• 한국컴퓨터정보학회논문지
• /
• 제11권6호
• /
• pp.175-184
• /
• 2006

컴퓨터 포렌식은 정보통신 기술의 순기능을 보호하고 역기능에 대한 증거를 추출하여 법정에 제출하는 과정을 다루게 된다. 컴퓨터 수사 현장에서 디지털증거의 무결성이 훼손된다면, 결정적인 증거가 기각당하거나 재판의 증거로서 채택되지 않는다. 본 논문에서는 이 문제점을 해결하는 방안으로 포렌식 자료의 무결성 확보를 위한 디스크 포렌식의 연계방안, 시스템 포렌식의 연계방안, 네트워크 포렌식의 연계방안, 모바일 포렌식의 연계방안, 데이터베이스 폰렌식의 연계방안을 연구한다. 제안된 연계방안으로 무결성이 입증되면, 수사 결과물들이 범죄 수사현장과 재판의 중요 증거 자료로 채택하게 될 것이다. 또한 실제 컴퓨터 포렌식 수사 현장에서의 디지털증거의 연계방안의 현장 수사의 문제점의 사례와 대안을 제시함으로서, 컴퓨터 디지털 포렌식의 발전과 정보보호의 현장 연구에 기여하게 될 것이다.

• 한국컴퓨터정보학회논문지
• /
• 제12권3호
• /
• pp.137-146
• /
• 2007

대한민국은 중국 일본과 같이 바다로 인접하여, 항해를 하거나 조업을 위한 배타적 경제수역(EEZ: Exclusive Economic Zone) 때문에 분재의 소지를 담고 있다. 특히 해상 사고에서 어선의 경우 조업일지와 항해장비의 부실 등으로 국가 간 분쟁 시 증거자료 채택할 수 있는 경우는 드물다. 해상에서 컴퓨터 등의 디지털 증거는 무결성이 훼손된다면 결정적인 증거가 재판정에서 기각당하거나 국제적으로 분쟁 시 증거로 채택되지 않는다. 본 논문에서는 이 문제점을 해결하는 방안으로 해상 디지털 포렌식을 제안하면서, 공해상 선박에서 디지털 포렌식 자료를 위한 주요내용, 요구사항, 적용사항 및 선박 디스크, 선박 네트워크, 선박 무선 포렌식 자료를 추출하고 이를 입증하는 방법을 제시한다. 그리고 실제 공해상에서 해상 디지털 포렌식의 사례에 관한 실증연구를 하여, 분쟁소지가 많은 선박에서 과학수사의 일환으로 활용될 것이며, 디지털 포렌식의 증거가 채택되는 국제간의 공해상 분쟁해결의 중요한 열쇠가 될 것이다.

• 한국컴퓨터정보학회지
• /
• 제15권1호
• /
• pp.209-217
• /
• 2007

우리나라는 중국 일본과 같이 3면이 바다로 둘러 쌓여 있으며, 특히 국가 간 해역의 거리가 근접한 관계로 타국으로 항해를 하거나 조업을 위하여 배타적 경제수역(EEZ: Exclusive Economic Zone)을 설정하여 분쟁의 소지를 담고 있다. 특히 해상에서 발생하는 여러 가지 사고의 경우에는 그 흔적이 해상이라는 특수성 때문에 존재하지 못하는 경우가 많고 어선의 경우 조업일지의 부실기재등으로 국가간 분쟁시 증거자료로 채택할 수 있는 경우는 드물다. 이에 해상 디지털 포렌식은 선박에 설치된 컴퓨터와 정보통신 기술의 순기능을 보호하면서 사고 등에 대한 디지털증거자료를 추출하여 분쟁을 해결하는 증거의 과정을 다루게 된다. 이러한 컴퓨터 등의 디지털증거는 무결성이 훼손된다면, 결정적인 증거가 재판정에서 기각당하거나 국제적으로 분쟁시 증거로서 채택되지 않는다. 본 논문에서는 이 문제점을 해결하는 방안으로 해상 디지털 포렌식을 제안하면서 디지털포렌식자료를 추출하고 이를 입증하는 방법을 제시한다. 이는 해상 교류가 더욱 증가하고 선박장비의 디지털화의 추세에 맞추어 해상에서도 과학수사의 일환으로 활용될 것이며, 이러한 디지털자료를 증거로 국제간의 분쟁 해결의 중요한 열쇠가 될 것이다.

