• Journal of Veterinary Science
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• v.23 no.5
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• pp.64.1-64.9
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• 2022

Background: Fluralaner is a novel drug belonging to the isoxazoline class that acts on external parasites of domestic animals. It is used systemically via drinking water, especially against red poultry mite in layer chickens. Fluralaner is frequently used in layers infected with D. gallinae. However, no study to date has investigated the effects of feed intake and water hardness. Objectives: This study aimed to investigate the effects of variable water hardness and feed intake on the pharmacokinetic profile of fluralaner. Methods: Layer chickens were divided into four groups (n = 8): fed + purified water (Group 1), feed restricted + purified water (Group 2), feed restricted + hard water (Group 3), and feed restricted + soft water (Group 4). After administering a single dose of the drug with drinking water, the blood samples were collected for 21 days. Fluralaner concentrations in plasma samples were determined by liquid chromatography/tandem mass spectrometry. The maximum plasma concentration (C_max), time to reach maximum plasma concentration (t_max), area under the concentration-time curve values (AUC_0-21d), half-life (t_1/2), and other pharmacokinetic parameters were calculated. Results: Although the highest maximum plasma concentration (C_max) was determined in Group 1 (fed + purified water), no statistically significant difference was found in the C_max, t_max, t_1/2, MRT_{0-inf_obs}, Vz/F_obs, and Cl/F_{_obs} parameters between the experimental groups. Conclusions: It was concluded that the feed intake or water hardness did not change the pharmacokinetic profile of fluralaner in layer chickens. Therefore, fluralaner could be used before or after feeding with the varying water hardness in poultry industry.

• Journal of Life Science
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• v.10 no.5
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• pp.467-474
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• 2000

Male mice (ddY strain) were fed a laboratory chow diet containing the water extract from stem bark of Rhus verniciflua Stokes (RVS) for 14 days. There were no significant difference in body weight gain, feed intake, the hepatic lipid profile and serum total cholesterol and phodpholipid concentrations. The concentration of triglyceride in serum was significantly lower in the RVS group than that in the control group. The concentration of high-density-lipoprotein cholestrol in serum was significantly higher in the RVS group than that in the control group. The methanol extract from RVS stem bark effectively inhibited the formation of thiobarbituric acid-reactive substances as a marker of lipid peroxidation of liver microsomes in a concentration-dependent manner. This study showed that the water extract from stem bark of RVS decreased the serum triglyceride concentration and methanol extract has an antioxidative activity.

• Macromolecular Research
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• v.11 no.6
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• pp.467-470
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• 2003

The dielectrophoretic technique was used to prepare density gradient polymers, polystyrene doped with a dipolar modifier, diphenyl sulfide. We have measured concentration gradients of the dopant by UV/Nis spectroscopy as a function of time in a nonuniform electric field. Measured concentration data at different positions of the sample confirmed that a concentration gradient arose after a nonuniform electric field was applied to the system, these data were used to compare the concentration profile with that predicted by the dielectrophoresis equation.

• Journal of Korean Society for Atmospheric Environment
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• v.16 no.5
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• pp.539-544
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• 2000

A simple analytic model is proposed here to analyze the concentration deficit field caused by a large area of vegetated area. With non-dimensional deposition velocity chosen as small parameter, the regular perturbation method is exploited to derive the mass balance equation and the dynamic equations for the concentration deficit field, Analytic solutions to those equations are obtained in a closed form for several cases of interest, assuming that the concentration field is stationary and the plume can be nicely approximated as Gaussian for a point source. The results suggest that quite a negligible fraction (less than 1%) of the gaseous air pollutants emitted into the air is removed by the vegetated area of which width is 4 km in wind-wise direction, the typical dimension of the Restricted Development Zones around the metropolitan regions in South Korea.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.6 no.1
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• pp.29-38
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• 1994

Particle contamination into and out of a cavity-cylindrical cavities with aspect ratios(width/depth) less than, equal to 1 and langer than 1, and also three dianensional T's attached to a cylindrical flow tube was studied numerically, using a finite difference method. In the process of unsteady particle diffusion, the particles contained in a concentration boundary layer near the tube wall plays an important role in the initial stage, after which a quasi-steady concentration profile is developed inside the cavity, resulting in an exponential change of concentration with time. Average concentration and its rate of change are observed to be closely correlated by a power law function in terms of Reynolds number and the logarithm of Schmidt number. Effects of the three parameters-Re, Sc, and aspect ratio-are analysed and well explained.

• Biotechnology and Bioprocess Engineering:BBE
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• v.5 no.1
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• pp.65-70
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• 2000

An approximated analytical solution of mathematical model for the three phase fluidized bed bioreactor (TFBBR) was proposed using the linearization technique to describe oxygen utilization rate in wastewater treatment. The validation of the model was done in comparison with the experimental results. Satisfactory agreement was obtained in the comparison of approximated analytical solution and numerical solution in the oxygen concentration profile of a TFBBR. The approximated solutions for three modes of the liquid phase flow were compared. The proposed model was able to predict the biomass concentration, dissolved oxygen concentration the height of efficient column, and the removal efficiency.

