• Journal of Veterinary Clinics
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• v.38 no.2
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• pp.98-102
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• 2021

Three dogs with different extents of corneal edema were presented to the Dana Animal Hospital Eye Center. The dogs (3 eyes) were diagnosed with corneal endothelial degeneration with clinical signs of corneal edema, conjunctival hyperemia, and mild blepharospasm through a full ophthalmic examination. For the treatment of corneal edema, superficial keratectomy using a crescent microsurgical knife was performed, and a conjunctival advancement hood flap was applied to the stromal defects. In two cases where corneal edema and opacity were observed only in a part of the cornea, corneal edema was reduced and did not progress to other parts of the cornea and corneal transparency and vision were also well-maintained during the follow-up on days 349 and 231 after the surgery. In a case where the whole cornea was edematous and cloudy, corneal edema and opacity had not clearly improved at the last follow-up on day 275 after the surgery. In conclusion, SKCAHF relieved corneal edema and improved vision, and the prognosis tended to be better when there was less corneal edema caused by CED.

• Journal of Korean Clinical Health Science
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• v.7 no.1
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• pp.1205-1214
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• 2019

Purpose: To investigate the effect of color soft contact lenses on the corneal thickness in young Korean population. Methods: The subjects consisted of 112 eyes (7 males, 49 females) with the mean age of $20.987{\pm}1.093years$ (range 20-25 years) in young Korean population during 2018. Test was compared the corneal thickness before and after wearing color soft contact lenses. The thinnest cornea thickness(TCT), central cornea thickness(CCT), pupil centre thickness(PCT), superior corneal thickness(SCT),inferior corneal thickness(ICT), medial corneal thickness(MCT), lateral corneal thickness(LCT) of the cornea was measured using the Pentacam pachymetry. The statistically analysis was perform the Shaparo-Wilk test. Results: The right eye was a statistically significant among the CCT,LCT, MCT and TCT values(p<0.001) in the compared the corneal thickness before and after wearing soft colour contact lenses. Also the left eye was a statistically significant among the LCT and MCT values(p<0.001) in the compared the corneal thickness before and after wearing soft colour contact lenses. However, there was no statistical difference (p>0.5) in the mean PCT between before and after wearing color soft contact lenses. Conclusion: These results suggested that the color soft contact lens wear can the effect the regional thickness of cornea. Therefore, the analysis of corneal topography with Pentacam can provide correct and useful diagnostic information of the morphology of the RGP contact lens fitting and diagnosis of corneal refraction surgery.

• Journal of Pharmaceutical Investigation
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• v.24 no.3
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• pp.49-57
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• 1994

The objective of this study was to determine whether Pz-peptide, an enhancer of hydrophilic solute permeability in the intestine, could elevate the paracellular permeability of the cornea and conjunctiva in the pigmented rabbit. The in vitro penetration of four hydrophilic solutes, mannitol (MW 182), fluorescein (MW 376), FD-4 (FITC-dextran, 4 KDa), and FD-10 (FITC-dextran, 10 KDa) across the pigmented rabbit cornea and conjunctiva was studied either in the presence or absence of 3 mM enhancers. Drug penetration was evaluated using the modified Ussing chamber. The conjunctiva was more permeable than the cornea to all four markers. EDTA and cytochalasin B showed higher effects on marker transport than Pz-peptide, but Pz-peptide elevated the corneal transport of mannitol, fluoresein, and FD-4 by 50%, 26%, and 50%, respectively, without affecting FD-10 transport. Possibly due to the leakier nature of the conjunctiva, 3 mM Pz-peptide elevated the transport of only FD-4 by about 45%, without affecting the transport of other markers. Furthermore, the transport of Pz-peptide itself across the cornea and conjunctiva increased with increasing concentration in the 1-5 mM range, suggesting that Pz-peptide enhanced its own permeability, possibly by elevating paracellular permeability. Effects of ion transport inhibitors on Pz-peptide transport were then investigated. PZ-peptide penetration was not changed by mucosal addition of $10\;{\mu}M$ amiloride or $10\;{\mu}M$ hexamethylene amiloride, inhibiting serosal $Na^{+}$ exit by $100\;{\mu}M$ ouabain, or replacing $Na^{+}$ with choline chloride in the mucosal side buffer. These results seggested that Pz-peptide enhanced the paracellular permeability of rabbit cornea and conjunctiva and further indicate that ion transporters were not involved in the Pz-peptide induced elevation of paracellular marker permeability.

• Journal of IKEEE
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• v.18 no.2
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• pp.240-247
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• 2014

Intraocular pressure is measured after a cornea air puff by observing biomechanical properties such as thickness or displacement of the cornea. In this paper, we deal with a frequency domain analysis of corneal deformation in the air puff tonometry that is used to diagnose glaucoma or lasik. We distinguish the patient from the normal by measuring the oscillation frequency in the neighborhood of the central cornea section. A binary image was obtained from the video images, and cornea vertical oscillation profile was extracted from the difference between the vertical displacement data and the curve fitting. In terms of Fourier transform, a vibration frequency of 479.2Hz for the patient was obtained as well as more higher 702.8Hz for the normal due to stiffness. Hilbert-Huang transform's empirical mode decomposition generally describes local, nonlinear, and nonstationary data. After the data were decomposed into intrinsic mode functions, a spectrum and power were analysed. Finally, we confirm that the patient has 6 times more higher power ratio for the specific intrinsic mode function between the patient and the normal.

