• Journal of the Korea Concrete Institute
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• v.21 no.3
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• pp.327-335
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• 2009

In the seismic region, non-ductile structures often form soft story and exhibit brittle collapse. However, structure demolition and new structure construction strategies have serious problems, as construction waste, environmental pollution and popular complain. And these methods can be uneconomical. Therefore, to satisfy seismic performance, so many seismic retrofit methods have been investigated. There are some retrofit methods as infill walls, steel brace, continuous walls, buttress, wing walls, jacketing of column or beam. Among them, the infilled frames exhibit complex behavior as follows: flexible frames experiment large deflection and rotations at the joints, and infilled shear walls fail mainly in shear at relatively small displacements. Therefore, the combined action of the composite system differs significantly from that of the frame or wall alone. Purpose of research is evaluation on the seismic performance of infill walls, and improvement concept of this paper is use of SHCCs (strain-hardening cementitious composites) to absorb damage energy effectively. The experimental investigation consisted of cyclic loading tests on 1/3-scale models of infill walls. The experimental results, as expected, show that the multiple crack pattern, strength, and energy dissipation capacity are superior for SHCC infill wall due to bridging of fibers and stress redistribution in cement matrix.

• Journal of the Korea Concrete Institute
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• v.14 no.5
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• pp.796-803
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• 2002

T-shaped walls have different strength, stiffness and ductility in the two opposite directions parallel to the web when subjected to horizontal in-plane loads. When the flange is in tension, the extent that the flange reinforcement contributes to the flexural strength will be subjected to shear-lag effect. Because of this shear-lag effect, the flange may not participate fully in the action with the web, and the effective flange width is needed for predicting the actual strength and stiffness of structures. The objective of this paper is to evaluate the effective flange width and actual strength of the T-shaped wall with Korean code specified detailing of the wall web. Three specimens were tested with cyclic lateral loading applied at top of the wall. A constant axial load of approximately 0.1f$\_$ck/$.$A$\_$g/ is maintained during the testing. Test results show that the effective flange width increases with increasing drift level, such that the entire overhanging flange of h/3 is effective at the maximum strength level. Therefore, the use of PCI or KBC(Korean Building Code) value of h/10 is unconservative with respect to detailing at the wall web boundary.

• Journal of Korean Society of Steel Construction
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• v.15 no.5 s.66
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• pp.579-589
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• 2003

Most beam-to-column connections are symmetrically reinforced because of the reverse action caused by earthquakes. However, in weak-earthquake regions like Korea, asymmetrically reinforced connections could be used. In particular, the connections between concrete-filled tube (CFT) column and H-shape beam could be applied using a simplified lower diaphragm. The tensile capacity or Combined Cross Diaphragm for upper reinforcing was tested using a simple tension test. Four types for lower reinforcing combined Cross, none, horizontal T-bar, and vertical plate were tested using the ANSI/AISC SSPEC 2002 loading program. Horizontal T-bar and stud bolts in vertical flat, bar transmit tensile stress from the beam's bottom flange to filled concrete. All test specimens satisfied 0.01 radian inelastic rotational requirement in ordinary moment frame of AISC seismic provision. According to the results of the parametric studies simplified lower diaphragms demonstrated outstanding strength, stiffness, and plastic deformation capacity which could lead to more sufficient seismic performance in the field.

• Journal of Chest Surgery
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• v.29 no.5
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• pp.487-494
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• 1996

The neurogenic responses of tracheal smooth muscles to electrical field stimulation (EFS) is biphasic, consisting firstly of cholinergic contraction followed by a slow and sustained relaxation. It is well known that a sustained relaxation involves the inhibitory non-adrenergic non-cholinergic systems. This study was done to Investigate the relaxing agents and their action mechanisms by use of an organ bath with plati- ilum . The tracheal smooth muscle relaxation due to EFS was suppressed by L-NAME, the WO (Nitric Oxide) synthase inhibitor, and these effects were reversed by L-arginine, the precursor of NO. Also, L-WAME (HG-nitro-L-arginine methyl ester) increased the basal tension. Nitroprusside, the NO-donor, suppressed the tracheal basal tension greatly. Methylene blue, the inhibitor of guanylate cyclase, decreased EFS-induced relaxations and increa ed basal tension. Forskolin and isoprenaline, which are activators of adenylate cyclase, suppressed tracheal basal tension in the same way as nitroprusside. TEA (tetraethylammonium), the non-specific K'channel blocker, and apamin, the Ca"-activated K'channel blocker, increased tracheal basal tension and EFS-induced relaxations. Our results indicate that Pr3 Is released upon stimulation of the NANC (Won Adrenergic Won Cholinergic) nerves in guinea-pig tracheal smooth muscle and that the release of NO related with the K+ channel, as well as the release of other inhibitory agents< e. g.)VIP (Vasoactive Intestinal Polypeptide), PHI (Peptide Histidine Isoleusine) > mediated via CAMP (cyclic Adenosine Monophosphate) may be Involved In sustained relaxation.

