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Rapamycin Inhibits Rabbit Corneal Neovascularization Induced by Angiogenin  

권영삼 (중앙대학교 의과대학)
김재찬 (중앙대학교 의과대학)
장광호 (경북대학교 수의과대학)
Publication Information
Journal of Veterinary Clinics / v.21, no.3, 2004 , pp. 309-313 More about this Journal
Abstract
The purpose of this study was to determine whether immunosuppresant, rapamycin could inhibit corneal angiogenesis induced by angiogenin and to evalutate the its role by micropocket assay. The rabbit's eye was implanted intrastromally into the superior cornea with pellet for the control group, pellet containing of angiogenin for the angiogenin group, and pellet containing of angiogenin and rapamycin for the rapamycin group. We could observed that the angiogen induced corneal angiogenesis was inhibited by rapamycin. The score of neovascularization was significantly decreased in the rapamycin group than in the angiogenin group at 7 and 10 days after pellet implantation (p < 0.05). Histologically, the cornea treated with rapamycin group also showed much less new vessels than the cornea treated with angiogenin. In conclusion, rapamycin appears to inhibit angiogenin induced angiogenesis in a rabbit corneal micropocket assay and may have therapeutic potential as an antiangiogenic agent.
Keywords
rapamycin; rabbit; neovascularization; angiogenin;
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