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A Case of Hemophagocytic Lymphohistiocytosis with Clonal Karyotype Abnormalities (클론성 염색체이상을 보인 혈구포식 림프조직구증 1예)

  • Choi, Gae-Ryung;Kim, Ha-Nui;Cho, Chi-Hyun;Yoo, Byoung-Joon;Kim, Myung-Han;Kim, Jang-Su;Lim, Chae-Seung;Lee, Kap No
    • Laboratory Medicine Online
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    • v.1 no.2
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    • pp.110-114
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    • 2011
  • There have been a few reports of hemophagocytic lymphohistiocytosis (HLH) with chromosomal abnormalities. Clonal chromosomal abnormalities in HLH patients are usually found in association with hematologic malignancies and rarely with epstein-barr virus (EBV) infection. Here, we report a fatal case of HLH with clonal karyotype abnormalities. A 75-yr-old man was admitted with persistent anorexia and high fever. Laboratory data revealed pancytopenia, hypofibrinogenemia, hyperferritinemia, prolonged prothrombin time and activated partial thromboplastin time, and marked elevated level of serum transaminases. In real time-PCR using whole blood, EBV DNA was not detected but cytomegalovirus (CMV) DNA was detected. The bone marrow aspiration smear showed hyperplasia of mature histiocytes with prominent hemophagocytosis. In chromosomal analysis of bone marrow aspirates, complex chromosomal abnormalities were found. In spite of steroid pulse therapy and antibiotic treatment, he died of disseminated intravascular coagulopathy.

Effects of Organizational Justice on Emotions, Job Satisfaction, and Turnover Intention in Franchise Industry (조직공정성이 감정, 직무만족 그리고 이직의도에 미치는 영향)

  • Han, Sang-Ho;Lee, Yong-Ki;Lee, Jae-Gyu
    • The Korean Journal of Franchise Management
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    • v.9 no.2
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    • pp.7-16
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    • 2018
  • Purpose - Turnover Intention in the franchise industry is becoming a very important issue. This study examines the structural relationships between organizational justice, emotion, job satisfaction, and turnover intention in the franchise industry. In this model, emotion was classified into two sub-dimensions such as positive and negative emotion. Research design, data, methodology - The sample of this study collected from employees of a food-service franchise company is representative. Copies of the questionnaire along with a cover letter were delivered by a research assistant to the human resources manager or the general manager of the selected food-service franchise firms after they agreed to participate in the study. In order to increase the response rate of the respondents, a small gift was provided to the respondents who completed the questionnaire. A total of 300 questionnaires were distributed and 285 returned responses, 9 responses were not usable due to missing information. Thus, a total of 276 responses were used using structural equation modeling with Smartpls 3.0. Results - The results showed that organizational justice had positive significant effects on positive emotion and job satisfaction. Job satisfaction had negative a significant effect on turnover intention. And negative emotion had positive significant effect on turnover intention. Conclusions - The results of this study provide some implications. If employees feel that the franchise headquarters is fair about the methods and procedures of decision making, resource allocation, information sharing, etc., it means that employees feel better. If the franchise's decision-making processes and methods and results are transparently disclosed and processed in accordance with the internal rules of the company, the employees will be able to fully understand and accept them. The results of this study also show that positive and negative emotions of service-based franchise employees have different effects on job attitude and organizational behavior. In particular, when negative emotions of employees are passed on to others and the results are negative, employees may feel that they are disoriented or wrong. Therefore, the franchise headquarters should try to inspire employees' sense of organizational community, and should pay attention to how to relieve the job stress and the fair distribution of work and rewards.

