Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Notch Inhibitor: a Promising Carcinoma Radiosensitizer

  • Yu, Shu-Dong (Department of Otolaryngology, Qianfoshan Hospital Affiliated to Shandong University) ;
  • Liu, Fen-Ye (Department of Traditional Chinese Medicine, Shandong Provincial Hospital Affiliated to Shandong University) ;
  • Wang, Qi-Rong (Department of Otolaryngology, Qianfoshan Hospital Affiliated to Shandong University)
  • Published : 2012.11.30
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Abstract

Radiotherapy is an important part of modern cancer management for many malignancies, and enhancing the radiosensitivity of tumor cells is critical for effective cancer therapies. The Notch signaling pathway plays a key role in regulation of numerous fundamental cellular processes. Further, there is accumulating evidence that dysregulated Notch activity is involved in the genesis of many human cancers. As such, Notch inhibitors are attractive therapeutic agents, although as for other anticancer agents, they exhibit significant and potential side effects. Thus, Notch inhibitors may be best used in combination with other agents or therapy. Herein, we describe evidence supporting the use of Notch inhibitors as novel and potent radiosensitizers in cancer therapy.

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References

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