• The Journal of Korean Society for Radiation Therapy
• /
• v.7 no.1
• /
• pp.92-96
• /
• 1995

All patients who will Undergo irraidiation of the oral cavity cancer will need dental before and during Radiotherapy. The extent of the region and the presence of numerous critical normal tissues(mucosa, gingiva, teeth and the alveolar ridge, alveolar bony structure, etc) in the oral cavity area, injury to which could result in serious functional impairment. Therefore I evaluate the Usefulness of custom-made intraoral shielding device before and during Radiotherapy in oral cavity cancer. Materials and Methods(1) : Manufacture process of Custom-made intraoral shielding device Containing Cerroband. A. Acquisition of impression B. Matrix Constitution C. Separation by Separator D. Sprincle on method E. Trimming F. Spacing G. Fill with Cerroband Materials and Methods (2) A. Preannealing B. TLD Set up C. Annealing D. TLD Reading = Results = Therefore dosimetric characteristics in oral cavity by TLD Compared to isodose curve dose distribution Ipsilateral oral mucosa, Contralateral oral mucosa, alveolar ridge, tongue, dose was reduced by intraoral shielding device containning Cerroband technique Compard to isodose plan = Conclusions = The custom-made intra-oral shielding device containing Cerroband was useful in reducing the Contralateral oral mucosa dose and Volume irradiated.

• Journal of Microbiology and Biotechnology
• /
• v.11 no.1
• /
• pp.118-123
• /
• 2001

The alginate lyase A1-III gene of Sphingomonas species A1 is composed of 1,077 nucleotides, encoding a protein (359 amino acids) with a molecular mass of 40,322 Da. Recombinant A1-III expressed in Escherichia coli exhibited the same full enzymatic activity as native A1-III. In order to identify the critical residue for activity, a site-directed mutation was introduced into the A1-III gene (H192A, His192->Ala). Recombinant A1-III (H192A) exhibited a significant decrease in enzyme activity (one-thirty thousandth of that of A1-III), without any conformational change, as detected by the CD spectra in the far UV region. Also, the chemical modification of wild-type A1-III with methyl 4-nitro benzene sulfonate resulted in a 40% decrease from the initial activity, whereas the same modification of A1-III (H192A) produced no change in the activity. The role of His192 on the catalytic process was also explored based on a model of A1-III docked with mannuronic acid into the active site.

• Journal of Agricultural Extension & Community Development
• /
• v.23 no.3
• /
• pp.243-255
• /
• 2016

This study aims to identify the characteristics of businesses influencing the choice of their type in the 6th industry and analyze how they work. This study analyzed data of 752 businesses certified as belonging to the 6th industry in 2015 through the classification and regression tree (CART) algorithm in decision tree analysis. The results of analysis showed that the type of agricultural product processing, region, the type of service, and the production percentage in a province affected a choice of the type. The most important variable that impacted how businesses in the 6th industry chose their type was the type of agricultural product processing, and if a business produced simple agricultural products, it was likely to specialize into $1st^*2nd$ or $1st^*3rd$. Access to large consumption areas was a critical factor in the growth of 2nd and 3rd industrial functions. These findings would contribute to establishing a model to develop the 6th industry and empirically demonstrate the importance of access to large consumption areas for agricultural businesses and rural tourism.

• The Transactions of the Korean Institute of Electrical Engineers P
• /
• v.63 no.4
• /
• pp.317-321
• /
• 2014

This paper describes the information for quantitative simulation of weakly ionized plasma. We must grasp the meaning of the plasma state condition to utilize engineering application and to understand materials of plasma state. Using quantitative simulations of weakly ionized plasma, we can analyze gas characteristic. In this paper, the electron Ionization and diffusion Coefficients in $CH_4$ has been analysed over the E/N range 0.1~300[Td], at the 300[$^{\circ}K$] by the two term approximation Boltzmann equation method and Monte Carlo Simulation. Boltzmann equation method has also been used to predict swarm parameter using the same cross sections as input. The behavior of electron has been calculated to give swarm parameter for the electron energy distribution function has been analysed in $CH_4$ at E/N=10, 100 for a case of the equilibrium region in the mean energy. A set of electron collision cross section has been assembled and used in Monte Carlo simulation to predict values of swarm parameters. The result of Boltzmann equation and Monte Carlo Simulation has been compared with experimental data by Ohmori, Lucas and Carter. The swarm parameter from the swarm study are expected to sever as a critical test of current theories of low energy scattering by atoms and molecules.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
• /
• 2004.05c
• /
• pp.43-46
• /
• 2004

This paper describes the information for quantitative simulation of weal이y ionized plasma. We must grasp the meaning of the plasma state condition to utilize engineering application and to understand materials of plasma state. Using quantitative simulations of weakly ionized plasma, we can analyze gas characteristic. In this paper, the electron transport characteristic in $CH_4$ has been analysed over the E/N range 0.1~300[Td], at the $300[_{\circ}K]$ by the two tenn approximation Boltzmann equation method and Monte Carlo Simulation. Boltzmann equation method has also been used to predict swarm parameter using the same cross sections as input. The behavior of electron has been calculated to give swarm parameter for the electron energy distribution function has been analysed in $CH_4$ at E/N=10, 100 for a case of the equilibrium region in the mean energy. The result of Boltzmann equation and Monte Carlo Simulation has been compared with experimental data by Ohmori, Lucas and Carter. The swarm parameter from the swarm study are expected to sever as a critical test of current theories of low energy scattering by atoms and molecules.