The Effects of Nursing Hospital Nurses' Caring Efficacy and Empathy Competence on Human-Centered Care (요양병원간호사의 돌봄효능감, 공감역량이 인간중심돌봄에 미치는 영향)

  • Gyeong Hye Kang;Nam Joo Je;Min Jung Lee
    • The Journal of the Convergence on Culture Technology
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    • v.9 no.4
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    • pp.363-374
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    • 2023
  • This study is a descriptive research study to confirm the care efficacy and empathy competency of nursing hospital nurses and analyze the factors to improve person-centered care behavior, provide theoretical and practical information accordingly, and prepare basic data. The study collected data from March 20, 2023 to April 20, 2023, targeting 146 nurses at a nursing hospital for the elderly in C region located in G province, and finally analyzed a total of 144 copies. Using IBM SPSS/25, descriptive statistics t-test, ANOVA, and correlation multiple regression analysis were analyzed. As a result of analyzing the variables that affect the subject's person-centered care by hierarchical multiple regression, the higher the caring efficacy and empathy capacity, the more the person-centered care was affected, and the explanatory power was 31.5%. As a result of this study, empathy competency and care efficacy were found to have an effect on person-centered care. It is thought that various measures should be prepared to improve the care efficacy and empathy competency for the efficient nursing performance of person-centered care of nursing hospital nurses.

The Effects of College Students' Motivation to Participate in Bodybuilding (Participation in Weight Training) on Behavioral Intention through Psychological Repulsion (대학생의 보디빌딩 참여하는(웨이트 트레이닝 참여) 동기가 심리적 반응을 통한 행동 의도에 미치는 영향)

  • Song Ki-Jae
    • The Journal of the Convergence on Culture Technology
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    • v.9 no.4
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    • pp.337-349
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    • 2023
  • Interest in bodybuilding, such as weight training, has increased, but research on the motivation and behavioral intention of college students is lacking. Therefore, this study aimed to examine the motives of bodybuilding participation for college students and to find out the effect on behavioral intention by mediating the psychological resistance that occurs during the bodybuilding. As for the research method, a questionnaire was conducted on 250 users through an online survey from May 30 to June 10, 2023, and a total of 232 copies were used for the final analysis. As a result of the study, first, among college students' motivation to participate in weight training, the health-oriented type and self-development type had a positive effect on voluntary acceptance. Second, among the motives for participating in weight training, the home-oriented type was found to have a negative effect on opportunistic acceptance. Finally, voluntary acceptance had a positive effect on learning outcomes, and opportunistic acceptance had a negative effect on learning outcomes. Using the results of this study, it is expected that it will be helpful to understand the factors and policies in promoting the physical health of college students.

Factors Influencing the Disaster Nursing Competency of Nursing College Students (간호대학생의 재난간호역량에 미치는 영향요인)

  • Nam Jiin;Cho Kyeonghwa;Park Meera
    • The Journal of the Convergence on Culture Technology
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    • v.9 no.4
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    • pp.383-392
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    • 2023
  • This study was a descriptive survey study for nursing college students to identify disaster awareness, attitude, disaster preparation, nursing professionals, social support, and disaster nursing capabilities, and to prepare measures to improve disaster nursing capabilities by identifying predictors of disaster nursing capabilities. Data collection was collected from 160 nursing students in G-do from March 27 to April 7, 2023, and a total of 158 copies were finally analyzed. Using the SPSS Win. 25.0 program, technical statistics, t-test, one-way ANOVA, Pearson correlation coefficient, and hierarchical multiple regression were analyzed. The result show that fourth grade(β=.20, p=.027), disaster nursing education is 'existent'(β=.15, p=.041), disaster readiness(β=.27, p<.001) nursing professional(β=.21, p=.012) was found to be a significant predictor of disaster nursing competency. Disaster preparation was found to be the best predictor of disaster nursing competency, followed by "nursing professionals," "fourth grade," and "disaster nursing education" with 26.3% of explanatory power. According to the findings of this study, it is necessary to develop an integrated education program for disaster nursing practice that can enhance awareness of disasters, attitudes toward disasters, disaster preparation, nursing professionals, and social support.

