• 통상정보연구
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• 제6권2호
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• pp.219-242
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• 2004

This study is conducted to find out whether companies which use electronic commerce for their business are collecting the least personal information. of consumers that are necessary for providing electronic commerce services to consumers. Investigators visited website of 799 electronic commerce companies, and checked out the personal informations of consumers that were asked when they join the site as a member. The collected data were analyzed with frequency, percentage, and cross-tab analysis using SPSS program. Generally most electronic commerces required more personal information of consumers than necessary for providing their services to consumers. These phenomena are partly due to the fact that regulations regarding consumer privacy in electronic commerce are advisory rather than mandatory at present. Therefore, it is suggested that mandatory regulation which makes companies poot their identification within a certain area of their web page has to enforced for the protection of consumer privacy in electronic commerce. And it would be more efficient if consumers are consistently educated about self protection guideline regarding personal information in using electronic commerce in addition to a mandatory regulation.

• Molecules and Cells
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• 제44권5호
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• pp.318-327
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• 2021

CD4+ T helper (Th) cells play a crucial role in the modulation of innate and adaptive immune responses through the differentiation of Th precursor cells into several subsets, including Th1, Th2, Th17, and regulatory T (Treg) cells. Effector Th and Treg cells are distinguished by the production of signature cytokines and are important for eliminating intracellular and extracellular pathogens and maintaining immune homeostasis. Stimulation of naive Th cells by T cell receptor and specific cytokines activates master transcription factors and induces lineage specification during the differentiation of Th cells. The master transcription factors directly activate the transcription of signature cytokine genes and also undergo post-translational modifications to fine-tune cytokine production and maintain immune balance through cross-regulation with each other. This review highlights the post-translational modifications of master transcription factors that control the differentiation of effector Th and Treg cells and provides additional insights on the immune regulation mediated by protein argininemodifying enzymes in effector Th cells.

• IMMUNE NETWORK
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• 제23권5호
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• pp.36.1-36.16
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• 2023

Thymic epithelial cells (TECs) play a critical role in thymic development and thymopoiesis. As individuals age, TECs undergo various changes that impact their functions, leading to a reduction in cell numbers and impaired thymic selection. These age-related alterations have been observed in both mice and humans. However, the precise mechanisms underlying age-related TEC dysfunction remain unclear. Furthermore, there is a lack of a comprehensive study that connects mouse and human biological processes in this area. To address this gap, we conducted an extensive transcriptome analysis of young and old TECs in mice, complemented by further analysis of publicly available human TEC single-cell RNA sequencing data. Our analysis revealed alterations in both known and unknown pathways that potentially contribute to age-related TEC dysfunction. Specifically, we observed downregulation of pathways related to cell proliferation, T cell development, metabolism, and cytokine signaling in old age TECs. Conversely, TGF-β, BMP, and Wnt signaling pathways were upregulated, which have been known to be associated with age-related TEC dysfunctions or newly discovered in this study. Importantly, we found that these age-related changes in mouse TECs were consistently present in human TECs as well. This cross-species validation further strengthens the significance of our findings. In conclusion, our comprehensive analysis provides valuable insight into the biological and immunological characteristics of aged TECs in both mice and humans. These findings contribute to a better understanding of thymic involution and age-induced immune dysfunction.

• 한국산학기술학회논문지
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• 제19권2호
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• pp.71-76
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• 2018

최근 도로시설물에 작용되는 하중을 저감시키기 위하여 다양한 기술이 개발되고 있으며, 그 중 풍하중 저감을 위한 유공판을 사용하는 기술이 일부 적용 중에 있다. 현재 국내 도로시설물 설계기준에서는 유공판의 항력계수에 대한 규정은 마련되어 있지 않다. 미국의 구조물 설계기준 'Minimum design loads for buildings and other structures'에서는 Letchford(2001)와 Giannoulis(2012)의 연구 내용을 바탕으로 건축물과 도로시설물의 유공판 항력계수 내용이 개정되었다. 본 연구에서는 유공판 항력계수 규정에 대한 준용 가능성을 분석하고자 관련 풍동실험을 수행하였다. 더불어 풍동실험 결과 값과 미국 설계기준의 항력계수 값을 비교 분석하였으며, 미국 설계기준 항력계수를 적용한 도로표지 지주 및 가로재의 부재 단면적 감소효과를 비교 분석하였다. 본 연구의 풍동 실험 결과 값과 미국 설계기준 값이 매우 유사한 수준으로 도출되었으며, 이에 따라 유공판 항력계수에 대한 준용이 가능할 것으로 판단된다. 항력계수 설계기준의 준용에 따른 유공형 도로표지 구조물의 단면적 감소효과 분석 결과, 지주는 약 9.45%, 가로재는 6.45%의 단면적이 감소하였다. 지주와 가로재를 합친 유공형 도로표지의 전체 구조물은 약 6.45%의 단면적 감소효과가 있는 것으로 나타났다.