• Advances in Traditional Medicine
• /
• 제6권4호
• /
• pp.286-292
• /
• 2006

In this study, we evaluated the antiproliferative effects of Panax notoginseng, ginsenoside Rb1, and notoginsenoside R1 in the human breast carcinoma MCF-7 cell line. Our results indicated that both Panax notoginseng radix extract (NRE) and Panax notoginseng rhizoma extract (NRhE) possess significant antiproliferative activities in MCF-7 cells. Compared to control group (100%), at the concentrations of 0.05, 0.5, and 1.0 mg/ml NRE, cell growth was concentration-dependently reduced to 81.0 ${\pm}$ 6.1 (P < 0.01), 34.2 ${\pm}$ 4.8 (P < 0.001), and 19.3 ${\pm}$ 1.9 (P < 0.001), respectively. Similar results with NRhE at concentrations of 0.5 and 1.0 mg/ml were obtained in these MCF-7 cells. To identify the responsible chemical constituent, we tested the antiproliferation effects of two representative saponins, ginsenoside Rb1 and notoginsenoside R1, on the MCF-7 cells. The data showed that ginsenoside Rb1 was endowed with antiproliferative properties, while notoginsenoside R1 did not have an inhibitory effect in the concentrations tested. Our studies provided evidence that Panax notoginseng extracts and ginsenoside Rb1 may be beneficial, as adjuvants, in the treatment of human breast carcinoma.

• 디지털융복합연구
• /
• 제13권9호
• /
• pp.341-349
• /
• 2015

본 연구는 융복합 시대에 중요한 능력인 비판적 사고와 관련되어 국내 간호대학 교육에서 연구된 논문(1996-2014) 75편을 분석한 문헌고찰 연구이다. 고찰 결과 2006년을 기점으로 비판적 사고 관련 연구가 크게 증가하였으며, 연구 설계는 관련 요인을 탐색하는 수준에서 경로모형 구축까지 진행되었음을 확인할 수 있었다. 비판적 사고에 영향을 미치는 요인으로 학력, 연령, 교우관계, 학업성적, 임상실습 기간, 전공만족도, 자아존중감, 자기효능감, 학습방법 등이 확인되었으며, 비판적사고 성향이 높을수록 임상실습 스트레스, 인지된 스트레스가 낮아지고, 문제해결 능력, 임상수행능력, 감정조절, 의사소통 능력이 증가하는 것으로 나타났다. 비판적 사고는 단기간에 획득, 향상되기 어려우므로 지금까지 연구에서 확인된 비판적 사고와 관련된 원인 및 결과변수를 바탕으로 간호교육과정에서 장기적이고 체계적으로 비판적 사고를 향상시키기 위한 교육 프로그램을 개발할 것을 제언한다.

• 한국간호교육학회지
• /
• 제16권1호
• /
• pp.150-155
• /
• 2010

Purpose: The purpose of this study is to develop evidence-based nursing practice guidelines for hemodialysis in the renal failure patients with risk of bleeding and to evaluate the guidelines by applying it to the practice. Method: Referring to the SIGN, the first draft for guidelines was developed based on the advices and recommendations obtained from the procedure of critical literature analysis. Then, the draft was modified by the procedures of the expert group evaluation and pilot application to the practice. The final draft was evaluated by the expert group using AGREE instrument. Result: The first draft of guidelines was developed through 8 stages of process and was evaluated by seven experts in terms of the appropriateness, applicability, and effectiveness using a 9 point scale. The mean score of 11 items was 7.90 or above. The quality of the final draft was evaluated by 5 experts using the AGREE instrument. The mean standard score was 73.0% or above in the 19 items. Conclusion: The clinical guidelines developed by this research can be utilized as systematic and scientific guidelines for hemodialysis in the renal failure patients with risk of bleeding. In addition, the research can contribute to improving care services.

