• 한국임상약학회지
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• 제8권1호
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• pp.19-22
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• 1998

Cefixime is an orally absorbed 3rd generation cephalosporin with a broad spectrum of activity against Gram-positive and Gram-negative bacteria and is highly resistant to $\beta-lactamase$ degradation. This study was carried out to evaluate the bioavailability of a new test drug of cefixime (100 mg/capsule) relative to the reference drug. The bioavailability was conducted on 20 healthy volunteers who received a single dose (400 mg) of the test and the reference drugs in the fasting state, in a randomized balanced 2-way crossover design. After dosing, serial blood samples were collected for a period of 12 hours. Plasma was analyzed for cefixime by a sensitive and validated HPLC assay. The major pharmacokinetic parameters $(AUC_{0-12hr},\;C_{max},\;T_{max})$ were calculated from the plasma concentration-time data of each volunteer. The $AUC_{0-12hr},\;C_{max}\;and\;T_{max}$ of the test drug were $36.91\pm11.85\;{\mu}g{\cdot}hr/ml,\;5.47\pm1.61\;{\mu}g/ml,\;and\;4.00\pm0.65\;hr,$ respectively, and those of the reference drug were $34.08\pm8.81\;{\mu}g{\cdot}hr/ml,\;5.25\pm1.40\;{\mu}g/ml,\;and\;4.20\pm0.62\;hr$, respectively. Mean differences of those parameters were 8.32, 4.29, and $4.76\%$, respectively, and the least significant differences at $\alpha$=0.05 for $AUC_{0-12hr},\;C_{max},\;T_{max}$ were 16.02, 13.78, and $11.76\%$, respectively. In conclusion, the test drug was bioequivalent with the reference drug.

• 한국산학기술학회:학술대회논문집
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• 한국산학기술학회 2010년도 춘계학술발표논문집 1부
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• pp.18-23
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• 2010

본 논문에서는 4$\times$4 버틀러 매트릭스에 대하여 연구 및 고찰 한다. 셀룰러 대역의 주파수인 824~894MHz대역에서 신호를 균등하게 통과시키고, 위상의 차이를 균일하게 분배시키는 회로로 구현 되었다. 기존의 버틀러 매트릭스는 단층 기판 구조로 구현 되었지만, 본 연구는 다층 기판구조로 설계하여 크기가 보다 더 축소되었다. 마이크로스트립 구조인 $90^{\circ}$ 하이브리드 커플러 대신에 크기를 보다 더 효율적으로 줄이기 위하여 LTCC 커플러를 사용한다. 4$\times$4 버틀러 매트릭스의 설계는 Ansoft사의 Designer V3.5와 HFSS V11을 사용한다. 그리고 시뮬레이션 한 후 실제 제작한 버틀러 매트릭스를 측정하여 비교한 결과 매우 우수한 특성을 얻었다.

• 한국지진공학회논문집
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• 제7권4호
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• pp.1-13
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• 2003

본 연구에서는 전단변형을 고려한 비대칭 박벽 곡선보의 자유진동해석을 수행할 수 있는 일반이론을 제시하기 위하여, 3차원 연속체에 대한 가상일의 원리로부터 전단변형 효과를 고려하고 비대칭 박벽단면과 ？(Warping)을 포함하는 변위장을 도심 축에 대해 정의한 후 곡선보의 변형도-변위관계로부터 공간 박벽 곡선보의 일반화된 탄성변형에너지와 운동에너지를 새롭게 유도한다. 또한, 전단변형이 고려된 곡선보의 총포텐셜에너지에 대해 변분을 취함으로써 평형방정식과 힘-변위관계를 제시한다. 한편, 제시된 이론에 대해 등매개 보요소를 도입하여 유한요소 정식화를 수행하였으며 곡선보의 동적 거동특성을 조사하기 위하여 전단변형, 곡률효과 그리고 진동모드에 대한 매개변수 연구를 수행한다. 마지막으로, 본 연구의 타당성을 입증하기 위하여, 다양한 해석예제에 대한 3차원 고유진동수를 산정하고 타 연구자들의 결과 및 ABAQUS의 쉘요소를 이용한 해석결과와 비교ㆍ검증한다.

