• Journal of Chest Surgery
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• 제21권3호
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• pp.462-470
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• 1988

1,597 cases of operation on the cardiovascular disease were performed at the Hanyang University Hospital from 1972 to 1987. Of these, 1,005 cases were open heart surgery. It was started from July 1975. Among the open heart cases, 725 were congenital heart diseases and 280 were acquired heart diseases. In congenital heart cases, 554 were acyanotic and 171 were cyanotic. The operative results were as follows; the overall mortality of cardiovascular surgery was 7.1%, the open heart mortality was 9.5%. This analyses were reported in memory of the achievement of 1,000 cases of open heart surgery.

• Journal of Chest Surgery
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• 제19권4호
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• pp.672-677
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• 1986

From April, 1984 to August, 1986, 214 cases of cardiovascular surgeries had been performed at Yeungnam University Hospital consisting 158 open heart surgeries and 56 non-open heart surgeries. The leading cardiac anomaly of open heart surgeries was ventricular septal defect which was 43% of congenital heart diseases, and most of remaining non-open heart surgeries were ligating patent ductus arteriosus. We had observed 33 postoperative complications such as wound problems, transient arrhythmia, postpericardiotomy syndrome, bleeding requiring reoperation and so on. 3 cases of surgical mortality were present [2 in congenital heart diseases and 1 in acquired heart disease], which resulting 1.9% of surgical mortality rate in the open heart surgeries.

• Journal of Chest Surgery
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• 제47권4호
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• pp.394-397
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• 2014

Numerous technical modifications and various complications of the Senning procedure have been described in the literature. We describe the excellent clinical status and anatomic result of a 33-year-old patient who underwent a modified Senning operation using the left atrial appendage for reconstruction more than 30 years prior to presentation.

• Investigative Magnetic Resonance Imaging
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• 제19권4호
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• pp.205-211
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• 2015

The human heart is a complex organ in which many complicated congenital defects may happen and some of them require surgical intervention. Due to the vast complexity of varied anatomical presentations, establishing an accurate and consistent nomenclature system is utmost important to facilitate effective communication among pediatric cardiologists, cardiothoracic surgeons and radiologists. The Van Praagh segmental approach to the complex congenital heart disease (CHD) was developed in the 1960s and has been used widely as the language for describing complex anatomy of CHD over the decades. It utilizes a systematic and sequential method to describe the cardiac segments and connections which in turn allows accurate, comprehensive and unambiguous description of CHD. It can also be applied to multiple imaging modalities such as echocardiogram, cardiac CT and MRI. The Van Praagh notation demonstrates a group of three letters, with each letter representative for a key embryologic region of cardiac anatomy: the atria, ventricles and great vessels. By using a 3-steps approach, we can evaluate complex CHD precisely and have no difficulties in communicating with other medial colleague. This pictorial essay revisits the logical steps of segmental approach, followed by a pictorial illustration of its application.

• Journal of Chest Surgery
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• 제20권3호
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• pp.489-497
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• 1987

Six hundred and twenty two cases of open heart surgery were performed at Sejong General Hospital in 1986. And also, 117 cases of non open heart cardiac surgery had been performed during same period. Among the 622 open heart cases, 548 were congenital cardiac diseases and 74 were acquired heart diseases. In congenital heart patients, 422 were acyanotic and 126 were cyanotic. There were 52 cases of infant open heart Surgery below 12 months. Acyanotic group were consisted of 314 VSD, 66 ASD, 13 AVSD, 9 PDA, 8 ASD + PS, 4 AS, and 8 other rare cardiac cases. And cyanotic group were consisted of 84 TOF, 15 DORV, 5 Trilogy, 4 Ebstein`s anomaly, 3 PS + TR, 3 TGA, 3 TAPVR, 3 Pulmonary atresia and 6 other rare cardiac diseases. Majority of the acquired heart cases were valvular heart diseases. And there were also 4 cardiac myxoma and one endomyocardial fibrosis in acquired heart disease group. The operative results were as follows: Overall operative mortality, 5.3%: acyanotic 2.4%: cyanotic 15.8% and acquired heart disease, 8.5%.

• Clinical and Experimental Pediatrics
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• 제64권6호
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• pp.269-279
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• 2021

Clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9 (CRISPR-Cas9) is an ancient prokaryotic defense system that precisely cuts foreign genomic DNA under the control of a small number of guide RNAs. The CRISPR-Cas9 system facilitates efficient double-stranded DNA cleavage that has been recently adopted for genome editing to create or correct inherited genetic mutations causing disease. Congenital heart disease (CHD) is generally caused by genetic mutations such as base substitutions, deletions, and insertions, which result in diverse developmental defects and remains a leading cause of birth defects. Pediatric CHD patients exhibit a spectrum of cardiac abnormalities such as septal defects, valvular defects, and abnormal chamber development. CHD onset occurs during the prenatal period and often results in early lethality during childhood. Because CRISPR-Cas9-based genome editing technology has gained considerable attention for its potential to prevent and treat diseases, we will review the CRISPR-Cas9 system as a genome editing tool and focus on its therapeutic application for CHD.

