A New Sesquiterpene Lactone from Artemisia rubripes Nakai

  • Published : 2004.01.01

Abstract

The chromatographic separation of a methylene chloride extract of Artemisia rubripes led to the isolation of a new sesquiterpene lactone (3), together with four known compounds, a coumarin (2) and three terpenes (1, 4, and 5). Their structures were characterized to be $1{\beta},6{\alpha}$- dihydroxy-4(15)-eudesmene (1), scopoletin (2), $1{\alpha},4{\beta}-dihydroxy-8{\alpha}$-acetoxy-guaia-2,10(14), 11(13)-triene-6,12-olide (3), $1{\alpha},4{\beta}$ -dihydroxy-8${\alpha}$-acetoxy-guaia-2,9,11(13)-triene-6,12-olide (4), and $\beta$ -sitosterol-3-O-${\beta}$-D-glycoside (5) by spectroscopic means.

Keywords

References

  1. Bohlmann, F., Ates, N. (Goren), King, R. M., and Robinson H., Two sesquiterpenes from Senecio species. Phytochemistry, 22,1675-1677 (1983) https://doi.org/10.1016/0031-9422(83)80109-5
  2. Jakupovic, J., Klemeyer, H., Bohlmann, F., and Graven, E. H., Glaucolides and guaianolides from Artemisia afra. Phytochemistry, 27,1129-1133 (1988) https://doi.org/10.1016/0031-9422(88)80288-7
  3. Khanina, M. A., Serykh, E. A., Berezovskaya, T. P., and Khan, V. A., Essential oil of Artemisia rubripes. Khim. Prir. Soedin., 6,859-860 (1991)
  4. Kim, D. K., Kwak, J. H., Song, K. W., Kwon, H. C., Zee, O., P, and Lee, K. R., Phytochemical constituents from Aconitum pseudolaeve var. erectum. Kor. J. Pharmacogn., 27, 75-79 (1996)
  5. Kwak, J. H., Jang, W. Y., Zee, O. P., and Lee, K. R., Artekeiskeanin A: a new coumarin-monoterpene ether from Artemisia keiskeana. Planta Med., 63, 389-486 (1997) https://doi.org/10.1055/s-2006-957719
  6. Kwon, H. C., Choi, S. U., and Lee, K. R., Phytochemical constituents of Artemisia stolonifera. Arch. Pharm. Res., 24, 312-315 (2001) https://doi.org/10.1007/BF02975098
  7. Kwon, H. C., Choi, S. Z., Lee, W. B., Min, Y. D., Yang, M. C., Chung, A. K., Lee, K. H., and Lee, K. R., Sesquiterpene lactones of Artemisia sylvatica. Yakhakhoechi, 45, 147-152 (2001)
  8. Lee, C. B., Illustrated Flora of Korea. Hyangmoonsa, Seoul, p. 760, (1979)
  9. Park, K. Y., Ha, J. O., Yu, Y. B., Lee, J. H., and Park, J. C., Antimutagenic effects of some Artemisia rubripes. Kor. J. Pharmacogn., 27, 96-100 (1996)
  10. Singh, P., Jakupovic, J., Bohlmann, F., King, R. M., and Robinson, H., Highly oxygenated guaianolides from Bishopanthus soliceps. Phytochemistry, 24, 2110-2112 (1985) https://doi.org/10.1016/S0031-9422(00)83133-7
  11. Vasconcelos, J. M. J., Silva, A. M. S., and Cavaleiro, J., A. S., Chromones and Ffavanones from Artemisia campestris subsp. maritima. Phytochemistry, 49,1421-1424 (1998). https://doi.org/10.1016/S0031-9422(98)00180-0