• Archives of Pharmacal Research
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• 제24권2호
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• pp.100-104
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• 2001

Differential pulse polarographic(DPP) analytical procedure for the rifampicin antibiotic, which can be applied to monitor its synthetic process from the starting antibiotic of rifamycin B or rifamycin SV has been developed based on the electrochemical reduction of an azomethine group. Rifampicin exhibited a cathodic peak due to the azomethine group in the side chain of 3-[(4-methyl-1-piperazinyl)imino]methyl moiety and another cathodic peak due to the carbonyl group in rifamycin SV by DPP. The experimental peak potential shift of an azomethine reduction was -73 mV/pH in the pH range between 3.0 and 7.5, agreeing with involvement of 4 e-and 5 $H^5$ in its reduction. By the cyclic voltammetric(CV) studies, the azomethine and the carbonyl reductions in rifampicin were processed irreversibly on the mercury electrode. The plot of peak currents vs. concentrations of rifampicin ranging $1.0{\times}10^{-7} M~$1.0{\times}10^{-5} M yielded a straight line with a correlation coefficient of 0.9996. The detection limit was $1.0{\times}10^{-8} M with a modulation amplitude of 50 mV DPP has been successfully applied for the determination of rifampicin in the pharmaceutical preparations.

• Bulletin of the Korean Chemical Society
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• 제32권3호
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• pp.836-840
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• 2011

This study examines the effects of a carbon coating on the electrochemical performances of $LiFePO_4$. The results show that the capacity of bare $LiFePO_4$ decreased sharply, whereas the $LiFePO_4$/C shows a well maintained initial capacity. The Li ion diffusivity of the bare and carbon coated $LiFePO_4$ is calculated using cyclic voltammetry (CV) to determine the correlation between the electrochemical performance of $LiFePO_4$ and Li diffusion. The diffusion constants for $LiFePO_4$ and $LiFePO_4$/C measured from CV are $6.56{\times}10^{-16}$ and $2.48{\times}10^{-15}\;cm^2\;s^{-1}$, respectively, indicating considerable increases in diffusivity after modifications. The Li ion diffusivity (DLi) values as a function of the lithium content in the cathode are estimated by electrochemical impedance spectroscopy (EIS). The effects of the carbon coating as well as the mechanisms for the improved electrochemical performances after modification are discussed based on the diffusivity data.

• 전기학회논문지
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• 제56권8호
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• pp.1450-1454
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• 2007

This paper presents a microfabricated Clark-type sensor which exactly can measure dissolved oxygen in the cell containing solution. We designed, fabricated, and characterized a microfabircated Clark-type oxygen sensor for measuring dissolved oxygen. The microfabricated oxygen sensor consists of 3-electrodes on a glass substrate, a FEP (Fluorinated ethylene propylene) oxygen-permeable membrane, and PDMS (Polydimethylsiloxane) reservoir for storing sample solution. Thin-film Ag/AgCl was employed as a reference electrode and its durability was verified by obtaining a stable open circuit potential for 2 hours against a commercial Ag/AgCl electrode and a stable cyclic voltammetry curve. Selectivity, response time, and linearity of the fabricated oxygen sensor were also verified well by cyclic voltammetry and amperometry depending. The fabricated oxygen sensor showed a 90% response time of 40sec and an excellent linearity with a correlation coefficient of 0.994.

• Structural Engineering and Mechanics
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• 제29권3호
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• pp.259-278
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• 2008

This paper presents a nonlinear finite element procedure accounting for the effects of geometric as well as material nonlinearities for reinforced concrete bridge piers supported by laminated rubber bearings. Reinforced concrete bridge piers supported by laminated rubber bearings and carrying a cyclic load were analyzed by using a special purpose, nonlinear finite element program, RCAHEST. For reinforced concrete, the proposed robust nonlinear material model captures the salient response characteristics of the bridge piers under cyclic loading conditions and addresses with the influence of geometric nonlinearity on post-peak response of the bridge piers by transformations between local and global systems. Seismic isolator element to predict the behaviors of laminated rubber bearings is also developed. The seismic performance of reinforced concrete bridge piers supported by laminated rubber bearings is assessed analytically. The results show good correlation between the experimental findings and numerical predictions, and demonstrate the reliability and robustness of the proposed analytical model. Additionally, the studies and discussions presented in this investigation provide an insight into the key behavioral aspects of reinforced concrete bridge piers supported by laminated rubber bearings.

