• Journal of Microbiology and Biotechnology
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• 제24권8호
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• pp.1065-1072
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• 2014

Doxorubicin, produced by Streptomyces peucetius ATCC 27952, is tightly regulated by dnrO, dnrN, and dnrI regulators. Genome mining of S. peucetius revealed the presence of the IclR (doxR) type family of transcription regulator mediating the signal-dependent expression of operons at the nonribosomal peptide synthetase gene cluster. Overexpression of doxR in native strain strongly repressed the drug production. Furthermore, it also had a negative effect on the regulatory system of doxorubicin, wherein the transcript of dnrI was reduced to the maximum level in comparision with the other two. Interestingly, the overexpression of the same gene also had strong inhibitory effects on the production of actinorhodin (blue pigment) and undecylprodigiosin (red pigment) in Streptomyces coelicolor M145, herboxidiene production in Streptomyces chromofuscus ATCC 49982, and spinosyn production in Saccharopolyspora spinosa NRRL 18395, respectively. Moreover, DoxR exhibited pleiotropic effects on the production of blue and red pigments in S. coelicolor when grown in different agar media, wherein the production of blue pigment was inhibited in R2YE medium and the red pigment was inhibited in YEME medium. However, the production of both blue and red pigments from S. coelicolor harboring doxR was halted in ISP2 medium, whereas S. coelicolor produced both pigmented antibiotics in the same plate. These consequences demonstrate that the on and off production of these antibiotics was not due to salt stress or media compositions, but was selectively controlled in actinomycetes.

• 한국분말야금학회:학술대회논문집
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• 한국분말야금학회 1997년도 추계학술강연 및 발표대회 강연 및 발표논문 초록집
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• pp.7-7
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• 1997

During sintering of very porous green bodies, as obtained by compaction of hard powders - such as tungsten carbide or ceramics - or by injection moulding, important shrinkage occurs. Due to heterogeneous green density field, gravity effects, friction on the support, thermal gradients, etc., this shrinkage is often non-uniform, which' may induce significant shape changes. As the ratio of compact dimension to powder size is very high, the mechanics of continuum is relevant to model such phenomena. Thus numerical techniques, such as the finite element method can be used to simulate the sintering process and predict the final shape of the sintered part. Such type of simulation has much been developed in the last decade firstly for hot isostatic pressing and next for die compaction. Finite element modelling has been recently applied to free sintering. The simulation of sintering should be based on constitutive equations describing the thermo-mechanical behaviour of the material under any state of stress and any temperature which may arise within the sintering body. These equations can be drawn either from experimental data or from micromechanical models. The experiments usually consist in free sintering and sinter-forging tests. Indeed applying more complex loading conditions at high temperature under controlled atmosphere is delicate. Micromechanical models describe the constitutive behaviour of aggregates of spheres from the deformation of two-sphere contact either by viscous flow or grain boundary diffusion. Such models are not able to describe complex microstructure and mechanisms as observed in real materials but they can give some basic information on the formulation of constitutive equations. Practically both experimental and theoretical approaches can be coupled to identify the constitutive equations. Such procedure has been performed for modelling the sintering of compacts obtained by die pressing of a mixture of tungsten carbide and cobalt powders. The constitutive behaviour of this material during sintering has been described by a linear viscous constitutive model, whose functions have been fitted from results of free sintering and sinter-forging experiments. This model has next been introduced in ABAQUS finite element code to simulate the sintering of heterogeneous green compacts of various geometries at constant temperature. Examples of simulations are shown and compared with experiments.

• 한국철도학회논문집
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• 제13권1호
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• pp.84-91
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• 2010

본 연구에서는 철도, 도로 등 대형 성토지반구조물의 주요 지반재료인 입경이 큰 조립재료에 대해 전단강도, 변형계수, 응력-변형 거동과 같은 지반공학적 설계정수를 평가 산정할 수 있는 대형삼축압축시험장비를 구축하고, 이를 활용한 도상자갈재료에 대한 정적삼축압축시험 결과를 통해 그 의미와 적용 가능성을 제시하였다. 도상자갈과 같이 지표면에 설치되어 포화 가능성이 낮고, 구속압이 작은 경우에는 진공압(vacuum)으로 구속압을 제어하는 방식이 효과적임을 확인할 수 있었다. 도상자갈 재료의 삼축압축시험 결과로부터 구속압별 전단강도, 변형계수, 입자파쇄 영향 등의 합리적인 결과와 경향을 확인하였으며, 모암의 입자강도, 구속압 등의 영향을 고려하여 전단강도 포락선을 예측할 수 있는 비선형식에 적합한 재료 상수를 산정, 적용하여 실험 결과를 근접하게 재현해낼 수 있었다.

