• Bulletin of the Korean Chemical Society
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• v.23 no.10
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• pp.1459-1462
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• 2002

The kinetics of the addition of X-substituted benzylamines (BA) to Y-substituted Benzylideneacetylacetones (BAA) have been investigated in acetonitrile at $25.0^{\circ}C$. The reaction is studied under pseudo-first-order conditions by keeping a large excess of BA over BAA. The addition of BA to BAA occurs in a single step in which the addition of BA to $C_\alpha$ of BAA and proton transfer from BA to $C_\beta$ of BAA take place concurrently with a four-membered cyclic transition state structure. The magnitude of the Hammett ($p_X$) and Bronsted ($\beta_x$) coefficients are rather small suggesting an early tansition state (TS). The sign and magnitude of the cross-interaction constant, $p_{XY}$ (= -0.49), is comparatible to those found in the normal bond formation processes in the $S_N2$ and addition reactions. The normal kinetic isotope effect ($K_H/K_D$ > 1.0) and relatively low $\Delta$H^{${\neq}$}$ and large negative $\Delta$S^{${\neq}$}$ values are also consistent with the mechanism proposed.

• Journal of Korean Academy of Nursing Administration
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• v.19 no.3
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• pp.351-360
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• 2013

Purpose: This study was done to investigate changes in nursing students' moral judgment throughout their professional education, and to identify more suitable ways to evaluate ethics education by using P (%) scores only and P (%) scores with 4th scores. Methods: The study consisted of cross-sectional and longitudinal surveys as well as a study using a nonequivalent control group pre-post experimental design. The participants were nursing students attending a university in Gyeongju, Korea. The data were collected from September 1, 2006 to October 31, 2009 using the Korean version of the Defining Issues Test. Results: In the cross-sectional survey, there was no significant difference in the nursing students' moral judgment scores according to their school grades. In the longitudinal survey, nursing students' moral judgment scores did not change significantly over the duration of their education. In the nonequivalent control group study, the effectiveness of nursing ethics education was identified by P (%) scores only. Conclusion: The evidence indicates that nursing professional education does not influence the development of nursing students' moral judgment, and using P (%) scores only seems to be a better way compared to other ways to evaluate the effects of nursing ethics education.

• Proceedings of the Korea Concrete Institute Conference
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• 2004.11a
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• pp.517-520
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• 2004

Concrete Filled steel Tube pipe structure is a rational type of structure that maximizes performance by combining the strong points of steel frame and concrete. In the structure, the confining effect of steel pipes increases the bearing power of infilled concrete and the strengthening of local bucking of steel pipes by infilled concrete increases the bearing power of members. and these result in the reduction of cross-sectional area and high transformation capacity. Moreover. the structure is economically efficient and widely applicable that it is used from super-high buildings to residential, business and apartment buildings. It enables the construction of multi-story buildings with long spans using columns of small cross-sectional area. In case of diaphragm, however, it is difficult to confirm the compactness of the closed inside of steel pipes. The present study examined the properties of super-high strength concrete over 80MPa by comparing it with 40MPa concrete through heat conductivity and length change tests based on a mixture ratio satisfying the mixture goal presented in the guideline for the design and construction of concrete-filled steel pipe structure. and evaluated the performance of super-high strength concrete according to the shape and size of the aperture ratio of diaphragm.

• Steel and Composite Structures
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• v.52 no.3
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• pp.249-271
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• 2024

In this scientific work, an analytical solution for the dynamic analysis of cross-ply and angle-ply laminated composite plates is proposed. Due to technical issues during the manufacturing of composite materials, porosities and micro-voids can be produced within the composite material samples, which can carry on to a reduction in the density and strength of the materials. In this research, the laminated composite plates are assumed to have new distributions of porosities over the plate cross-section. The structure is modeled using a simple integral shear deformation theory in which the transverse shear deformation effect is included. The governing equations of motion are obtained employing the principle of Hamilton's. The solution is determined via Navier's approach. The Maple program is used to obtain the numerical results. In the numerical examples, the effects of geometry, ratio, modulus ratio, fiber orientation angle, number of layers and porosity parameter on the natural frequencies of symmetric and anti-symmetric laminated composite plates is presented and discussed in detail. Also, the impacts of the kinds of porosity distribution models on the natural frequencies of symmetric and anti-symmetric laminated composite plates are investigated.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.54 no.2
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• pp.165-171
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• 2009

The objective of this study was to characterize the main-effect QTLs, epistatic QTLs and QTL-by-environment interactions (QE), which are involved in the control of protein content. A population of 120 doubled haploid (DH) lines derived from a cross between 'Samgang' and 'Nagdong', was planted and determined for protein content over three years. Based on the population and a genetic linkage map of 172 markers, QTL analysis was conducted by WinQTLcart 2.5 and QTLMAPPER. Three main-effect QTLs affecting protein content of brown rice were detected from 2004 to 2006 on chromosomes 1 and 11. The qPC11.2 was repeatedly detected across two years. Seven pairs of epistatic loci were identified on eight chromosomes for protein content and collectively explained 39.15% of phenotype variation. These results suggest that epistatic effects might be an even more important component of the genetic basis for protein content and that the segregation of the DH lines for protein content could be largely explained by a few main-effect QTLs and many epistatic loci.