• Journal of the Korea institute for structural maintenance and inspection
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• v.16 no.5
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• pp.137-147
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• 2012

In the steel-free bridge concrete deck, steel straps are generally used instead of conventional steel rebar while laterally restrained in the perpendicular direction to the traffic in order fir the arching effect of concrete deck. In this paper, the minimum amount of FRP bar is to be suggested based on the structural strength, crack propagation, stress level and others in order to control cracks. As a result of laboratory tests, the structural strength of deck with 0.15 percentage of steel strap showed improved structural strength including ductility. The long-term serviceability of steel strap deck with FRP bar proved to satisfy the requirements and to be structurally stable while showing the amount of crack and residual vertical displacement within the allowable limits after two million cyclic loadings. The structural failure of RC bridge deck is generally caused from the punching shear rather than moment. Therefore, the ultimate load at failure could be estimated using the shear strength formula in the two-way slab based on ACI and AASHTO criteria. However the design criteria tend to underestimate the shear strength since they don't consider the arching effects and nonlinear fracture in bridge deck with lateral confinement. In this paper, an equation to estimate the punching shear strength of steel strap deck is to be developed considering the actual failure geometries and effect of lateral confinement by strap while the results are verified in accordance with laboratory tests.

• Journal of the Korea institute for structural maintenance and inspection
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• v.21 no.1
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• pp.117-125
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• 2017

The role of fly ash in concrete become impotent with finding the characteristics of fly ash in which it is used as cement replacement material. In this paper, corrosion test results obtained by two test methods such as the long-term exposure corrosion test and the accelerated corrosion test method, were compared to investigated the corrosion resistance between fly ash concrete and normal concrete. Corrosion initiation time was measured in two types of concrete, i.e., one mixed with fly ash(FA) and the other without admixture(OPC). The accelerated corrosion test was carried out by four case, i.e., two samples is a cyclic drying-wetting method combined without carbonation(case 1) and combined with carbonation(case 2), and the other two samples is a artificial seawater ponding test method combined without carbonation(case 3) and combined with carbonation(case 4). Whether corrosion occurs, it was measures using half-cell potential method. The ponding test combined without carbonation was most effective in accelerating corrosion time of steel bars. The results indicated that the corrosion of rebar embedded in concrete occurred according to the order of OPC, FA. The delay relative ratio of corrosion obtained by corrosion initiation time between FA and OPC is 1.04 to 1.27. Consequently, fly ash concrete as the age increases its corrosion resistance was improved compared with OPC concrete.

• The Korean Journal of Physiology and Pharmacology
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• v.19 no.5
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• pp.435-440
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• 2015

This study aimed to investigate the effect of pituitary adenylate cyclase-activating peptide (PACAP) on the pacemaker activity of interstitial cells of Cajal (ICC) in mouse colon and to identify the underlying mechanisms of PACAP action. Spontaneous pacemaker activity of colonic ICC and the effects of PACAP were studied using electrophysiological recordings. Exogenously applied PACAP induced hyperpolarization of the cell membrane and inhibited pacemaker frequency in a dose-dependent manner (from 0.1 nM to 100 nM). To investigate cyclic AMP (cAMP) involvement in the effects of PACAP on ICC, SQ-22536 (an inhibitor of adenylate cyclase) and cell-permeable 8-bromo-cAMP were used. SQ-22536 decreased the frequency of pacemaker potentials, and cell-permeable 8-bromo-cAMP increased the frequency of pacemaker potentials. The effects of SQ-22536 on pacemaker potential frequency and membrane hyperpolarization were rescued by co-treatment with glibenclamide (an ATP-sensitive $K^+$ channel blocker). However, neither $N^G$-nitro-L-arginine methyl ester (L-NAME, a competitive inhibitor of NO synthase) nor 1H-[1,2,4]oxadiazolo[4,3-${\alpha}$]quinoxalin-1-one (ODQ, an inhibitor of guanylate cyclase) had any effect on PACAP-induced activity. In conclusion, this study describes the effects of PACAP on ICC in the mouse colon. PACAP inhibited the pacemaker activity of ICC by acting through ATP-sensitive $K^+$ channels. These results provide evidence of a physiological role for PACAP in regulating gastrointestinal (GI) motility through the modulation of ICC activity.

