• Experimental and Molecular Medicine
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• v.50 no.11
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• pp.12.1-12.12
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• 2018

Drugs targeting the epidermal growth factor receptor (EGFR), such as cetuximab and panitumumab, have been prescribed for metastatic colorectal cancer (CRC), but patients harboring KRAS mutations are insensitive to them and do not have an alternative drug to overcome the problem. The levels of ${\beta}$-catenin, EGFR, and RAS, especially mutant KRAS, are increased in CRC patient tissues due to mutations of adenomatous polyposis coli (APC), which occur in 90% of human CRCs. The increases in these proteins by APC loss synergistically promote tumorigenesis. Therefore, we tested KYA1797K, a recently identified small molecule that degrades both ${\beta}$-catenin and Ras via $GSK3{\beta}$ activation, and its capability to suppress the cetuximab resistance of KRAS-mutated CRC cells. KYA1797K suppressed the growth of tumor xenografts induced by CRC cells as well as tumor organoids derived from CRC patients having both APC and KRAS mutations. Lowering the levels of both ${\beta}$-catenin and RAS as well as EGFR via targeting the $Wnt/{\beta}$-catenin pathway is a therapeutic strategy for controlling CRC and other types of cancer with aberrantly activated the $Wnt/{\beta}$-catenin and EGFR-RAS pathways, including those with resistance to EGFR-targeting drugs attributed to KRAS mutations.

• Korean Journal of Social Welfare Studies
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• v.40 no.3
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• pp.243-265
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• 2009

Using the children supplements of Korea Welfare Panel Study(first wave), this study examined that the correlation and differences between income-poverty(minimum cost of living)and housing- poverty(sub-standard housing) and analyzed the effects of living in sub-standard housing conditions on children's school achievement. The findings of the study are as follows. First, there is low correlation between income-poverty and housing-poverty. Second. there is differences of household characteristics between only housing-poverty household and only income-poverty household or income and housing poverty household. Third, living in sub-standard housing conditions has statistically significant negative effect on school achievement even after controlling for income-poverty, sex, self-esteem, adaptation to school life, family type, mother's education, private education cost, rearing behavior. The findings of this study suggest that more active housing policy approach is needed to support development of children living in sub-standard housing conditions. Based on this research, we present needed policies in the conclusion.

• Journal of the Korea Convergence Society
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• v.12 no.10
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• pp.321-331
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• 2021

The purpose of this study was to understand and define the health-promotion behavior of adolescents in Korea. This study collected data from twelve high school students using group and individual in-depth interviews. Data were analyzed qualitative study with grounded theory method by Strauss and Corbin(1998). As for the study result, the core phenomenon was the Lifestyle without health promotion and the mediation conditions for controlling were Parents' Care for Health, Friends with Health Behavior, and lack of exercise environment, and the action/interection strategy to correspond to this situation was Strengthening the will to practice health promotion, Imitate a friend with a nice body, Learning parental health behavior. This study will serve as basic data in developing health promotion programs for the practice health promoting behaviors of high school students.

• Geomechanics and Engineering
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• v.18 no.3
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• pp.259-266
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• 2019

This paper presents a comparison between experimental measurements and numerical estimations of penetration length of a cement grout injected in discrete joints. In the experiment, a joint was generated by planar acryl plates with a certain separation distance (; aperture) and was designed in such a way to vary the separation distances. Since a cement grout was used, the grout viscosity can be varied by controlling water-cement (W/C) ratios. Throughout these experiments, the influence of joint aperture, cement grout viscosity, and injection rate on a penetration length in a discrete joint was investigated. During the experiments, we also measured the time-dependent variation of grout viscosity due to a hardening process. The time-dependent viscosity was included in our numerical simulations as a function of elapsed time to demonstrate its impact on the estimation of penetration length. In the numerical simulations, Bingham fluid model that has been known to be applicable to a viscous cement material, was employed. We showed that the estimations by the current numerical approach were well comparable to the experimental measurements only in limited conditions of lower injection rates and smaller joint apertures. The difference between two approaches resulted from the facts that material separation (; bleeding) of cement grout, which was noticeable in higher injection rate and there could be a significant surface friction between the grout and joint planes, which are not included in the numerical simulations. Our numerical simulation, meanwhile, could well demonstrate that penetration length can be significantly over-estimated without considering a time-dependency of viscosity in a cement grout.

• The Journal of the Korea Contents Association
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• v.19 no.4
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• pp.129-137
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• 2019

The aim of this study was to investigate the association between self-rated oral health, self-rated health, and quality of life (QOL) among older population from the 7th Korea National Health and Nutrition Examination Survey (KNHANES VII-1, 2016). Data of 1,866 older adults (Mean age 69.5 years) were analyzed with hierarchical logistic regression analyses with IBM SPSS 23.0. Over 87.7% of the subjects rated their oral health as fair or poor. Women and less educated participants more likely to report their perceived oral health as poor (p<.05). Older participants who rated their general health positively were more likely to rate their oral health as good (F=19.04, p<.001). Elders who had bad perceived health (OR: 2.86, 95% CI: 1.5~5.5), had carries in permanent teeth (OR: 2.68, 95% CI: 1.67~4.32) and anxiety or depression (OR: 1.45, 95% CI: 1.42~2.57) had negative oral health perception after controlling for covariates. In conclusion, perceived oral health and QOL were associated with each other in Korean older adults. Therefore, it is recommended to approach holistic strategy for improve health and quality of life in the elderly population.