Co-occurrence Analyses of Antibiotic Resistance Genes and Microbial Community in Human and Livestock Animal Feces (사람 및 가축 유래 분변 미생물 군집과 항생제 내성 유전자 간 상관 관계에 대한 연구)

  • Jiwon Jeong;Aprajita Bhandari;Tatsuya Unno
    • Korean Journal of Environmental Agriculture
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    • v.41 no.4
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    • pp.335-343
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    • 2022
  • BACKGROUND: Antibiotics used in animal husbandry for disease prevention and treatment have resulted in the rapid progression of antibiotic resistant bacteria which can be introduced into the environment through livestock feces/manure, disseminating antibiotic resistant genes (ARGs). In this study, fecal samples were collected from the livestock farms located in Jeju Island to investigate the relationship between microbial communities and ARGs. METHODS AND RESULTS: Illumina MiSeq sequencing was applied to characterize microbial communities within each fecal sample. Using quantitative PCR (qPCR), ten ARGs encoding tetracycline resistance (tetB, tetM), sulfonamide resistance (sul1, sul2), fluoroquinolone resistance (qnrD, qnrS), fluoroquinolone and aminoglycoside resistance (aac(6')-Ib), beta-lactam resistance (blaTEM, blaCTX-M), macrolide resistance (ermC), a class 1 integronsintegrase gene (intI1), and a class 2 integrons-integrase gene (intI2) were quantified. The results showed that Firmicutes and Bacteroidetes were dominant in human, cow, horse, and pig groups, while Firmicutes and Actinobacteria were dominant in chicken group. Among ARGs, tetM was detected with the highest number of copies, followed by sul1 and sul2. Most of the genera belonging to Firmicutes showed positive correlations with ARGs and integron genes. There were 97, 34, 31, 25, and 22 genera in chicken, cow, pig, human, and horse respectively which showed positive correlations with ARGs and integron genes. In network analysis, we identified diversity of microbial communities which correlated with ARGs and integron genes. CONCLUSION(S): In this study, antibiotic resistance patterns in human and livestock fecal samples were identified. The abundance of ARGs and integron genes detected in the samples were associated with the amount of antibiotics commonly used for human and livestocks. We found diverse microbial communities associated with antibiotics resistance genes in different hosts, suggesting that antibiotics resistance can disseminate across environments through various routes. Identifying the routes of ARG dissemination in the environment would be the first step to overcome the challenge of antibiotic resistance in the future.

Analysis of the Mediating Effect of Academic Self-efficacy in the Effect of Motivation to Participate of Online Lifelong Education Using YouTube on Learning Flow (유튜브를 활용한 온라인 평생교육의 참여동기가 학습몰입에 미치는 영향에서 학업적 자기효능감의 매개효과 분석)

  • Kim, Tae-Rin
    • The Journal of the Korea Contents Association
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    • v.22 no.5
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    • pp.527-541
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    • 2022
  • This study analyzed the structural relationship between motivation to participate in online lifelong education through YouTube, academic self-efficacy, and learning flow, where learners are rapidly increasing due to the spread of COVID-19. For this study, an online survey was conducted from July 16 to 30, 2021 for adult learners living in the metropolitan area. A total of 428 people participated in the survey, and a total of 409 copies of the results were analyzed, excluding 19 insincere responses. The main analysis results are as follows. First, The fitness of the research model was verified to be suitable for all analysis. Second, as a result of confirming the coefficients and statistical significance of each pathway in the research model, the motivation to participate in YouTube lifelong education was learning flow and academic self-efficacy, and academic self-efficacy also had a positive effect on learning flow. Third, it was confirmed that the effect of participation motivation in YouTube lifelong education on learning flow through academic self-efficacy was a statistically significant partial mediation. This study is meaningful in that it verified the structural relationship analysis between participation motive, academic self-efficacy, and learning flow in online lifelong education using YouTube reflecting the digital transformation of lifelong education due to COVID-19. Reflecting the need for re-regulation of lifelong education formed after COVID-19 and the flow of digital transformation through the research results, we discussed how lifelong education can enhance learners' motivation to participate and strengthen learning flow through academic self-efficacy as a medium.