• Journal of Animal Science and Technology
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• 제61권2호
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• pp.98-108
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• 2019

Four Korean native steers ($511{\pm}17.2kg$; $2{\times}2$ replicated crossover design) fitted with duodenal cannulas were used to investigate the influence of oral administration of soluble whey protein (WP; 82.29% crude protein) on ruminal fermentation, gastrointestinal (GI) hormone secretion in the blood, pancreatic ${\alpha}$-amylase activity in the duodenum, and disappearance rate in each segment of the GI tract. Steers were orally fed the basal diet (control; TMR [total mixed ration] 9 kg/d) or the basal diet with enriched WP (400 g/d) for 14 days. The apparent crude protein disappearance rate in the rumen of the WP was higher than in control (p < 0.05). However, no difference between groups was observed in the apparent crude protein disappearance rate in the intestine and the apparent starch disappearance rates in the rumen, GI tract. The level of cholecystokinin, secretin, and ghrelin in serum and pancreatic ${\alpha}$-amylase activity in the duodenum of the WP also did not change. The changes in the level of blood urea nitrogen related to protein metabolism were higher in the WP than in the control (p < 0.05). However, the levels of total protein, lipid, carbohydrate and mineral metabolites did not change. Consequently, we suggest that the oral administration of WP in steers assisted in ruminal fermentation due to the population increase of microbes in the rumen but did not improve the starch digestion rate in the small intestine because GI hormone secretion in the blood and pancreatic ${\alpha}$-amylase activity did not change.

• Journal of Animal Science and Technology
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• 제61권5호
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• pp.254-259
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• 2019

The objective of this study was to evaluate the nutritive value of polished rice (PR) vs unpolished rice (UPR) as a potential feedstuff for sheep in order to use as a replacer to corn in sheep diet, and as well as to present the application in the formulation of cattle diet. Six corriedale ewe were randomly assigned to each treatment. UPR and PR were provided as a dietary treatment together with timothy grass as a basal diet in a crossover design for two period with 15-d duration for each period. The ratio of experimental and basal feeds were 33.3% and 66.7%, respectively. The differences in the total digestible nutrient (TDN) contents between sheep and cattle was determined according to the references. The number of data collected sheep and cattle was 9 and 17, respectively. The PR showed higher nutrients digestibility than UPR. Similarly, higher TDN content was observed PR than UPR (p < 0.05). As a result, the replacement of corn in the formulate feed with UPR and PR feed rice could be possible with the ratio of 91.2% and 100.0%, respectively. The result of comparation the TDN contents of UPR and PR in sheep and cattle, the PR has no difference in the nutritive value which suggests the applicability of the results of sheep to cattle. On the other hand, UPR has known to have different nutritive value between sheep and cattle, so caution should be taken when preparing formula feeds for cattle.

• 치위생과학회지
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• 제19권3호
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• pp.205-212
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• 2019

Background: Sleep disorder is a precursor to depression, which is one of the psychological factors associated with periodontal disease that, in turn, affects general and periodontal health. This study aimed to investigate the relationship between sleep duration, depression, and periodontitis in older people aged over 65 years. Methods: A total of 2,002 older adults aged 65 years or older were included in the study. Their general and health aspects, including smoking, drinking, diabetes, hypertension, and depression, were investigated. Periodontitis was examined using the Community Periodontal Index (CPI). Data were analyzed through a complex sampling design method. Frequency and crossover analyses were conducted to investigate the relationship between depression and periodontitis. To investigate the effect of depression on periodontitis, a logistic regression analysis was performed. Results: Regarding depression and participants' general characteristics, statistically significant differences were found in sex, economic activity, smoking habit, and CPI (p<0.05). In the presence of depression, the odds ratio for periodontitis was 1.84, and the adjusted odds ratio for age, sex, economic activity, residence type, household income, education level, smoking habit, drinking, hypertension, and diabetes was 1.72, representing a significant difference (p<0.05). Conclusion: This study examined the relationship between depression and periodontitis in older persons and confirmed a significant correlation. As the population of older adults increases, we should pay attention to their mental and oral health as well as systemic diseases. Various programs for the health promotion of older persons need to be implemented to improve the quality of life of older people.

• Asian-Australasian Journal of Animal Sciences
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• 제32권8호
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• pp.1122-1127
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• 2019

Objective: The objective of current study was to investigate the lactation performance and rumen fermentation characteristics of dairy cows fed a diet with alfalfa hay replaced by corn stover but supplemented with molasses. Methods: Sixteen Holstein cows in mid-lactation were randomly assigned to 1 of 2 dietary treatments: i) alfalfa based diet (AH), and ii) corn stover based diet supplemented with molasses (CSM). The experiment was conducted according to a $2{\times}2$ crossover design with 22-d each period, consisting of 17 d for adaptation and 5 d for data and samples collection. Results: Dry matter intake and milk yield were higher for cows fed AH than CSM (p<0.01). Milk protein content and nitrogen conversion were higher (p<0.05), while milk urea nitrogen was lower (p<0.01) for cows fed AH than CSM-fed cows. Contents of milk total solids, fat and lactose were not different between two groups (p>0.10). Total rumen volatile fatty acid concentration tended to be higher (p = 0.06) for cows fed AH than CSM-fed cows. Molar proportion of acetate was lower (p = 0.04), but valerate was higher (p = 0.02) in cows fed AH than CSM-fed cows. Rumen concentration of propionate, and isobutyrate, and ratio of acetate to propionate tended to be different (p<0.10) between two groups. The feed cost per kilogram of milk was lower in CSM than AH (p<0.01). No differences were found in feed efficiency and most plasma parameters tested (p>0.10). Conclusion: In comparison with AH diet, CSM diet could be fed to dairy cows without negative effect on feed efficiency, ruminal fermentation, but economically beneficial, indicating that CSM could be an alternative choice for dairy farms instead of AH to feed midlactation dairy cows.

