• Journal of Microbiology and Biotechnology
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• v.26 no.6
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• pp.1140-1147
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• 2016

The plasma and serum of Crocodylus siamensis have previously been reported to exhibit potent antimicrobial, antioxidant, and anti-inflammatory activities. During wound healing, these biological properties play a crucial role for supporting the formation of new tissue around the injured skin in the recovery process. Thus, this study aimed to evaluate the wound healing properties of C. siamensis plasma and serum. The collected data demonstrate that crocodile plasma and serum were able to activate in vitro proliferation and migration of HaCaT, a human keratinocyte cell line, which represents an essential phase in the wound healing process. With respect to investigating cell migration, a scratch wound experiment was performed which revealed the ability of plasma and serum to decrease the gap of wounds in a dose-dependent manner. Consistent with the in vitro results, remarkably enhanced wound repair was also observed in a mouse excisional skin wound model after treatment with plasma or serum. The effects of C. siamensis plasma and serum on wound healing were further elucidated by treating wound infections by Staphylococcus aureus ATCC 25923 on mice skin coupled with a histological method. The results indicate that crocodile plasma and serum promote the prevention of wound infection and boost the re-epithelialization necessary for the formation of new skin. Therefore, this work represents the first study to demonstrate the efficiency of C. siamensis plasma and serum with respect to their wound healing properties and strongly supports the utilization of C. siamensis plasma and serum as therapeutic products for injured skin treatment.

• Journal of the Korean Society of Safety
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• v.11 no.4
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• pp.143-150
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• 1996

This is an explicit-Implicit, finite element analysis for linear as well as nonlinear hygrothermal stress problems. Additional features, such as moisture diffusion equation, crack element and virtual crack extension(VCE ) method for evaluating J-integral are implemented in this program. The Linear Elastic Fracture Mechanics(LEFM) Theory is employed to estimate the crack driving force under the transient condition for and existing crack. Pores in materials are assumed to be saturated with moisture in the liquid form at the room temperature, which may vaporize as the temperature increases. The vaporization effects on the crack driving force are also studied. The Ideal gas equation is employed to estimate the thermodynamic pressure due to vaporization at each time step after solving basic nodal values. A set of field equations governing the time dependent response of porous media are derived from balance laws based on the mixture theory Darcy's law Is assumed for the fluid flow through the porous media. Perzyna's viscoplastic model incorporating the Von-Mises yield criterion are implemented. The Green-Naghdi stress rate is used for the invariant of stress tensor under superposed rigid body motion. Isotropic elements are used for the spatial discretization and an iterative scheme based on the full newton-Raphson method is used for solving the nonlinear governing equations.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.22 no.6
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• pp.79-88
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• 2008

In this study electromagnetic fields near electric power lines were derived by dipole antenna theory and electromagnetic fields near 3 phase power lines with vertical configurations were formulated and could be computed easily using these formula. It seems that those formula could be applicable to the consideration of electromagnetic fields during the design of transmission and distribution lines. Those formulated equations on elements of electromagnetic fields were applied to the model of a transmission-line system and were calculated by Matlab programs. The calculation results are follows. For variation of horizontal distance profiles of $E_y$ and $B_z$ are same each other, and also those of $B_y$ and $E_z$ are same each other. This means that coupled elements of E and B are perpendicular each other and have the propagation direction of the right-hand system such as $x{\rightarrow}E_y{\rightarrow}B_z$. Resultant electric field E is dominated by the element $E_y$ and resultant magnetic field B is dominated by the element $B_z$.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.11
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• pp.4656-4663
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• 2010

In this study, the 3D computational fluid dynamics (CFD) was performed in relation to the internal fluid characteristics, flow distribution, air mean ages, and residence time for the development of the most optimal model in the complex post-disposal device. As it is expected that a channeling (drift) would be made by the semi-dry reactor due to the large difference in the flow distribution by the compartment in the bag filter, a structural improvement should be urgently made for more uniformed flow distribution in the bag filter. In addition, it showed the possibility that the velocity field and distribution characteristics of the residence time could be improved through a modification to inlet structure of the spray dryer reactor. The complex post-disposal device, modified and supplemented with this analysis, integrated the semi-dry reactor and the bag filter in a single body, so it follows that the improvement can make the device compact, the installation area, the operation fee, and management more convenient.