• Design & Manufacturing
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• v.12 no.3
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• pp.5-12
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• 2018

Plastic containers which provides the opportunity to reduce transportation costs are lighter and less brittle than glass containers. As a results, efforts to replace glass with plastic are ongoing. The blow molding method is a typical approach in producing plastic containers. Single-stage injection blow molding (ISBM) is one of the blow molding methods. However, the difficulty in controlling the temperature during the injection molding process is considered its main disadvantage. In this study, ISBM process analysis of relatively thick walled containers such as cosmetic containers is carried out. The initial temperature distribution of the preform is deemed to be the most influential factor in the accuracy of blow molding for the thick vessel. In order to accurately predict this, all heat transfer processes of the preform are considered. The validity of this analytical procedure is verified by comparing the cross-sectional thickness with the actual product. Finally, the validated analytical method is used to evaluate the factors affecting the thickness of the final molded part. The ISBM analysis technique for thick walled vessels developed through this study can be used as an effective predictor for preform design and blow process.

• Journal of Software Engineering Society
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• v.26 no.1
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• pp.1-16
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• 2013

Variable length information message is a communication protocol standard in order for computer network systems to provide efficient delivery of information. The variable length information messages were developed for varying and controlling details of information in accordance with message receiver's required information level or information access level. In the previous studies, data compressing techniques have been in use for information message optimization technologies in order to reduce physical sizes of information messages. In optimization technologies for information messages, accuracy of information is considered as the most important factor; therefore, only non-loss compression techniques are applied to the optimization technologies. However, the non-loss compression based information message optimization methods are not efficient in data compression, and these are limited to efficient delivery of information in wireless network environments that have constraint bandwidth. In this paper, we attempt to optimize information in the variable length information messages at message fields in order to reduce physical sizes of messages more efficiently. To demonstrate the efficiency of our approach, we conduct optimization experiments for variable length information messages.

• Asia-Pacific Journal of Business
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• v.11 no.4
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• pp.205-224
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• 2020

Purpose - This study aimed to identify the effects of ownership structures on agency costs in internationally diversified firms listed on the KOSDAQ market. Design/methodology/approach - A total of 5,824 samples were finally selected and empirically analyzed for a total of nine years from 2011 to 2019, during which the International Accounting Standards had been mandatory for firms listed on the KOSDAQ market. Findings - The results of this study showed that the effects of ownership structures on the ratio of asset turnover are positive for the major share and foreign equity ratios of international diversified firms. Moreover, by selecting the ratio of entertainment expenses as a proxy for agency expenses, this study confirmed that the effects of the ownership structure of an international diversified entity on entertainment expenditure were determined to show a significantly negative relation to entertainment expenditure, thus indicating that the higher the ratio of major shareholders, the more appropriately control the expenditure of entertainment expenses through arbitrary private deviations of the management.Furthermore, considering the effect of the ownership structure on the expenditure of sales and administrative expenses as a proxy variable for agency costs, this study verified that the majority share ratio of international diversified firms was negative to the expenditure of sales and administrative expenses, confirming that the higher the share of major shareholders, the lower the selling and administrative costs, but insignificant.Finally, as a result of determining whether the ownership structure of an international diversified firm affects the holding of free cash, the majority share of this firm shows a significantly negative relation to the ratio of the holding of surplus cash, indicating that the higher the proportion of major shareholders, the more appropriately control the holding of the entity's free cash through arbitrary private deviance by the manager. Research implications or Originality - Major shareholders of an internationally diversified firm listed on the KOSDAQ market play a positive role in the firm's performance by properly controlling agency costs that may be incurred by the management.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.19 no.5
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• pp.33-38
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• 2019

In this paper, we propose a new blockchain technology that could comply with GDPR. The proposed model can prevent illegal access by controlling access to the personal information according to a access policy. For example, it can control access to the information on a role-basis and information validation period. The core mechanism of the proposed model is to encrypt the personal information with public key which is associated with users attributes policy, and then decrypt it with a private key and users attributes based on a Attribute-based Encryption scheme. It can reduce a trusted third-part risk by replacing it with a number of nodes selected from the blockchain. And also the private key is generated in the form of one-time token to improve key management efficiency. We proved the feasibility by simulating the proposed model using the chaincode of the Hyperledger Fabric and evaluate the security.

• Tribology and Lubricants
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• v.37 no.1
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• pp.25-30
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• 2021

The surface texture produced via surface texturing is an important approach for controlling the tribological behavior of friction behavior of mechanical devices. The purpose of this study is to investigate the effect of grooves generated via ultrasonic nanocrystal surface modification (UNSM) technology on the tribological performance of AISI 4150 steel against stainless steel 316L. In the study, tribological tests are performed under two different regimes, namely mixed and hydrodynamic lubrication, by varying the applied normal load and reciprocating speed during the tests. According to the test results, the friction coefficient decreases as static load (10 N, 30 N, and 50 N) of UNSM technology increases in the mixed lubrication regime. Conversely, the friction coefficient increases as the static load (10 N, 30 N, and 50 N) of UNSM technology increases in the hydrodynamic lubrication regime. Hence, the results indicate that micro-grooves generate hydrodynamic pressure in the outlet, which increases the oil film thickness between the two mating surfaces. This potentially leads to a reduction in friction in the mixed lubrication regime due to the prevention of contact of asperities and debris. However, the results indicate an adverse effect in the hydrodynamic lubrication regime. In this regard, additional experiments should be performed to investigate the effect of grooves generated by UNSM technology at varying conditions on the friction behavior of AISI 4150 steel, which in turn can be controlled by the generated pressure and oil film thickness at the contact interface.