• 대한한방부인과학회지
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• 제22권3호
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• pp.223-235
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• 2009

Purpose: To evaluate thermal effect and medication compliance of red ginseng extract. Methods: Randomized, double-blind, placebo-controlled, cross-over clinical study was performed. Twenty four healthy, married women aged 30-45 years with FSFI score below 25 were randomly divided into two groups; red ginseng group(N=12) and placebo group(N=12). During the first 6-week period (Study1), each group was dosed with red ginseng or placebo twice a day. Before starting the second 6-week period(Study2), a crossover design was chosen with a 2-week break(Washout period). Interchanging two groups after Washout period, red ginseng and placebo were dosed to each group. The efficacy of thermal effect was measured with subjective warm sensation scale and lower abdomen temperature by Digital Infrared Thermographic imaging(DITI) before and after each 6-week period. A medication compliance was assessed after each 6-week period and the correlation medication compliance between Sasang Constitution and subjective warm sensation was analyzed. Results: Overall 23 participants completed the study. In subjective warm sensation scale, after taking placebo, all participants exhibited an improving trend, but there was no significant difference. In lower abdomen temperature by DITI, statistically significant objective thermal effect of red ginseng was also not shown. A medication compliance was higher in Yin constitution(Taeumin, Soeumin), and showed an upward trend with decreasing subjective warm sensation. But no statistically significant difference was exhibited. Conclusion: Statistically significant thermal effect of red ginseng was not shown in this study. We anticipate if a long-term clinical trial is practiced, significant thermal effect of red ginseng will be shown.

• 예술인문사회 융합 멀티미디어 논문지
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• 제8권4호
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• pp.259-267
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• 2018

부분집합 합 문제는 유한개의 정수로 이루어진 집합이 있을 때 이 집합의 부분집합 중에서 그 집합의 원소들의 합이 특정 값이 되는 경우가 있는지를 알아내는 문제로, 잘 알려진 다항식 시간 내에 풀기 어려운 NP-완비 문제이다. 유전 알고리즘은 선택과 교차, 돌연변이 등의 연산을 통해 주어진 문제의 최적해를 구하는 알고리즘이다. 동적 계획법은 주어진 문제를 풀기 위해서 문제를 하나 또는 여러 개의 하위 문제로 나누어 풀이하는 방법이다. 본 논문에서는 부분집합 합 문제를 풀이하는 유전 알고리즘을 설계 및 구현하고, 답을 찾는 데까지 걸리는 시간 성능을 동적 계획법의 경우와 실험적으로 비교하였다. 양의 정수인 원소 63 개를 가진 집합에서 '쉬움'과 '어려움'의 난이도를 고려하여 총 17 개의 문제를 선정하고, 이 문제들을 풀이하는 두 알고리즘의 성능을 비교하는 실험을 진행하였다. 17 개의 문제 중 13 개의 문제에서 본 논문에서 제시한 유전 알고리즘은 동적 계획법과 비교하여 약 84%가 우수한 시간 성능을 보였다.

• 운동영양학회지
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• 제13권1호
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• pp.75-81
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• 2009

This study aims to find out the effect of ingestion of 3 mg·kg^-1 caffeine on fluid-electrolyte balance and Tty change during exercise under heat environment of 30~32℃ (40-50% humidity). Five trained males who routinely trained for approximately 60 min·d^-1, 3-6 d·wk^-1 (age; 28.20±3.56yrs, height; 174.56±5.46 cm, body mass; 76.13±9.02 kg, body fat(%); 14.24±3.99, VO₂max; 54.00±4.30 mL·kg^-1·min^-1, exercise career; 4.20±1.95yrs) performed 40min of treadmill running in heat chamber. The study was a double-blind, randomized, crossover design. Body mass change following exercise was higher for the PLAC (Placebo) and CAFF (Caffeine) in comparison to the CON (Control), there was no significant difference between the CAFF, PLAC, CON (p= .997). The U_sg not significant differences (p= .731) and Osm_urine not significant differences between the CAFF, PLAC, CON (p= .901). There also were not significant between the CAFF, PLAC, CON for [Na⁺]_urine and [K⁺]_urine (p= .928, p= .469). In the case of Tty, although the increase rate of Tty was the highest for the CAFF on exercise early, exercise the second half in comparison to the CON and PLAC, there was not significant interaction effect between the CAFF, PLAC, and CON of Tty (p= .067), In conclusion, it was confirmed that the 3 mg·kg^-1 caffeine ingestion prior to exercising in heat environment does not impart negative effect on body fluid, electrolyte balance and changes in Tty.