• 한국임상수의학회지
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• 제38권2호
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• pp.98-102
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• 2021

Three dogs with different extents of corneal edema were presented to the Dana Animal Hospital Eye Center. The dogs (3 eyes) were diagnosed with corneal endothelial degeneration with clinical signs of corneal edema, conjunctival hyperemia, and mild blepharospasm through a full ophthalmic examination. For the treatment of corneal edema, superficial keratectomy using a crescent microsurgical knife was performed, and a conjunctival advancement hood flap was applied to the stromal defects. In two cases where corneal edema and opacity were observed only in a part of the cornea, corneal edema was reduced and did not progress to other parts of the cornea and corneal transparency and vision were also well-maintained during the follow-up on days 349 and 231 after the surgery. In a case where the whole cornea was edematous and cloudy, corneal edema and opacity had not clearly improved at the last follow-up on day 275 after the surgery. In conclusion, SKCAHF relieved corneal edema and improved vision, and the prognosis tended to be better when there was less corneal edema caused by CED.

• 한국임상보건과학회지
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• 제7권1호
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• pp.1205-1214
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• 2019

Purpose: To investigate the effect of color soft contact lenses on the corneal thickness in young Korean population. Methods: The subjects consisted of 112 eyes (7 males, 49 females) with the mean age of $20.987{\pm}1.093years$ (range 20-25 years) in young Korean population during 2018. Test was compared the corneal thickness before and after wearing color soft contact lenses. The thinnest cornea thickness(TCT), central cornea thickness(CCT), pupil centre thickness(PCT), superior corneal thickness(SCT),inferior corneal thickness(ICT), medial corneal thickness(MCT), lateral corneal thickness(LCT) of the cornea was measured using the Pentacam pachymetry. The statistically analysis was perform the Shaparo-Wilk test. Results: The right eye was a statistically significant among the CCT,LCT, MCT and TCT values(p<0.001) in the compared the corneal thickness before and after wearing soft colour contact lenses. Also the left eye was a statistically significant among the LCT and MCT values(p<0.001) in the compared the corneal thickness before and after wearing soft colour contact lenses. However, there was no statistical difference (p>0.5) in the mean PCT between before and after wearing color soft contact lenses. Conclusion: These results suggested that the color soft contact lens wear can the effect the regional thickness of cornea. Therefore, the analysis of corneal topography with Pentacam can provide correct and useful diagnostic information of the morphology of the RGP contact lens fitting and diagnosis of corneal refraction surgery.

• Journal of Pharmaceutical Investigation
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• 제24권3호spc1호
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• pp.49-57
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• 1994

The objective of this study was to determine whether Pz-peptide, an enhancer of hydrophilic solute permeability in the intestine, could elevate the paracellular permeability of the cornea and conjunctiva in the pigmented rabbit. The in vitro penetration of four hydrophilic solutes, mannitol (MW 182), fluorescein (MW 376), FD-4 (FITC-dextran, 4 KDa), and FD-10 (FITC-dextran, 10 KDa) across the pigmented rabbit cornea and conjunctiva was studied either in the presence or absence of 3 mM enhancers. Drug penetration was evaluated using the modified Ussing chamber. The conjunctiva was more permeable than the cornea to all four markers. EDTA and cytochalasin B showed higher effects on marker transport than Pz-peptide, but Pz-peptide elevated the corneal transport of mannitol, fluoresein, and FD-4 by 50%, 26%, and 50%, respectively, without affecting FD-10 transport. Possibly due to the leakier nature of the conjunctiva, 3 mM Pz-peptide elevated the transport of only FD-4 by about 45%, without affecting the transport of other markers. Furthermore, the transport of Pz-peptide itself across the cornea and conjunctiva increased with increasing concentration in the 1-5 mM range, suggesting that Pz-peptide enhanced its own permeability, possibly by elevating paracellular permeability. Effects of ion transport inhibitors on Pz-peptide transport were then investigated. PZ-peptide penetration was not changed by mucosal addition of $10\;{\mu}M$ amiloride or $10\;{\mu}M$ hexamethylene amiloride, inhibiting serosal $Na^{+}$ exit by $100\;{\mu}M$ ouabain, or replacing $Na^{+}$ with choline chloride in the mucosal side buffer. These results seggested that Pz-peptide enhanced the paracellular permeability of rabbit cornea and conjunctiva and further indicate that ion transporters were not involved in the Pz-peptide induced elevation of paracellular marker permeability.