• 한국언론정보학보
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• 제26권
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• pp.209-257
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• 2004

본 연구는 한국을 비롯한 세계 각국의 비교광고에 관한 다양한 규제들의 내용과 그 특성을 고찰하고 현재 한국의 비교광고 규제의 특성을 도출해내는 데 그 목적이 있다. 이러한 특성을 정확하게 도출해 내기 위해 현재 세계 각국의 비교광고 규제의 특성을 고찰하고 보드윈(Boddewyn)의 1978년의 연구결과와 비교하여 어려한 변화를 보이고 있는지를 살펴보았다. 연구결과, 각국의 비교광고에 대한 규제를 살펴보면, 점차적으로 비교광고에 대한 합법화가 이루어지고 있으며, 과거의 규제와 비교하여 비교광고에 대한 허용범위와 가이드라인을 법적으로 좀더 구체적으로 명시하고 있음을 발견하였다. 현재 한국의 비교광고에 관한 법적 규제 내용에는 과거와 비교하여 좀 더 구체적인 기이드라인이 제시되어 있고, 이는 유럽 국가들의 가이드라인의 수준과 유사함을 발견할 수 있었다.

• 한국식물학회:학술대회논문집
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• 한국식물학회 1987년도 식물생명공학 심포지움 논문집 Proceedings of Symposia on Plant Biotechnology
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• pp.149-155
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• 1987

Growth and development of a higher plant, or any living organism for that matter, could be defined as an orderly expression of the genome in time and space in close interaction with the environment. During differentiation and development of a tissue or organ a group of genes must be selectively turned on or turned off mainly by trans-acting regulators. In this general concept of regulation of regulation of gene expression, a DNA molecule is recognized at a specific nucleotide sequence by DNA-binding factors. Molecular biology of the regulatory factors such as hormones, and their receptors, target DNA sequences and DNA-binding proteins are well advanced. What is not clearly understood is the molecular basis of the interactions between DNA and binding factors, expecially of the usages of the dyad symmetry of the target DNA sequences and the dimeric nature of the DNA-binding proteins. A unique 3-dimensional structure of DNA has been proposed that may play an important role in the orderly expression of the gene. A foldback intercoil (FBI) DNA configuration which was originally found by electron microscopy among mtDNA molecules from pearl millet has some unique features. The FBI configuration of DNA is believed to be formed when a flexible double helix folds back and interwines in the widened major grooves resulting in a four stranded, intercoil DNA whose thickness is the same as that of double stranded DNA. More recently, the FBI structure of DNA has been also induced in vitro by a novel enzyme which was purified from pearl millet mitochondria. It has been proposed that the FBI DNA could be utillized in intramolecular recombination which leads to inversion or deletion, and in intermolecular recombination which can lead to either site-specific recombination, genetic recombination via single strand invasion, or cross strand recombination. The structure and function of DNA in 3-dimensional aspect is emphasized for better understanding orderly expression of genes during growth and development.

• International Journal of Computer Science & Network Security
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• 제21권5호
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• pp.113-120
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• 2021

The adoption of the General Data Protection Regulation (EU) 2016/679 transformed approaches and concepts to the implementation of the personal data protection mechanism in the European Union. Within the EU, almost all countries have adapted a new protection mechanism, which requires a study of the specifics of its use. The article intends to assess the legal provisions of the current mechanism of personal data protection in the EU. The author studied the mechanism of personal data protection under the General Data Protection Regulation (EU) 2016/679 (GDPR) based on the concept of contextual integrity and analysis of EU legislation on personal data protection. The scientific publications for 2016-2020 were reviewed for the formation of ideas of a new personal data protection mechanism in the EU, informative and transparent analysis of legal provisions. The article notes that the personal data privacy and protection is increasing, there is an ongoing unification of the legal status of personal data protection and the formation of a digital market for dissemination, exchange, control, and supervision of data. Cross-border cooperation is part of the personal data protection mechanism. The author proved that the GDPR has changed approach to personal data protection: the emphasis is now shifting to the formation of a digital market, where the EU's role in ensuring regulation is crucial. The article identifies the emergence of a new protectionist legal system and strengthening of legal provisions regarding privacy. This legal system needs unification and harmonization in accordance with national legislation, is territorially fragmented and differentiated within the EU.

