• Journal of the Korean Statistical Society
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• 제18권2호
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• pp.125-134
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• 1989

This paper presents optimum simple step-stress accelerated life test plans for the case where the test process is observed periodically at intervals of the same length. Two types of failure data, periodically observed complete data and periodically observed censored data, are considered. An exponential life distribution with a mean that is a log-linear function of stress, and a cumulative exposure model for the effect of changing stress are assumed. For each type of data, the optimum test plan which minimizes the asymptotic variance of the maximum likelihood estimator of the mean life at a design stress is obtained and its behaviors are studied.

• International Journal of Reliability and Applications
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• 제17권1호
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• pp.85-105
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• 2016

In this paper accelerated life testing is incorporated in quality control technique of acceptance sampling plan to induce early failures in high reliability products.Stress under accelerated condition can be applied in constant-stress, step-stress and progressive-stress or combination of such loadings. A ramp-stress results when stress is increased linearly (from zero) with time. In this paper optimum failure-censored ramp-stress accelerated life test sampling plan for log-logistic distribution has been formulated with cost considerations. The log-logistic distribution has been found appropriate for insulating materials. The optimal plans consist in finding optimum sample size, sample proportion allocated to each stress, and stress rate factor such that producer's and consumer's interests are safeguarded. Variance optimality criterion is used when expected cost per lot is not taken into consideration, and bilevel programming approach is used in cost optimization problems. The methods developed have been illustrated using some numerical examples, and sensitivity analyses carried out in the context of ramp-stress ALTSP based on variable SSP for proportion nonconforming.

• 한국환경성돌연변이발암원학회지
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• 제23권4호
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• pp.115-130
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• 2003

Idiopathic Parkinson's disease (IPD) represents a common neurodegenerative disorder. While epidemiological studies have suggested a number of risk factors including age, gender, race, and inherited disorder, the cumulative evidence supports the view that environmental or occupational exposure to certain chemicals may contribute to the initiation and progress of Parkinsonism. More recently, clinical and laboratory investigations have led to the theory that dysregulation of iron, an essential metal to body function, may underlie IPD by initiating free radical reaction, diminishing the mitochondrial energy production, and provoking the oxidative cytotoxicity. The participation of iron in neuronal cell death is especially intriguing in that iron acquisition and regulation in brain are highly conservative and thus vulnerable to interference from other metals that bear the similar chemical reactivity. Manganese neurotoxicity, induced possibly by altering iron homeostasis, is such an example. In fact, the current interest in manganese neurotoxicology stems from two primary concerns: its clinical symptoms that resemble Parkinson's disease and its increased use as an antiknock agent to replace lead in gasoline. This article will commence with addressing the current understanding of iron-associated neurodegenerative damage. The major focus will then be devoted to the mechanism whereby manganese alters iron homeostasis in brain.

• 대한산업공학회지
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• 제22권3호
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• pp.459-471
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• 1996

This paper considers ramp tests for exponential lifetime distribution when there are limitations on test stress and test time. The inverse power law and a cumulative exposure model are assumed. Maximum likelihood (ML) estimators of model parameters and their asymptotic covariance matrix are obtained. The optimum ramp test plans are also found which minimize the asymptotic variance of the ML estimator of the log mean life at design constant stress. For selected values of the design parameters, tables useful for finding optimal test plans are given. The effect of the pre-estimates of design parameters is studied.

• International Journal of Reliability and Applications
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• 제18권2호
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• pp.21-44
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• 2017

Accelerated life tests (ALTs) are frequently used in manufacturing industries to evaluate the reliability of products within a reasonable amount of time and cost. Test units are subjected to elevated stresses which yield quick failures. Most of the previous works on designing ALT plans are focused on tests that involve a single stress. Many times more than one stress factor influence the product's functioning. This paper deals with the design of optimum modified ramp-stress ALT plan for Burr type XII distribution with Type-I censoring under two stress factors, viz., voltage and switching rate each at two levels- low and high. It is assumed that usage time to failure is power law function of switching rate, and voltage increases linearly with time according to modified ramp-stress scheme. The cumulative exposure model is used to incorporate the effect of changing stresses. The optimum plan is devised using D-optimality criterion wherein the ${\log}_{10}$ of the determinant of Fisher information matrix is maximized. The method developed has been explained using a numerical example and sensitivity carried out.