• Experimental and Molecular Medicine
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• v.50 no.12
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• pp.2.1-2.12
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• 2018

Glucagon-like peptide-1 (GLP-1) has a broad spectrum of biological activity by regulating metabolic processes via both the direct activation of the class B family of G protein-coupled receptors and indirect nonreceptor-mediated pathways. GLP-1 receptor (GLP-1R) agonists have significant therapeutic effects on non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) in animal models. However, clinical studies indicated that GLP-1 treatment had little effect on hepatic steatosis in some NAFLD patients, suggesting that GLP-1 resistance may occur in these patients. It is well-known that the gut metabolite sodium butyrate (NaB) could promote GLP-1 secretion from intestinal L cells. However, it is unclear whether NaB improves hepatic GLP-1 responsiveness in NAFLD. In the current study, we showed that the serum GLP-1 levels of NAFLD patients were similar to those of normal controls, but hepatic GLP-1R expression was significantly downregulated in NAFLD patients. Similarly, in the NAFLD mouse model, mice fed with a high-fat diet showed reduced hepatic GLP-1R expression, which was reversed by NaB treatment and accompanied by markedly alleviated liver steatosis. In addition, NaB treatment also upregulated the hepatic p-AMPK/p-ACC and insulin receptor/insulin receptor substrate-1 expression levels. Furthermore, NaB-enhanced GLP-1R expression in HepG2 cells by inhibiting histone deacetylase-2 independent of GPR43/GPR109a. These results indicate that NaB is able to prevent the progression of NAFL to NASH via promoting hepatic GLP-1R expression. NaB is a GLP-1 sensitizer and represents a potential therapeutic adjuvant to prevent NAFL progression to NASH.

• Proceedings of the Korea Water Resources Association Conference
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• 2018.05a
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• pp.104-104
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• 2018

이수안전도의 기준이 되는 갈수량에 대해 기후변화 시나리오에 따른 전망을 제시하였다. 충주 댐 유역을 대상으로 기준기간(1986~2000년)에서의 기상청의 관측 기상자료와 IPCC 보고서의 RCP 4.5/8.5 시나리오를 대상으로 CMIP5(Coupled Model Intercomparison Project Phase 5)에서 제공하는 기후변화 자료 중 5개의 모델(ACCESS1.3 CanESM2, CNRM-CM5, GFDL-ESM2G, HadGEM2-AO)의 기준기간과 미래기간(2011~2100년)의 기상자료를 수집하였다. 기후변화 자료는 정상성/비정상성 분위사상법과 베이지안 모델 평균기법을 통해 불확실성과 통계적 오차를 저감하였다. 미래기간에서, 강우는 RCP 4.5에서 1.74mm/year, RCP 8.5에서 3.22mm/year, 실제증발산은 RCP 4.5에서 1.09mm/year, RCP 8.5에서 1.78mm/year의 증가율을 보였다. 실제증발산을 입력자료로 활용할 수 있도록 IHACRES모델의 CMD(Catchment Moisture Deficit) 비선형 모듈의 매개변수를 변이하여 유효강우량 산정 과정을 개선하였다. 기준기간에서 관측유량자료와 IHACRES의 시뮬레이션을 통해 산정된 유량자료의 R-squared는 0.65이다. 기준기간에서의 매개변수를 고정하여 미래기간의 유량을 산정하고 유황분석을 통해 갈수량 전망하였다. 유량은 RCP 4.5에서 4.41MCM/year, RCP 8.5에서 9.66MCM/year의 증가율을 보였다. 갈수량은 RCP 4.5에서 0.30MCM/year, RCP 8.5에서 -0.47MCM/year의 증감율을 보였다. 연간 강수량 대비 실제증발산의 비율의 추세분석 결과, RCP 4.5에서는 홍수기에는 0.014%/year, 비홍수기에는 0.027%/year의 증가율을 보이며 거의 변화가 없는 추세를 확인할 수 있었다. RCP 8.5의 홍수기에는 -0.042%/year, 비홍수기에서는 0.167%/year의 증감율을 보이며 홍수기에는 실제증발산에 비해 강수량의 증가가 확연히 보였으며 비홍수기에는 강수량에 비해 실제증발산의 증가가 뚜렷이 확인되었다. RCP 8.5에서 비홍수기의 강수량 대비 실제증발산의 증가가 갈수량의 감소로 반영된 것을 확인할 수 있었다. 미래기간의 RCP 4.5/8.5에서 실제증발산의 증가로 인하여 강수량이 증가함에 따라 유입량이 증가함에도 불구하고 갈수량의 증가로 이어지지 않았다. 미래 갈수량의 감소는 하천의 건전성과 이수안전도의 위협이 될 수 있다.

• Ocean and Polar Research
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• v.43 no.4
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• pp.205-217
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• 2021

A shallow channel between Jeju and Udo Islands, which is located in the northeastern Jeju Island, is influenced by storm- or typhoon-induced currents and surface waves as well as strong tidal currents. This study examines the typhoon-induced current and wave patterns in the channel, using Acoustic Doppler Current Meter (ADCP) measurements and an ocean-wave coupled modeling experiment. Three typhoons were chosen - Chaba (2016), Soulik (2018), and Lingling (2019) - to investigate the responses of currents and waves in their pathways. During the pre-typhoon periods, dominant northward flow and wave propagation were observed in the channel due to the southeasterly winds before the three typhoons. After the passage of Chaba, which passed over the eastern side of Jeju Island, the northward flow and wave propagation were totally reversed to the opposite direction, which was attributed to the strong northerly winds on the left side of the typhoon. In contrast, in the cases of Soulik and Lingling, which passed over the western side of Jeju Island, strong southerly winds on the right side of the typhoons continuously intensified the northward current and wave propagation in the channel. The model-simulated current and wave fields reasonably coincided with observational data, showing southward/northward flow and wave propagation in response to the right/left side of the typhoon pathways. Typhoon-induced downwind flows, and surface waves could enhance up to 2m/s and 3m due to the strong winds that lasted for more than 12 hours. This suggests that the flow and wave patterns in the Udo channel are highly sensitive to the pathway of typhoons and accompanying winds; thus, this may be a crucial factor with regard to the movement of seabed sediments and subsequent coastal erosion.

