• Title/Summary/Keyword: coumarin glycoside

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Coumarin Glycosides from the Roots of Angelica dahurica (구릿대 뿌리의 Coumarin 배당체(2))

  • Kwon, Yong-Soo;Kim, Chang-Min
    • Korean Journal of Pharmacognosy
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    • v.23 no.4
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    • pp.221-224
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    • 1992
  • From the roots of Angelica dahurica Bentham et Hooker(Umbelliferae), three coumarin glycosides have been isolated and identified as skimmin, $8-O-{\beta}-D-glucopyranosyl$ xanthotoxol and $tert.-O-{\beta}-D-glucopyranosyl-heralenol$. $8-O-{\beta}-D-Glucopyranosyl-xanthotoxol$ was isolated for the first time from plant source.

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Constituents of the Aerial Parts of Lonicera etrusca Growing in Saudi Arabia

  • Alqasoumi, Saleh I.;Al-Rehaily, Adnan J.;Abdel-Kader, Maged S.
    • Natural Product Sciences
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    • v.15 no.3
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    • pp.121-124
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    • 2009
  • Phytochemical investigation of the aerial parts of Lonicera etrusca resulted in the isolation of three iridoids including two aglycones, loganin aglycone (log-1) (1) and lonicerin (log-2) (2), and the known common glycoside loganin (4). The study also afforded a coumarin derivative, 7-hydroxycoumarin (3), and a flavonoid glycoside, luteolin-7-O-$\beta$-D-glucoside (5). The structures were determined utilizing physical, chemical and spectral methods.

Phytochemical Constituents from the Whole Plants of Diodia teres

  • Kim, Dae-Keun;Park, Hee-Wook;Eun, Jae-Soon;Baek, Nam-In
    • Proceedings of the PSK Conference
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    • 2003.10b
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    • pp.200.4-201
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    • 2003
  • Ten compounds were isolated from the methanolic extract of the whole plants of Diodia teres through repeated silica gel and Sephadex LH-20 column chromatography. Their chemical structures were elucidated as three iridoid glycosides, a coumarin glycoside, and six flavonoids by spectroscopic analysis. These compounds were isolated for the first time from D. teres.

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Apoptosis in Leukemic Cells Induced by Anti-Proliferative Coumarin Isolated from the Stem Bark of Fraxinus rhynchophylla

  • Lee, Beom Zoo;Lee, Ik Soo;Pham, Chau Ha;Jeong, Soon-Kyu;Lee, Sulhae;Hong, KwangWon;Yoo, Hee Min
    • Journal of Microbiology and Biotechnology
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    • v.30 no.8
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    • pp.1214-1221
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    • 2020
  • Esculetin 6-O-β-D-arabinofuranosyl-(1 → 6)-β-D-glucopyranoside (EAG) is a coumarin glycoside isolated from the stem bark of Fraxinus rhynchophylla. This study scrutinized the anti-proliferative activity of EAG on blood cancer-derived Jurkat leukemic cells. Cell viability assays in leukemic cancer cells determined that EAG possesses potent anti-proliferative effects. Moreover, treatment with EAG increased the proportion of apoptotic cells, resulted in cell cycle arrest being induced at the subG0/G1 phase, and reduced the proportion of cells present in the S phase. In addition, mitochondrial membrane potential was reduced by EAG in Jurkat cells. Additionally, EAG triggered apoptosis that was mediated by the downregulation of BCL-XL, p-IκBα, and p-p65 expressions in addition to the upregulation of cleaved Caspase 3 and BAX expressions. These findings revealed that the toxic effect of EAG was mediated by intracellular signal transduction pathways that involved a mechanism in which reactive oxygen species (ROS) were upregulated. Thus, this study concludes that EAG could potentially serve as a therapeutic agent for leukemia.

Studies on the Chemical Constituents of Tilia Plants in Korea ( I ) -On the Chemical Constituents of the Stem-Bark of Tilia mandsurica- (국산 피나무속(屬) 식물(植物)의 성분연구(成分硏究)( I ) -찰피나무 수피(樹皮)의 성분(成分)-)

  • Kim, Chang-Min;Kang, Sam-Sik;Park, Young-Soon;Kim, Eun-Young
    • Korean Journal of Pharmacognosy
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    • v.19 no.3
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    • pp.174-176
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    • 1988
  • From the stem barks of Tilia mandsurica, fraxin ( I ) and 1, 10-decanedicarboxylate ( II ) were isolated and characterized by spectral data. 1, 10-decanedicarboxylate was the first isolation from Tilia plants.

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A New Sesquiterpene Lactone from Artemisia rubripes Nakai

  • Lee, Kyu-Ha;Min, Yong-Deuk;Choi, Sang-Zin;Kwon, Hak-Cheol;Cho, Ock-Ryun;Lee, Kang-Choon;Lee , Kang-Ro
    • Archives of Pharmacal Research
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    • v.27 no.10
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    • pp.1016-1019
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    • 2004
  • The chromatographic separation of a methylene chloride extract of Artemisia rubripes led to the isolation of a new sesquiterpene lactone (3), together with four known compounds, a coumarin (2) and three terpenes (1, 4, and 5). Their structures were characterized to be $1{\beta},6{\alpha}$- dihydroxy-4(15)-eudesmene (1), scopoletin (2), $1{\alpha},4{\beta}-dihydroxy-8{\alpha}$-acetoxy-guaia-2,10(14), 11(13)-triene-6,12-olide (3), $1{\alpha},4{\beta}$ -dihydroxy-8${\alpha}$-acetoxy-guaia-2,9,11(13)-triene-6,12-olide (4), and $\beta$ -sitosterol-3-O-${\beta}$-D-glycoside (5) by spectroscopic means.