• International Journal of Reliability and Applications
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• 제18권2호
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• pp.45-63
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• 2017

In this paper, we have formulated optimum Accelerated Life Test (ALT) plan for a parallel system with two independent components using masked data with ramp-stress loading scheme and Type-I censoring. Consider a system of two independent and non-identical components connected in parallel. Such a system fails whenever all of its components has failed. The exact component that causes the system to fail is often unknown due to cost and time constraint. For each parallel system at test, we observe its system's failure time and a set of component that includes the component actually causing the system to fail. The stress-life relationship is modelled using inverse power law, and cumulative exposure model is assumed to model the effect of changing stress. The optimal plan consists in finding out the optimum stress rate using D-optimality criterion. The method developed has been explained using a numerical example and sensitivity analysis carried out.

• Tuberculosis and Respiratory Diseases
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• 제42권6호
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• pp.923-933
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• 1995

연구배경: 석면분진의 흡입으로 인한 호흡기 변화중 가장 조기에 그리고 가장 빈번하게 발견되는 것은 늑막 변화이다. 늑막변화에는 늑막상출액, 늑막반, 미만성늑막섬유화로 분류되기도 하나 일반적으로 늑막비후를 단순히 석면폭로의 지표로 여기고 간과하는 경우가 많다. 그러나 석면에 관련된 질환은 대부분이 만성적이고 뒤에 질환이 발현되는 경우가 빈번하여 늑막변화를 나타내는 근로자에 대한 합리적인 관리와 검사가 필요할 것으로 생각된다. 방법: 석면분진을 취급하는 9개 시업장의 작업장 부서별 석면분진농도를 측정하고 석면을 취급하는 업무에 종사하고 있는 222명을 대상으로 하여 설문조사, 흉부 방사선 사진, 폐기능검사를 실시하여 우리나라 석면 취급 근로자들에서 발생되는 늑막변화에 대한 역학조사와 함께 늑막변화에 따른 폐기능의 변화, 그리고 폐기능의 저하에 미치는 인자들에 대한 조사를 실시 하였고 성적은 SAS을 이용하여 분석하였다. 결과: 1) 조사대상 사업장은 총 9개 였으며 대상 사업장중 1개소를 제외하고는 석면분진 농도는 허용농도 이하였다. 조사대상 근로자중 폐기능 검사를 실시한 222명을 대상으로 하였고 남자가 196명(88.3%), 여자 26명(11.7%)였으며 평균 연령은 $41.9{\pm}9.8$세 이었고 평균 석면분진 폭로기간은 $10.6{\pm}7.8$년 이었다. 2) 흉부 방사선 소견상 정상소견을 보인 198명(89.19%), 결핵병변이 관찰된 경우 6명(2.7%), 늑막비후가 보인 경우 17명(7.66%), 망상형 간질성 음영이 의심되는 경우 2명(0.90%)이었다. 3) 늑막비후가 있는 군과 없는 군 사이에 평균신장, 흡연력, 분진농도에는 차이가 없으나, 늑막비후가 없는 군에 비하여 있는군에서 연령, 흡연자의 누적 흡연력, 분진 폭로기간이 유의하게 증가되어 있었다. 4) 늑막비후가 있는 군과 없는 군에서 폐기능의 차이를 보면, 모든 폐기능의 지표에서 늑막비후가 있는 군에서 늑막비후가 없는 군에 비해 유의한 감소를 보였다. 5) 단순회귀분석에서 누적흡연력이 클수록, 폭로기간이 길수록, 그리고 분진농도가 높을 수록 폐기능지표들은 감소하였으며 특히 소기도폐색의 지표인 $FEF_{75}$에서 유의하게 변화하였고 누적흡연력은 $FEF_{50}$의 변화에 유의한 영향을 미쳤다. 6) 다중회귀분석시 폐기능지표등이 누적흡연력이 증가할수록 감소하는 경향을 보였으나 주로 소기도폐색지표에 유의한 감소를 보였으며, 늑막비후가 있는 군에서 없는 군에 비하여 폐기능이 현저히 감소하였다. 결론: 석면 취급 근로자에서 여러가지 폐기능 검사 항목과 석면분진농도등 영향을 미칠수 있는 인자를 조사한 결과 분진폭로농도와 폭로기간에 따라 $FEF_{50}$와 $FEF_{75}$이 특히 민감하게 반응하여 석면에 대한 폐질환의 조기진단을 위하여 도움이 될 것으로 생각되며, 본 연구에서 폐실질병변은 없으나 늑막비후만 관찰되는 경우에도 폐기능이 현저하게 감소한 것으로 미루어 이에 대한 적극적인 관리가 필요하다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권11호
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• pp.4699-4704
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• 2015