• Asia-Pacific Journal of Business
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• v.15 no.1
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• pp.99-111
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• 2024

Purpose - This study aims to quantify the long tail effect in the digital economy. It also investigates the role of digital platform before and after the COVID-19 pandemic. Design/methodology/approach - We take advantage of a granular data set from one of the biggest digital platforms in Korea. Rather than computing the absolute number of products sold or the Gini coefficient, we estimate the slope of the log-linear relationship of the non-parametric sales distribution. Findings - We find that the use of online food order and delivery services is positively associated with individual restaurant's sales growth. We also document that the long tail effect is increasing over time. Long tail effects are clustered in the cross-section where average revenue per order is high or the restaurant belongs to the top 50% of the sales distribution. Research implications or Originality - The findings may indicate that digital platforms are contributing to the development of the digital economy in Korea. Also, we confirm that digital platforms make it possible for small and sole proprietors to go through the difficulties induced by the COVID-19 pandemic.

• Journal of Digital Convergence
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• v.18 no.9
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• pp.9-15
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• 2020

This study is to analyze the influence of the digital divide on the digital daily life of the elderly. Adaptation tendencies for digital divide were measured and classified into groups for elderly people over 60 years old. And digital communication skills, digital confidence, digital self-control, and digital life satisfaction were measured. The research model used a cross over design model and a dual mediation model. As a result of the study, first, it was found that a group with high adaptive accessibility to the digital divide had a positive effect on the overall digital daily life. Second, a group with high adaptive literacy to the digital divide had a positive effect on the digital self-control. Third, digital communication skill has a positive effect on digital life satisfaction, and digital confidence and digital self-control play a mediating role. Based on these findings, we discussed strategies to overcome the digital divide in old age.

• Korean Journal of Clinical Pharmacy
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• v.18 no.2
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• pp.106-113
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• 2008

The aim of this study was to evaluate the bioequivalence of two domperidone preparations. Bioequivalence assessment was conducted on 34 healthy volunteers who received two tablets (Domperidone Maleate, 12.72 mg/tablet) in the fasting state, in a randomized balanced $2{\times}2$ cross-over study design. This whole study was performed according to the implementation guidelines of the Korea Food Drug Administration. After dosing of two tablets, blood samples were collected serially for a period of 36 hours. Plasma was analyzed for domperidone by using LC/MS/MS assay method. The analysis system was validated in specificity, accuracy, precision, and linearity. $AUC_t$, (the area under the plasma concentration-time curve from the zero-time to 36 hr) was calculated through the trapezoidal rule. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma domperidone concentration-time data of each volunteer. No significant sequence effect was found for the bioavailability parameters indicating that the cross-over design was properly performed. The 90%-Confidence intervals of the $AUC_t$ ratio and the $C_{max}$ were from log 0.8007 to log 1.1240 and log 0.8645- log 1.2483, respectively. These values were within the acceptable bioequivalence intervals between 0.80 and 1.25. Therefore, this study demonstrated that two formulations have bioequivalence with respect to the rate and extent of absorption.

• Journal of Korean Orthopaedic Sports Medicine
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• v.2 no.1
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• pp.50-55
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• 2003

Purpose: To investigate the effects of an 8 weeks of plyometric training on the total work of knee and ankles Joint. Methods: Nine university man aged 20$\~$22 years was divided in 2 group. Exercisers (N=5) performing plyometrics (pike jump, double leg hop, double leg bound, single leg hop, stride jump cross over, alternate leg bound, box jump) for 8 weeks. Controls (N=4) maintained their usual activities. The total work of knee and ankle joint were tested prior to and after the training. Results: Plyometric training resulted in significantly greater in the total work of high speed of knee and ankle motion(p<0.05). Conclusions: The plyometric training were partially improved the total work of flexion and extension on the ankle joint. Also plyometric training could influence athletic performance.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.19 no.2
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• pp.91-100
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• 2015

Objectives The aim of this study is to develop a structured clinical protocol related with acquisition of radial pulse wave in the randomized, $2{\times}2$ cross-over design, and cold-heat intervention trial for a pilot and preliminary study. Methods The protocol was contrived based on wide ranging literature searches for cold-heat intervention experiments and radial pulse diagnoses. Results Sample size of 60 subjects was calculated based on an effect size derived from the previous study designed to detect the pre-post cold-heat differences in the radial pulse. Each subjects will be randomly assigned to the cold (first) to heat (last) group (n=30) or heat (first) to cold (last) group (n=30). All subjects will fill out a case report form and questionnaires related with pattern identification, dietary patterns, sleep quality, and physical activity will be surveyed and used as a secondary outcomes. Safety assessment will be reported at the final stage. Conclusions This protocol will provide an additional reference to future studies related with observation of radial pulse during any interventions and also expect to be used as a guideline for acquisition of reliable radial pulse wave data.