• Journal of Chest Surgery
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• 제26권5호
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• pp.360-364
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• 1993

From October 1989 to 1991 May, 100 cases of open heart surgery were performed under the cardiopulmonary bypass. 1. There were 47 male and 53 female patients ranging in age from 2 months to 64 years. 2. Of 100 cases of open heart surgery, 65 cases were congenital heart diseases, and 35 cases were acquired heart diseases. 3. In 65 cases of congenital heart diseases, there were 60 cases[92 %] with acyanotic heart anomaly and 5 cases [8 %] with cyanotic heart anomaly. 4. Among the 42 patients less than 15 years of age, 21 patients[50%] were below 10 kg and the operative mortality was 0.05 %. 5. The overall mortality was 4 %, and the operative mortality of congenital and acquired heart disease was 3.1% and 5.6%.

• Journal of Yeungnam Medical Science
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• 제3권1호
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• pp.215-219
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• 1986

영남대학교 의과대학 흉부외과학교실에서는 1986년 한해동안 111예의 개심술을 시행하였으며 그 결과는 다음과 같았다. 1. 전 111예중 선천성 심질환이 88예로 79.2%를 차지했고 후천성 심질환은 23예로 20.8%를 차지했다. 2. 환자의 연령은 선천성 심질환의 경우 생후 5개월에서 52세까지였고 후천성 심질환의 경우 14세부터 55세까지였다. 3. 남녀의 비는 선천성 및 후천성 심질환 모두 남자가 1.3배 많았다. 4. 선천성 심질환 88예중 심실중격결손증이 45예로 가장 많았으며 다음이 심방중격 결손증으로 16예였고 활로씨 4증후군이 14예였다. 5. 후천성 심질환은 심장판막질환이 대부분으로 23예를 차지했고 1예가 해리성대동맥류이었다. 6. 수술사망은 선천성 심질환에서 2예 후천성 심질환에서 1예로 총 사망율은 2.7%였다.

• Journal of Chest Surgery
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• 제19권1호
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• pp.116-121
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• 1986

Patients over 15 years of age who have undergone a surgical correction of a congenital cardiac malformation during period of January 1958 through January 1986 have been reviewed. During this period there were 3957 congenital cardiac lesions consisting of 2712 acyanotic and 1245 cyanotic cases. Among them, a total of 725 adults [18.3%] with a variety of congenital heart lesions, 548 acyanotic group and 177 cyanotic group were operated on. 372 patients were male and 252 patients were female. There were 280 patients under 20 years of age, 206 between 20-24 years, 102 between 25-29 years, 48 between 30-34 and 89 over 35 years. The most common defects were atrial septal defect which accounted for 207 cases [28.6%] and other common anomalies were VSD [140 cases, 19.3%], TOF [136 cases, 18.6%], PDA [120 cases, 16.6%] and PS [33 cases, 4.6%] in order of incidence. Overall operative mortality for this series was 3.6% [1.8% of a cyanotic group and 9.0% of cyanotic group] compared with 2.8% of total cases of congenital heart disease [acyanotic group 1.1% and cyanotic group 6.5%]. This reviewed series reveals the incidence of operable congenital heart defects appearing in any adult life and demonstrates that surgical repair can be accomplished with a satisfactory low mortality rate.

• Journal of Chest Surgery
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• 제19권3호
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• pp.399-406
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• 1986

131 cases of open heart surgery were performed in the Department of Thoracic and Cardiovascular Surgery, Kyungpook National University Hospital in 1985. There were 116 congenital cardiac anomaly and 15 acquired heart diseases. Out of 116 congenital cardiac anomaly, 73 cases of acyanotic group and 43 cases of cyanotic group were noted. In 73 cases of acyanotic group, 17 ASD, 52 VSD and 4 other acyanotic anomaly were noticed. In 43 cases of cyanotic group, 4 Trilogy of Fallot, 34 TOF, 1 Pentalogy, 3 DORV and 1 DCRV were included. Of the 15 acquired valvular heart disease cases, individual incidence was in mitral valve 10, double valve 3, and simple aortic valve 2 cases. Total number of valve replaced was 16, and 13 for mitral, 2 for aortic, and 1 for tricuspid in position, including 1 cases of double valve replacement. Overall operative mortality for 131 cases of open heart surgery was 4.5%, and the operative mortality was 5.5% in congenital acyanotic group, 2.3% in congenital cyanotic group, 0% in TOF group and 6.7% in acquired group.