• 약학회지
• /
• 제59권6호
• /
• pp.245-250
• /
• 2015

Middle East respiratory syndrome - coronavirus infection has posed substantial threat to public health with extremely high mortality rate in 2015. Although there are no approved novel medications for coronavirus, several antiviral agents such as ribavirin and interferon have been tried to MERS patients according to the in-vitro inhibitory effect, therapeutic effect on the animal model and experience from the severe acute respiratory syndrome - coronavirus infection. The aim of this study is to evaluate the clinical evidence of the antiviral treatment for MERS-CoV infection. After systematically searching the medical literature databases, I found five studies described the clinical efficacy of antiviral treatment on MERS patients. All of them were about the combination therapy of ribavirin and interferon (IFN). Two of them were retrospective cohort studies with quality of evidence (QOE) II and the others were observational study and case reports with QOE III. As a result of critical appraisal, it is concluded that none of those studies represented confirmatory clinical evidence of the efficacy of ribavirin and interferon combination therapy on MERS patients. Although Omrani et al. represented that ribavirin and IFN treatment had significantly improved survival at 14 days, it was not enough time to conclude the effect.

• Journal of Preventive Medicine and Public Health
• /
• 제42권6호
• /
• pp.360-370
• /
• 2009

Genetic factors clearly play a role in carcinogenesis, but migrant studies provide unequivocal evidence that environmental factors are critical in defining cancer risk. Therefore, one may expect that the lower availability of substrate for biochemical reactions leads to more genetic changes in enzyme function; for example, most studies have indicated the variant MTHFR genotype 677TT is related to biomarkers, such as homocysteine concentrations or global DNA methylation particularly in a low folate diet. The modification of a phenotype related to a genotype, particularly by dietary habits, could support the notion that some of inconsistencies in findings from molecular epidemiologic studies could be due to differences in the populations studied and unaccounted underlying characteristics mediating the relationship between genetic polymorphisms and the actual phenotypes. Given the evidence that diet can modify cancer risk, gene-diet interactions in cancer etiology would be anticipated. However, much of the evidence in this area comes from observational epidemiology, which limits the causal inference. Thus, the investigation of these interactions is essential to gain a full understanding of the impact of genetic variation on health outcomes. This report reviews current approaches to gene-diet interactions in epidemiological studies. Characteristics of gene and dietary factors are divided into four categories: one carbon metabolism-related gene polymorphisms and dietary factors including folate, vitamin B group and methionines; oxidative stress-related gene polymorphisms and antioxidant nutrients including vegetable and fruit intake; carcinogen-metabolizing gene polymorphisms and meat intake including heterocyclic amins and polycyclic aromatic hydrocarbon; and other gene-diet interactive effect on cancer.

• The Journal of Asian Finance, Economics and Business
• /
• 제8권8호
• /
• pp.647-658
• /
• 2021

Analysts' forecasts are important for providing useful guidance to investors, especially individual or small investors, and therefore it becomes critical to identify the elements which can potentially increase errors in analysts' forecasts. This study investigates potential factors which can lead to errors in forecasting by analysts, specifically in terms of the level and attributes of corporate earnings. Utilizing a sample of firms listed on the Korean stock markets, this study provides evidence that firms with more volatile and unpredictable earnings feature less accurate analyst forecasts. This study fills a void in the literature by conducting empirical tests for earnings attributes in terms of volatility and unpredictability that could potentially undermine the forecast accuracy. The negative association between the quality of earnings and forecast accuracy is more pronounced for firms with negative net income values. Additional analysis demonstrates that forecast accuracy is significantly lower for the fourth quarter than for other fiscal quarters and that fourth quarter earnings tend to be more volatile and unpredictable. This study contributes to the literature by providing new empirical evidence regarding the comprehensive effects of earnings quality and level on analysts' forecasting accuracy and further suggests potential factors contributing to the fourth quarter anomaly in analyst forecasts in terms of earnings attributes.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권11호
• /
• pp.5345-5351
• /
• 2012

Radiotherapy is an important part of modern cancer management for many malignancies, and enhancing the radiosensitivity of tumor cells is critical for effective cancer therapies. The Notch signaling pathway plays a key role in regulation of numerous fundamental cellular processes. Further, there is accumulating evidence that dysregulated Notch activity is involved in the genesis of many human cancers. As such, Notch inhibitors are attractive therapeutic agents, although as for other anticancer agents, they exhibit significant and potential side effects. Thus, Notch inhibitors may be best used in combination with other agents or therapy. Herein, we describe evidence supporting the use of Notch inhibitors as novel and potent radiosensitizers in cancer therapy.