• BMB Reports
• /
• v.37 no.2
• /
• pp.139-143
• /
• 2004

The antioxidant responsive element (ARE) is a cis-acting regulatory element of genes encoding phase II detoxification enzymes and antioxidant proteins, such as NAD(P)H: quinone oxidoreductase 1, glutathione S-transferases, and glutamate-cysteine ligase. Interestingly, it has been reported that Nrf2 (NF-E2-related factor 2) regulates a wide array of ARE-driven genes in various cell types. Nrf2 is a basic leucine zipper transcription factor, which was originally identified as a binding protein of locus control region of ss-globin gene. The DNA binding sequence of Nrf2 and ARE sequence are very similar, and many studies demonstrated that Nrf2 binds to the ARE sites leading to up-regulation of downstream genes. The function of Nrf2 and its downstream target genes suggests that the Nrf2-ARE pathway is important in the cellular antioxidant defense system. In support of this, many studies showed a critical role of Nrf2 in cellular protection and anti-carcinogenicity, implying that the Nrf2-ARE pathway may serve as a therapeutic target for neurodegenerative diseases and cancers, in which oxidative stress is closely implicated.

• BMB Reports
• /
• v.41 no.11
• /
• pp.820-825
• /
• 2008

Bacillus thuringiensis Cyt2Aa toxin is a mosquito-larvicidal and cytolytic $\delta$-endotoxin, which is synthesized as a protoxin and forms crystalline inclusions within the cell. These inclusions are solubilized under alkaline conditions and are activated by proteases within the larval gut. In order to assess the functions of the N-and C-terminal regions of the protoxin, several N- and C-terminal truncated forms of Cyt2Aa were constructed. It was determined that amino acid removal at the N-terminal, which disrupts the $\beta$1 structure, might critically influence toxin production and inclusion formation. The deletion of 22 amino acids from the C-terminus reduced the production and solubility of the toxin. However, the removal of more than 22 amino acids from the C-terminus or the addition of a bulky group to this region could result in the inability of the protein to adopt the proper folding. These findings directly demonstrated the critical roles of N- and C-terminal amino acids on the production and folding of the B. thuringiensis cytolytic $\delta$-endotoxin.

• Structural Engineering and Mechanics
• /
• v.63 no.5
• /
• pp.575-583
• /
• 2017

The study covers the behavior of reinforced concrete deep beams loaded under 4-point bending, failed by shear and repaired using bonding glass fiber reinforced plastics fabrics (GFRP) patches. Two rehabilitation methods have been used to highlight the influence of the composite on the ultimate strength of the beams and their failure modes. In the first series of trials the work has been focused on the reinforcement/rehabilitation of the beam by following the continuous configuration of the FRP fabric. The patch with a U-shape did not provide satisfactory results because this reinforcement strategy does not allow to increase the ultimate strength or to avoid the abrupt shear failure mode. A second methodology of rehabilitation/reinforcement has been developed in the form of SCR (Strips of Critical Region), in which the composite materials reinforcements are positioned to band the inclined cracks (shear) caused by the shear force. The results obtained by using this method lead a superior out come in terms of ultimate strength and change of the failure mode from abrupt shearing to ductile bending.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.33 no.1
• /
• pp.17-27
• /
• 2009

Water jet impingement cooling is used to remove heat from high-temperature surfaces such as hot steel plates in the steel manufacturing process (thermo-mechanical cooling process; TMCP). In those processes, uniform cooling is the most critical factor to ensure high strength steel and good quality. In this study, experiments are performed to measure the heat transfer coefficient together with the inverse heat conduction problem (IHCP) analysis for a plate cooled by planar water jet. In the inverse heat transfer analysis, spatial and temporal variations of heat transfer coefficient, with no information regarding its functional form, are determined by employing the conjugate gradient method with an adjoint problem. To estimate the two dimensional distribution of heat transfer coefficient and heat flux for planar waterjet cooling, eight thermo-couple are installed inside the plate. The results show that heat transfer coefficient is approximately uniform in the span-wise direction in the early stage of cooling. In the later stage where the forced-convection effect is important, the heat transfer coefficient becomes larger in the edge region. The surface temperature vs. heat flux characteristics are also investigated for the entire boiling regimes. In addition, the heat transfer rate for the two different plate geometries are compared at the same Reynolds number.

• Proceedings of the KSME Conference
• /
• 2008.11b
• /
• pp.2434-2439
• /
• 2008

This paper was studied on the cavitation instability of a Solution Pump Inducer in an absorption chiller-heater. Inlet pressure of LiBr and rotational speed at nominal mode are 2,800 Pa and 3,500 rpm respectively. Due to the marginal operation of available NPSH, the cavitation performance of the inducer is critical for the stable operation without the deterioration of head performance. In the study, cavitation performance and its mode of instability was investigated experimentally. Water was used as the working fluid and the test inducer was scaled up as 1.75 times for detail measurements and flow visualization. Inlet pressure was controlled by a vacuum pump. This research focused on types of cavitation instability and phenomena to investigate the possibility of harmful damage due to cavitation instability. Casing wall pressure and instantaneous inlet pressure was measured to observe the unsteady flow characteristics. Through the visualization and spectrum analysis of pressure, the occurrence region and intensity of asymmetric cavitation and cavitation surge are analyzed in the test inducer.