• Mass Spectrometry Letters
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• v.3 no.4
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• pp.108-111
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• 2012

An experimental study on the nascent product of the OH heterogeneous reaction with NaCl was performed under dry and wet conditions using a bead-filled flow tube system coupled to a high-pressure chemical ionization mass spectrometer. The ozone concentration in the flow tube for the atomic hydrogen removal was varied in order to control the conversion reaction of molecular chlorine into HCl for the identification of the nascent product. The mass spectrometric observation was that the $O_3$ introduction reduced the concentration HCl, while it increased the concentration of $Cl_2$ and ClO. Based on the experimental results, we suggest that the nascent product of the titled reaction is gaseous $Cl_2$, which is followed by fast conversion into HCl in presence of H. No significant difference in the concentration profile between under dry and wet (RH = 2%) conditions was observed.

• Journal of Environmental Science International
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• v.28 no.4
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• pp.413-422
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• 2019

The objective of this study was to estimate the trends of air quality in the study area by analyzing monthly and seasonal concentration trends obtained from sampled data. To this aim, the mass concentrations of $PM_{2.5}$ in the air were analyzed, as well as those of metals, ions, and total carbon within the $PM_{2.5}$. The mean concentration of $PM_{2.5}$ was $22.7{\mu}g/m^3$. The mass composition of $PM_{2.5}$ was as follows: 31.1% of ionic species, 2.2% of metallic species, and 26.7% of carbonic species (EC and OC). Ionic species, especially sulfate, ammonium, and nitrate, were the most abundant in the $PM_{2.5}$ and exhibited a high correlation coefficient with the mass concentration of $PM_{2.5}$. Seasonal variations of $PM_{2.5}$ showed a similar pattern to those of ionic and metallic species, with high concentrations during winter and spring. $PM_{2.5}$ also had a high correlation with the ionic species $NO_3{^-}$ and $NH_4{^+}$. In addition, $NH_4{^+}$ was highly correlated with $NO_3{^-}$. Through factor analysis, we identified four controlling factors, and determined the pollution sources using the United States Environmental Protection Agency(U.S. EPA) pollution profile. The first factor, accounting for 19.1% of $PM_{2.5}$ was attributed to motor vehicles and heating-related sources: the second factor indicated industry-related sources and secondary particles, and the other factors indicated soil, industry-related and marine sources. However, the pollution profile used in this study may be somewhat different from the actual situation in Korea, since it was obtained from US EPA. Therefore, to more accurately estimate the pollutants present in the air, a pollution profile for Korea should be produced.

• Archives of Pharmacal Research
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• v.19 no.4
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• pp.297-301
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• 1996

Plasma profile of niflumic acid following oral administration of talniflumate tablets (Somalgen) was compared to that of niflumic acid tablets in man. Plasma niflumic acid was assayed by HPLC method. Plasma niflumic acid profile from the tainiflumate tablets was similar to that from the niflumic acid tablets resulting in no differences in $AUC, C_max, t_max$ and MRT. It demonstrates that talniflumate is a prodrug of niflumic acid, and undergoes extensive first-pass biotransformation to niflumic acid. However, plasma niflumic acid concentration at 30 min after tainiflumate dosing was significantly (p<0.05) higher than that of niflumic acid dosing. The more potent analgesic activity of talniflumate than niflumic acid might be related to this higher plasma drug concentration at the earlier phase. Considering that tainiflumate is less irritant to gastrointestinal mucosa than niflumic acid, talniflumate seems to be advantageous over niflumic acid in terms of activity and side effects.

• Asian Journal of Atmospheric Environment
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• v.9 no.1
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• pp.22-30
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• 2015

This study evaluated road shape and roadside barrier impact on near-road air pollution dispersion using FLUENT computational fluid dynamics (CFD) model. Simulated road shapes are three types, namely at-grade, depressed, and filled road. The realizable k-${\varepsilon}$ model in FLUENT CFD code was used to simulate the flow and dispersion around road. The selected concentration profile results were compared with the wind tunnel experiments. The overall concentration profile results show good agreement with the wind tunnel results. The results showed that noise barriers, which positioned around the at-grade road, decrease the horizontal impact distance (In this study, the impact distance was defined as the distance from road surface origin coordinate to the position whose mass fraction is 0.1.) lower 0.33~0.65 times and change the vertical air pollution impact distance larger 2.0~2.27 times than those of no barrier case. In case of filled road, noise barriers decrease the horizontal impact distance lower 0.24~0.65 times and change the vertical air pollution impact distance larger 3.33~3.55 times than those of no barrier case. The depressed road increase 1.53~1.68 times the vertical air pollution impact distance. It contributes the decrease of horizontal air pollution impact distance 0.32~0.60 times compare with no barrier case.