Medical diagnostic X-ray workers are one occupational group that expose to the long-term low-dose external radiation over their working lifetime, and they may under risk of different cancers. This study aims to determine the relationship between the occupational X-ray radiation exposure and cancer risk among these workers in Jiangsu, China. We conducted Nested case-control study to investigate the occupational X-ray radiation exposure and cancer risk. Data were collected through self-administered questionnaire, which includes but not limits to demographic data, personal behaviors and family history of cancer. Retrospective dose reconstruction was conducted to estimate the cumulative doses of the x-ray workers. Inferential statistics, t-test and 2 tests were used to compare the differences between each group. We used the logistic regression model to calculate the odds ratio (OR) and 95% confidence interval (CI) of cancer by adjusting the age, gender. All 34 breast cancer cases and 45 esophageal cancer cases that detected in a cohort conducted among health workers between 1950~2011 were included in this presented study, and 158 cancer-free controls were selected by frequency-matched (1:2). Our study found that the occupational radiation exposure was associated with a significantly increased cancer risk compared with the control, especially in breast cancer and esophageal cancer (adjusted OR=2.90, 95% CI: 1.19-7.04 for breast cancer; OR=4.19, 95% CI: 1.87-9.38 for esophageal cancer, and OR=3.43, 95% CI: 1.92-6.12 for total cancer, respectively). The occupational X-ray radiation exposure was associated with increasing cancer risk, which indicates that proper intervention and prevention strategies may be needed in order to bring down the occupational cancer risk.

• Safety and Health at Work
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• 제14권4호
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• pp.451-456
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• 2023

Background: We conducted a case-control study to identify high-risk occupations and exposure to occupational hazards for acute myeloid leukemia (AML). Methods: When patients with AML admitted to the Department of Hematology in the study hospital for the first time are referred to the Department of Occupational and Environmental Medicine, data on occupation are collected by investigators to evaluate work-relatedness. Community-based controls were recruited through an online survey agency, and four controls per case were matched. Occupational information was estimated using structured questionnaires covering 27 specific occupations and 32 exposure agents. Conditional logistic regression analysis was performed by pairing cases and controls. Results: In the analysis of the risk of AML according to occupational classification, a significant association was found in paint manufacturing or painting work (OR = 2.22, 95% CI: 1.03-4.81) and aircrew (OR = 6.00, 95% CI: 1.00-35.91) in males, and in pesticide industry (OR = 6.89, 95% CI: 1.69-28.07) and cokes and steel industry (OR = 2.00, 95% CI: 1.18-22.06) in ≥60 years old. Moreover, the risk of AML increased significantly as the cumulative exposure to thinners increased. In the analyses stratified by sex and age, the association between pesticide exposure and AML was significant in males (OR = 3.28, 95% CI: 1.10-9.77) and in ≥60 years old (OR = 6.22, 95% CI: 1.48-26.08). Conclusion: This case-control study identified high-risk occupational groups in the Republic of Korea including paint manufacturers and painters, aircrew, and those who are occupationally exposed to pesticides or paint thinners.

• 한국산업정보학회논문지
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• 제6권4호
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• pp.12-21
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• 2001

최근 들어 작업강도가 심화, 노동환경의 변화 등으로 단순반복작업자의 누적외상장애가 많이 발생하고 있다. 따라서, 본 연구는 단순반복작업자의 근피로도를 분석하기 위하여 수작업과 Air Balance 시스템 설계장치를 이용할 때 각 근육의 피로도의 차이를 밝히고 단순반복작업의 기계에 의한 시스템설계제안을 목적하였다. 연구 결과, 내화벽돌 적재작업시에 수작업과 Air Balance 시스템을 이용한 근피로도 비교에서 Air Balance를 이용한 적재작업에서는 수작업 대비 근육별 AEMG 64.1%, MF 65.3%, MPF 64.3%, ZCR 63.6%로 근피로도가 낮게 나타났다. 근육의 동원정도는 전체적으로 비슷한 천이를 보였다. 즉, Aire Balance시스템을 사용하는 것이 수작업보다 근피로도 값은 낮게 나타났으며, 누적외상성 질환에 대한 노출도 작은 것으로 나타났다.