• Korean Journal of Agricultural and Forest Meteorology
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• v.23 no.4
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• pp.405-414
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• 2021

This study predicted waxy corn harvest date in South Korea using 30-year (1991-2020) hindcasts (1-6 month lead) produced by the Pusan National University Coupled General Circulation Model (PNU CGCM)-Weather Research and Forecasting (WRF) chain. To estimate corn harvest date, the cumulative temperature is used, which accumulated the daily observed and predicted temperatures from the seeding date (5 April) to the reference temperature (1,650~2,200℃) for harvest. In terms of the mean air temperature, the hindcasts with a bias correction (20.2℃) tends to have a cold bias of about 0.1℃ for the 6 months (April to September) compared to the observation (20.3℃). The harvest date derived from bias-corrected hindcasts (DOY 187~210) well simulates one from observation (DOY 188~211), despite a slight margin of 1.1~1.3 days. The study shows the possibility of obtaining the gridded (5 km) daily temperature and corn harvest date information based on the cumulative temperature in advance for all regions of South Korea.

• Journal of the Korean earth science society
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• v.43 no.2
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• pp.265-282
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• 2022

This study analyzes the impact of long-range transport of biomass burning emissions from northeastern China on the concentration of particulate matter of diameter less than 10 ㎛ (PM₁₀) in Korea using the Weather Research and Forecasting model coupled with Chemistry (WRF-Chem). Korea was impacted by anthropogenic emissions from eastern China, dust storms from northern China and Mongolia, and biomass burning emissions from northeast China between April 4-and 7, 2020. The contributions of long-range PM₁₀ transport were calculated by separating biomass burning emissions from mixed air pollutants with anthropogenic emissions and dust storms using the zeroing-out method. Further, the radiation energy budget over land and sea around the Korean Peninsula was analyzed according to the distribution of biomass burning emissions. Based on the WRF-Chem simulation during April 5-6, 2020, the contribution of long-range transport of biomass burning emissions was calculated as 60% of the daily PM₁₀ average in Korea. The net heat flux around the Korean Peninsula was in a negative phase due to the influence of the large-scale biomass burning emissions. However, the contribution of biomass burning emissions was analyzed to be <45% during April 7-8, 2020, when the anthropogenic emissions from eastern China were added to biomass burning emissions, and PM₁₀ concentration increased compared with the concentration recorded during April 5-6, 2020 in Korea. Furthermore, the net heat flux around the Korean Peninsula increased to a positive phase with the decreasing influence of biomass burning emissions.

• Advances in aircraft and spacecraft science
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• v.9 no.5
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• pp.415-431
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• 2022

Secondary flows have a huge impact on losses generation in modern low pressure gas turbines (LPTs). At design point, the interaction of the blade profile with the end-wall boundary layer is responsible for up to 40% of total losses. Therefore, predicting accurately the end-wall flow field in a LPT is extremely important in the industrial design phase. Since the inlet boundary layer profile is one of the factors which most affects the evolution of secondary flows, the first main objective of the present work is to investigate the impact of two different inlet conditions on the end-wall flow field of the T106A, a well known LPT cascade. The first condition, labeled in the paper as C1, is represented by uniform conditions at the inlet plane and the second, C2, by a flow characterized by a defined inlet boundary layer profile. The code used for the simulations is based on the Discontinuous Galerkin (DG) formulation and solves the Reynolds-averaged Navier-Stokes (RANS) equations coupled with the Spalart Allmaras turbulence model. Secondly, this work aims at estimating the influence of viscosity and turbulence on the T106A end-wall flow field. In order to do so, RANS results are compared with those obtained from an inviscid simulation with a prescribed inlet total pressure profile, which mimics a boundary layer. A comparison between C1 and C2 results highlights an influence of secondary flows on the flow field up to a significant distance from the end-wall. In particular, the C2 end-wall flow field appears to be characterized by greater over turning and under turning angles and higher total pressure losses. Furthermore, the C2 simulated flow field shows good agreement with experimental and numerical data available in literature. The C2 and inviscid Euler computed flow fields, although globally comparable, present evident differences. The cascade passage simulated with inviscid flow is mainly dominated by a single large and homogeneous vortex structure, less stretched in the spanwise direction and closer to the end-wall than vortical structures computed by compressible flow simulation. It is reasonable, then, asserting that for the chosen test case a great part of the secondary flows details is strongly dependent on viscous phenomena and turbulence.