• 한국학교보건학회지
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• 제18권2호
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• pp.27-43
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• 2005

Purpose： The purpose of this study was to estimate obesity rate among mentally disabled children in six public schools in Korea. Furthermore, this study identified several factors that correlated with these children's obesity. The results of this study can help identify mentally disabled children who are at an increased risk for obesity and can be used to promote good health in this population. Methods： 1,102 subjectsfrom six public special schools were classified 4 groups who assessed for BMI for age-gender specific reference chart(1998) based on our previous data. Moreover, 207 parents were surveyed to identify predisposing factors for children's obesity, including characteristics of the children and parents, socioeconomic factors, children's eating habits, and children's exercise habits. Results： The prevalence of obesity among the 1,102 mentally disabled children was 17.3%. There was a statistically significant correlation between obesity and factors, such as age, maternal education, parents' perceptions about their child's obesity, frequency of breakfast, and exercise habits. Each of these factors was determined to have a statistically significant influence on obesity when all other factors were controlled in a multivariate analysis with multiple logistic regression analysis. Conclusions： Parental perceptions had an especially strong impact on the weight of their mentally disabled child. This is presumably due to the great influence that parents have on the lifestyles of their children, including dietary habits and frequency of exercise. Furthermore, the rate of obesity was directly proportional to the age of the child. The results of this study strongly indicate the need for preemptive health education programs that stress weight management for mentally disabled elementary school students.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2008년도 추계 학술발표회 제20권2호
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• pp.89-92
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• 2008

최근 빈번하게 발생되는 지진으로 인해 내진규정이 강화된 바 있으며, 국내에서도 인접 국가들의 지진피해 발생으로 인해 지진에 대한 안전지대가 될 수 없다는 인식이 고조되어 건축구조설계기준에 서의 내진규정이 강화되었다. 그러나 기존 비내진상세를 갖는 건축물을 해체하여 요구성능을 얻고자 하는 경우 경제적, 환경적 손실이 크므로 비내진상세를 갖는 라멘구조물을 끼움벽을 통해 보강하는 것이 합리적일 것이라 판단된다. 따라서 본 연구에서는 변형경화형 시멘트 복합체인 SHCC를 끼움벽에 적용하였으며, 일반배근 및 대각보강근에 따른 내진성능을 정량적으로 평가함으로써 SHCC 적용에 따른 배근상세 감소 및 시공성 향상을 꾀하고자 한다. 실험체는 1/3 축소모형의 프리캐스트 끼움벽으로 제작되었으며, 실험결과 다수의 미세균열이 발생하여 기존 콘크리트에서 발생되는 명확한 전단균열 및 급격한 내력저하는 발생하지 않았다. 이는 SHCC 내 혼입된 PVA 및 PE 섬유의 가교작용에 의한 것으로 벽체에 전달되는 횡하중에 의한 응력을 재분배했기 때문인 것으로 사료된다.

• 한국지반공학회논문집
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• 제19권1호
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• pp.173-180
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• 2003

토목섬유 경계 접촉면들의 동적거동을 이해하는데 매우 중요할 수도 있음에도 불구하고 접촉면들의 동적마찰저항과 변위속도 관계에 관한 연구가 아직까지는 미비한 실정이다. 이에 따라 토목섬유에 대한 실험적 인 연구를 진동대를 이용하여 수행하였다. 반복적, 변위속도 조절장치를 개발하여 사용하였으며 토목섬유 경계 접촉면들의 동적마찰저항과 변위속도사이의 관계를 조사하였다. 실험으로부터 지오텍스타일이 포함된 경계 접촉면에서는 변위속도 증가에 따라 전단강도도 증가한다는 중요한 결과를 얻었다. 이와는 달리 수침상태에서는 접촉면 사이에 갇힌 물에 의한 윤활 효과 등으로 인해 접촉 전단강도가 변위속도에 민감하지 않다는 결과를 얻었다. 본 시험결과는 토목섬유에 비교적 낮은 수직응력이 작용하는 매립장 덮개 및 사면의 동적안정 해석등에 적용할 수 있다.

• 중환자간호학회지
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• 제11권2호
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• pp.75-85
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• 2018

Purpose : The purpose of this study was to examine the possible direction of critical care nursing research in the future by analyzing the trends of recent Korean studies. Method : Using a database search, we selected 263 articles on critical care nursing that were published in Korean journals between 2008 and 2017. Then, we conducted an integrative review of the contents of the selected articles and analyzed the English abstracts using the relevant packages and functions of the R program. Results : The number of studies concerning critical care nursing has increased over the 10-year period, and the specific topic of each study has diversified according to the time at which it was conducted. In terms of quality, the majority of the research was published in high-level academic journals. The key words regularly studied over the past decade were: knowledge, delirium, education, restraint, stress, and infection. Studies related to vancomycin-resistant enterococci infection, compliance, and standards have decreased, while studies related to death, communication, and safety have increased. Conclusion : Randomized controlled trials and protocol research for evidence-based critical care need to be conducted, as does research on family involvement. The key word analysis of unstructured text used in this study is a relatively new method; it is suggested that this method be applied to various critical care nursing research and develop it methodologically.

