death under autophagy-inducing conditions. Taken together, our results suggest that ATM is involved in autolysosome formation and that the use of ATM inhibitors in cancer therapy may be expanded.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 2005년도 추계학술발표회
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• pp.330-331
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• 2005

• 대한기계학회논문집
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• 제19권8호
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• pp.1915-1926
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• 1995

The Fatigue characteristics of 8-harness satin woven CFRP composites with a circular hole are experimentally investigated under constant amplitude tension-tension loading. It is found in this study that the fatigue damage accumulation behavior is very random and history-independent, and the fatigue cumulative damage is linearly related with the mean number of cycles to a specified damage state. From these results, it is known that the fatigue characteristics of CFRP composites satisfy the basic assumptions of Markov chain theory and the parameter of Markov chain model can be determined only by mean and variance of fatigue lives. The predicted distribution of the fatigue cumulative damage using Markov chain model shows a good agreement with the test results. For the fatigue life distribution, Markov chain model makes similar accuracy to 2-parameter Weibull distribution function.