• Journal of Veterinary Clinics
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• v.21 no.3
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• pp.309-313
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• 2004

The purpose of this study was to determine whether immunosuppresant, rapamycin could inhibit corneal angiogenesis induced by angiogenin and to evalutate the its role by micropocket assay. The rabbit's eye was implanted intrastromally into the superior cornea with pellet for the control group, pellet containing of angiogenin for the angiogenin group, and pellet containing of angiogenin and rapamycin for the rapamycin group. We could observed that the angiogen induced corneal angiogenesis was inhibited by rapamycin. The score of neovascularization was significantly decreased in the rapamycin group than in the angiogenin group at 7 and 10 days after pellet implantation (p < 0.05). Histologically, the cornea treated with rapamycin group also showed much less new vessels than the cornea treated with angiogenin. In conclusion, rapamycin appears to inhibit angiogenin induced angiogenesis in a rabbit corneal micropocket assay and may have therapeutic potential as an antiangiogenic agent.

• Journal of Korean Clinical Health Science
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• v.4 no.3
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• pp.652-661
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• 2016

The analysis of cornea morphology using corneal topographers is a clinical practice for the diagnosis of keratoconus in contact lens fitting. The recently technique has developed with the possibility of achieving a great number of measuring points of both anterior and posterior corneal surfaces in cornea. Also these data are used to extract a series of topographic valuation indices that permit to offer the most exact clinical diagnosis of keratoconus in contact lens fitting. This study describes the technologies in which current corneal topographers are based on the morphological characteristics that the keratoconus status observe on corneal surface. Therefore, this paper can provide that the analysis of corneal topographers applied for the diagnosis of keratoconus in contact lens fitting.

• Journal of Veterinary Clinics
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• v.37 no.5
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• pp.282-285
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• 2020

A 14-year-old neutered-male Shih-Tzu was referred for glaucoma and hyphema accompanied by systemic hypertension. After topical corticosteroid and antiglaucoma medications, the left eye (OS) progressed phthisically, but ocular hypertension redevelop one-year-and-seven-months later. Suspected limbal melanoma developed in peripheral cornea/limbal sclera with heavily pigmented cornea OS. Ultrasound biomicroscopy and ocular ultrasonography differentiated ciliary body origin-heterogeneous mass from limbal mass. Persistent hyphema and pigmented cornea might obscure intraocular lesion and advanced diagnostic methods played a crucial role. Unlike the generally benign limbal melanoma, aggressive treatment was recommended for uveal tumor. Histopathology of enucleated OS confirmed malignant uveal melanoma with chronic hypertensive vasculopathy.

• Journal of Yeungnam Medical Science
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• v.35 no.2
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• pp.232-235
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• 2018

Fabry disease (FD) is an X-linked, recessively inherited, rare, progressive, disorder of glycosphingolipid metabolism affecting multiple organs resulting in organ dysfunction. It is rare to find only one FD affected subject with a de novo mutation. Here we report a case of a 41-year-old Asian male diagnosed with de novo FD. Comprehensive ophthalmological evaluation was performed using slit lamp, color fundus photography, optical coherence tomography, fluorescein angiography, and indocyanine green angiography. On slit lamp examination, cornea verticillata and slightly tortuous, and aneurysmal dilatation of inferior bulbar conjunctival vessels were observed. Other imaging modalities showed unremarkable findings. Cornea verticillata and inferior bulbar conjunctival vascular abnormalities may be detected earlier than other ocular abnormalities in de novo FDs like hereditary FDs.

• Journal of Korean Ophthalmic Optics Society
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• v.17 no.2
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• pp.143-151
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• 2012

Purpose: The present study was conducted to investigate whether there is any difference in the centration of spherical RGP lens on cornea according to corneal types, corneal astigmatism and lens fitting states. Methods: Spherical RGP lens was fitted on 29 eyes of round-typed cornea and 45 eyes of symmetric bowtie-typed cornea with 0.00~2.75 D of corneal astigmatism in alignment, steep or flat. Their lens centrations on cornea were analyzed by taking photographs. Results: The centration of spherical RGP lens in the vertical direction was decentrated to downward direction in all cases, and the degree of decentration was not consistent. The lens centration in horizontal direction was significantly more-decentrated to the temporal meridian as base curve of lens was increased, and the degree of decentration was different according to the corneal type, corneal astigmatism and fitting states. With the same degree of astigmatism, the lens decentration to the temporal meridian was bigger in round-typed cornea than that in symmetirc bowtie-typed cornea. Conclusions: The centration of spherical RGP lens varies depending on lens fitting states, corneal astigmatism, and corneal types. Thus, the consideration of these factors may improve the success rate in RGP lens prescription.

• Journal of Veterinary Clinics
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• v.18 no.4
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• pp.324-328
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• 2001

This study was performed to evaluate the effects of $AS_2O_3$ upon antiangiogenesis in rat cornea, to examine it\`s possible application as an anticancer drug and to provide basic data for further studies of antiangiogenetic mechanism of $AS_2O_3$ . Angiogenesis was induced by cornea micropocket assay, as previously described. Sixteen of forty-eight eyes of Sprague-Dawley rats were randomly assigned to one of three groups, namely, only a bFGF group(control group), and a group treated by $AS_2O_3$ ($AS_2O_3$ group). After pellet implantation, we measured the number of new vessels, vessel length and clock hour of neovascularization, and area of neovascularization was determined using a mathematical formula. New vessels growing began at day 3, number of vessels in $AS_2O_3$ group were significantly more less than those in control group (p<0.05). The length of vessels of $AS_2O_3$ group was significantly shorter than that of control group after day 3(p<0.05). The clock hours of all group were slowly increased at all days but $AS_2O_3$ group was inhibited more than control group. Neovascularization areas of $AS_2O_3$ group were more significantly inhibited than those of control group (p<0.05). This study showed that $AS_2O_3$ had powerful antiangiogenetic effects and it would be useful in the choice of anticancer drug.