Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Nested Case-control Study of Occupational Radiation Exposure and Breast and Esophagus Cancer Risk among Medical Diagnostic X Ray Workers in Jiangsu of China

  • Wang, Fu-Ru (Department of Radiation protection, JiangSu Provincial Center for Disease Prevention and Control) ;
  • Fang, Qiao-Qiao (Department of Respiratory Medicine, Nanjing Children's Hospital Affiliated to Nanjing Medical University) ;
  • Tang, Wei-Ming (Department of Epidemiology, Fielding School of Public Health, University of California) ;
  • Xu, Xiao-San (Department of Radiation protection, JiangSu Provincial Center for Disease Prevention and Control) ;
  • Mahapatra, Tanmay (Department of Epidemiology, Fielding School of Public Health, University of California) ;
  • Mahapatra, Sanchita (Department of Epidemiology, Fielding School of Public Health, University of California) ;
  • Liu, Yu-Fei (National Institute for Radiological Protection) ;
  • Yu, Ning-Le (Department of Radiation protection, JiangSu Provincial Center for Disease Prevention and Control) ;
  • Sun, Quan-Fu (National Institute for Radiological Protection)
  • Published : 2015.06.26
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Abstract

Medical diagnostic X-ray workers are one occupational group that expose to the long-term low-dose external radiation over their working lifetime, and they may under risk of different cancers. This study aims to determine the relationship between the occupational X-ray radiation exposure and cancer risk among these workers in Jiangsu, China. We conducted Nested case-control study to investigate the occupational X-ray radiation exposure and cancer risk. Data were collected through self-administered questionnaire, which includes but not limits to demographic data, personal behaviors and family history of cancer. Retrospective dose reconstruction was conducted to estimate the cumulative doses of the x-ray workers. Inferential statistics, t-test and 2 tests were used to compare the differences between each group. We used the logistic regression model to calculate the odds ratio (OR) and 95% confidence interval (CI) of cancer by adjusting the age, gender. All 34 breast cancer cases and 45 esophageal cancer cases that detected in a cohort conducted among health workers between 1950~2011 were included in this presented study, and 158 cancer-free controls were selected by frequency-matched (1:2). Our study found that the occupational radiation exposure was associated with a significantly increased cancer risk compared with the control, especially in breast cancer and esophageal cancer (adjusted OR=2.90, 95% CI: 1.19-7.04 for breast cancer; OR=4.19, 95% CI: 1.87-9.38 for esophageal cancer, and OR=3.43, 95% CI: 1.92-6.12 for total cancer, respectively). The occupational X-ray radiation exposure was associated with increasing cancer risk, which indicates that proper intervention and prevention strategies may be needed in order to bring down the occupational cancer risk.

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References

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