• 한국물환경학회지
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• 제22권2호
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• pp.203-208
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• 2006

A continuous feed and cyclic draw SBR process was developed to overcome flow rate fluctuation and to maximize organic matters utilization efficiency for nitrogen and phosphorus removal. The developed SBR process was operated with two parallel reactors. Influent was supplied to one reactor which was not obligately aerated. At the same time, the other reactor was just aerated without supplying influent. In addition this mode was changed periodically. Cycle time was 6hr and aeration time ratio($t_{aer}/t_{total}$) was 0.33, respectively. $COD_{cr}$ and SS removal efficiencies of 95% or higher were achieved. Nitrogen removal was so greatly influenced by influent $COD_{cr}/T-N$ ratio. At influent $COD_{cr}/T-N$ ratio of 5.7, removal efficiencies of ammonia-N, T-N and T-P were 96%, 78% and 55%, respectively. Influent $COD_{cr}/T-N$ of 4 or higher ratio was necessary to achieve 60% or higher nitrogen removal. Organic matters of influent was efficiently utilized in denitrification reaction and consumed COD has a good correlation with removed T-N(about 6.5 mgCOD/mgTN). Continuous feed and cyclic draw SBR process could be one of alternative processes for the removal of nutrients in rural area where $COD_{cr}/T-N$ ratio was low and fluctuation of flow rate was severe.

• 융합신호처리학회논문지
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• 제6권4호
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• pp.206-211
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• 2005

본 논문에서는 블루투스 기저대역에 적용하기 위한 상관기와 액세스 코드 생성모듈의 설계에 대해 다룬다. 상관기와 액세스 코드 생성 모듈은 블루투스 유닛 사이의 연결설정과 패킷판별, 클록 동기화를 수행한다. 상관기 모듈은 1Mb/s 전송속도를 가지는 입력신호에 대해 슬라이딩 윈도우 상관을 취하여 유용한 패킷판별과 클록 동기화를 행하며, 그 구성은 Wallace tree 구조의 CSA(Carry Save Adder)와 임계 값 판별기로 구성된다. 액세스 코드 생성모듈은 블루투스 표준안에서 제시한 4단계의 생성과정에 따라 설계하였으며 BCH(Bose-Chadhuri-Hocquenghem)순회 부호기(cyclic code)와 제어장치로 구성된다. 의사 랜덤 시퀀스는 동기화 문제를 해결하기 위해 임의의 저장장치에 저장된 형태로 사용하였다. 본 논문에서 제시한 상관기와 액세스 코드 생성모듈은 하드웨어 묘사언어인 VHDL로 설계되었으며 시뮬레이션 및 테스트를 위해 Xilinx FPGA를 사용하여 검증하였다. 설계된 회로의 합성결과는 치대 4.689ns의 임계지연과 최대 7-bit까지의 상관허용 오차를 보여준다.

• Bulletin of the Korean Chemical Society
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• 제34권10호
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• pp.2983-2988
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• 2013

Second-order rate constants ($k_N$) have been measured spectrophotometrically for the reactions of 4-chloro-2-nitrophenyl X-substituted-benzoates (1a-1h) with a series of cyclic secondary amines in 80 mol % $H_2O$/20 mol % DMSO at $25.0{\pm}0.1^{\circ}C$. The Hammett plot for the reactions of 1a-1h with piperidine consists of two intersecting straight lines, while the Yukawa-Tsuno plot exhibits an excellent linear correlation with ${\rho}_X $ = 1.25 and r = 0.58, indicating that the nonlinear Hammett plot is not due to a change in the rate-determining step (RDS) but is caused by ground-state stabilization through resonance interactions for substrates possessing an electron-withdrawing group in the benzoyl moiety. The Br${\o}$nsted-type plot for the reactions of 4-chloro-2-nitrophenyl benzoate (1d) with a series of cyclic secondary amines curves downward with ${\beta}_2$ = 0.85, ${\beta}_1$ = 0.24, and $pK_a{^o}$ = 10.5, implying that a change in RDS occurs from the $k_2$ step to the $k_1$ process as the $pK_a$ of the conjugate acid of the amine exceeds 10.5. Dissection of $k_N$ into the microscopic rate constants $k_1$ and $k_2/k_{-1}$ ratio associated with the reaction of 1d reveals that $k_2$ is dependent on the amine basicity, which is contrary to generally held views.