• Journal of Periodontal and Implant Science
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• v.31 no.3
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• pp.611-623
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• 2001

Cyclosporin A is a cyclic polypeptide produced by the metabolism of fungi. It is widely used at present as immunosuppressive treatment following organ transplants. It is also used to deal with autoimmune diseases such as rheumatoid arthritis or type II diabetes. Gingival hyperplasia is one of the most frequent side-effects associated with the prescription of Cyclosporin A. The mechanisms involved in Cyclosporin A induced gingival hyperplasia are not yet clear. In vitro Cyclosporin A promotes proliferation of gingival fibroblasts, that Cyclosporin A act as a mitogen. Its action is based on mitosis of gingival fibroblasts regulated by cell cycle regulatory proteins. It was the purpose of the present study to examine the effects of Cyclosporin A on human gingival fibroblasts by means of biological and biochemical criteria. In this present study, we examined change of cell proliferation, cell activity, cell viability and cell cycle progression after application of Cyclosporin A. We also examined expression of cell cycle regulatory proteins by western blot analysis. Human gingival fibroblasts were cultured for 48 hours with application of Cyclosporin A at concentrations of 0.01, 0.1, 1, and 10 ng/ml. Cyclosporin A(1 ng/ml) significantly increased the cell activity of gingival fibroblast. Proliferation and viability of gingival fibroblasts were also increased in group treated with 1 ng/ml of Cyclosporin A compared to control group. In the cell cycle analysis, S phase was increased and G1 phase was decreased in the group treated with 1 ng/ml of Cyclosporin A. Cyclosporin A increased the expression of cdk4 and inhibited the expression of pRB and p21. These results suggest that 1 ng/ml of Cyclosporin A may increase the cell cycle progression of human gingival fibroblasts, and its mechanisms may increase the expression of cdk4 and decrease the expression of pRB and p21.

• Earthquakes and Structures
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• v.8 no.3
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• pp.665-679
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• 2015

The strain rate of reinforced concrete (RC) structures stimulated by earthquake action has been generally recognized as in the range from $10^{-4}/s$ to $10^{-1}/s$. Because both concrete and steel reinforcement are rate-sensitive materials, the RC beam-column joints are bound to behave differently under different strain rates. This paper describes an investigation of seismic behavior of RC beam-column joints which are subjected to large cyclic displacements on the beam ends with three loading velocities, i.e., 0.4 mm/s, 4 mm/s and 40 mm/s respectively. The levels of strain rate on the joint core region are correspondingly estimated to be $10^{-5}/s$, $10^{-4}/s$, and $10^{-2}/s$. It is aimed to better understand the effect of strain rates on seismic behavior of beam-column joints, such as the carrying capacity and failure modes as well as the energy dissipation. From the experiments, it is observed that with the increase of loading velocity or strain rate, damage in the joint core region decreases but damage in the plastic hinge regions of adjacent beams increases. The energy absorbed in the hysteresis loops under higher loading velocity is larger than that under quasi-static loading. It is also found that the yielding load of the joint is almost independent of the loading velocity, and there is a marginal increase of the ultimate carrying capacity when the loading velocity is increased for the ranges studied in this work. However, under higher loading velocity the residual carrying capacity after peak load drops more rapidly. Additionally, the axial compression ratio has little effect on the shear carrying capacity of the beam-column joints, but with the increase of loading velocity, the crack width of concrete in the joint zone becomes narrower. The shear carrying capacity of the joint at higher loading velocity is higher than that calculated with the quasi-static method proposed by the design code. When the dynamic strengths of materials, i.e., concrete and reinforcement, are directly substituted into the design model of current code, it tends to be insufficiently safe.

• The Korean Journal of Zoology
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• v.33 no.2
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• pp.175-182
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• 1990

Progesterone production and oocyte maturation in ovarian follicles of Rana nigromaculata and Rana rugosa were investigated. Addition of frog pituitary homogenate (FPH) to the in utiro cultured follicles of R. nigromaculata stimulated a marked increase in the accumulation and secretion of progesterone (P$_4$) by the follicles and induced their oocyte maturation (germinal vesicle breakdown, GVBD) in a dose dependent manner. The FPH (0.1 pituitary equivalent/2 ml)-inducted P4 peak appeared in 3-6 hours and followed by the oocyte GVBD in 9-12 hours after the hormone stimulation. lncreae of intrafollicular cAMP levels with forskolin (an adenylatecyclase stimulator) and 3-isobutyl-1-methylxanthine (IBMX, a phosphodiesterase inhibitor) mimic the FPH action in the stimulation of P$_4$ production but not in the induction of oocyte maturation. The in uitro cultured follicies of R. rugosa behaved very differently from other amphibian follicles. Addition of FPH-(0. 1 pit. equivl2 ml) to the culture medium neither stimulated P$_4$ production by the follicles nor induced the oocyte GVBD. However, treatment of the follicles with forskolin and IBMX drastically stimulated both the intrafollicular accumulation (800 pg/follicle) and secretion (1700 pg/follicle) of P$_4$ by the follicles during culture period. Thus, the data suggest that the follicles are ready to respond to cAMP increase but not to the FPH stimulation in terms of P$_4$ production.