• Journal of Microbiology and Biotechnology
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• 제26권1호
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• pp.66-71
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• 2016

PikD is a widely known pathway-specific regulator for controlling pikromycin production in Streptomyces venezuelae ATCC 15439, which is a representative of the large ATP-binding regulator of the LuxR family (LAL) in Streptomyces sp. RapH and FkbN also belong to the LAL family of transcriptional regulators, which show greatest homology with the ATP-binding motif and helix-turn-helix DNA-binding motif of PikD. Overexpression of pikD and heterologous expression of rapH and fkbN led to enhanced production of pikromycin by approximately 1.8-, 1.6-, and 1.6-fold in S. venezuelae, respectively. Cross-complementation of rapH and fkbN in the pikD deletion mutant (ΔpikD) restored pikromycin and derived macrolactone production. Overall, these results show that heterologous expression of rapH and fkbN leads to the overproduction of pikromycin and its congeners from the pikromycin biosynthetic pathway in S. venezuelae, and they have the same functionality as the pathwayspecific transcriptional activator for the pikromycin biosynthetic pathway in the ΔpikD strain. These results also show extensive "cross-communication" between pathway-specific regulators of streptomycetes and suggest revision of the current paradigm for pathwayspecific versus global regulation of secondary metabolism in Streptomyces species.

• 성인간호학회지
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• 제25권4호
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• pp.389-399
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• 2013

Purpose: The purpose of the study was to examine the relationships between cognitive coping, hope, depression, and life satisfaction of hemodialysis patients based on the stress-coping model. Methods: For this cross-sectional survey, 142 participants were recruited from 10 local clinics in Seoul and Daegu during 2012-2013. The data collection instruments included the Cognitive Emotion Regulation Questionnaire, the Herth Hope Index, the Hospital Anxiety and Depression Scale, and the Satisfaction with Life Scale. The data were analyzed using descriptive statistics, t-test, ANOVA, Pearson's correlation analysis, and stepwise multiple regression. Results: The cognitive coping scores were significantly related to hope, depression, and life satisfaction. The coping strategies explained 80%, 37%, and 38% of the variances in hope, depression, and life satisfaction, respectively. The most powerful coping strategy was positive refocusing, explaining 73% in hope, 25% in depression, and 25% in life satisfaction. Conclusion: The results of the study indicate that cognitive coping plays an essential role for psychological adaptation of hemodialysis patients. Thus, interventions integrating positive refocusing would help instilling hope of hemodialysis patients in Korea.

• 통상정보연구
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• 제8권4호
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• pp.71-88
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• 2006

This article want to discuss on comparative research between CHIPS and Fedwire as the cross-border payment systems which America have and use at present. CHIPS is a New York-based automated private-sector clearing facility for large-dollar transfers. It is a central switch communication and settlement system whose 53 participating banks exchange same-day payment messages over dedicated communication lines linking each one to the CHIPS central computer. On January 22, 2001, CHIPS introduced immediate finality for payment released from the CHIPS queue. Unlike the Fedwire system, The CHIPS system is not a real-time gross settlement system. Instead, CHIPS is hybrid system that uses a computer program to select payment order in a queue for release to the receiving bank. CHIPS are governed by CHIPS Rules and Administrative Procedures. Fedwire system is a nationwide electronic fund-transfer system facilitating same-day transfers throughout the United States. It is a gross settlement system providing immediate credit to the receiving bank's master account. Communicating between a Federal Reserve Bank and Fedwire users can be either on-line or off-line. Fedwire transfers are governed by Subpart B of Regulation J, issued by the Federal Reserve Board, which incorporates U.C.C. Article 4A but preempts or supersedes any of its inconsistent provisions.