• 한국지역사회생활과학회지
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• 제17권4호
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• pp.49-56
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• 2006

The purpose of this study was to evaluate the thermal and subjective comfort of various pesticide-proof clothes made from different material. Seven male adults took part in the study, conducted in a climate-chamber controlled with an ambient temperature of $30^{\circ}C$ and a relative humidity of 60%RH. The thermal and subjective responses of subjects wearing pesticide-proof clothing made of Goretex(coating treatment), polyester (water-repellent treatment), non-woven(coating) and nylon(coating) were measured. The main results were summarized as follows: (1) Change of rectal temperature and clothing microclimate were inhibited more effectively in pesticide-proof clothing made of Goretex, polyester and non-woven than nylon materials. (2) Mean skin temperature at the end of the experiment was significantly higher in subjects who wore nylon than non-woven and Goretex, and was lowest in those with pesticide-proof clothing made of polyester. (3) Change of heart rate was significantly lower in subjects with Goretex and polyester clothiing than those with non-woven, and in those with nylon, it was highest. (4) Subjective comfort was greater in subjects with Goretex, polyester and nonwoven clothing than nylon, except for thermal sensation. Thermal sensation was greater in order of polyester, Goretex, non-woven and nylon. Thus, it was concluded that pesticide-proof clothing made of Goretex, polyester and non-woven material could reduce thermal stress during the spraying of pesticides in summer.

• 디지털콘텐츠학회 논문지
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• 제19권9호
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• pp.1819-1824
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• 2018

본 논문에서는 사용자의 스트레스 해소와 주의력 향상에 도움이 될 수 있는 ASMR(autonomous sensory meridian response) 콘텐츠 제어 기법을 제안한다. 제안된 기법은 뇌파 측정 디바이스로부터 EEG(electroencephalography), 집중도, 명상도, 눈 깜빡임 데이터를 측정하고 안드로이드 IoT(internet of things) 앱을 통해 oneM2M 표준을 준용한 IoT 서버 플랫폼으로 전송한다. 서버 플랫폼에 수집된 EEG, 집중도 및 명상도 데이터를 사용하여 사용자의 정신건강상태를 분류하기 위한 SVM(support vector machine) 모델을 생성하고, 이 모델을 통해 분류된 사용자의 정신건강상태와 눈 깜빡임 데이터에 따라 ASMR 콘텐츠를 제어한다. 데이터 사용형태에 따라 SVM 모델을 비교한 결과, 집중도와 명상도 데이터를 사용하는 SVM 모델이 85.7%의 정확도를 나타내었고 이 SVM 모델이 분류한 정신건강상태와 눈 깜빡임 데이터의 변화에 따라 ASMR 콘텐츠 제어 알고리즘이 정상적으로 동작하는 것을 확인하였다.

• 한국작물학회지
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• 제49권1호
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• pp.46-51
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• 2004

The film coated snap bean (Phaseolus vulgaris) seeds with five different coating materials treated with 3% increase in seed weight were planted at sandy loam soil controlled moisture content of 18, 19, 20 and 21 %. The oxygen diffusion rate (ODR) was calculated from the different moisture content soil. The number of normal seedlings, seedling vigor, and seedling capability in field (seed vigor x dry matter weight) were observed at 9 days after planting and compared to the changes of ODR. The germination rate and ODR were sharply decreased simultaneously in the seeds planted at 21 % soil moisture content. Seedling emergence did not occur at all as the soil moisture content increased above 22 %. Hence this value should be considered as the threshold of soil moisture content for seedling emergence. An ODR value under 20% did not influence the percent emergence significantly. The certain difference observing in the emergence at the same ODR was not related clearly to the condition of soil. So it can be assumed that the limit of soil moisture content for the emergence of snap bean was approximately 20%. The value of 18% soil moisture content may be considered as the optimum for snap bean emergence. There was close relationship between the mean value of ODR in different soil moisture contents and the emergence. The germination rates of the seeds coated with the different materials were quite different when the seeds were planted at 21 % soil moisture. Dry weight of the seedlings from film coated seeds was decreased slightly, but the germination rates were not much different from the non-treated control under relatively higher soil moisture content (21 %). Major factor lowering emergence rate was oxygen stress while film coating act as a minor constraint for snap bean sown in excess soil moisture condition.