• 수면정신생리
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• 제17권2호
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• pp.75-84
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• 2010

The cyclic alternating pattern (CAP) is a periodic EEG activity in NREM sleep, characterized by sequences of transient electrocortical events that are distinct from background EEG activities. A CAP cycle consists of two periodic EEG features, phase A and subsequent phase B whose durations are 2-60 s. At least two consecutive CAP cycles are required to define a CAP sequence. The CAP phase A is a phasic EEG event, such as delta bursts, vertex sharp transients, K-complex sequences, polyphasic bursts, K-alpha, intermittent alpha, and arousals. Phase B is repetitive periods of background EEG activity. The absence of CAP more than 60 seconds or an isolated phase A is classified as non-CAP. Phase A activities can be classified into three subtypes (A1, A2, and A3), based on the amounts of high-voltage slow waves (EEG synchrony) and low-amplitude fast rhythms (EEG desynchrony). CAP rate, the percentage of CAP durations in NREM sleep is considered to be a physiologic marker of the NREM sleep instability. In insomnia, the frequent discrepancy between self-reports and polysomnographic findings could be attributed to subtle abnormalities in the sleep tracing, which are overlooked by the conventional scoring methods. The conventional scoring scheme has superiority in analysis of macrostructure of sleep but shows limited power in finding arousals and transient EEG events that are major component of microstructure of sleep. But, it has recently been found that a significant correlation exists between CAP rate and the subjective estimates of the sleep quality in insomniacs and sleep-improving treatments often reduce the amount of CAP. Thus, the extension of conventional sleep measures with the new CAP variables, which appear to be the more sensitive to sleep disturbance, may improve our knowledge on the diagnosis and management of insomnia.

• 대한화학회지
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• 제40권7호
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• pp.483-491
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• 1996

Cyclopentadiene과 exo-cyclic 이중결합을 가진 5각고리 화합물간의 Diels-Alder반응을 PM3 방법을 이용하여 연구하였다. Dienophile의 종류가 바뀌어도 전이상태의 구조는 커다란 변화를 나타내지 않았다. 반면에 dienophile의 exocyclic C(=O)-R 결합의 회w전에 의하여 나타나는 두 conformer들은 서로 다른 생성물을 얻을 수 있었으며, 이들의 반응성을 FMO들의 energy gap을 이용하여 설명하였다. 반면에 dienophile의 접근방향에 따른 exo, endo경로의 선택성을 살펴보기 위하여 전이상태에서의 deformation enerhy와 활성와 에너지간의 상관관계를 살펴보았다. 반응의 최저 에너지 경로를 Curtin-Hammett principle을 사용하여 논의 하였다.

• 한국전산구조공학회논문집
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• 제16권4호
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• pp.353-367
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• 2003

이 논문에서는 단조증가하중 하에서 철근콘크리트 전단벽의 수치해석을 위해 개발된 재료모델을 반복하중을 포함한 일반적인 하중 하에서의 구조 거동을 효과적으로 모사하기 위한 해석모델로 확장하여 제안하고 있다. 먼저 재료모델을 구성함에 있어 하중이력에 따라 인장과 압축이 교대로 작용하는 콘크리트는 기본적으로 회전균열모델을 따르는 직교이방성 재료로써 가정하였고, 직교하는 축에 대해 인장과 압축을 오가는 이력곡선을 중심으로 등가의 일축응력-변형률 관계를 정의하였다. 나아가 철근은 평균응력-변형률 개념을 통해 단조증가 상태의 응력-변형률 관계를 구성하였고, 역전된 반복하중으로 인해 발생하는 Bausc-hinger 효과를 고려하여 이력곡선을 정의하였으며, 전단 효과를 고려하기 위해 전단지간 비에 따라 기존에 제안된 이력곡선을 수정하였다. 특히 해석과정의 효율성을 도모하고 변형연화 거동특성 등 일반적인 하중-변위 평형경로를 갖는 철근콘크리트 구조물의 비선형 해석을 위해 arc-length 기법을 도입하였다. 또한 제안된 수치해석모델에 대한 효율성을 검증하기 위해 요소단위의 철근콘크리트 판넬 시험체와 대표적인 전단벽 시험체의 반복하중 이력에 따른 하중-변위 관계 등 전단에 의해 지배를 받는 구조체에 대한 해석 결과와의 비교가 이루어졌다.