• 전기전자학회논문지
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• 제18권2호
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• pp.240-247
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• 2014

안압의 측정은 각막에 air puff 후 각막의 변형 즉, 각막의 두께나 변위 등 생역학적 성질을 관찰함으로써 이루어진다. 본 논문에서는 녹내장이나 라식의 진단을 위하여 사용되는 안압계의 air puff에 의한 각막의 변형을 주파수 영역에서 분석하였다. Air puff 후 각막의 중심부 주변의 변위에 대한 진동 주파수를 측정함으로써 환자와 정상인을 구별한다. 동영상으로부터 이진 영상을 구하고, 상하 변위 데이터와 곡선 정합의 차를 구하여 시간에 따른 각막 상하 진동 프로파일 데이터를 추출하였다. Fourier 변환으로 비정상인의 진동 주파수는 479.2Hz를 얻었고 정상인의 경우 단단함으로 인하여 702.8Hz의 고주파 성분을 볼 수 있었다. 또한 Hilbert-Huang 변환의 EMD 방법을 이용, 고유 모드 함수로 분해하여 국소적, 비선형, 비정상성을 가지는 데이터를 얻고 주파수와 전력을 분석하였다. 마지막으로 특정 고유 모드 함수에 대한 환자와 정상인의 전력비가 6배 이상 차이가 나는 것을 확인하였다.

• 한국임상보건과학회지
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• 제12권1호
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• pp.1654-1659
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• 2024

Purpose: The aim of this study was to determine Correlation analysis of central corneal thickness, anterior chamber volume, and anterior chamber depth in Koreans aged 20 to 24 years using the Pentacam tool. Methods: The subjects of this study were 53 Korean adults with healthy eyes. The central corneal thickness(CCT), anterior chamber volume(ACV), and anterior chamber depth(ACD) was measured with Pentacam device. Data was analyzed by means of the Pearson's correlation cofficient. P-values<0.001 were considered statistically significant. Results: Mean age of subjects was 22.0±2.01 years. The mean +/- central corneal thickness of the right eye and left eye were 546.66±32.221mmg and 545.70±32.759mm, respectively. Also The mean central cornea thickness was 546.19 um in the whole sample. The mean anterior chamber volume the right eye and left eye was 181.66±33.738 mm³ and 180.12±30.84 mm³, respectively. The mean anterior chamber depth was 3.158±0.257 mm and 3.122±0.233 mm in right eye and left eye, respectively. There was a statistically significant difference between anterior camber volume and anterior chamber depth(p<0.001, Pearson's correlation). However there was no statistically significant difference between central cornea thickness and anterior chamber volume. Also there was no statistically significant difference between central cornea thickness and anterior chamber depth. Conclusion: The results of this study could be used as a clinical reference data for diagnosis and treatment of cornea in Korean adolescents.

• 한국임상수의학회지
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• 제21권3호
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• pp.309-313
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• 2004

The purpose of this study was to determine whether immunosuppresant, rapamycin could inhibit corneal angiogenesis induced by angiogenin and to evalutate the its role by micropocket assay. The rabbit's eye was implanted intrastromally into the superior cornea with pellet for the control group, pellet containing of angiogenin for the angiogenin group, and pellet containing of angiogenin and rapamycin for the rapamycin group. We could observed that the angiogen induced corneal angiogenesis was inhibited by rapamycin. The score of neovascularization was significantly decreased in the rapamycin group than in the angiogenin group at 7 and 10 days after pellet implantation (p < 0.05). Histologically, the cornea treated with rapamycin group also showed much less new vessels than the cornea treated with angiogenin. In conclusion, rapamycin appears to inhibit angiogenin induced angiogenesis in a rabbit corneal micropocket assay and may have therapeutic potential as an antiangiogenic agent.