The Effect of Service Quality of a Local Festival on Visitor Participation Behavior : The Moderating Effect of Involvement - Focusing on 'Festival to the World by Geoje Sea' - (지역축제 서비스품질이 방문객 참여행동에 미치는 영향 : 관여도 조절효과 '2019 거제 바다로 세계로' 축제를 중심으로)

  • Choi, Soo-Yong;Han, Jeong-Hoon
    • Journal of Korea Entertainment Industry Association
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    • v.13 no.8
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    • pp.55-67
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    • 2019
  • This study was surveyed the visitors who visited the festival for 4 days from August 01, 2019 to August 04, 2019 .For the questionnaire, 367 copies of valid questionnaires were used as the final analysis data in four beaches: Hakdong Black Pearl Beach, Gujora Beach, Wahyeon Beach, and Jicell Port. The results of this study are as follows. First, all three sub-factors of regional festival service quality, such as confidence, empathy, and credibility, had a positive effect on participation behavior. Second, the result of the moderating effect of the influence of involvement on the quality of service and visitor participation behavior of local festivals is based on the individual moderating effects of service quality and visitor participation behavior. There was a moderating effect. Visitors should be aware of the program, which is faithful to the festival's original purpose, and provide visitors with information about the festival quickly and accurately to feel the efficacy of participating in the festival. And The more satisfied the tourists who visited the local festivals, the more likely it will be to be a successful and successful festival. By speeding up, unexpected positive customer behavior will come from places that are not important.

A Study on the Factors Influencing the Continuity of Volunteer Activities of Middle-aged Women (중년 여성의 자원봉사활동 지속성에 영향을 미치는 요인에 관한 연구)

  • Eun-Yeong Kim;Ji-Yeon Park
    • Journal of Industrial Convergence
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    • v.21 no.8
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    • pp.59-67
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    • 2023
  • This study aims to examine how individual variables (motivation to participate, leadership life skills, aging awareness), interpersonal variables (relations with subjects, colleagues, and employees), and institutional variables (recognition compensation, institutional education) affect the continuity of volunteer activities. To this end, a survey was conducted on women aged 40 to 64 working at volunteer centers and local volunteer institutions in Seoul for 20 days from August 2, 2019, and a total of 300 questionnaires were distributed and 298 copies were collected, of which 180 were used for the final analysis. For data analysis, frequency analysis, descriptive statistical analysis, correlation analysis, and hierarchical regression analysis were conducted. As a result of the analysis, it was found that leadership life skills and motivation for participation, relationships with colleagues as interpersonal variables, and recognition compensation as institutional variables had a positive effect on the continuity of volunteer activities. This study aims to provide practical and policy suggestions to revitalize and maintain the continuity of volunteer activities of middle-aged women, and basic data for the development of programs to be used in the field of practice.

A Study on Human Rights Sensitivity of Occupational Therapists in the Republic of Korea (국내 작업치료사들의 인권감수성 조사연구)

  • Chang, Ki-Yeon;Lee, Eun-Jin;Kong, Myung-Ja;Gang, Mi-Yeong
    • Therapeutic Science for Rehabilitation
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    • v.12 no.4
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    • pp.123-134
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    • 2023
  • Objective : This study aimed to investigate the level of human rights sensitivity of occupational therapists and compare the differences in the level of human rights sensitivity between variables to provide a basis for awareness, human rights behavior, and the development of human rights education programs. Methods : A questionnaire consisting of general characteristics and 10 human rights susceptibility episodes was distributed, and 131 copies were analyzed. Results : The average score for human rights sensitivity was 58.75 for male and 55.44 for female therapists. As for the difference in human rights sensitivity by episode by sex, statistically significant differences were found in the right to avoid illegal arrest and restriction and the right to freedom from imprisonment. In addition, as a result of differences in changes in human rights sensitivity by subcategory, there was a statistically significant difference between males and females in the perception of responsibility. In the case of males, the average score for perception of responsibility was the highest, and in the case of females, the average score for perception of the situation was the highest. Conclusion : Based on the results of this study, it is necessary to strengthen the content of educational programs in clinical settings to improve human rights consciousness and behavior.