• 한국임상보건과학회지
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• 제4권3호
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• pp.652-661
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• 2016

The analysis of cornea morphology using corneal topographers is a clinical practice for the diagnosis of keratoconus in contact lens fitting. The recently technique has developed with the possibility of achieving a great number of measuring points of both anterior and posterior corneal surfaces in cornea. Also these data are used to extract a series of topographic valuation indices that permit to offer the most exact clinical diagnosis of keratoconus in contact lens fitting. This study describes the technologies in which current corneal topographers are based on the morphological characteristics that the keratoconus status observe on corneal surface. Therefore, this paper can provide that the analysis of corneal topographers applied for the diagnosis of keratoconus in contact lens fitting.

• 한국임상수의학회지
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• 제37권5호
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• pp.282-285
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• 2020

A 14-year-old neutered-male Shih-Tzu was referred for glaucoma and hyphema accompanied by systemic hypertension. After topical corticosteroid and antiglaucoma medications, the left eye (OS) progressed phthisically, but ocular hypertension redevelop one-year-and-seven-months later. Suspected limbal melanoma developed in peripheral cornea/limbal sclera with heavily pigmented cornea OS. Ultrasound biomicroscopy and ocular ultrasonography differentiated ciliary body origin-heterogeneous mass from limbal mass. Persistent hyphema and pigmented cornea might obscure intraocular lesion and advanced diagnostic methods played a crucial role. Unlike the generally benign limbal melanoma, aggressive treatment was recommended for uveal tumor. Histopathology of enucleated OS confirmed malignant uveal melanoma with chronic hypertensive vasculopathy.

• Journal of Yeungnam Medical Science
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• 제35권2호
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• pp.232-235
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• 2018

Fabry disease (FD) is an X-linked, recessively inherited, rare, progressive, disorder of glycosphingolipid metabolism affecting multiple organs resulting in organ dysfunction. It is rare to find only one FD affected subject with a de novo mutation. Here we report a case of a 41-year-old Asian male diagnosed with de novo FD. Comprehensive ophthalmological evaluation was performed using slit lamp, color fundus photography, optical coherence tomography, fluorescein angiography, and indocyanine green angiography. On slit lamp examination, cornea verticillata and slightly tortuous, and aneurysmal dilatation of inferior bulbar conjunctival vessels were observed. Other imaging modalities showed unremarkable findings. Cornea verticillata and inferior bulbar conjunctival vascular abnormalities may be detected earlier than other ocular abnormalities in de novo FDs like hereditary FDs.

• 한국안광학회지
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• 제17권2호
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• pp.143-151
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• 2012

목적: 각막형상이나 각막난시도, 피팅상태가 구면 RGP 렌즈를 피팅함에 있어서 각막 중앙안정위치(stable centration)에 어떠한 영향을 미치는지를 밝히고자 하였다. 방법: 각막난시가 0.00~2.75 D인 원형 각막 29안 및 대칭나비형 각막 45안을 대상으로 RGP 렌즈를 양호한 피팅상태, 스팁한 피팅상태, 플랫한 피팅상태로 착용시키고 각막에서의 렌즈 위치를 촬영하여 분석하였다. 결과: 구면 RGP 렌즈의 수직방향 렌즈 안정 위치는 모든 경우에 아래 쪽으로 중심이탈되었으며 중심이탈 정도는 일관성이 없었다. 수평방향의 렌즈 안정위치는 렌즈의 베이스커브가 커짐에 따라 귀 쪽으로 렌즈 중심이 이탈되는 정도가 통계적으로 유의하게 커졌으며 각막형상과 난시도, 피팅상태에 따라 렌즈 중심의 이탈 정도에 차이가 있었다. 동일한 난시도를 가진 원형 각막은 대칭나비형 각막에 비해 렌즈 중심이 귀쪽방향으로의 이탈 정도가 더 컸다. 결론: 구면 RGP 렌즈의 피팅상태, 난시도 및 각막형상에 따라 중심안정위치가 달라지며 이를 고려하면 RGP 렌즈 처방 시 성공률을 높일 수 있을 것으로 보인다.